Gene TBK1 (Sea Urchin)
TBK1
Sequence
Protein domains of TBK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | TBK1.AA | IKK | 15-298 | 53 | 8.8e-164 | 550.41 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 15-298 Range on HMM: 1-297/297 Sequence Identity: 53% (160 aa) WYLKDVLGTGATSSVYLGRHKKNGDVVAVKMFNHLSYMRPRDVQQREFEVLLKLNHK-------NIIHLDQIEED---QISKQPVIVMELCTGGSLYTYL |...|.||.||...||..||||.|..||||..||.|.||.|.|..||||....|||. ||..|..|||| ||.||||||||.||||.||.|| WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQWQICKQPVIVMEYCTGGDLYKYL DTPENLYGLKE-KEFLQVLNDVSAGMKHLR-DKGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDDEAFKSLYGTEEYLHPDLYERAVLGKRNRT ..|.| .|||| .|||||..|..|||.||. ..|||||||||||||..||||| ..||..|||.|||..|||.|.|.||||||||||.||||||.|.... NSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVLRKPHQK EFTAQTDLWSLGVTFFHTATGSLPFRAHGG-RNNRDVMHRITTTKKSSMISGVQEVPNGPIIWSEDLPKTCHFSPDMRHQVKTLLSHTMECNIQKMW ...|..|.||.||||.|.|||.|||..|.. |... .|..||| | | ..|||| |||. || .|| .|| . . |.. .. | . .. | PYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSHLPQYCHLCQIIHEQMEPWCIMMLEWHQDQCW |
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Kinase | TBK1.AA | Pkinase | 15-252 | 25 | 5.5e-46 | 163.68 | Pfam | 1-240 (293) | Show / Hide |
Range on Protein: 15-252 Range on HMM: 1-240/293 Sequence Identity: 25% (65 aa) WYLKDVLGTGATSSVYLGRHKKNGDVVAVKMFNHLSYMRPRDVQQR---EFEVLLKLNHKNIIHLDQIEEDQISKQPVIVMELCTGG----SLYTYLD-- . .. ..| |. ..||...||..|..|||| .. . |.. | | .....|||.||. | . || .. . .|||.| || .|..|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW TPENLYGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGEDGVI---VYKLADFGAARE--LEDDEAFKSLYGTEEYLHPDLYERAVLGKRN ..| . |.| .. . |.... ..||.|||.|| ||... ..|.| | |..||| |. . .. .... || .|. | . RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACV-KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-------G RTEFTAQTDLWSLGVTFFHTATGSLPFRAH----GGRNNRDVMHRITTTKKSSMIS ... . | ||.|.... ..| .||. | . .. . .. || .. .. .. GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWP |
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Kinase | TBK1.AA | S_TKc | 15-330 | 19 | 7.8e-45 | 156.18 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-330 Range on HMM: 1-231/231 Sequence Identity: 19% (64 aa) WYLKDVLGTGATSSVYLGRHKKNGDVVAVKMFNHLSYMRPRDVQQREFEVLLKLNHKNIIHLDQIEEDQISKQPVIVMELCTG--GSLYTYLDTPENL-- . . ...| || ..||..|||| | .||.|. . . .|| ..| | .|.||..| . .| . .|||.| | |.|..|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL -YGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDDEAFKSLYGTEEYLHPDLYERAVLGKRNRTEFTA-QT ... | . .. . ..... ..||.|||.|| ||.. . . |..||| ||.| ... || .|. | . .. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-----------GYGKCKC DLWSLGVTFFHTATGSLPFRAHGGRNNRDVMHRITTTKKSSMISGVQEVPNGPIIWSEDLPKTCHFSPDMRHQVKTLLSHTMECNIQKMWTFDIFFDFVQ | ||.|.... ..| ||. . ....| . . ||.. DWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------------------------------SPEAKDFIR RLTSMRPVDVFVAPTCEC-------HIVY .. . | . | . | KCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | TBK1.AA | CAMK | 20-229 | 19 | 6.4e-40 | 125.83 | In-house | 1-336 (425) | Show / Hide |
