Gene IKKe (Sea Urchin)

IKKe

Species: Sea Urchin
Alias: IKKe, SPU_007638, Spk163
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
IKKe.AA Protein None 953 None Fasta, JSON
IKKe.kin_dom Protein Kinase Domain None 213 None Fasta, JSON

Protein domain

Protein domains of IKKe.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IKKe.AA IKK 39-323 46 2.3e-157 529.07 In-house 1-297 (297) Show / Hide 
Range on Protein: 39-323
Range on HMM: 1-297/297
Sequence Identity: 46% (138 aa)

IFLDTPLGQGATSKVYGGRHKKLGKRVACKVPHTANLFRMGTDMERESQVLLRLRNQ-------NIVCLEAIEKD---QISKENILIMELCTGGSLYDVL
......|||||...||..||||.|..||.|........|. ....||.....||..|       ||.||..||.|   ||.|.....||.||||.||..|
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL

EKPENSCGLAE-KAFLQVLADMTAGMKYLR-DNGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDDENFTSLHGTEEYLHPKVFERAVLRKPAAL
..|.|.|||.| ..||||..|..|||..|. .||.||||.|||||||.|...|.||||..|||.||...|||.|.|..||||||||...||||||||.. 
NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK

PFDARIDLWSIGATLYHLATGQLPFRPHGG-RKNSRMMFHLTTKKAPGVISGVQTGPLDHEITWSRELPETCRLSIGLKKLITPLLAGLLESNPSTVW
|..|..|.||.|.|.||.|||.|||.||.. |..   | | ||.|. ||..|||   .  .. || .||..|.|. .......|... .|| ..   |
PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEE-MNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW
Kinase IKKe.AA S_TKc 39-335 22 1e-40 142.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 39-335
Range on HMM: 1-231/231
Sequence Identity: 22% (70 aa)

IFLDTPLGQGATSKVYGGRHKKLGKRVACKVPHTANLFRMGTDMERESQVLLRLRNQNIVCLEAIEKDQISKENILIMELCTG--GSLYDVLEKPENS--
  .  ..|.|| .||| .|||| |..||.|. .         ...|| |.| . .  ||| |  .  |   ..  ..||.| |  |.|.|...|      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-CGLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDDENFTSLHGTEEYLHPKVFERAVLRKPAALPFDA-RI
 ... |     ... .  ...|. ..|..|||.|| ||.. .        |..||| ||||      |.. || .|. | |.           ...  ..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC

DLWSIGATLYHLATGQLPFRPHGGRKNSRMMFHLTTKKAPGVISGVQTGPLDHEITWSRELPETCRLSIGLKKLITPLLAGLLESNPSTVWSFQHFFQ--
| ||.| .|| ...|. ||.      .  |||..                                     . ..  .. ..|. .|.  ..    .|  
DWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE

----ASQAI
    . . .
WDIKCHPWF
Kinase IKKe.AA Pkinase 39-257 26 3e-36 129.25 Pfam 1-221 (293) Show / Hide 
Range on Protein: 39-257
Range on HMM: 1-221/293
Sequence Identity: 26% (63 aa)

IFLDTPLGQGATSKVYGGRHKKLGKRVACKVPHTANLFRMGTDME----RESQVLLRLRNQNIVCLEAIEKDQISKENILIMELCTGG----SLYDVLEK
. .  ..|.|. ..|| ..||. ||.||.|.       ... |..    .| |...||.  ||| |  .  |  ...  ..||.| ||    .|.|... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

PENSCGL--AEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQ--LTDDENFTSLHGTEEYLHPKVFERAVLRKPAAL
 ......   |.    ..  .  |..|. ..|..|||.|| ||.. ...|  .. |..||| |.|  .  .. .|.. || .|. | |     .|   . 
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV-----IR--GGQ

PFDARIDLWSIGATLYHLATGQLPFRPH----GGR
. . ..| ||.| .|| ...|..||. |    . .
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-H
Kinase IKKe.AA CAMK 44-252 17 3.4e-36 113.6 In-house 1-335 (425) Show / Hide 
Range on Protein: 44-252
Range on HMM: 1-335/425
Sequence Identity: 17% (58 aa)

