Gene Clik1 (Sea Urchin)

Clik1

Species: Sea Urchin
Alias: SPU_003710, Spk182, Clik1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: NKF4

Sequence

Name Sequence Type Origin Length Description Download
Clik1.AA Protein None 406 None Fasta, JSON
Clik1.kin_dom Protein Kinase Domain None 61 None Fasta, JSON

Protein domain

Protein domains of Clik1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Clik1.AA NKF4 102-296 38 1.3e-47 153.23 In-house 122-326 (336) Show / Hide 
Range on Protein: 102-296
Range on HMM: 122-326/336
Sequence Identity: 38% (82 aa)

LNAYLLSRHDRLNDDAYKSLMMQLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQ----AVVKVGDYGLTQVCG------SACNENYKPDG------QLA
.| ||||||.|||||.|||.||||||||.|||.|...|..|.||..|||||.|||    .||||.|.||  ||          ... |.          |
MNQYLLSRHPRLNDDTYKSFMMQLAQAMAHLHKNHIIHRDLKPYNIIIVEGRKGQSDLEPVVKVADFGLSKVCAGLAPRGKEGQQDNKNVNVNKCWLSTA

KSLDFYLPPEAADEGWGHPGQANTTTDIFMLGLMFSAMAEHAVLEGADQNEETIIATFVKFPGYGAVPIGKFLNTNPSINLDQHLHRK--LSHELRSLVR
   |||. ||     |   |      ||| ||..  || |      ..   | .. |..|  |   ||.|  |  || . |     |.  ..  .. |..
CGTDFYMAPEV----WE--GHYTAKADIFALGIIIWAMIERITFIDTETKKE-LLGTYIKQ-GTEIVPVGEALLENPKMELHIPQKRRTSMNERMKQLIK

RMTLSDVDSRPPA
 |       || |
DMLAANPQDRPDA
S_TKc Clik1.AA S_TKc 4-305 15 4.4e-10 -29.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-305
Range on HMM: 1-231/231
Sequence Identity: 15% (50 aa)

YIEVEKLRAGYFGTEYKYRERGIKGKERLAKLVPVSKRGKAKWVLEQYYR-KMVLRLPKHDNLVKIKAAFLNKVAEDGDDEEDMFLCTVWKVC--GENSL
|  ..|.  | ||. || |...  |..   | ..           |. .|   .|.  .|.|.||.. .| .         .......       |.   
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGD---

NLNAYLLSRHDR-----LNDDAYKSLMMQLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQAVVKVGDYGLTQVCGSACNENYKPDGQLAKSLDFYLPPE
 |  |. .|  .     ..    ...| |...|.|..||.|  |  | |  . . |      ..|..| ||  .              .  .. .|..||
-LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------TTFCGTP-WYMAPE

AADEGWGHPGQANT-TTDIFMLGLMFSAMAE-HAVLEGADQNEETIIATFVKFPGYGAVPIGKFLNTNPSINLDQHLHRKLSHELRSLVRRMTLSDVDSR
          . ..   |.  .| ..  |.      .    ......   .                              |.|.....|..   | . |
VL--------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKR

PPANGVIH-------MLTA
| |  . .       .   
PTA-EALQDEWDIKCHPWF
Kinase Clik1.AA PEK 124-166 34 1.2e-05 14.82 In-house 435-478 (655) Show / Hide 
Range on Protein: 124-166
Range on HMM: 435-478/655
Sequence Identity: 34% (15 aa)

QLAQAMEHLHSNGTAHNALTPYSVII-VEGVKGQAVVKVGDYGL
|.. .....||.|  |  |.|  . . ..| ..| .||.||.||
QILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGL
Kinase Clik1.AA NEK6 124-166 39 8.5e-05 11.44 In-house 111-149 (252) Show / Hide 
Range on Protein: 124-166
Range on HMM: 111-149/252
Sequence Identity: 39% (17 aa)

QLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQAVVKVGDYGL
||..|.||.||    |  . |  | |     .. .||.|| ||
QLCSALEHMHSKRVMHRDIKPANVFIT----ANGIVKLGDLGL
Pkinase Clik1.AA Pkinase 54-136 20 0.000138 17.3 Pfam 52-128 (293) Show / Hide 
Range on Protein: 54-136
Range on HMM: 52-128/293
Sequence Identity: 20% (18 aa)