Range on Protein: 20-229 Range on HMM: 1-336/425 Sequence Identity: 19% (66 aa) VLGTGATSSVYLGRHKKNG------------DVVAVKM-------------------FNHLSYMR------PRDVQ--QREFEVLLK-------LNHKNI .||.|. . |.|..||... ||.|. .. . |.| . .|| |.. | |.|.|| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI IHLDQIEED-----------QISK-------QPVIVM---ELCTGG----SLYTYLDTPENL------------YGLKEKEFLQVLNDVSAGMKHLRDKG |.| .. || || . ..|| |.|.|| |. |. .. ..|.| .. . ..... ... IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IVHRDIKPGNIMMVKGEDGVI-------------VYKLADFGAARELED------------------------DEAFKSLYGTEEYLH-PDLYER---AV |||||.|| ||.... .|. |..||| |..... .. .| || || | . .. . IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN LGKRN-----RTEFTAQTDLWSLGVTFFHTATGSLPFRA . | .. . ..| ||.|| . .| .||.. MQ--NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYG |
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Kinase | TBK1.AA | ULK | 15-233 | 27 | 9.7e-39 | 132.89 | In-house | 1-261 (329) | Show / Hide |
Range on Protein: 15-233 Range on HMM: 1-261/329 Sequence Identity: 27% (73 aa) WYLKDVLGTGATSSVYLGRHKKN----GDVVAVKM-----FNHLSYMRP----RDVQQREFEVLLKLN----HKN----IIHLDQIEEDQISKQPVIVME ..|...|| |. || ||.||. . .||.|| .| ..... . ..| ... ||. ||| |. | . |.. .. |.|| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME LCTGGSLYTYLDT----PENL---YGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGE---------DGVIVYKLADFGAARELEDD---- .| || | .|. . ||. | |.| .|.. . .|.|.|....|.|||||| ||.. .| .|.|.|||| |. ...| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ EAFKSLY------GTEEYLHPDLYERAVLGKRNRTEFT-AQTDLWSLGVTFFHTATGSLPFRAHGGR . ... || | | . .. . ... . .|.||||. |. .| ||.| . QMMMTCVNEKRLCGTPLYMAPQILQGQG----EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FN |
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Kinase | TBK1.AA | ULK | 15-234 | 25 | 1.3e-36 | 127.48 | In-house | 1-258 (324) | Show / Hide |
Range on Protein: 15-234 Range on HMM: 1-258/324 Sequence Identity: 25% (68 aa) WYLKDVLGTGATS-SVYLGRHKKN---GDVVAVKMFN-----HLSYMRP----RDVQQREFEVLLKLN---HKN--IIHLDQIEEDQISKQPVIVMELCT ..|...|| |. || ||.||. . .||.|| . ..... . ...| ... ||. |.| |. | . |.. .. |.||.| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN GGSLYTYLDTPENL------YGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGE---------DGVIVYKLADFGAARELEDD----EAFK || | .|. . .| | |.| .|.. . .|.|.|....|.|||||| ||.. .| .|.|.|||| |. .... .. GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMCQ SLY------GTEEYLHPDLYERAVLGKRN--RTEFT-AQTDLWSLGVTFFHTATGSLPFRAHGGRN .. || | | . . .. . ... . .|.||||. |. .|. ||.. .. TCVNEKRIKGTPLYMAPQILQ------GQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FND |
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Kinase | TBK1.AA | Ciliate-E2 | 15-227 | 19 | 1.1e-32 | 109.55 | In-house | 1-296 (365) | Show / Hide |
Range on Protein: 15-227 Range on HMM: 1-296/365 Sequence Identity: 19% (60 aa) WYLKDVLGTGATSSVYLGRHKKNGD-----------------------VVAVKMF--NHLSYMRPRDVQQREFE----------VLLKLNHKNIIHLDQI . ..|.|. .|||.....|.. .|.|.. | . .. . . || . .| .|||.||| . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC EEDQISKQPVIVMELCTGGSLYTYLD-----TPENLY---GLKEKEFLQVLNDVSA---------------GMKHLRDKG-IVHRDIKPGNIMMVKGEDG ... . .|||.| ||.|. |. .... ..||| ... . ....| |. |.|||||| ||.. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ VIVYKLADFGAARELEDD--------------------------------EAFKSLYGTEEYLHPDLYE-RAVLGKRNRTEFTAQTDLWSLGVTFFHTAT |..||| .... || . |....|| .|. | .. . .... . . |.|||||... . ---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF GSLPF | .|| GKPPF |
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Kinase | TBK1.AA | TKL | 21-170 | 21 | 2.4e-27 | 95.55 | In-house | 1-204 (364) | Show / Hide |
Range on Protein: 21-170 Range on HMM: 1-204/364 Sequence Identity: 21% (45 aa) LGTGATSSVYLGRHKKNG--------DVVAVKMFNHLS--------------------------YMRPRDVQQREFEVLLKLNHKNIIHLDQ--IEEDQ- .| |. . || |... .| .||||.|. . ... |. .| ....|.| ||... ..... IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG --------ISKQPVIVMELCTGGSLYTYLDTPENLYGLKEKEFLQVLNDVSAGMKHLRD--------KGIVHRDIKPGNIMMVKGED----------GVI ..|. ||||.| ||||. || ... |.. || .| ..|.|||.|. ||. . . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW VYKLADFGAAREL . |..||| .|.. CCKICDFGLSRFM |
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Kinase | TBK1.AA | CAMKL | 15-185 | 25 | 3.9e-27 | 83.52 | In-house | 1-199 (297) | Show / Hide |
Range on Protein: 15-185 Range on HMM: 1-199/297 Sequence Identity: 25% (52 aa) WYLKDVLGTGATSSVYLGRH-KKNGDVVAVKMFN-----HLSYMR--------PRDV-QQREFEVLLKLN---HKNIIHLDQIEEDQIS----KQPVIVM . . ..||.|. . | |..| . .| ||.|. . .|. ..|. .|| . . .|| |.|||.| .. |.. |. ..|| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM ELCTGGS--LYTYLDTPENLY-GLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMV-KGEDGVIVYKLADFGAARELED-----DEAFKSLYGTE |.| ||. |. |.. .. ..|.| . . ...... ..||||||||| ||. .| . |..||| . . .. .. .| |. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP EY .| PY |
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Kinase | TBK1.AA | STE | 15-227 | 21 | 1.2e-26 | 91.17 | In-house | 1-268 (359) | Show / Hide |
Range on Protein: 15-227 Range on HMM: 1-268/359 Sequence Identity: 21% (61 aa) WYLKDVLGTGATSSVYLGRHKK---------------NGDVVAVKMFNH--------------LSYMRPRDVQ--QREFEVLLKLN--HKNIIHLDQIEE | . ...| ||. .||.....| .|...|.| |. |. . . ..| ..| ... |.| |.||.. .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF -----DQISKQPVIVMELCTGGSLYTYLD----TPENL-------YGLKEKEFLQVLNDVSAG-MKHLRDKGIVHRDIKPGNIMMVKGEDGVIVYKLADF .. . |.||.. |||| .. ....| ..|.. .. .. | ...| ...|.||||||.||.. ||.|| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDF GAARELED-----------------DEAFKSLYGTEEYLHPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPF | . |.| .. ... || . | .. | | . . ... | |||| | . ||| |. GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R-DKGYDTKCDIWSLGCTIIEMATGKPPW |
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Kinase | TBK1.AA | Ciliate-E2-Unclassified | 15-227 | 18 | 9.2e-26 | 86.35 | In-house | 1-270 (352) | Show / Hide |
Range on Protein: 15-227 Range on HMM: 1-270/352 Sequence Identity: 18% (50 aa) WYLKDVLGTGATSSVYLGRHKKNGDVV-------AVKMFNHLSYMRPRDVQQREFEVLLKLN-----------------HKNIIHLDQIEEDQISKQPVI . ..|.|. ..||. .|||.. . ..... ...|. .| . . ... |.... . ....| . . | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI VMELCTGGSLYTYLDTPENL--------------YGLKEKEFL-----QVLNDVSAGMKHLRDKG-IVHRDIKPGNIMMVKGEDGVIVYKLADFGAAREL |||.| ||.| |. ... . |.. . . . . | ..| |. |.|||||| ||.. .. |..||| .... VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKY EDD----------------EAFKSLYGTEEYL----HPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPF ... . ... || .|. | .... ... . | ||||| .. .| .|| QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----YKCDIWSLGVILYEMLFGYYPF |