PLGQGATSKVYGGRHKKLG------------KRVACKVPHTANLFR---------------------------MGTDMERESQVLLR-------LRNQNI
 ||.|. .||. ..||. .            ..||.|.  .  |                             .   ..|| ... .       |.  ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VCLEAIEKD-----------QISK-------ENILIM---ELCTGG----SLYDVLE-KPENSCG-----------LAEKAFLQVLADMTAGMKYLRDNG
. |  .  |             ||       . ...|   |.|.||     |.| .  .. ....           . |.   ..   .  ...|. ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDVKPGNIMCFKDDHGH-------------TIYKLADFGAARQLTD------------------------DENFTSLHGTEEYLH-PKVFER----A
.|||| || ||.. ... .                 |..||| |.....                        .. ..   || ||   | |...    .
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

VLRKPA----ALPFDARIDLWSIGATLYHLATGQLPFR
     |      . .  .| ||.|  || . .| .||.
MQ-N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase IKKe.AA STE 40-254 20 1.9e-26 90.49 In-house 1-274 (359) Show / Hide 
Range on Protein: 40-254
Range on HMM: 1-274/359
Sequence Identity: 20% (59 aa)

FLD-TPLGQGATSKVYGGRHKK---------------LGKRVACK-VPHTANLF---------------RMGTDMERESQVLLRLR--NQNIV-CLEAIE
. .   .|.||. .|| ....|                |...| | ...  .                     . ..| ... ...   .||| .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

K----DQISKENILIMELCTGGSLYDVLE-KPENSCGLA----------EKAFLQVLADMTAG-MKYLRDNGVVHRDVKPGNIMCFKDDHGHTIYKLADF
|    ..   |  ..||.. |||| |... | .  ..|           |.    .. .   | ..|| .....|||.||.||.           ||.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF

GAARQLTD-----------------DENFTSLHGTEEYLHPKVFERAVLRKPA-ALPFDARIDLWSIGATLYHLATGQLPF---RPH
| . ||||                 ... ... ||  .  |   |.   .. .   . |.. | ||.| |. ..|||. |.    |.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAP---EVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM
Kinase IKKe.AA TKL 45-252 17 2.9e-25 87.93 In-house 1-290 (364) Show / Hide 
Range on Protein: 45-252
Range on HMM: 1-290/364
Sequence Identity: 17% (53 aa)

LGQGATSKVYGGRHKKLG--------KRVACKVPHTAN-LFRMGTD----------------------MERESQVL---LRLRNQNIVCLEA--IEKDQ-
.|.|. ..|| |...  |        | || |. .. |  ... ..                      ...| ...   .||| .||| . .  .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-ISKE-------NILIMELCTGGSLYDVLEKPENSCGLAEKAFLQVLADMTAGMKYLRDNG--------VVHRDVKPGNIMCFKDDH----------GHT
 .. .         ..||.| ||||...|             ...   |.  || ||  ..        ..||| |. ||. ... .           . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

IYKLADFGAARQLTDDEN--------------------FTSLHGTEEYLHPKVFERAVLRKPAA--------LPFDARIDLWSIGATLYHLATGQLPFR
  |..||| .| .. ..|                      .  ||  .. | |.. .   . ..        .... ..| .| |  |. ..|...|..
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase IKKe.AA ULK 39-206 24 3.1e-23 79.34 In-house 1-210 (324) Show / Hide 
Range on Protein: 39-206
Range on HMM: 1-210/324
Sequence Identity: 24% (52 aa)

IFLDTPLGQGATS-KVYGGRHKKL---GKRVACKVPHTANLFRMGTDM----------ERESQVLLRLR---NQN--IVCLEAIEKDQISKENILIMELC
. |.  ||.|.   ||| ||.||    .. ||||.    . ...   .          ..| |..  |    ..|  ||.|  . ... ..   .|||.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKM-IDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

