Gene HIPKb (Sea Urchin)

HIPKb

Species: Sea Urchin
Alias: HIPKb, SPU_004962, Spk342
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
HIPKb.AA Protein None 450 None Fasta, JSON
HIPKb.kin_dom Protein Kinase Domain None 160 None Fasta, JSON

Protein domain

Protein domains of HIPKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HIPKb.AA HIPK 2-273 56 1.5e-122 387.97 In-house 58-329 (329) Show / Hide 
Range on Protein: 2-273
Range on HMM: 58-329/329
Sequence Identity: 56% (153 aa)

DDYNSVAMYNNFPHKFHSCIIIELLERNVYDLLLRDAMSSIPTPCVLPIYSFLCTVLVTLPRLGQIYYDFDDSRTLQCTPSCQPFQNKFYETGTSVHV*K
|.|. | .|  | || | |.. |.|| | || .     . .|   . ||     | |. |  || |  |      .   |. .|.  |  . |   || |
DEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSK

SQYS*LCLQRSCRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFKRDIESNFPLWRLKNPEEHE
   .     |  |||||||||||||..||||||||.|||||||||||||.||||||||.|||.||.||||.||.|..|||.||..|.|..||||..||||
VVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHE

TETSVKSKEARKYIFNCLDDIAGVNLPTDLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALNHPFV
..||||||||||||||||||.. ||. .|.|..||..||.||||||..||||.|.|..|||||.||||||||
QQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase HIPKb.AA DYRK 114-273 36 1e-70 241.25 In-house 171-320 (320) Show / Hide 
Range on Protein: 114-273
Range on HMM: 171-320/320
Sequence Identity: 36% (59 aa)

RAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAA--TKTTRFFKRDIESNFPLWRLKNPEEHETETS-VKSKE
||||.|||.|.|.|||||||||..||||.||||.||..||||...| ...|.| .......  .....||..           . ..|....|   |...
RAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC-----------FMYCECDEWTKQNKITD

ARKYIFNCLDDIAGVNLPTDLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALNHPFV
........ ... |...| . .  |.. . .|...|. ..||.|..||.||||| .||.||..
HYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase HIPKb.AA CMGC 114-273 23 8.7e-43 137.84 In-house 292-513 (513) Show / Hide 
Range on Protein: 114-273
Range on HMM: 292-513/513
Sequence Identity: 23% (55 aa)

RAPEIILGLP----------FCEAIDMWSLGCVVAELFLG--------WPLYPGASE-----------YDQIRYISQTQGLPAEHLLSA-------ATKT
|||||.|| .          ....|||||.||. ||...|        .|| || ||           .||.  | .. | |  .....       ....
RAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHE

TRFFKRDIESNFPL------WRLKNPEEHETETSVKSKEARKYIFN-CLDDIAGVNLPTDLEGSDYL----------------------------AEKAD
  ....    ....      |      .  |.|. .|. ||.||.. .       .  ..|.  .                              ..| .
EEWPNMIKLPWYNKFPKKWNW------Q--TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCC

RREFVELLKKMLTIDPDKRITPLEALNHPFV
  ....||||||..|||||||. .||.||. 
DPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase HIPKb.AA DYRK1 1-273 30 1.7e-35 121.89 In-house 58-321 (321) Show / Hide 
Range on Protein: 1-273
Range on HMM: 58-321/321
Sequence Identity: 30% (84 aa)

DDDYNSVAMYNNFPHKFHSCIIIELLERNVYDLLLRDAMSSIPTPCVLPIYSFLCTVLVTL--PRLGQIYYDFDDSRTLQCTPSCQPFQNKFYETGTSVH
.. |. | . . | .. | |...|||  |.||||       .    .  .   .|| |. .  | |  |  |      | | |     . |  . | | .
EMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQ

V*KSQYS*LCLQRSCRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFKRDIESNFPLWRLKNPE
. .  |  .   |  |.||..||...  |||||||||.. |.  | ||. |..| ||.  |    |.| .|..  | |. ..|..| .     | .|  .
LGQRIYQYIQ-SRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDN---TWYCKKTR

