Gene Spk368 (Sea Urchin)

Spk368

Species: Sea Urchin
Alias: SPU_009852, Spk368
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
Spk368.AA Protein None 205 None Fasta, JSON
Spk368.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of Spk368.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Spk368.AA TKL-Sp1 1-196 27 1.2e-23 70.44 In-house 72-263 (263) Show / Hide 
Range on Protein: 1-196
Range on HMM: 72-263/263
Sequence Identity: 27% (56 aa)

MELIDGFTLNDAVFKYKL--KNLQTDRGKLTTAMKVSDAIAHIHSKGLTHSDIKPDNILIRLSDNEPFVCDLGLGHAVT---LSKNTSSGKRIPILKWAP
|. |.|  | . .|. .   |   .   |.   . |  |.  .|     | |||| |...      |..||||| |  .   .|  || .       . |
MQFIEGPSLHTVIFPDRDDVKIPLDWAKKMQISCEVLQAVTFMHACNILHLDIKPANVMVERATRRPYICDLGLAHIKNRNHMSQSTSMVNMRGTPCHMP

PESFKRHDVVTYAR---DVWSLACVLLEMFTGHRLWEDIASHRMGDEHDEELSIYEILHRFDGDNVTPDIISRVDNTAVRGALQSCFTKNPQERPSAKKL
||   ...         |.|| || ..|..   |||.| .         | ..    .  . |    |.|   || . |.  |. || . | .|||| .|
PEMVQKQEPGWRHPNKHDIWSVACTFVELYSMKRLWGDSM---------EFMALMRRI--LTGQMSKPEILTKVD-PKVQKILEPCFDQKPEKRPSAEDL

TEIF
 . |
LDQF
Kinase Spk368.AA Other-Unique 6-195 10 3.2e-18 58.86 In-house 1-249 (249) Show / Hide 
Range on Protein: 6-195
Range on HMM: 1-249/249
Sequence Identity: 10% (27 aa)

GFTLNDAVFKYKLKNLQTDRGKLTTAMKVSDAIAHIHSKG--------------------------------------------------------LTHS
.....  ....  |.... ..|.   ... . | |....                                                         ... 
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEHWMN

DIKPDNILIRLSDNEPFVCDLGLGHAVTLSKNTSSGKRI----------PILKWAPPESFKRHDVVTYARDVWSLACVLLEMFTGHRLWEDIASHRMGDE
. . .. |  | .|. ..||. . . .    |.   ...           . ..  .. .. . ....| .. |. ... |.|....|.| |  . .|. 
CCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFGCY

HDEELSIYEILHRFDGDNVTPDIISRVDNTAVRGALQSCFTKNPQERPSAKKLTEI
| .. ....|.|..|  .. |...|..|.  ..  .. |...   ..|....  ..
HFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase Spk368.AA TKL 31-196 15 2.5e-13 44.36 In-house 138-364 (364) Show / Hide 
Range on Protein: 31-196
Range on HMM: 138-364/364
Sequence Identity: 15% (36 aa)

AMKVSDAIAHIHS--------KGLTHSDIKPDNILIRLSDNE-------------PFVCDLGLGHAVTLSKNTSSG---------------KRIPIL---
|. .. .... ||        ... | |.|..|||.    .              . .||.||   .. |.| . .               .....    
ALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTP

KWAPPESFKRHDVVTYAR---------------DVWSLACVLLEMFTGHRLWEDIASHRMGDEHDEELSIYE----ILHRFDGDNVTPDIIS--------
 | .|| .. ..  | .                ||.| . || |..|. |           ......  |      .    ..|.  .  |         
RWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHK

-RVDNTA---VRGALQSCFTKNPQERPSAKKLTEIF
    ...   ..  .| |   .|..|||........
MCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Spk368.AA Ciliate-E1 1-112 20 3.5e-13 39.64 In-house 81-202 (202) Show / Hide 
Range on Protein: 1-112
Range on HMM: 81-202/202
Sequence Identity: 20% (25 aa)

MELIDGFT----LNDAVFKYKLKNLQTD-RGKLTTAMKVSDAIAHIHSKGLTHSDIKPDNILIRLSDNEPFVCDLGLGHAVTLSKNTSSGKRIPILKWAP
..| | ..    | . ..... .. | .   |.  ..   |... .|.....|.||||.||||  . ..   ||.|...   ...| .. ..  . . .|
CSLKDYLQNHNRL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYP

PESFK-------RHDVVTYARDVW
||  .       . . ..|  |. 
PEQYNCPEQEHNKNQKINYKSDIY
Kinase Spk368.AA Pkinase 34-196 21 8.2e-13 46.38 Pfam 117-293 (293) Show / Hide 
Range on Protein: 34-196
Range on HMM: 117-293/293
Sequence Identity: 21% (40 aa)

VSDAIAHIHSKGLTHSDIKPDNILIRLSDNEP----FVCDLGLGHAVTLSKNTSSGKRIPI--LKWAPPESFKRHDVVTYARDVWSLACVLLEMFTGHRL
.  .....||.|  | |.||.||||  .....     .|| ||   .      .|    .   . ...||  . .   ... |.||. |.| ||..|. .
ILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP

WEDIASHRMGDEHDEELSIYEILH-RFDGDNVTPDIISR-------------VDNTAVRGALQSCFTKNPQERPSAKKLTEI--F
. .       . ||.   |..|.. ... |  ... ||.               . . .  . .|..|.|..||.|. . .   |
FPGHC--WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Spk368.AA C8 19-118 27 5.2e-12 38.09 In-house 116-226 (226) Show / Hide 
Range on Protein: 19-118
Range on HMM: 116-226/226
Sequence Identity: 27% (30 aa)

KNLQ-TDRGKLTTAMKVSDAIAHIHSKGLTHSDIKPDNILIRLSDNEP---FVCDLGLGHAVTLSKNTSSGKR---IPILKWAPPESFKR----HDVVTY
|..| ..  |.  |... | .  ||.|   | ||||.|.|..|. |..     ||.|.  .|. .|.    |    .  ...  ||  |         . 
KQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAPEIEKKQDNQYKQYRI

ARDVWSLACVL
  |..|.  ||
QSDLFSVGLVL
Kinase Spk368.AA Ciliate-C8 15-118 20 1.3e-11 38.16 In-house 108-238 (238) Show / Hide 
Range on Protein: 15-118
Range on HMM: 108-238/238
Sequence Identity: 20% (27 aa)

KYKLKNLQ-TDRGKLTTAMKVSDAIAHIHSKGLTHSDIKPDNILIRLS-DNEPFV--CD------LGLGHAVTLSKN-TSSGK---RIPILKW-------
... |... ..  |.  |  . | .. .| .   | ||||.|.|  .. .. | .  ||      .|.  ... .|.  .| |    . ....       
RCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEMYFCGNWG

-APPESFKR-----HDVVTYARDVWSLACVL
  .||  |       |. .  .|..|.  ||
YFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase Spk368.AA S_TKc 7-196 14 5.7e-09 -45.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 7-196
Range on HMM: 1-231/231
Sequence Identity: 14% (39 aa)

FTLND--------AVFKYKLKN-------------------LQT-------------------------DR--GKLTTAMK-------------------
... .         |.| . |.                   .                           |   | | . .|                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

--VSDAIAHIHSKGLTHSDIKPDNILIRLSDNEPFVCDLGLGHAVTLSKNTSSGKRIPILKWAPPESFKRHDVVTY-ARDVWSLACVLLEMFTGHRLWED
  . .|....||.|  | |.||.|||.     .  .|| ||   .           .  . . .|| .      .. . |.||. |.| ||..|  ... 
YQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-

IASHRMGDEHDEELSIYEILHRFDGDNVTPDIISRVDNTAVRGALQSCFTKNPQERPSAKKLTE---------IF
           ..  .....                    ..  .. |..|.|..||.| .. .          |
-----------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Spk368.AA STE 37-136 25 1.6e-08 26.32 In-house 163-276 (359) Show / Hide 
Range on Protein: 37-136
Range on HMM: 163-276/359
Sequence Identity: 25% (32 aa)

A-IAHIHSKGLTHSDIKPDNILIRLSDNEPFVCDLG-LGHAVTLSKN--------------TSSGKR-----IPILKWAPPESFKR-----HDVVTYARD
.  ...||..  | ||||.|||.         . |   |..  |...              |...||      |   |  ||  ..      .  ..  |
GLLYYLHSHHIIHRDIKPANILL---------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQGRDKGYDTKCD

VWSLACVLLEMFTGHRLWEDIASHRM
.||| |...|| ||.  | |   .|.
IWSLGCTIIEMATGKPPWHDMHPMRA
Kinase Spk368.AA TK 31-123 17 5.1e-08 22.16 In-house 240-389 (486) Show / Hide 
Range on Protein: 31-123
Range on HMM: 240-389/486
Sequence Identity: 17% (26 aa)

AMKVSDAIAHIHSK------GLTHSDIKPDNILIRLSDN----------EPFVCDLGLG------HAVTLSKN----TSS--------------------
.. .... ...|||      .. | |.   |.|.  ...             ..| ||       .|  . ..    ..|                    
CWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYY

----GKRIPILKWAPPESFKR--------HDVVTYARDVWSLACVLLEMFT
    | ..|| .| .||...         . . | . ||||. ... |.||
RQQSGGKLPI-RWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase Spk368.AA GSK 37-58 54 4.2e-07 17.11 In-house 128-149 (328) Show / Hide 
Range on Protein: 37-58
Range on HMM: 128-149/328
Sequence Identity: 54% (12 aa)

AIAHIHSKGLTHSDIKPDNILI
..|..||.|  | ||||.|||.
GLAYLHSHGICHRDIKPQNILV
Kinase Spk368.AA TyrKc 7-196 14 6e-06 -126.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 7-196
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

FTLND--------AVFKYKL------------------------KNL-------------------------------------------QTDRGKLTTA
 ||..         |.| ..                        ..|                                           .  |.||...
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

MKVSDAI------AHIHSKGLTHSDIKPDNILIRLSDNEPFVCDLGLGHAVTLS-------KNTSS----GKR--IPILKWAPPESFKRHDVVTYARDVW
 ..| ..      ...|||.. | |.   |.|.        ..| ||  ...         .  ..    |..  .|| .| .||.. .. . | . |||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-RWMAPECI-NYGKFTTKSDVW

SLACVLLEMFT-GHRLWEDIASHRMGDEHDEELSIYEILHRFDGDNVTPDIISRV------DNTAVRGALQSCFTKNPQERPSAKKLTEIF
|   .. |.|| |   ..... .         .| .|.... .  .  |   .          ...    ..|   .| .||. . . |.|
SFGVCMWEIFTYGQQPYPGMIQQ--------MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Spk368.AA STE11-Unclassified 110-131 45 4.8e-05 13.9 In-house 220-241 (308) Show / Hide 
Range on Protein: 110-131
Range on HMM: 220-241/308
Sequence Identity: 45% (10 aa)

DVWSLACVLLEMFTGHRLWEDI
|.||| |. .||.|| . |...
DIWSLGCTVIEMATGKHPWSNC
Kinase Spk368.AA TK 175-196 31 7e-05 11.46 In-house 465-486 (486) Show / Hide 
Range on Protein: 175-196
Range on HMM: 465-486/486
Sequence Identity: 31% (7 aa)

LQSCFTKNPQERPSAKKLTEIF
.|.|. ..|..||. . | | .
MQQCWHYDPEDRPTFSQLHEQL
Kinase Spk368.AA STE 175-195 30 0.000142 12.21 In-house 334-359 (359) Show / Hide 
Range on Protein: 175-195
Range on HMM: 334-359/359
Sequence Identity: 30% (8 aa)

LQSCFTKNPQERPSAKKLTE-----I
.. |..|.|..||.|..| .     |
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase Spk368.AA STE11-Unclassified 42-58 64 0.000352 10.78 In-house 124-140 (308) Show / Hide 
Range on Protein: 42-58
Range on HMM: 124-140/308
Sequence Identity: 64% (11 aa)

HSKGLTHSDIKPDNILI
||.| .| |||..||||
HSHGIIHRDIKGANILI
Kinase Spk368.AA GSK 110-125 56 0.000549 7.41 In-house 201-216 (328) Show / Hide 
Range on Protein: 110-125
Range on HMM: 201-216/328
Sequence Identity: 56% (9 aa)

DVWSLACVLLEMFTGH
||||. ||. ||..|.
DVWSCGCVMAEMLKGQ
Kinase Spk368.AA STE11-Unclassified 158-192 34 0.01378 5.06 In-house 269-302 (308) Show / Hide 
Range on Protein: 158-192
Range on HMM: 269-302/308
Sequence Identity: 34% (12 aa)

VTPDIISRVDNTAVRGALQSCFTKNPQERPSAKKL
|  | || .. .. .  |. ||. .|..||.|  |
VC-DFISCWISQECKDFLRKCFQIDPKKRPTANQL