Gene MAK (Sea Urchin)

MAK

Species: Sea Urchin
Alias: SPU_025893, MAK, Spk151
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: CMGC
Family: RCK
Subfamily: MAK

Sequence

Name Sequence Type Origin Length Description Download
MAK.AA Protein None 608 None Fasta, JSON
MAK.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of MAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAK.AA MAK 4-284 62 1.5e-243 783.94 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-352/352
Sequence Identity: 62% (220 aa)

YQVTKQLGDGTYGSVILGCR------------------------------FDNGEKVAIKKMKKKFYSWNECMELREVKSLKKLN-HANIVKLKEVIR--
||..|||||||||.|.|..|                              .|.|||||||.||||||||.|||.||||||||||| |.||||||||||  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

EDNILYFVFEYMTENLYELMKGRDR-LLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGP-----------------ELIKIADFGLARETRS
|...||||||||.||||..||.||| ..||||||||.||||||.|..||.|||||||||||..|.||                 |||||||||||||.||
ENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRS

RPPYTDYVSTRWYRAPEVLLRSTKYSSPIDMWAVGCIMAELYTLRPLFPGSSEVDEIFKITTVLGTPKKEE----------------WVEGFRLASQMNF
.||||||||||||||||||||||.|||||||||||||||||||.|||||||||.|.||||..|||||||..                |..|..||..|||
KPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNF

KFPQCVA---MPLKTIIPNASP-ESIHLIRDMLLWDPQKRPTAAQCLKYKYF
.|||||.   ||||..|||.|. ..|.|..|||.|||.|||||.||.||.||
RFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase MAK.AA RCK 4-284 64 9.3e-238 762.48 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-298/298
Sequence Identity: 64% (192 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECMELREVKSLKKLN-HANIVKLKEVIREDN--ILYFVFEYMTENLYELMKG---RDRLL
||..|||||||||.|........||.|||||||.|||||.|||.|||.|||.||| |.||.|||||||...  .|||||||| .|||..||.   |...|
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRKYL

PEPV--IRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCG---------PELIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRSTKYSSPIDMWAV
||..  |.||.||||||.|..||.||||||.||||..|.|         ...||||||||.|| ||.||||||||||||||||.|||.|.|.||.|.|||
PENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWAV

GCIMAELYTLRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDMLLWDPQKRPTAAQCLKYKYF
||||.|||.||||||||||.|.||||..|.|||.|..| .|..|||||||.||||..||||..|||.|.. |.|...|| ||||||.||.|.|...||
GCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase MAK.AA CMGC 4-284 27 2.1e-133 441.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-513/513
Sequence Identity: 27% (141 aa)

YQVTKQLGDGTYGSVILGCR--------------FDNGEKVAIKKMKKKFYSWNEC----------MELREVKSLKKLN-----------------HANI
|.. |..| |||| |  .                 ...|.|||||.|..|| . ..          . |||.| ||.||                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLKEVIREDN-----------------ILYFVFEYMTENLYELMKG--------RDRLLPEPV------------IRNIV------YQILQGMA--YIH
|||..... .|                  ||.|||||  .||...|         | . |.| .            |....      ||||.|..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KNG--FFHRDMKPENLLCCGPEL--------------------IKIADFGLAR--ETRSRP--------------------PYTDYVSTRWYRAPEVLLR
...  ..|||.||||.| .                        .||.||||||  ...|..                    |||.||.||||||||.||.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

S---------TKYSSPIDMWAVGCIMAELYT--------LRPLFPGSSE-----------VDEIFKITTVLGTPK---------------KE--------
.         ..|..|||||.||||.||.||        ..|||||.||           .| .|||  |||||                .|        
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

-----------------EWVEGFRLASQMNFKFPQCVAMPLKTIIPN-----------------------------------ASPESIHLIRDMLLWDPQ
                 .| |. |.. |.|..||..   |.| ..|.                                   ..|. |.|.  || .||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRPTAAQCLKYKYF
||.||.|.|.  ||
KRITAEQALQHPYF
Kinase MAK.AA CDK 4-284 35 1.1e-101 326.17 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-284/284
Sequence Identity: 35% (112 aa)