KMVLRLPKHDNLVKIKAAFLNKVAEDGDDEEDMFLCTVWKVCG-ENSLNLNAYLL-SRHDRL--NDDAYKSLMMQLAQAMEHLHSNG
.. .|| .|.| |... .| .        . .. ... .  .| .  . | .|.  .|| ..   ..  |. | |.....|..||.|
QIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG
Kinase Clik1.AA MOK 109-165 28 0.000246 8.93 In-house 93-144 (283) Show / Hide 
Range on Protein: 109-165
Range on HMM: 93-144/283
Sequence Identity: 28% (16 aa)

RHDRLNDDAYKSLMMQLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQAVVKVGDYG
|   | ..  .  | || ....|.| ||  |    |  ..|      | ..|..|.|
RRHYLPQKKIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIK-----QDHLKLADFG
Kinase Clik1.AA NKF5 121-150 40 0.000289 8.96 In-house 17-46 (176) Show / Hide 
Range on Protein: 121-150
Range on HMM: 17-46/176
Sequence Identity: 40% (12 aa)

LMMQLAQAMEHLHSNGTAHNALTPYSVIIV
|..|.| |.  ||. |  | .|  | | |.
LLLQIADALRYLHFQGFIHRSLSSYAVHII
TyrKc Clik1.AA TyrKc 4-303 15 0.00033 -154.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-303
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)

YIEVEKLRAGYFGTEYKYRERGIKGKERLAKLVPVSKRGKAKWVLEQYYR--KMVLRL-PKHDNLVKIKAAFLNK----VAEDGDDEEDMFLCTVWKVCG
    .||  | ||. || . .     .   | .  ..       .|  .|  ..  .| ..|.|.|.. .. . .    .       ..  |. |   . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFM-------YIEPLMIVMEYMP

ENSLNLNAYLLSRHDRLNDDAYKSLMMQLAQAMEHLHSNGTAHNALTPYSVI----------IVEGVKGQAVVKVGDYGLTQVCGSA-----CNENYKPD
    .|. || .....|. .   | . | |. ||.|||.           .|          . |.     .||..| ||.   ..        . |.. 
H--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKK

G-QLAK--SLDFYLPPEAADEGWGHPGQANTTTD----------IFMLGLMFSA------MAEHAVLEGADQN-EETIIAT----FVKFPGYGAVPIGKF
. . .|       ..||. ..|       .| .|          || .| .         |    |.|  .|     . .                    
EHKGGKTMLPIRWMAPECINYG-----KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------

LNTNPSINLDQHLHRKLSHELRSLVRRMTLSDVDSRPPANGVIHML
                 . |. .. ..    | ..||  . ... .
------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Clik1.AA DCAMKL 121-166 26 0.000418 8.06 In-house 120-165 (279) Show / Hide 
Range on Protein: 121-166
Range on HMM: 120-165/279
Sequence Identity: 26% (12 aa)

LMMQLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQAVVKVGDYGL
.|..|..|...||. .  |  . |    ...   |.  .| .| ||
MMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGL
Kinase Clik1.AA TKL-Unique 124-166 22 0.000508 10.28 In-house 118-163 (290) Show / Hide 
Range on Protein: 124-166
Range on HMM: 118-163/290
Sequence Identity: 22% (11 aa)

QLAQAMEHLHSNG--TAHNALTPYSVIIVEG-----VKGQAVVKVGDYGL
. ||.|..||...  ..| .|.. .. ....     ..    .|. | ||
DIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWN----IKICDFGL
Kinase Clik1.AA MELK 109-166 31 0.00091 8.4 In-house 90-143 (254) Show / Hide 
Range on Protein: 109-166
Range on HMM: 90-143/254
Sequence Identity: 31% (18 aa)

RHDRLNDDAYKSLMMQLAQAMEHLHSNGTAHNALTPYSVIIVEGVKGQAVVKVGDYGL
|.|||...  . .. |.  |. ..|| | ||  | |  ... |  .    .|. |.||
RQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHH----LKLIDFGL