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Kinase | TBK1.AA | CAMK-Unique | 15-229 | 19 | 1.6e-24 | 77.67 | In-house | 1-295 (363) | Show / Hide |
Range on Protein: 15-229 Range on HMM: 1-295/363 Sequence Identity: 19% (58 aa) WYLKDVLGTGATSSVYLGRHKKNGDVVAVKMFNHLSYMRPRDVQ-------------------QREFEVLLKLNHKNIIHLDQI-----EEDQ------I . . ..|.|. . || . ...|. |.||.. . . .| || .......| |||.| .. . .. | YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI SKQP------VIVMELCTGGSLYTYLDTPEN-----------------LYGLKE--KEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGEDG---- | | .||||.|.|| |. ... . | . ... . ... ...|||||.|. ||| . .. IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH --------VIVYKLADFGAARELEDDEAFK---SLYGTEEYLHPDLYERAVLGKRNRTEFTA------QT----DLWSLGVTFFHTATGSLPFRA ||.||| ..... .. . ||..|. | .. . | | . | |.|||||. . ..|..|| . RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDC |
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Kinase | TBK1.AA | Pkinase_Tyr | 17-142 | 31 | 1.7e-16 | 56.49 | Pfam | 3-137 (270) | Show / Hide |
Range on Protein: 17-142 Range on HMM: 3-137/270 Sequence Identity: 31% (44 aa) LKDVLGTGATSSVYLGRHK----KNGDVVAVKMFNHLSYMRP----RDVQQREFEVLLKL-NHKNIIHLDQIEEDQ---ISKQPVIVMELCTGGSLYTYL . .|| || .||.|. | ... ||||| .. ..| . .| . | ... .| .|.||. | . || . |. ||||.. .|.|..|| FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYL DTP-ENLYGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDI .. |. |. |. || ....|| .| .|...|||. RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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Kinase | TBK1.AA | TyrKc | 17-290 | 22 | 1.8e-13 | -4.98 | SMART | 3-280 (280) | Show / Hide |
Range on Protein: 17-290 Range on HMM: 3-280/280 Sequence Identity: 22% (70 aa) LKDVLGTGATSSVYLGRHKKNGDVVAVKMFNHLSYMRPRDVQQREFEVLLKL--NHKNIIHLDQIEEDQ-----ISKQPVIVMELCTGGSLYTYLDTPEN |...|| || ||.|. | ||||| .. . | || ... || .|.||. | . .| .... ||||.. .|.| || ... LGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP LYGLKEKEFLQVLNDVSAGMKHLRDKGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDD-------EAFKSLY--GTE----------EYLHPDL |. |..|. ....|| .| .|...|||. |.. .. . | .||| .|...|| . .. |. | . K--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---- YERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPFRAHGG-----RNNRDVMHRITTTKKSSMISG-----VQEVPNGPIIWSEDLPKTC-HFSPDMR | .|| ..| || ||. . | . . | .|..|.... . . . | . . |.| |. |..| ---------NYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQ-IMKQCWHEDPEDR HQVKTLLSHTM ... . . PTFSEI-HECF |
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Kinase | TBK1.AA | CAMKL | 207-247 | 26 | 0.032467 | 2.7 | In-house | 216-259 (297) | Show / Hide |
Range on Protein: 207-247 Range on HMM: 216-259/297 Sequence Identity: 26% (12 aa) QTDLWSLGVTFFHTATGSLPFRAH-----GGRNNRDVMHRITTTKK ..| ||.||. . .| |||.. | |. ...| .. . KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y |