Gene NEK1a (Sea Urchin)

NEK1a

Species: Sea Urchin
Alias: Spk171, NEK1a, SPU_019021
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
NEK1a.AA Protein None 1429 None Fasta, JSON
NEK1a.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of NEK1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK1a.AA NEK1 4-258 67 8.99999999999e-206 689.89 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-276/276
Sequence Identity: 67% (187 aa)

YIKKKQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESFEERGN--LYIVMDYCDGGDLYQAINRR--KGVL
|...|||||||||||.|||.|.||..|||||||..||..||.|||..|||.|.||||||||.|.|||||.|.  |||||.|||||||.|.|||.  ||.|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLT--RKG---------------IVKMGDFGIARVLNNTMELARTCIGTPYYLSPEMCENKPYNN
|.||.||.||.||||||.|.||||||||||||||||||  ..|               .||.|||||||.||.|||.|.||||||||||||.|.||||||
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWALGCVLYETLTLKHAFEAGNMKNLVLKIIRGSYPPVSPRYSYEVRNLVAQLFKRSARDRPSINSVLKKPFV
|||||.|||||||..||||.|||.|.|||||||..|.|||..|.||||...||.|.|||..|.|||.|..|..||.
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK1a.AA NEK 4-258 51 1e-169 570.11 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-286/286
Sequence Identity: 51% (148 aa)

YIKKKQIGEGSFGKALLVKSKADGKE-----YVIKEINISKMKRKEKEESK-KEVAVLRKMKHPNIVSYAESFEERG--NLYIVMDYCD-GGDLYQA---
| . |.||.|||||. .|..| |||.     ||.|.||...|..|||...  .|| .|...||||||.| .||.|..   |.|||.||. ||||||    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

INRRK--GVLFPEDEIMDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTRKGI----VKMGDFGIARVLNNTMELART-CIGTPYYLSPEMCENKP
|...|  | .|.|..|.|||.|.|||||..|||     ||||||||.||||||....    ||.|||||..|||.|...|.| ..|||||.|||.|.|||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNNKSDIWALGCVLYETLTL--KHAFEAG--NMKNLVLKIIRG-SYPPVSPR--YSYEVRNLVAQLFKRSARDRPSINSVLKKPFV
||||||||.|||||||  ||  ||.|||   ||..|..||..|  |||....  || . .||. |.....  .|||.|..|..||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK1a.AA NEK8 4-258 42 5.69999999999e-137 393.64 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

YIKKKQIGEGSFGKALLVKSKADG--KEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESFEERGNLYIVMDYCDGGDLYQAINRRKGVLFP
|..   .| |.|| . |   |.|.  .  ..|.|| . |  ||      |. || .  ||||.|| ..|.| . | |.| |.||| ||| |..... || 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EDE-----------------IMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRK-GIVKMGDFGIARVLNNT--MELARTCIGTPYYLSPEMCENKPYN
| .                 | . |.|.|.|. |.|.  |||||.| ||||.||  ..|| |||||. ..|    |  ..| .|||||.|||||| ||||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

NKSDIWALGCVLYETLTLKHAFEAGNMKNLVLKIIRG-SYPPVSPRYSYEVRNLVAQLFKRSARDRPSINSVLKKPFV
.|||.||||||||| ..|| |||| |  .||.||...  | |.| .|| |.| || .. .  .  |||   ... | .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK1a.AA NEK4 4-258 47 7.79999999999e-131 440.96 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-257/257
Sequence Identity: 47% (123 aa)

YIKKKQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESFEERGN--LYIVMDYCDGGDLYQAINRRKGVLFP
|   |..| ||.|   ||... |.| ||.| ..  .  |.|. .  .|. .| ..||||||.| ||.|   .  ||||| .|.|||||.   ..|. . .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIVKMGDFGIARVLNNTMELARTCIGTPYYLSPEMCENKPYNNKSDIWALGCVLYETLTLKH
|  ...||||| .||   |...||||| | ||||||.| |.|.|||||.|||||  ..|.| ||||||.|||.  |.||. |||||.||| .||  ||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

