Gene SCYL2 (Sea Urchin)
SCYL2
Sequence
Protein domains of SCYL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SCYL2.AA | SCY1 | 38-316 | 35 | 8.70000000001e-126 | 424.19 | In-house | 1-337 (337) | Show / Hide |
Range on Protein: 38-316
Range on HMM: 1-337/337
Sequence Identity: 35% (118 aa)
WKIYHAVKRSTKQEAGVFVFEKKLLERFAKRDRD-PLLEILRKGSTQLTRLRHPCVLTVQHPLEETRESLAFATEPVFASLANILGCHDNMPS-------
|||. ..|..|.|| ||||.||..|. .| ... |.|.| ..|.|||||..|...|||||.. ....|||..|..|.| |. .|| .|
WKIHNGTKKYTGQECSVFVFDKKNIEKWHKDSWWEEICEFLKKQAKRLKRLRHPNILQYIHPLEESKDCMMYATEEIFQPLENVLKKWDNKKSCQTQKTQ
----------PIPPYIGEHKLFEVEIKYGLLQLTDALKFLHNDVHMVHGNITPASIILNSNGAWKLAG---------FDFVIPSSSPPDQPAIFPLREL-
|. . ..||.|.|...|..|..|||.|||||.||||.||.|.||..| ||.||..| .|||........|. ||..|.
DVDFGQNTQPQRPYHKKDWKLDELEVCWGIFQILDALSFLHNDCHMVHNNICPESIFVNKNGDWKIGGDDDDAGGWGMDFVCDIQNGNPQMPWFPCQEWR
------------MNDVSAVLQPNLNYLAPEYLLT-------------QSCDMSSDLFSLGMLMYSVINTGKLFHDCNEN-LSTFKQKSEQLRSLSISLLS
.|......|||...|||||... |.|...||.||||.|...|.|..|....||.| .|||....||....|.....
EMDYISVSSTKPDNKYPPPCQPNPDWLAPEYIHEDQHTPASYNWGQEQKCTWASDMFSLGCLIWWVYNGKKPQITCNSNPYSTFHRYMEQWNAMSHCWWD
SLPDGLKEY----VKMLLSTTPTIRPDADQLGKVNTE
..|. |.|. ...||...||.|||..|. .. .
HIPKELQEHLGHCYCHLLHQDPTCRPDPQQFLQHCYF
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| Kinase | SCYL2.AA | S_TKc | 23-319 | 16 | 8.9e-10 | -33.56 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 23-319
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)
YEIIRHVGSGGPGCLWKIYHAVKRSTKQEAGVFVFEKKLLERFAKRDRDPLLEILRKGSTQLTRLRHPCVLTVQHPLEETRESLAFATEPVFA---SLAN
|||.|..|.|. |. .| .| | | |.. | .|. | . .|| . . .. ..| . .| . .|
YEILRKIGKGAFGKVYKCRHKK-------TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFD
ILGCHDN------MPSPIPPYIGEHKLFEVEIKYGLLQLTDALKFLHNDVHMVHGNITPASIILNSNGAWKLAGFDFVIPSSSPPDQPAIFPLRELMNDV
.. . .| | .... . |. .||...|. . .| . |. | |.. |.. | .
YIKKRGRHGLRFPFP-------------E-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------------------
SAVLQPNLNYLAPEYLLTQSCDM-SSDLFSLGMLMYSVINTGKLFHDCNENLSTFKQKSEQLRSLSISLLSSLPDGLKEYVKMLLSTTPTIRPDADQLGK
. ..|.||| | . . ..| |.| ..| . |. . . .||. .. .|. .. .| |. || | .. .
-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
----VNTERNM
.. .