TGGSLYDVLE----KPENS---CGLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHG--------HTIYKLADFGAARQLTDD-ENFTSL
 || | . ..    .||       | |.  .|.. .  .|.|.|......||| || ||.  .....        . ..|.|||| |... .. .. . .
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

H---------GT
.         ||
QTCVNEKRIKGT
Kinase IKKe.AA Ciliate-E2b 114-251 26 3.2e-22 64.47 In-house 77-210 (272) Show / Hide 
Range on Protein: 114-251
Range on HMM: 77-210/272
Sequence Identity: 26% (38 aa)

LIMELCTGGSLYDVLEKPENSCGLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDDEN----FTSLHGTEEY
..||.| |..| ||.    .  .| ..  .   | .  ...||  .....||.|| |||   |  |.   ||.|.|.|  . . .      ... || .|
FMMEFCNGMELFDVIRE-IGRLLLSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMV--DHKGY--MKLIDMGTAKHMYKKNEQMTRTFTIIGTPHY

LHPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLPF
. | . .     .|   .     |.||.| .|| .  |..|.
MAPEIIQSL---QPGGKGYTYKVDIWSVGICLYEFMCGYVPW
Kinase IKKe.AA ULK 39-200 25 4.6e-22 73.88 In-house 1-200 (329) Show / Hide 
Range on Protein: 39-200
Range on HMM: 1-200/329
Sequence Identity: 25% (51 aa)

IFLDTPLGQGATSKVYGGRHKKL----GKRVACKVPHTANLFRMGTD---------MERESQVLLRLR--------NQNIVCLEAIEKDQISKENILIME
. |.  ||.|.  ||| ||.||     .. ||||.     . .   .          ..| ... .|         ..|||.|  . ... ..   .|||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCTGGSLYDVLE----KPENS---CGLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHG--------HTIYKLADFGAARQLTDD--ENF
.| || | . ..    .||.      | |.  .|.. .  .|.|.|......||| || ||.  .....        . ..|.|||| |.....|  |..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ
Kinase IKKe.AA Ciliate-E2 114-251 20 2.4e-20 66.51 In-house 111-296 (365) Show / Hide 
Range on Protein: 114-251
Range on HMM: 111-296/365
Sequence Identity: 20% (41 aa)

LIMELCTGGSLYDVLE---KPENSC-----GLAEKAFLQVLADMTA---------------GMKYLRDNG-VVHRDVKPGNIMCFKDDHGHTIYKLADFG
|.||.| ||.|.| ..   | .|..      . ||  ... .  .                ...||  .. ..||| || ||.           |..|||
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

AARQLTDD----------ENFTSLH-----------------------GTEEYLHPKVFE-RAVLRKPAALPFDARIDLWSIGATLYHLATGQLPF
 .....||          ....  .                       || .|. | ...        .  . |  .|.||.| .|| . .|..||
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
Kinase IKKe.AA Ciliate-E2-Unclassified 39-251 18 7.5e-20 65.55 In-house 1-270 (352) Show / Hide 
Range on Protein: 39-251
Range on HMM: 1-270/352
Sequence Identity: 18% (52 aa)

IFLDTPLGQGATSKVYGGRHKKLGKRV-----ACKVPHTANLFRMGT-DMERESQVLLRLR-----------------NQNIVCLEAIEKDQISKENILI
  .   .|||. .|||  .||| .  .     ..|. . . .  |   .. .| . . ..                  ..... .  .. .|  .  ...
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MELCTGGSLYDVLEKPEN--------------SCGLAEKAFL-----QVLADMTAGMKYLRDNG-VVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLT
||.| ||.| . ..| ..              .. . |.. .     . .|    | .||  .. ..||| || ||. |.....    |..||| .... 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENIL-FDNNGKNYYIKIIDFGISKKYQ