AFEAGNMKNLVLKIIRGSYPPVSPRYSYEVRNLVAQLFKRSARDRPSINSVLKKPFV
||.| .|  |. .|| |  ||..| || .  ||| |. ..   .|||| .....|..
AFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK1a.AA S_TKc 4-258 31 3.1e-92 313.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

YIKKKQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESFEERGNLYIVMDYCDG--GDLYQAINRRKG----
| . ..||.|.|||  ... | .|... ||.|.         |  ..|...|.| .||||| . ..|.. ..||.||.||||  |||.. | .|..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

VLFPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIVKMGDFGIARVLNNTMELARTCIGTPYYLSPEMCENKPYNN-KSDIWALGCVLYET
. ||| ..  .. |||.||.. |...|.|||.| .||.|..   .| .|||.||.|       .|..|||.|..||..   .|.  |.|.|..||.||| 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTLKHAFEAGNMKNLVLKIIRGSYPPVSPRYSYEVRNLVAQLFKRSARDRPSINSVLK-------KPFV
|. .  |.     ....|.|.          | |..... .....  ..||..  .|.        |..
LCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK1a.AA Pkinase 4-258 26 1.6e-81 281.94 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-293/293
Sequence Identity: 26% (78 aa)

YIKKKQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKK--EVAVLRKMKHPNIVSYAESFEERGNLYIVMDYCDGG----DLYQAIN-RRK
| ....||.||||.  . . | .||....|.|. .. | .....  .  |........||||| . ..||.....|.||.||.||    ||.  |  .|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GVL-FPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIV----KMGDFGIARVL-NNTMELARTCIGTPYYLSPEMCE-NKPYNNKSDIWAL
|.. |.|.|. ... ||. .|.. |...|.|||.|..||.. ..| .    | .|||.|... .   . . |  |||.|..|| .  ...|  |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVLYETLTLKHAFEAG------NMKNLVLKIIRGSYPPVSPRYS--------------------YEVRNLVAQLFKRSARDRPSINSVLKKPFV
||.||| |. .  |         ... .. .| .. ..  .|  .                     | . ..  ....   .||..  .|. |..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK1a.AA NEK-Unclassified 4-258 38 1.9e-81 269.42 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-258/258
Sequence Identity: 38% (100 aa)

YIKKKQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESFEERGNLYIVMDYCDGGDLYQAINRRKGV--LFP
| |   .| |  |   ||. .   .  | .   ||| |.| |   |  . .| ...|| || | .|| |   |.   ||||||.| . | .. .    | 
YDKITTLGQGGGGAVYLVRHQISKRHLVQQ---ISKRKKKKKRQNK--IIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIVKMGDFGIARVLNNTMELARTCIGTPYYLSPEMCENKPYNNKSDIWALGCVLYETLTLKH
|  || |..|.  |.  .| |||.||| | ||||||   .| ||||||.|... | . ||||.||. ..||| |. .||||.||.|.|||..||  |   
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEP

AFEAGNMKNLVLKIIRGSY------PPVSPRYSYEVRNLVAQLFKRSARDRPSINSVLKKPFV
.| . ||  .  || ..         |||  ||    ...  . .|    |||   ..  ...
FFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase NEK1a.AA CAMK 9-258 19 5.6e-74 237.57 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-258
Range on HMM: 1-425/425
Sequence Identity: 19% (84 aa)

QIGEGSFGKALLVKSKADG------------KEYVIKEINISKMK--------------------------RKEKEESKKEVAVLRK-------MKHPNI
..|.|||||  |.. | ..            ... || |. .|.|                           | ... ..|.....|       ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYAESFEERGN-------------------LYIVM---DYCDGG----DLYQAINRRKG-------------VLFPEDEIMDWFVQICLALKHVHDRKI
..  | .| . .                   .|.||   .||.||    ||.. | ....               |.|.|   .| ||| |... |...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDIKSQNIFLTRK-----------------GIVKMGDFGIARVLNN-----------------------TMELARTCIGTPYYLS-PEMCEN------
 |||.|  || |. .                 . .|  ||| |....                        . .. .|. |||.| . ||. .       
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KPYNNKSDIWALGCVLYETLTLKHAFEAG-------------NMKNLVLKIIRGSYPPVSPRYSY-----------------------EVRN
        ..|. |.|.|..|..||  |. .  |..              |...|  ||..| |   .|  |                        |...
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVAQLFKRSARDRPSINSVLKKPFV
|. .. ..   .|..|  .|. |..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase NEK1a.AA ULK 4-258 29 2.7e-71 243.19 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-329/329
Sequence Identity: 29% (98 aa)

YIKKKQIGEGSFG---KALLVKSKAD--GKEYVIKEINISKMKRKEKEES--------KKEVAVLRKMK--------HPNIVSYAESFEER--GNLYIVM
|......|.||||   |.  .|.| |  .. ...| | ..||..|..|          |.|. ...|.|        ||||| . . ||.    |.||.|
YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

DYCDGGDLYQAINRRKG--------VLFPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRK------------GIVKMGDFGIARVLNNT-M--
.||.|||| | |...|.          ..|.|.   | ||. ..|. |...| ||||| ||| .. .            |..| .||| |....|  |  
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

ELARTCI------GTPYYLSPEMCE----NKPYNNK-SDIWALGCVLYETLTLKHAFEAGNMKNLVLKIIRGS-------------YPPVSPR------Y
... ||       |||.| .|.  .    .|||... .||| |||..|| |. |  |.|     ..|.||.                |.  |        
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SYEVRNLVAQLFKRSARDRPSINSVLKKPFV
| |...|  .....  .|| |.  ... |..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase NEK1a.AA NEK2 8-258 33 3.1e-69 232.25 In-house 5-319 (319) Show / Hide 
Range on Protein: 8-258
Range on HMM: 5-319/319
Sequence Identity: 33% (106 aa)

KQIGEGSFGKALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKMKHPNIVSYAESF--EERGNLYIVMDYCDGGDLYQAINRRKG--VLFPED
. ||.||||.   |. | |||  | |||.  .|  ||.     |. .||. |||||| |      ..   ||||| || |||| | | . .     ..| 
YTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEE

EIMDWFVQICLALKHVHD---------------------RKILHRDIKSQNIFLTRKGI---------------------------------------VK
 |   . |.|.||. .|                      . |||||||  ||||  ..                                        ||
FIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQVVVK

MGDFGIARVLNNTMELARTCIGTPYYLSPEMCENKPYNNKSDIWALGCVLYETLTLKHAFEAGNMKNLVLKIIRGSYPPVSPRYSYEVRNLVAQLFKRSA
 |||| ||.||     | | .||||| |||  .  .|| |||||..||..||  .|.  |.| | . |  ||  | . ..  .|| .   ...   .   
LGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMINVDH

RDRPSINSVLKKPFV
. ||||.  |. |..
YHRPSIEEILQHPQI
Kinase NEK1a.AA ULK 4-258 29 1.6e-68 233.92 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

YIKKKQIGEGSFG----KALLVKSKADGKEYVIKEINISKMKRKEKEES--------KKEVAVLRKMK---HPN--IVSYAESFEER--GNLYIVMDYCD
|......|.||||    |.  .|..  .. . .| |...||. |..|          |.|. ...|.|   |||  || . . ||.    |.||.|.||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLYQAINRRKG-------VLFPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRK------------GIVKMGDFGIARVLNNTM---ELART
|||| | |...|.         ..|.|.   | ||| ..|. |...| ||||| ||| .. .            |..| .||| |....| .    .  |
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CI------GTPYYLSPEMCE----NKPYNNK-SDIWALGCVLYETLTLKHAFEAGNMKNLVL---KIIRG---------SYPPVSP------RYSYEVRN
|       |||.| .|.  .    .|||... .||| |||..|| |. |  |..    ...|   | |.            |   |        | |...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LVAQLFKRSARDRPSINSVLKKPFV
|  .....  .|| |.  ... |..
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase NEK1a.AA Ciliate-E2 4-258 22 9e-68 231.47 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-258
Range on HMM: 1-365/365
Sequence Identity: 22% (84 aa)