YQVTKQLGDGTYGSVILGCRFDNG-----EKVAIKKMKKKF------YSWNECMELREVKSLKKLNHANIVKLKEVIRED-----------NILYFVFEY
|.  ...| |||| |  .   ..|     . ||.|| .              .  .||.. ||.| |.|||||..|.  .           | ||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MTENLYELMKGRDRLLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPEL-----IKIADFGLARETRS-------RPPYTDYVSTRWYRAPE
|   |...|.          |... .|.|.|..|.|.|.. |||.|| |.|           .|||||||||.  .       . .||  | |.||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLRSTKYS--SPIDMWAVGCIMAELYT---LRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDM
.|| |..||   |||||.||||.||..|    .|||||.|| | .|||  ..|||  . | .   |                            .|.  |
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LLWDPQKRPTAAQCLKYKYF
|  ||.|| .| |.|. .||
LCYDPKKRISAEQALQHPYF
Kinase MAK.AA Pkinase 4-284 31 3e-101 347.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECMELR---EVKSLKKLNHANIVKLKEVIREDNILYFVFEYMTE-----NLYELMK-GRD
|.. ...| |..|.| .... ..|..||.|..||.  ........|   |.. .|.||| |||.|... .... .|.|.||.        |.....  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RLL--PEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELI----KIADFGLARE--TRSRPPYTDYVSTRWYRAPEVLLRSTKYSSPIDMWAV
. .  .| ......||||.|..|.|..|. |||.||||.|.     |    ||.|||||.   . . . .|... |.||.||||.. ...|....|||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMAELYTLRPLFPGS----SEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDMLLWDPQKRPTAAQCLKYK
|||..|... ||.|||.    . .|....|  ..|.| ...| .  .    . |.. .     ..|  .|.|.| ...|...| .||.|||||.|.|. .
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase MAK.AA S_TKc 4-284 31 4e-98 333.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECMELREVKSLKKLNHANIVKLKEVIREDNILYFVFEYMTE---NLYELMKGRDRL----
|.. ...| |..|.| ..   . |..||||..|        .. .||.. ||| .| |||||..|... . ||.|.||.     .|....| | |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRSTKYSS-PIDMWAVGCIMAELY
 .|| ..| ..|||.....|.|..|. ||| ||||.|..    |||.||||||.       | .. |.||.|||||    .|.  ..|.|..|||..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

TLRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDMLLWDPQKRPTAAQCLK-------YKYF
. .|.||   .....||.                                         ||| ...|| .| .||.||||| ..|.         .|
CGYPPFP---QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAK.AA CDK7 4-284 38 1.3e-97 260.54 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-288/288
Sequence Identity: 38% (110 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECME------LREVKSLKKLNHANIVKLKEVIREDNILYFVFEYMTENLYELMKGRDRLL
|.  |..| |... | ..|    |..||||| | |  . .|         .||.| |. . | |.. |  ..     .. ||..|   | .  |    .|
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIK-KLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

PEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARETRS-RPPYTDYVSTRWYRAPEVLLRSTKYSSPIDMWAVGCIMAELYTL
    | ..  ..|||. | |.|   |||.|| |||      .|||||||||   |    ||  | |||||||| |     | . .|||.||||.|||   
TPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLR

RPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFK-FPQCVAMPLKTIIPNASPESIHLIRDMLLWDPQKRPTAAQCLKYKYF
 | .|| |..| . .|   ||||  ||| .   ... . || ||    .||. |   || . ..|.  |.. .|.|| |..|||| .||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase MAK.AA CDC2 4-284 39 1e-96 297.78 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-301/301
Sequence Identity: 39% (121 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECME-------LREVKSLKKLN-HANIVKLKEVIREDNILYFVFEYMTENLYELMK---G
||  . .| |||| |. .   . .. ||.|| . .    .|  .       .||   ||.|. | |||||..|| . | || ||||.  .| ..|.   .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLE----QEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIP

RDRLLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARE-TRSRPPYT--DYVSTRWYRAPEVLLRSTKYSSPIDMWAVGCI
 .  .|. ..... ||||||... | .. .||| || |.|      ||||||||||  .    .||    | |.||||||.||.. .|| |.|||..|||
KNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

MAEL---YTLRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFRLASQMNFKFPQCVAMPLKTIIPN---------ASPESIHLIRDMLLWDPQKRPTAAQ
.||.    | .|||.| || |..|||  .||||. ..| .|       . .||.  .  |..|.||         . || | |.. ||  ||||| .| .
FAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTW-PGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

CLKYKYF
 |. .||
ALQHPYF
Kinase MAK.AA MOK 4-284 39 1.2e-90 284.27 In-house 1-283 (283) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECMELREVKSLKKLN-HANIVKLKEVI--REDNILYFVFEYMTENLYELMKGRDRLLPEP
|.   ..|.||.  |.    . .|.  | |.||..| | ..  .|||.. ...|| |.||..|.||.  |    |  . | |  |.|||..||   ||. 
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

VIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARETRSRPPYTDYVSTRWYRAPEVLLRSTKYSSPIDMWAVGCIMAELYTLRPLF
 |.. .||... .  .|.|| ||||.||||.|    . .|.||||  |   |. |||.|.||||||||| ||    |.  .|||.|||.  |.  |.|||
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQ-DHLKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVFYEIASLHPLF

PGSSEVDEIFKITTVLGTPKKEEWVEGFR-LASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDMLLWDPQKRPTAAQCLKYKYF
||  ||| | ||  |.||| ... .. |.  .  ||. ||      .. ..||...  . ..  |  .||  | || | ..  ||
PGVNEVDQISKIHDVMGTP-CQKILNKFKNQSRAMNYDFPFKKGSGIEKLTPNLTKQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase MAK.AA MAPK 4-284 34 2.8e-86 292.97 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-328/328
Sequence Identity: 34% (113 aa)

YQVTKQLGDGTYGSVILGCRFD------NGEKVAIKKMKKKFYSWNECME-LREVKSLKKL-NHANIVKLKEVIRE------DNI-----LYFVFEYMTE
||  |..| | || |             .|.||||||. . | .   |   .||.| |. . .| ||.||.....       ...     .|.|.|.|  
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLYELMKGRDRLLPEPVIRNIVYQILQG--MAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARETRSRPPY---------------TDYVSTRWYRA
.|. ..| ..  | .  |. ..|||| |  . |||  .  ||| ||.|.|.    . ||.|||||| . .   .               |.||.||||||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLR--STKYSSPIDMWAVGCIMAELYT-LRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGFR---LASQMNFKF---PQCVAMPLKTIIPN----AS
||..|   ...|.  .|||.||||.||..|  .|||||.. .| ...|. ||||| .|| ..       | ..   .   |.. . |.....||    |.
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PESIHLIRDMLLWDPQKRPTAAQCLKYKYF
|. |.|.  || .||.|| |....|   ||
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase MAK.AA ERK 4-284 36 2.1e-74 253.51 In-house 1-307 (307) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-307/307
Sequence Identity: 36% (112 aa)

YQVTKQLGDGTYGSVILGCRFDN------GEKVAIKKMKKKFYSWNECME-LREVKSLKKLN-HANIVKLKEVIRED-----NILYFVFEYMTENLYELM
|| .||.|.|.|| |.  ... .      |.|||||| .. |    .|   ||| | |. .. | ||..|. .....     | .|.|.|.|.  |    
YQIIKQIGHGAYG-VVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQII

KGRDRLLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLAR----ETRSR-----PPYTDYVSTRWYRAPEVLLRSTKYSSPI
. . .| ..  . . .|||| |. |||  . .||| || |.|.      ||.||||||    .  ..     . .|.||.||||||||..|  .||....
NSQQELSDD-HCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DMWAVGCIMAELYTLRPLFPGSSEVDEIFKITTVLGTPKKEEWVEGF--RLASQMNFKFPQ--CVAMPLKTIIPNAS--PESIHLIRDMLLWDPQKRPTA
|.|..|||.||..  .||||| . |. |. |. ..|||  || .. .    | .. ...|   . . |...|.|||.  |. | |.. || .||.|| |.
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