DD----------------ENFTSLHGTEEYL----HPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLPF
..                .....  || .|.     | |...    ...|      .| || |  || . .|..||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGYYPF
Kinase IKKe.AA CAMKL 39-209 21 3.5e-19 57.73 In-house 2-199 (297) Show / Hide 
Range on Protein: 39-209
Range on HMM: 2-199/297
Sequence Identity: 21% (44 aa)

IFLDTPLGQGATSKVYGGRHKKL-GKRVACKVPHTANLF--RMGTDM------------ERESQVLLRLR---NQNIVCLEAIEKDQIS----KENILIM
....  ||.|. .||  ..|... |..|| |. .   .      ...            .|| | . .|.    .||. |  .  ..      |.  |.|
RIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCTGGS--LYDVLEKPENSC-GLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDD-HGHTIYKLADFGAARQLTD-----DENFTSLHGTE
|.| ||.  |.| ..| ..    . |.   .    . ....|. ..|.|||| || ||.  ... .     |..||| . . ..     .. ..   |. 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

EY
.|
PY
Kinase IKKe.AA Pkinase_Tyr 39-166 29 2e-12 42.74 Pfam 1-137 (270) Show / Hide 
Range on Protein: 39-166
Range on HMM: 1-137/270
Sequence Identity: 29% (41 aa)

IFLDTPLGQGATSKVYGGRHK----KLGKRVACKVPHTANLFRMG---TDMERESQVLLRL-RNQNIVCLEAIEKDQ---ISKENILIMELCTGGSLYDV
| ..  ||.||  .|| |. |    . .  || |.    .         |. || ...  | ...|||.| ..  ||   .  . ...||.. .|.|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LEKP-ENSCGLAEKAFLQVLADMTAGMKYLRDNGVVHRDV
| |. |.   |  |  ||  ..  .|| || ... .|||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase IKKe.AA TyrKc 39-301 20 8.8e-11 -48.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 39-301
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

IFLDTPLGQGATSKVYGGRHKKLGKRVACKVPHTANLFRMGTDMERESQVLLRL--RNQNIVCLEAIEKDQ-----ISKENILIMELCTGGSLYDVLEKP
| |.  || ||  .|| |. |     || |. .         |. || ... .|  ...|||.| ..  .|      ..   ..||.. .|.| | | |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

ENSCGLAEKAFLQVLADMTAGMKYLRDNGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDD-ENFTSLHGTEEYLHPKV--FERA----------
..   |  | .|.   .  .|| || .....|||    |..  ..     . | .||| .| ..|| ..       ..| ..|    ...          
RPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPE

VLRKPAALPFDARIDLWSIGATLYHLATGQLPFRPHGG-----RKNSRMMFHLTTKKAPGVISG------VQTGPLDHEIT---WSRELPE-----TCRL
..       |    | || | ... . |  .   |. |      .|.... .. . . .           |   .  ..|    | ..  .     ... 
CI---NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

SI
 .
CF
Kinase IKKe.AA CAMKL 232-252 47 0.000913 7.73 In-house 217-237 (297) Show / Hide 
Range on Protein: 232-252
Range on HMM: 217-237/297
Sequence Identity: 47% (10 aa)

IDLWSIGATLYHLATGQLPFR
.| ||.| .|| . .|.|||.
VDIWSCGVILYAMVCGYLPFD
Kinase IKKe.AA ULK 233-258 30 0.003836 6.92 In-house 238-262 (329) Show / Hide 
Range on Protein: 233-258
Range on HMM: 238-262/329
Sequence Identity: 30% (8 aa)

DLWSIGATLYHLATGQLPFRPHGGRK
|.||.|  .| . .|. ||.    ..
DIWSLGCIFYEMLYGKPPFYAW-FND
Kinase IKKe.AA ULK 233-258 30 0.005054 6.64 In-house 234-258 (324) Show / Hide 
Range on Protein: 233-258
Range on HMM: 234-258/324
Sequence Identity: 30% (8 aa)

DLWSIGATLYHLATGQLPFRPHGGRK
|.||.|  .| . .|. ||.    ..
DIWSLGCIFYEMLYGKYPFFSW-FND