YIKKKQIGEGSFGKALLVKSKADGKEY------------------VIKEINISKMKRKEKEESKKEVAVLRKMK----------------HPNIVSYAES
|.. |.||.|.||.  ..| . ..|..                   ||....  || ...|. |.|  ..|...                ||||. . |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--ERGNLYIVMDYCDGGDLYQ-----AINRRKGVL----FPEDEIMDWFVQICL---------------ALKHVHDRK-ILHRDIKSQNIFLTRKGIV
|.   . |.|.||.||.||||..      ..| .       | | || . . ||.                ||.. | .. |.||||| .||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KMGDFGIARVLNNTME-------------------------------LARTCIGTPYYLSPEMCENKP---------YNNKSDIWALGCVLYETLTLKHA
|  |||... ... ..                               ...|..|||.|..||. ..|.         |. |.|||.||..||| |. |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEAGNMKNLVLKIIRG---SYPPV---------------SPRYSYEVRNLVAQ----LFKRSARDRPS-INSVLKKPFV
|         ...|     ..|.                    | |. .|  .    ....    |.. .. .|. |. 
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK1a.AA TyrKc 4-265 19 8e-18 65.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

YIKKKQIGEGSFG---KALLVKSKADGKEYVIKEINISKMKRKEKEESKKEVAVLRKM--KHPNIVS---YAESFEER----GNLYIVMDYCDGGDLYQA
  ..|..||| ||   |. .        .  .| .. ..     .|.  .|  ...|   .|||||    .. . ...    . |.||| |...||| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

INRRKGVLFPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIVKMGDFGIARVLNNT------MELART-----CI--GTPYYLSPEMCENK
. ....  .. ..  .. .||.    . |.... |||.   |. ......|| .||| .| . .        .  |.     .        ..||    .
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

PYNNKSDIWALGCVLYETLTLKHAFEAG------NMKNLVLKIIRGSYPPVSPR--------YSYEVRNLVAQLFKRSARDRPSINSVLKKPFVQKRIEK
 .. |||.|. | ...| .|.      |      . . .. .. .| ..|  |          . |. ..  |  .. . |||. . .         .|.
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI---------HEC

F
|
F
Kinase NEK1a.AA Pkinase_Tyr 50-156 26 2.8e-17 59.13 Pfam 52-164 (270) Show / Hide 
Range on Protein: 50-156
Range on HMM: 52-164/270
Sequence Identity: 26% (30 aa)

KEVAVLRKM-KHPNIVS-YAESFEERGN--LYIVMDYCDGGDLYQAINRR--KGVLFPEDEIMDWFVQICLALKHVHDRKILHRDIKSQNIFLTRKGIVK
.|....... .|||||. |.   ....   .|||| |. .|||.    ..   .  ..  .. .. .||. .. . ..... |||.   |. .|....||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

MGDFGIARVLNNT
 .||| || . |.
ICDFGLARDIYND
Kinase NEK1a.AA Pkinase_Tyr 183-199 41 0.159921 5.78 Pfam 194-210 (270) Show / Hide 
Range on Protein: 183-199
Range on HMM: 194-210/270
Sequence Identity: 41% (7 aa)

KSDIWALGCVLYETLTL
|||.|. | ...| .|.
KSDVWSFGVLMWEIFTY
Kinase NEK1a.AA Pkinase_Tyr 4-17 42 1.229388 2.78 Pfam 1-14 (270) Show / Hide 
Range on Protein: 4-17
Range on HMM: 1-14/270
Sequence Identity: 42% (6 aa)

YIKKKQIGEGSFGK
 .. |..|||.||.
ITFGKKLGEGAFGE