AQCLKYKYF
..||.  ||
EECLEHPYF
Kinase MAK.AA CDKL 4-218 41 1.1e-73 251.17 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-218
Range on HMM: 1-218/286
Sequence Identity: 41% (93 aa)

YQVTKQLGDGTYGSVILGCRF-DNGEKVAIKKMKKKFYSWNECME----LREVKSLKKLNHANIVKLKEVIREDNILYFVFEYMTENLYELMKGRDRLLP
|     .| | || |.. ||  ..|. ||||| |    | .. |.    .||.| || | | ||| |.|| |  . |. ||||.  .. .. . . . ..
YEKLGKVGEGSYG-VVMKCRNKETGQIVAIKKFKE---SEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVD

EPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCC-GPELIKIADFGLARETRSRPP--YTDYVSTRWYRAPEVLLRSTKYSSPIDMWAVGCIMAELYT
| |.|....|||.. .. ||.   ||| ||||.|       .|. |||.|| . . |   ||||| |||||||| |.  |.|..|.|.||.||.|||. .
EHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMID

LRPLFPGSSEVDEIFKITTVLGT
  ||.||.|..|  ..|  .||.
GQPLWPGQSDIDQLYHIQKCLGP
Kinase MAK.AA Pkinase_Tyr 4-125 27 3.1e-17 58.99 Pfam 1-136 (270) Show / Hide 
Range on Protein: 4-125
Range on HMM: 1-136/270
Sequence Identity: 27% (37 aa)

YQVTKQLGDGTYGSVILGCRF----DNGEKVAIKKMKKKFYSWNE---CMELREVKSLKKL-NHANIVKLKEVIR-EDNI--LYFVFEYMTE-NLYELMK
 .  |.|| | .|.| .|  .    ... .||.|.. |  ..  .    . .||.| .|.| .| |||.|  |.  ..    .| |.|||   .|..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

GR---DRLLPEPVIRNIVYQILQGMAYIHKNGFFHRD
 .   .. |. . . .. .|| .||.| . ... |||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRD
Kinase MAK.AA TyrKc 4-284 21 9e-16 32.33 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-284
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YQVTKQLGDGTYGSVILGCRFDNGEKVAIKKMKKKFYSWNECME-LREVKSLKKL--NHANIVKLKEVIRED-------NILYFVFEYMTE-NLYELMKG
 .  |.|| | .| | .|      ..||.|..|.        .. .|| . ..||  .| |||.|  |....         |. |.|||   .| .  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RDRLLPEPVIRNIVYQILQGMAYIHKNGFFHRDMKPENLLCCGPELIKIADFGLARETRSR-------PPYT------DY--VSTRWYRAPEVLLRSTKY
. . |. .   .. .|| .||.|.|.... |||    | |   .  .||.||||.|.  .          |.          .  ||. |||.. .  |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

SSPIDMWAVGCIMAELYTL-RPLFPGS----SEVDEIFKITTVLGTPKKEEW----VEGFRLASQMNFKFPQCVAMPLKTIIPNASPESIHLIRDMLLWD
..  | |. |  | |..|.  .  ||      . .|...     . ... .                               . ...|   ....    |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------F-VCCPDEMYQIMKQCWHED

PQKRPTAAQCLKYKYF
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PEDRPTFSEI--HECF
Kinase MAK.AA CDKL 245-284 31 5.6e-08 23.36 In-house 246-286 (286) Show / Hide 
Range on Protein: 245-284
Range on HMM: 246-286/286
Sequence Identity: 31% (13 aa)

PLKTIIPNAS-PESIHLIRDMLLWDPQKRPTAAQCLKYKYF
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PLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase MAK.AA Pkinase_Tyr 131-196 27 0.054997 7.35 Pfam 143-210 (270) Show / Hide 
Range on Protein: 131-196
Range on HMM: 143-210/270
Sequence Identity: 27% (20 aa)

LLCCGPELIKIADFGLARETRSRPPYTDYVST------RWYRAPEVLLRSTKYSSPIDMWAVGCIMAELYTL
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LVTENN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTY