Gene Aur (Sea Urchin)
Aur
Sequence
Protein domains of Aur.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Aur.AA | Aur | 72-266 | 61 | 8.49999999999e-188 | 500.9 | In-house | 57-257 (257) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 57-257/257 Sequence Identity: 61% (123 aa) KHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRA--GRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLG-LLGDLKIADFGWSVHAP-SS .|||||...|||.|. |.||||||||.|||||.||.. .||||||.| |..|...||.|||||..|||||||||.||. . |..||.|||||||.| .. NHPNILKMYGYFHDDQRIYLILEYAPGGELYKELQKQPNKRFDEQRAAKYMYQICNALDYCHSKNIIHRDIKPENILLDQCNGNIKICDFGWSVHCPNNN RRNTLCGTMDYLPPEMIEGRMHDDKVDLWSLGVLCYEFLVGKPPFEA-EGSTETYRRIT-KVHYQFPSYVSAGARDVIKRLLQHNPANRLPLEQVLAHPW ||.|.|||.||.||||.||.|||.|||.|.|||||||...|.||||. | |||.|| ||..||||..| .|.| |...|||.| .|..|.|...||| RRMTFCGTLDYMPPEMVEGQMHDHKVDIWCLGVLCYELCHGCPPFESNENHDETYDRIKNKVDIQFPSHISKEAKDLISKILQHDPKQRMTLDQIMNHPW I | I |
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| Kinase | Aur.AA | AGC | 70-266 | 26 | 4.4e-93 | 240.33 | In-house | 85-395 (395) | Show / Hide |
Range on Protein: 70-266
Range on HMM: 85-395/395
Sequence Identity: 26% (84 aa)
EPK--HPNILR-LFGYFYDESR--VYLILEYAP---------RG-ELYKQLQ---RAGRFDEQRTASYISQ-------LADALKYCHS-KKVIHRD-IKP
. | ||.| . |. | |... .|...||.| | ||. .|| . |||||.|. |... .. || | || ...|||| .||
I-KSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKP
ENLLLGLLGDLKIADFGWSVHAPSS----------------------------------------------------RRNTLCG--TMDYLPPEMIEGRM
||.|| | .|..||| . ... | .|.|| | .|..||..
ENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----
HDDKVDLWS--LGVLCYEFLVGKPPFEAEGST----------ETYRRIT--------KVHYQFP--------SYVSAGARDVIKRLLQHNPANRLP----
.. .| || ||.| ||.|.|.||| .. |.. .| ||.. || ...| |.| ||.||. .|..||
YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGN
------LEQVLAHPWI
|.. .|||
DFGDKGAEEIKNHPWF
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| Kinase | Aur.AA | CAMK | 72-266 | 23 | 2.9e-77 | 248.35 | In-house | 96-425 (425) | Show / Hide |
Range on Protein: 72-266
Range on HMM: 96-425/425
Sequence Identity: 23% (77 aa)
KHPNILRLFGYFYD-------------------ESRVYLIL---EYAPRGEL----YKQLQRA---------------GRFDEQRTASYISQLADALKYC
.||||..|. .. | ....|... ||.. ||| . ... |||.|. .. |. |...|..||
DHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYC
HSKKVIHRDIKPENLLLGLL-----------------GDLKIADFGWSVHAPSSR-------------------------RNTLCGTMDYLP-PEMIEG-
||....|||.||||.|| ...||.||| . . ... .| ||| | . ||...|
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK
-------------RMHDDKVDLWSLGVLCYEFLVGKPPFEAE-------------GSTETYRRITKVHYQFPSY------------------------VS
. .. |.| ||.||..| |.|.|||... |....|.| |.||.. ||
GHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVS
AGARDVIKRLLQHNPANRLPLEQVLAHPWI
. ..| |...|| .| .|. .||.|.|||.