DEWDIKCHPWF
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| Kinase | SCYL2.AA | Ciliate-E2 | 134-248 | 17 | 4.6e-09 | 27.23 | In-house | 124-287 (365) | Show / Hide |
Range on Protein: 134-248 Range on HMM: 124-287/365 Sequence Identity: 17% (30 aa) YIGEHKLF------------EVEIKYGLLQLTD---------------ALKFLHNDVHMVHGNITPASIILNSNGAWKLAGFDFVIPSSSPPDQPAIFPL || ..|.. | |||| |... ||..||. . .| .| | |.. |.. | . . . .. .... YIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQ RELMNDVS-------------------AVLQPNLNYLAPEYLLTQS---------CDMSSDLFSLGMLMY .... . . . ...|.||| | .. | ..|..|||...| CKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY |
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| Kinase | SCYL2.AA | Ciliate-E2-Unclassified | 142-248 | 21 | 5e-06 | 16.8 | In-house | 137-261 (352) | Show / Hide |
Range on Protein: 142-248 Range on HMM: 137-261/352 Sequence Identity: 21% (28 aa) EVEIK-----YGLLQLTDALKFLHNDVHMVHGNITPASIILNSNG---AWKLAGFDFVIPSSSPPDQPAI-------FPLRELMNDVSAVLQPNLNYL-- | ..| . . |. ..|..|| . .| .|.| |....|| |...| . . . ..... .. ...|.... ..||. EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCG----TPNYMPQ --APEYLLTQSCD----MSSDLFSLGMLMY |||.| | | ..| .|||...| YTAPEVLQGQNYDHSKAYKCDIWSLGVILY |
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| Kinase | SCYL2.AA | Dicty3 | 142-190 | 20 | 5e-06 | 15.63 | In-house | 110-184 (351) | Show / Hide |
Range on Protein: 142-190 Range on HMM: 110-184/351 Sequence Identity: 20% (15 aa) EVEIKYGLLQLTDALKFLHNDVHMVHGNITPASIILNSNG--------------------------AWKLAGFDF | ||. . .|. .|...|.. | .|..|.. |.|. . ||| .|.. EHEISKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDIQCYYSNEINWKLIDFGL |
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| Kinase | SCYL2.AA | AGC | 222-248 | 41 | 1.6e-05 | 8.68 | In-house | 272-296 (395) | Show / Hide |
Range on Protein: 222-248 Range on HMM: 272-296/395 Sequence Identity: 41% (12 aa) NYLAPEYLLTQSCDMSSDLFS--LGMLMY .|.||| | .. . | | || ||| EYMAPEIL----YGKACDWWSFGLGCLMY |
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| Kinase | SCYL2.AA | urch | 222-244 | 41 | 1.9e-05 | 16.96 | In-house | 194-217 (217) | Show / Hide |
Range on Protein: 222-244 Range on HMM: 194-217/217 Sequence Identity: 41% (10 aa) NYLAPEYLL-TQSCDMSSDLFSLG ...|||..| |.| .|| .|.| CHIAPECVLDGQPCSIASDVYSVG |
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| Kinase | SCYL2.AA | RTKE | 223-256 | 32 | 3.3e-05 | 13.64 | In-house | 193-226 (293) | Show / Hide |
Range on Protein: 223-256 Range on HMM: 193-226/293 Sequence Identity: 32% (11 aa) YLAPEYLLTQSCDMSSDLFSLGMLMYSVINTGKL ..||| ...| .. .|| .. | |.. | | | . WWAPEVWKDQHFSFKSDVWAYGCLCWEVWNNGQM |
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| Kinase | SCYL2.AA | Akt | 223-248 | 40 | 4.2e-05 | 12.16 | In-house | 168-194 (264) | Show / Hide |
Range on Protein: 223-248 Range on HMM: 168-194/264 Sequence Identity: 40% (11 aa) YLAPEYLLTQSCDMSSDLFS-LGMLMY ||||| |. . .....| . || .|| YLAPEILNGNGHTKAVDWWGSLGCVMY |
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| Kinase | SCYL2.AA | WEE | 136-167 | 31 | 9.4e-05 | 11.96 | In-house | 104-135 (297) | Show / Hide |
Range on Protein: 136-167 Range on HMM: 104-135/297 Sequence Identity: 31% (10 aa) GEHKLFEVEIKYGLLQLTDALKFLHNDVHMVH . |.|.| .|. |... .|...|. .||| WNHWLPEWMIWQILVDICQGLHHIHSNCGMVH |
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| Kinase | SCYL2.AA | ERK7 | 140-188 | 28 | 0.000276 | 10.21 | In-house | 97-144 (292) | Show / Hide |
Range on Protein: 140-188 Range on HMM: 97-144/292 Sequence Identity: 28% (14 aa) LFEVEIKYGLLQLTDALKFLHNDVHMVHGNITPASIILNSNGAWKLAGF | .. .| . || |.|..| ...| . |. | |.|. |.. | LKDIHKQYIMYQLLRAIKYMHS-GNVIHRDLKPSNILLDSECMVKVCDF |
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| Kinase | SCYL2.AA | ERK7 | 23-41 | 47 | 0.014494 | 4.23 | In-house | 1-19 (292) | Show / Hide |
Range on Protein: 23-41 Range on HMM: 1-19/292 Sequence Identity: 47% (9 aa) YEIIRHVGSGGPGCLWKIY |||.. .| | | || | YEIRKRLGKGAYGIVWKAY |
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| Kinase | SCYL2.AA | WEE | 223-248 | 37 | 0.022937 | 3.83 | In-house | 199-227 (297) | Show / Hide |
Range on Protein: 223-248 Range on HMM: 199-227/297 Sequence Identity: 37% (11 aa) YLAPEYLL-TQSCDMS--SDLFSLGMLMY |.||| | .. .. .| ||||. .| YMAPEILQGYYHYTHLYKADIFSLGITIY |
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| Kinase | SCYL2.AA | Dicty3 | 222-247 | 39 | 0.091992 | 1.37 | In-house | 260-287 (351) | Show / Hide |
Range on Protein: 222-247 Range on HMM: 260-287/351 Sequence Identity: 39% (11 aa) NYLAPEYLLTQSCD--MSSDLFSLGMLM .| ||| .| .| .|| .||| .. HYMAPEIKLNNQCCACRKSDIWSLGCTV |
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