Gene PRPK (Sea Urchin)
PRPK
Sequence
Protein domains of PRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PRPK.AA | Bud32 | 19-238 | 45 | 2.2e-134 | 432.5 | In-house | 1-269 (269) | Show / Hide |
Range on Protein: 19-238 Range on HMM: 1-269/269 Sequence Identity: 45% (123 aa) SKLTLLK--------QGAEARIYL--------------STFMGR------SSIVKQRFKKSYRHPKLDAKLSQKRTGQEVRTIVKCRKAGITTPVVYFVD . | |.| ||||||... | || |.| || |.|||| ||..|. .|| |||| .|||||| .|.|||.| MSLELYKDVDIAPISQGAEARVFYTCYLTVSKQKVYTTCNFQGRAKDSHQQCIIKERFPKAYRHPQLDQQLTKHRTKQEVRAMNRCRKAGICVPYVYFCD NDTHSIHMEYIEDS------LTVREYIQQIQNSGES-NDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDS-----RLIMIDFGLSQISH |..|.|.|||||.| .||..||.|.|..... ..|..|.....|||.....||...|||||||||||.||.||.|. ....|||||| || NYNHCIYMEYIEESPGGHGFYTVKNYIWQHQETQKEDQHDQCLREFCKKVGRQIGKMHWNHIIHGDLTTSNMMLRHPYADWTKLYGQMHLIDFGLSYISN MS-EDKGVDLYVLERAFLSSHPNTEE-----LFKTVLDVYA---ENYKKSGEVLKKLEEVRQRGRKRVM |||||||||||||||| ||..|. .| ... .| . ||. .||||..||| ||||| | SVPEDKGVDLYVLERAFLSTHPKCEQKYNAWIFEHFMENYRKQDTKCKKFKAVLKKFNEVRLRGRKRTM |
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| Kinase | PRPK.AA | Dicty3 | 87-183 | 23 | 1e-06 | 18.02 | In-house | 69-194 (351) | Show / Hide |
Range on Protein: 87-183
Range on HMM: 69-194/351
Sequence Identity: 23% (30 aa)
YFVDNDT--HSIHMEYIEDSLTVRE----YIQQIQNSGESNDDERLVSLASKVGTTLASMHNVD-IIHGDLTTSNMLLRQPYE-----------------
| .||.. | | ||||| . . . . ... . |..|. .... . ||.. |. |||.|... | .| . .
YCCDNNNDNHYIYMEYIEGEIPISFVKTNNMLKKHKNNRFNEHEI-SKIICDLVKTLNYIHKNCHIIHRDIKCDNIMLDNDEQHQCNNNNNKMSSTCRDI
------DSRLIMIDFGLS-QISHMSEDK
. |||||| .|| | ..
QCYYSNEINWKLIDFGLSKNISYYS-NN
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| Kinase | PRPK.AA | Ciliate-E8 | 141-174 | 44 | 1e-06 | 16.6 | In-house | 106-138 (138) | Show / Hide |
Range on Protein: 141-174 Range on HMM: 106-138/138 Sequence Identity: 44% (15 aa) HNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLS || ||| |. | |. |. |.. .|||| | HNNNIIHCDFKLNNILV-QRNDDTKIKIIDFGFS |
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| Kinase | PRPK.AA | RSK | 136-183 | 22 | 2e-06 | 20.19 | In-house | 116-163 (278) | Show / Hide |
Range on Protein: 136-183 Range on HMM: 116-163/278 Sequence Identity: 22% (11 aa) TLASMHNVDIIHGDLTTSNMLLRQPYED-SRLIMIDFGLSQISHMSEDK .. .| .||| || .|.|. . . .. .|||.. ... .. . AVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQ |
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| Kinase | PRPK.AA | Ciliate-E2 | 137-178 | 32 | 4e-06 | 17.11 | In-house | 173-207 (365) | Show / Hide |
Range on Protein: 137-178 Range on HMM: 173-207/365 Sequence Identity: 32% (14 aa) LASMHNVD-IIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQISH | ..|. ||| |. .| |. . ||||||.. . LEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYD |
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| Kinase | PRPK.AA | TKL | 137-183 | 22 | 1.1e-05 | 16.5 | In-house | 145-210 (364) | Show / Hide |
Range on Protein: 137-183 Range on HMM: 145-210/364 Sequence Identity: 22% (15 aa) LASMHNVD--------IIHGDLTTSNMLLRQPYE-----------DSRLIMIDFGLSQISHMSEDK .. .|. . ||| ||...| |. . .. | .. |||||. ..|... MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNM |
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| S_TKc | PRPK.AA | S_TKc | 18-240 | 17 | 2.5e-05 | -98.89 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 18-240 Range on HMM: 1-220/231 Sequence Identity: 17% (44 aa) QSKLTLLKQGAEARIYLSTFMG--RSSIVKQRFKKSYRHPKLDAKLSQKRTGQEVRTIVKCRKAGITTPVVYFVDNDTHSIHMEYIE-DSLTVREYIQQI .| .. .|| .. |. . . | .|. ... .|.. | . | . .|.| | . |||.. | ....||.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR QNSG--ESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQISHMSE--------------DK-GVD----------L . | . . ... . |. .|. ||| || .| || . .. .||||. . .. .| .| . GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEM YVLERAFLSSHPNTEELFKTVLDVYAENYKKSGEVL----KKLE-EVRQRGRKRVMLG .. . | . ...|| .. | |.. | |. . ..| | LCGYPPFP----QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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| Kinase | PRPK.AA | Ciliate-F2 | 137-176 | 40 | 3.4e-05 | 15.09 | In-house | 108-145 (200) | Show / Hide |
Range on Protein: 137-176 Range on HMM: 108-145/200 Sequence Identity: 40% (16 aa) LASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI || . |. .|||| ..||. . | | .. ||.| || LAELENLGLIHGDIKIENMIYNRP--KQRFMFDDFQLIQI |
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| Kinase | PRPK.AA | Ciliate-E1 | 109-212 | 18 | 4.6e-05 | 12.95 | In-house | 94-202 (202) | Show / Hide |
Range on Protein: 109-212 Range on HMM: 94-202/202 Sequence Identity: 18% (21 aa) EYIQQIQNSGESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQ--ISHMSEDKGVDLYVLERAFLSSHP------N ||.||.|. . ... ..... |. .|. |||.|. .| | . . .... |||.|. ... ... .. | . | EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINN--Q-GNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHN TEELFKTVLDVY .. . .|.| KNQKINYKSDIY |
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| Kinase | PRPK.AA | NZAK | 90-176 | 26 | 5e-05 | 12.26 | In-house | 73-154 (329) | Show / Hide |
Range on Protein: 90-176 Range on HMM: 73-154/329 Sequence Identity: 26% (23 aa) DNDTHSIHMEYIE-DSLTVREYIQQIQNSGESNDDERLVSLASKVGTTLASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI |. | | ||..| . || ... . . .. .. .. ... . |. .| ||| |....|..| | .|||| | | DDNYHCIYMEWMEGGNLT--QFLMNDKKQLRFKEHRI-IKMIADIAETMSYLHKHHIIHRDIKSNNVILDF---NKNLKLIDFGSSII |
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| Kinase | PRPK.AA | MSK | 137-176 | 32 | 5e-05 | 12.92 | In-house | 114-153 (277) | Show / Hide |
Range on Protein: 137-176 Range on HMM: 114-153/277 Sequence Identity: 32% (13 aa) LASMHNVDIIHGDLTTSNMLLRQPYEDSRLIMIDFGLSQI . .|| . |||.|| | |. .. .. .||||.. . VDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARL |
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