Gene Pink1 (Sea Urchin)

Pink1

Species: Sea Urchin
Alias: Pink1, SPU_013990, Spk181
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: NKF2

Sequence

Name Sequence Type Origin Length Description Download
Pink1.AA Protein None 747 None Fasta, JSON
Pink1.kin_dom Protein Kinase Domain None 196 None Fasta, JSON

Protein domain

Protein domains of Pink1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Pink1.AA NKF2 387-625 49 1.8e-156 526.15 In-house 115-365 (365) Show / Hide 
Range on Protein: 387-625
Range on HMM: 115-365/365
Sequence Identity: 49% (124 aa)

HPNIVLMHRAFVDDVRVPSLSSAVSLFDVALPVRLNPMGAGADTTMYIVMKRYRTSLRDYLSMECDLPDHTVMVIVAQLLEAVGYLGNQGVVHRDLKSNN
||||| | |||.| |||  |  |. .. ..|. |..| | | ..|||.||||||..||.||.|.|.....|.|...||.|||...|...||.|||.||.|
HPNIVCMFRAFCDSVRV--LPDAHEDYPDMLHQRYWPEGYGHNMTMYLVMKRYRCTLRQYLWMQCHPSYWTRMMMIAQMLEACDHLHQHGVAHRDMKSDN

ILVDYEEASGASPHVVIADFGCALSLRGRNLQDSVSVEDRNRQGNSALMAPEVTKGYHHDCLHYHDYLKADAWAVGAIIYEVCGQKNPFYS---------
|||.|....||.|..|||||||.|.......|...|..|..|.||..|||||...|.|..|.|.|||.|||.||.|||.||..||||||||         
ILVEYDFDDGACPWLVIADFGCCLACKHHGWQLPYSSWDVDRGGNACLMAPEIFTGAHPGCNHVHDYEKADTWACGAIAYEIFGQKNPFYSSSGGMAREQ

--DGVNSCG--YEAGDLPQL-QSQAVGLKIISKLLLQKDPGERPSAQVAANIL
  ....||.  |....|||. ||....|......|||.||..|||.|.|||.|
GEMHLDSCNSDYQEDQLPQMPQSCPPVLRQLVYNLLQRDPSKRPSPQIAANVL
Kinase Pink1.AA Pkinase 383-628 20 9.9e-27 95.59 Pfam 55-293 (293) Show / Hide 
Range on Protein: 383-628
Range on HMM: 55-293/293
Sequence Identity: 20% (60 aa)

LRSSHPNIVLMHRAFVDDVRVPSLSSAVSLFDVALPVRLNPMGAGADTTMYIVMKRYRT-----SLRDYLS--MECDL--PDHTVMVIVAQLLEAVGYLG
.| .||||| ....| |                             .. .|.||   .      .| ||.|  ... .  .....  .. |.|... |. 
KRLNHPNIVRLYDWFED-----------------------------KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH

NQGVVHRDLKSNNILVDYEEASGASPHVVIADFGCALSLRGRNLQDSVSVEDRNRQGNSALMAPEVTKGYHHDCL-HYHDYLKADAWAVGAIIYEVCGQK
..|..|||||. |||.| .   .|  .| |.|||.|  ..        ..    . | .  |||||       .. . ..  |.| |..| |.||..  .
SMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEV-------IRGGQYYGPKVDMWSCGCILYEMLCGR

NPFYSD------GVNSCGYEAGD-LPQLQSQ-----------------------AVGLKIISKLLLQKDPGERPSAQVAANILHL--L
 ||...        . . .. ..  .  ...                         ....|.. .|.||| .||.   |. ||.   .
PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW-CLCKDPKKRPT---AEQILQHPWF
Kinase Pink1.AA RRM 297-367 16 7.2e-18 66.61 SMART 1-121 (121) Show / Hide 
Range on Protein: 297-367
Range on HMM: 1-121/121
Sequence Identity: 16% (20 aa)

TLFVGNL--DRTIDKDELHDAF--------------CKFGDIVHIEIKK------------------------PQSAQPFAFLQFSNIDSVVKA--RKKL
|.|||||  . ......|...|               .||.||.. | .                              ||| .|.. ... ||   ...
TIFVGNLNDPWDVTEEDLREFFKDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDAEKAMVIEMM

D---GEYV--GKNK---VKTY
.   | ..  . ..   ..  
NASKGHEFRDDGRPTGHIRVK
Kinase Pink1.AA RRM_1 298-365 28 1.1e-16 60.57 Pfam 1-73 (73) Show / Hide 
Range on Protein: 298-365
Range on HMM: 1-73/73
Sequence Identity: 28% (21 aa)

LFVGNLDRTIDKDELHDAFCKFGDIVHIEIKK-----PQSAQPFAFLQFSNIDSVVKARKKLDGEYVGKNKVK
.||||| . .....| |.| |||.|..|.|..       .  .||| .| . ... || ....| ... ....
IFVGNLPWDCTEEDLRDLFSKFGPIESIRIMRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
Kinase Pink1.AA Ciliate-E2 461-627 16 1.5e-16 53.32 In-house 165-365 (365) Show / Hide 
Range on Protein: 461-627
Range on HMM: 165-365/365
Sequence Identity: 16% (41 aa)

IVAQLLEAVGYLGNQG-VVHRDLKSNNILVDYEEASGASPHVVIADFG-----------------CALSLRGR--------NLQDSVSVEDRNRQ-----
..|....|. || ... ..|||.| .|||.           . |.|||                 | . .  .        ...          |     
YIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD----------QIIQQN

------GNSALMAPEVTK--GYHHDCLHYHDYLKADAWAVGAIIYEVCGQKNPFYSDGVNSCGYEAGDLPQLQSQAVGLKIISK----------------
      |.   ||||. .  .|  . .. .   |.| |..| |.|| .  | ||                        ...| .                
MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------QQQIKQCKIDFPCPEWQKDTQC

--------------------L----LLQKDPGERPS-AQVAANILHL
                         .||||| .|.. .. . |   .
IQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Pink1.AA S_TKc 341-629 20 8.2e-15 40.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 341-629
Range on HMM: 1-231/231
Sequence Identity: 20% (65 aa)

FSNID--------SVVKARKKL-DGEYVGKNKVKTYFPNNHGYWENRPNGSLRSSHPNIVLMHRAFVDDVRVPSLSSAVSLFDVALPVRLNPMGAGADTT
.  ..        .| |.|.|  . ..  |      . .     ..         ||||| .. .|.|                              . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--------HHPNIVKLYDVFQD------------------------------DH

MYIVMKRYRT---SLRDYLSMECD------LPDHTVMVIVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIADFGCALSLRGRNLQDSVS
.|.||    .   .|.||.           .|  ..  ...|...|. |. ..|..|||||  |||.|         |. |.||| |  |          
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL----------

VEDRNRQGNSALMAPEVTKGYHHDCLHYHDYLKADAWAVGAIIYEVCGQKNPFYSDGVNSCGYEAGDLPQLQSQAVGLKIISKLLLQKDPGERPSAQVAA
   .   |    |||||           ... |.| |..| |.|| .  . ||.        ..  ..         .| . . .||||| .||.|  | 
---TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EAL

N-----ILHLLL
.      .|  .
QDEWDIKCHPWF
Kinase Pink1.AA CAMK-Unique 461-507 36 1.4e-13 40.97 In-house 162-218 (363) Show / Hide 
Range on Protein: 461-507
Range on HMM: 162-218/363
Sequence Identity: 36% (21 aa)

IVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEA--------SGA--SPHVVIADFG
|...||.|| |. .|..||||||  ||.| |..         ..     |....|||
IMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFG
Kinase Pink1.AA CDC2 410-507 27 3.9e-13 36.21 In-house 64-148 (301) Show / Hide 
Range on Protein: 410-507
Range on HMM: 64-148/301
Sequence Identity: 27% (28 aa)

VSLFDVALPVRLNPMGAGADTTMYIVMKRYRTSLRDYLSMECD----LPDHTVMVIVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIAD
|.|.||                 |.| ...   |. |. |.      .| ..|  .  |.|..| ..  ....|||||  |||.| . .      . |||
VKLHDVIHQ-----------NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN------IKIAD

FG
||
FG
Kinase Pink1.AA STE-Unique 464-575 21 1.3e-12 40.58 In-house 411-553 (616) Show / Hide 
Range on Protein: 464-575
Range on HMM: 411-553/616
Sequence Identity: 21% (33 aa)

QLLEAVGYLGNQG--VVHRDLKSNNILVDYEEASGASPHVVIADFGCALSLRGR---------------------------------NLQDSVSVEDRNR
|.||. .||  |.  ..|||||..||. . .   |   .|.|.||| | ..                                     | ....  ....
QILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGK-GRVCKVKICDFGHATCCQPDHFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCC

QGNSALMAPEVTKGY-----HHDCLHYHDYLKADAWAVGAIIYEVCGQKNPF
 |.   |.|||. .      ..|       .|.| |  |... . | .  |.
-GTPCYMCPEVINCRNQINNPYD-------TKVDIWSLGCMCFHMCCGCPPW
Kinase Pink1.AA Trio 464-520 33 3e-12 27.04 In-house 103-159 (258) Show / Hide 
Range on Protein: 464-520
Range on HMM: 103-159/258
Sequence Identity: 33% (20 aa)

QLLEAVGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIADFGCALSLRGR--NLQDS
|.|||| || |... | |.|. |....  .. .  | . |.||| | .| .    .|..
QMLEAVHYLHNCHILHLDIKPENMMMW--HYNAGRPQIKICDFGDAQQLWPHKVEPQHH
Kinase Pink1.AA CAMK 461-566 24 6.8e-12 33.88 In-house 184-325 (425) Show / Hide 
Range on Protein: 461-566
Range on HMM: 184-325/425
Sequence Identity: 24% (35 aa)

IVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEASG----------ASPH-VVIADFGCALSLRG------RNLQDSVSVEDRN-------------RQG
.. |...|| |. ....||||||  |||.|. . .            . . . |.||| |  ...       . ... .   .|             . |
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCG

NSALMA-PEVTKGYHHDCLHY-----HDY--LKADAWAVGAIIY
  . || ||| .| .|.   .     ..|   |.| |..| | |
TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase Pink1.AA CAMKL 461-507 38 1.2e-11 33.32 In-house 132-174 (297) Show / Hide 
Range on Protein: 461-507
Range on HMM: 132-174/297
Sequence Identity: 38% (18 aa)

IVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIADFG
.  |...|| |. ..|.||||.|  |||.|.   .     . |.|||
YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN----NIKIIDFG
Kinase Pink1.AA STE 26-509 5 1.7e-11 36.93 In-house 83-194 (359) Show / Hide 
Range on Protein: 26-509
Range on HMM: 83-194/359
Sequence Identity: 5% (28 aa)

HYSRDSRDGYRDENSMSPSAYREGRSRERTSYNRNYYSQHSRGNSGDTPYTQDQSETYFKENFTSSRSDGDGFSDSGSRKSRTKANQRTGSGTTNHSHSP
. ...                                                                                               
KKCNH-----------------------------------------------------------------------------------------------

RSVRSRSFSRSRSRSRSRSRSTDSRSSVSGSDNWSRRSQCSKDPESDRESRNTENTQSSGSSLKYSGLCVRNLPSRSSDSSIKDGLFHEFKKYGQVTAVT
                                                                                                    
----------------------------------------------------------------------------------------------------

VQGAGDDRVGIVFFKRTEDMEKAMSASKGKLFFGCEMKLSPWEGAADISVDDSEVKYFEKELDEFHPRATRTLFVGNLDRTIDKDELHDAFCKFGDIVHI
                                                                                                    
----------------------------------------------------------------------------------------------------

EIKKPQSAQPFAFLQFSNIDSVVKARKKLDGEYVGKNKVKTYFPNNHGYWENRPNGSLRSSHPNIVLMHRAFVDDVRVPSLSSAVSLFDVALPVRLNPMG
                                                             |||||  . ..... .                       
-----------------------------------------------------------M-HPNIVKYYGCYFKEGHN----------------------

AGADTTMYIVMKRYR-TSLRDYLS----MECDLP----------DHTVMVIVAQLLEA-VGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIADFGCA
 ..|.. .|.|      ||.| .     . ..|.           . . .|. |.|..   || .....|||.|. |||.           | ..|||..
HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----------VKLCDFGVC
Kinase Pink1.AA Ciliate-E2-Unclassified 429-627 16 1.8e-11 36.07 In-house 93-352 (352) Show / Hide 
Range on Protein: 429-627
Range on HMM: 93-352/352
Sequence Identity: 16% (46 aa)

DTTMYIVMKRYR-TSLRDYLS----------------ME-CDLPDHTVM-----VIVAQLLEAVGYLGNQG-VVHRDLKSNNILVDYEEASGASPHVVIA
. ..||||   .  .|..|..                .. . ...  .       . ||.|..  ||  .. ..|||.| .|||.| .       .. |.
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---NYYIKII

DFGC-------------------------ALSLRGRNLQDSVSVEDRNRQGNSALMAPEVTKGYHHD---CLHYHDYLKADAWAVGAIIYEVCGQKNPFY
|||                          . .  | .   . .           . |||| .| ..|           |.| |..| |.|| . .. |||
DFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q-----------YTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLFGYYPFY

SDGVNS---------C-----GYEAGDLPQ-------------LQSQAVGLKIIS---KLLLQKDPGERPSAQVAANILHL
.   ..         .      ..   . .              ...  .  .|.   . .|.|.|..|.... . |   .
DNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Pink1.AA RRM 192-265 13 1.9e-05 25.24 SMART 1-121 (121) Show / Hide 
Range on Protein: 192-265
Range on HMM: 1-121/121
Sequence Identity: 13% (17 aa)

GLCVRNLPSRSSDSSIKDGLFHEF--------------KKYGQVTAVTVQGAGD-------------------------DRVGIVFFKRTEDMEKA--MS
 . |.||.   ...  .. |   |              ...| .. . .    |                            . | |.  ||.|||  ..
TIFVGNLN--DPWDVTEEDLREFFKDMHSVHIHQCNCCSQFGPIVDCRIMRDKDNIHYYRCSRFCQMHQLGKNSNTGRSRGFAFVEFEDEEDAEKAMVIE

ASK---GKLF--FGCE---MKLS
.     |. |   | .   ....
MMNASKGHEFRDDGRPTGHIRVK
Kinase Pink1.AA TyrKc 390-625 16 0.000538 -158.02 SMART 1-280 (280) Show / Hide 
Range on Protein: 390-625
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

IVLM-----------HRAFVDDVRVPSLSSAVSLFDVALPVRLNPMGAGADTTMYI----VMKRY--------------RT-------------------
|.|            ...  .              .||  |     .|     . .    .|...              ..                   
ITLGKKLGEGAFGEVYKGTWK-------------IQVA--VKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

--SLRDYL-SMECDLPDHTVMVIVAQLLEAVGYLGNQGVVHRDLKSNNILVDYEEASGASPHVVIADFGCALSLRGR-NLQDSVSVEDRNR---QGNSAL
  .|.||| . . .|.  .   .  |  .   ||  ....||||   |.||. .       .| |.||| .  .    .     .   | .   .|.. |
HGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTML

----MAPEVTKGYHHDCLHYHDYLKADAWAVGAIIYEV---CGQKNP------FYSDGVNSCGYEAGDLPQLQS--------QAVGLKIISKLLLQKDPG
    ||||.         ..    | | |. |  ..|.   ..|  |         . |  .  . . .|| ..            .  | |   . || 
PIRWMAPECI-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE

ERPSAQVAANIL
.||. .    ..
DRPTFSEIHECF
Kinase Pink1.AA RRM_1 193-263 27 0.007341 12.76 Pfam 1-73 (73) Show / Hide 
Range on Protein: 193-263
Range on HMM: 1-73/73
Sequence Identity: 27% (22 aa)

LCVRNLPSRSSDSSIKDGLFHEFKKYGQVTAVTVQGAGD--------DRVGIVFFKRTEDMEKAMSASKGKLFFGCEMK
. |.|||   ... ..|     |.|.|... . .    |         ... | |.  ||.|||..|  || | |.|..
IFVGNLPWDCTEEDLRD----LFSKFGPIESIRI--MRDNTRETGRSRGFAFVEFEDHEDAEKAIQAMNGKEFNGREIR
Kinase Pink1.AA Trio 607-619 53 0.058467 0.09 In-house 238-250 (258) Show / Hide 
Range on Protein: 607-619
Range on HMM: 238-250/258
Sequence Identity: 53% (7 aa)

LLQKDPGERPSAQ
.|| || .||.|.
VLQEDPWKRPCAS