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | Aur.AA | RSK | 72-266 | 34 | 2.6e-72 | 246.56 | In-house | 59-278 (278) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 59-278/278 Sequence Identity: 34% (76 aa) KHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRAGR---FDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGL---LGDLKIADFGWSVH-A .||.| .|. | .|. .|||.|| . |||.. ||. .. |.| . . |..... |... |....||||.|||| |. | .|. ||| . QHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFR PS--SRRNTLCGTMDYLPPEMIE---GRM-HDDKVDLWSLGVLCYEFLVGKPPFEA---EGSTETYRRITKVH--YQFP--SYVSAGARDVIKRLLQHNP .. .. .| |.| .|..|||. .. || .|.|||||| || |.|.||| . . . |. .|| | . .| .|.|. |.| |...|. .| CDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDP ANRLP-----LEQVLAHPWI ..|| .|....|||. HKRLGCGPQDAEEIKQHPWF |
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| Kinase | Aur.AA | CAMKL | 72-266 | 34 | 1.5e-71 | 227.58 | In-house | 73-297 (297) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 73-297/297 Sequence Identity: 34% (78 aa) KHPNILRLFGYFYDESR------VYLILEYAPRGE--LYKQLQRA----GRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGD--LKIAD ||||| .|. ..... .||..||.. || |. ... ||..| . | |. .|..||||....||||||||.|| |. .||.| KHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIID FGWS-----V-HAPSSRRNTLCGTMDYLPPEMIEG--RMHD-DKVDLWSLGVLCYEFLVGKPPFEAE--------GSTETYRRITKVHYQFP--SYVSAG || | . | .| ||. | .||...| . .| ||| ||.||. | ..|. ||... . |..| . |..| ..|| FGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-D ARDVIKRLLQHNPANRLPLEQVLAHPWI .|| |...||.|| | ..|.. ||| CRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | Aur.AA | MARK | 72-266 | 40 | 6.4e-71 | 231.1 | In-house | 57-262 (262) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 57-262/262 Sequence Identity: 40% (84 aa) KHPNILRLFGYFY--DESR-VYLILEYAPRGELYKQLQRA--GRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLG--DLKIADFGWSVHA .|||| .|| .. .|.. .|||.|||..|||| .. . || | . . .|. |..||||| ..||||||||.|. | . ||.|||.|.. DHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI -PSSRRNTLCGTMDYLPPEMIEGRMHD-DKVDLWSLGVLCYEFLVGKPPFEAEG--STETYRRITKVHYQFPSYVSAGARDVIKRLLQHNPANRLPLEQV | .. || ||| | .||..... | ||| |||||. | ..|. ||.. . | |..|.. .|..|..||...|. |.|||..|| | .|.. PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEI LAHPWI . |||. MKHPWM |
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| Kinase | Aur.AA | Pkinase | 72-266 | 32 | 2.7e-70 | 244.65 | Pfam | 58-293 (293) | Show / Hide |
Range on Protein: 72-266
Range on HMM: 58-293/293
Sequence Identity: 32% (77 aa)
KHPNILRLFGYFYDESRVYLILEYAPRG----ELYKQLQ--RAGRF--DEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDL----KIADFG
.||||.||...|.|....|...||.. | .|. .. | |.| .|. .|. |.. .|.||||...||||.||||.|. |.. ||.|||
NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG
WSV---HAPSSRRNTLCGTMDYLPPEMIE-GRMHDDKVDLWSLGVLCYEFLVGKPPFEAE------GSTETYRRITKVHYQFPSYVS-------------
. . ..| .|.||| .|..|| | |.... ||| ||.|...||.| |.||| . . ..|| . . |... .
LAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF
--------AGARDVIKRLLQHNPANRLPLEQVLAHPWI
..|.||..|. .|. |. ||.| |||.
HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| S_TKc | Aur.AA | S_TKc | 19-266 | 27 | 1.8e-69 | 238.04 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-266 Range on HMM: 1-231/231 Sequence Identity: 27% (76 aa) YFLHTR---------YECYEPI--DAFCQKVASSLNRGTTAQARTQPVKSAENGHGHDDKQMEPKHPNILRLFGYFYDESRVYLILEYAPR--GELYKQL | .. | |.. . |. . |. . .. .|||| .|...|.| ...|...||.. |.|.. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI QRAGR------FDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWSVHAPSSRRNTLCGTMDYLPPEMIEGRMHDD-KVDLWSL .. || |.| ....|. |...||.||||...||||.||||.|| .||.||| . . .|.||| .|..||.. .. |.| ||. KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSC GVLCYEFLVGKPPFEAEGSTETYRRITKVHYQFPSYVSAGARDVIKRLLQHNPANRLPLEQVLA-------HPWI |.. ||.|.|.|||. .....| | |.| |...|| .|..|. ..|. |||. GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Aur.AA | CAMK-Unique | 72-266 | 24 | 5.8e-68 | 223.39 | In-house | 74-363 (363) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 74-363/363 Sequence Identity: 24% (70 aa) KHPNILRLFGY----FYDES---------------RVYLILEYAPRGELYKQLQR--------------------AGRFDE--QRTASYISQLADALKYC .||||..|... | |. . |...||.. |.|.. .|. |.| | |.... .|. |..| DHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYM HSKKVIHRDIKPENLLLGLLGD----------------LKIADFGWSVHAPSSRRN----TLCGTMDYLPP--------------EMIEGRMHDDKV--- ||....|||.|.||... .. .|..||| ..| ... . | ||| .|. | |.|... | .. HSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPA -DLWSLGVLCYEFLVGKPPFEAEGST--------ETYRRITKVHY------QFPS--YVSAGARDVIKRLLQHNPANRLPLEQVLAHPWI |.|||||. |. |.|.|||..|.. |....|.| | .. . |.| .| |..|.... |. |..... | |.|| SDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI |
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| Kinase | Aur.AA | PLK | 72-266 | 39 | 8e-66 | 213.37 | In-house | 57-258 (258) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 57-258/258 Sequence Identity: 39% (79 aa) KHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRA-GRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWS--VHAPSSR .||||... .| |.. ||. |||.....| . | |. | . .|. |.. .||| |....||||.|. ||.| .||.||| . . . | HHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGER RNTLCGTMDYLPPEMIEGRM--HDDKVDLWSLGVLCYEFLVGKPPFEAEGSTETYRRITKVHYQFPSY--VSAGARDVIKRLLQHNPANRLPLEQVLAHP ..|.||| | || .| |. .|| ||||. | .|.||||||.. |||.||.. || ||.. .|. |.| |...|. ||. |. ..|.| || KKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHP WI . FF |
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| Kinase | Aur.AA | Ciliate-E2 | 72-266 | 26 | 5.4e-63 | 215.08 | In-house | 90-365 (365) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 90-365/365 Sequence Identity: 26% (78 aa) KHPNILRLFGYFY--DESRVYLILEYAPRGELYKQLQ------------RAGRFDEQRTASYISQLAD---------------ALKYCHSKK-VIHRDIK .||||.... .|. |.. .||..||. |.|.. .. ..|.|. . .. |... ||.|.|||. .|||||| NHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIK PENLLLGLLGDLKIADFGWSVHAPSSRRNTL---------------------------------CGTMDYLPPEMIEGRM---------HDDKVDLWSLG |||.|. .||.||| | . .. |.. ||| |..||...| .| |.|.|||| PENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG VLCYEFLVGKPPFEAEGSTETYRRITKVHYQFP------------------SYVSAGARDVIKR----LLQHNPANRLP-LEQVLAHPWI |. ||.| ||||| .. | . ..|| ..| . | ||. .|| .| .|. ||.| |||. VILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | Aur.AA | MSK | 72-266 | 33 | 8.2e-63 | 211.16 | In-house | 59-277 (277) | Show / Hide |
Range on Protein: 72-266 Range on HMM: 59-277/277 Sequence Identity: 33% (73 aa) KHPNILRLFGYFYDESRVYLILEYAPRGELYKQLQRAGRFDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLL---GDLKIADFGWSVHAPSS- .|||| |.. | |.. ||..||. ||| . . ..|||.. . .. .| |... |.|..||||.||||.|. | .|. ||| . |.. QHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDE --RRNTLCGTMDYLPPEMIE----GRM-HDDKVDLWSLGVLCYEFLVGKPPFE--AEGST-------ETYRRITKVHYQFP----SYVSAGARDVIKRLL | .. |.|..| .|||.. . .|. .|.|||||. |. |.|. || ... | .|| | || . .|. |.| |..|| EWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLL QHNPANRLPLEQVLAHPWI . .|. || .. .|| |. TKDPKKRLGMNDLRAHEWK |
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| Kinase | Aur.AA | Pkinase_Tyr | 71-140 | 29 | 1.8e-13 | 46.25 | Pfam | 61-137 (270) | Show / Hide |
Range on Protein: 71-140 Range on HMM: 61-137/270 Sequence Identity: 29% (23 aa) PKHPNILRLFGYFY-DESR--VYLILEYAPRGELYKQLQR----AGRFDEQRTASYISQLADALKYCHSKKVIHRDI ..||||.|| | . .. .|...||.| | |.. |.. .... .. .. | |... | .||. ||||. GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL |
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| TyrKc | Aur.AA | TyrKc | 25-266 | 18 | 1.1e-12 | -17.89 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 25-266 Range on HMM: 1-280/280 Sequence Identity: 18% (56 aa) YECYEPID--AFCQKVASSLNRGTTAQARTQPV--KSAENGHGHDDKQM---------EP--KHPNILRLFGYFYDE-------SRVYLILEYAPRGELY . . . ||.. . .. ..| |. ... ... . .||||.||.|. .. .....||.| | | ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK KQLQRAGR-FDEQRTASYISQLADALKYCHSKKVIHRDIKPENLLLGLLGDLKIADFGWSVHAPSS------RRNTLC----GTMD-----YLPPEMIEG . |.. .. . . |. | |. | |||..||||. | |.| . ||.||| | . |. . ..|| | DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY RMHDDKVDLWSLGVLCYEFL-VGKPPFEA-----EGSTETYRRITKVHY-QFPSY--------VSAGARDVIKRLLQHNPANRLPLEQVLAHPWI .. | | || ||...| . |..| . .| .... . .. | . .. ...|. ...|..| ... | . GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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