EHETETSVKSKEARKYIFNCLDDIAGVNL--PTDLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALNHPFV
... .   |.  .||     |..| ||.   |      .     .|   | .|.|.||  || .||||..|| |.|.
DKKKH--YKEPCTRK-----LHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase HIPKb.AA YAK 110-183 47 1.3e-32 107.84 In-house 168-241 (347) Show / Hide 
Range on Protein: 110-183
Range on HMM: 168-241/347
Sequence Identity: 47% (35 aa)

QRSCRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFKR
||  |.||||.. ..| .||||||||.||||||| |..||.|||.||  |  . | |   ..      ...|..
QRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHC
Kinase HIPKb.AA CDK 114-273 26 1.4e-27 85.15 In-house 186-284 (284) Show / Hide 
Range on Protein: 114-273
Range on HMM: 186-284/284
Sequence Identity: 26% (44 aa)

RAPEIILGLPFC---EAIDMWSLGCVVAELFL---GWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFKRDIESNFPLWRLKNPEEHETETSVK
||||. ||        .|||||.||. ||.|.   . || || || ||.  |... | | |      ||   .                           
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

SKEARKYIFNCLDDIAGVNLPTDLEGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALNHPFV
                                        .|| |||. ||.|||.  .||.||. 
----------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase HIPKb.AA DYRK2 114-183 40 2.1e-26 82.6 In-house 169-243 (318) Show / Hide 
Range on Protein: 114-183
Range on HMM: 169-243/318
Sequence Identity: 40% (30 aa)

RAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAA-----TKTTRFFKR
||||.|||...  ||||||.||..|||. | || ||  | ||. ..    |.| ..... .     ...  ||..
RAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNS
Kinase HIPKb.AA MAPK 114-172 39 4e-15 48.55 In-house 198-260 (328) Show / Hide 
Range on Protein: 114-172
Range on HMM: 198-260/328
Sequence Identity: 39% (25 aa)

RAPEIILG---LPFCEAIDMWSLGCVVAELFL-GWPLYPGASEYDQIRYISQTQGLPAEHLLS
|||||.|.       .|.||||.||  ||.   . || || .  ||.  | .. | | |....
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQ
Kinase HIPKb.AA RCK 245-273 51 2.6e-14 41.53 In-house 270-298 (298) Show / Hide 
Range on Protein: 245-273
Range on HMM: 270-298/298
Sequence Identity: 51% (15 aa)

EFVELLKKMLTIDPDKRITPLEALNHPFV
. .||..|||..||.||||. .||.||. 
DCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase HIPKb.AA p38 114-172 40 2.1e-13 41.88 In-house 170-229 (289) Show / Hide 
Range on Protein: 114-172
Range on HMM: 170-229/289
Sequence Identity: 40% (24 aa)

RAPEIILG-LPFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLS
|||||.|    . ...|.||.||. |||  | .|.||    ||.. | .  | |.| ...
RAPEIMLNWMHYTQTVDIWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQ
Kinase HIPKb.AA RCK 114-156 45 4.5e-13 37.55 In-house 180-223 (298) Show / Hide 
Range on Protein: 114-156
Range on HMM: 180-223/298
Sequence Identity: 45% (20 aa)

RAPEIILGL-PFCEAIDMWSLGCVVAELFLGWPLYPGASEYDQI
||||..|      . .|.|..||. .||   .||.||.|| |||
RAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQI
Kinase HIPKb.AA MAPK 245-273 58 2.6e-12 38.66 In-house 300-328 (328) Show / Hide 
Range on Protein: 245-273
Range on HMM: 300-328/328
Sequence Identity: 58% (17 aa)

EFVELLKKMLTIDPDKRITPLEALNHPFV
. . ||.|||..|||||||  |||.||..
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase HIPKb.AA Pkinase 114-220 24 9.3e-12 42.66 Pfam 178-275 (293) Show / Hide 
Range on Protein: 114-220
Range on HMM: 178-275/293
Sequence Identity: 24% (29 aa)

RAPEIIL-GLPFCEAIDMWSLGCVVAELFLGWPLYPGA----SEYDQIRYISQTQG------LPAEHLLSAATKTTRFFKRDIESNFPLWRLKNPEEHET
.|||.|. | .   ..||||.||...|...| |..||.    . .||.  | .. |       | ..  |  . ...   .              . |.|
MAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWT

ETSVKSKEARKYIFNCLD
     |.|... | .||.
F-HNWSEECKDFIKWCLC
Kinase HIPKb.AA p38 240-273 50 3.3e-11 34.28 In-house 257-289 (289) Show / Hide 
Range on Protein: 240-273
Range on HMM: 257-289/289
Sequence Identity: 50% (17 aa)

KADRREFVELLKKMLTIDPDKRITPLEALNHPFV
.|.. . ..|| ||| .|||||||  ||. ||. 
GANPQA-IDLLEKMLELDPDKRITAEEAMQHPYF
Kinase HIPKb.AA Pkinase 244-273 36 8.2e-09 32.25 Pfam 264-293 (293) Show / Hide 
Range on Protein: 244-273
Range on HMM: 264-293/293
Sequence Identity: 36% (11 aa)

REFVELLKKMLTIDPDKRITPLEALNHPFV
.|. ...|..|. || ||.|. ..|.||..
EECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HIPKb.AA S_TKc 4-273 12 2.9e-08 -55.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-273
Range on HMM: 1-231/231
Sequence Identity: 12% (43 aa)

Y-----------------------------------------------NSVAMYNNFPHKFHSCIIIELLER---NVYDLLLRDAM----SSIPTPCVLP
|                                               | | .|  | .  | ... |...    ...|.. .       . .|   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IYSFLCTVLVTLPRLGQIYY-----------------DFDDSRTLQCTPSCQPFQNKFYETGTSVHV*KSQYS*LCLQRSCRAPEIILGLPFCE-AIDMW
.   .|  |  . .. .| .                 ||  .| |                           . .|  .  .|||..   ..   ..|.|
YMYQICCALEYCHSH-GIIHRDLKPENILLDEHIKICDFGLARQL---------------------------TTFCGTPWYMAPEVL---GYGKCKCDWW

SLGCVVAELFLGWPLYPGASEYDQIRYISQTQGLPAEHLLSAATKTTRFFKRDIESNFPLWRLKNPEEHETETSVKSKEARKYIFNCLDDIAGVNLPTDL
|.||...|.. | |..|   ..  .. |                                                                        
SCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------------------------------------------------

EGSDYLAEKADRREFVELLKKMLTIDPDKRITPLEALN-------HPFV
            .|. ....|.|. ||.||.|  |||.       ||..
-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HIPKb.AA DYRK2 246-273 39 4.6e-08 21.96 In-house 291-318 (318) Show / Hide 
Range on Protein: 246-273
Range on HMM: 291-318/318
Sequence Identity: 39% (11 aa)

FVELLKKMLTIDPDKRITPLEALNHPFV
|.. .|. .. ||..|.|| .||.||. 
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase HIPKb.AA YAK 239-273 28 7.4e-07 18.9 In-house 313-347 (347) Show / Hide 
Range on Protein: 239-273
Range on HMM: 313-347/347
Sequence Identity: 28% (10 aa)

EKADRREFVELLKKMLTIDPDKRITPLEALNHPFV
..  |  |. ..  .|  .| .| .|  |  |||.
NNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase HIPKb.AA DYRK 1-34 50 1.4e-05 17.09 In-house 58-91 (320) Show / Hide 
Range on Protein: 1-34
Range on HMM: 58-91/320
Sequence Identity: 50% (17 aa)

DDDYNSVAMYNNFPHKFHSCIIIELLERNVYDLL
|| |. | ||. | |. | ||. |||. | |..|
DDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFL
Kinase HIPKb.AA YAK 7-34 42 0.000158 10.86 In-house 68-95 (347) Show / Hide 
Range on Protein: 7-34
Range on HMM: 68-95/347
Sequence Identity: 42% (12 aa)

VAMYNNFPHKFHSCIIIELLERNVYDLL
. ||  | || | |.. |.|. | |..|
LRMYDFFVHKNHFCLVFEMLSNNLYEYL
Kinase HIPKb.AA DYRK2 1-34 38 0.057329 1.81 In-house 58-91 (318) Show / Hide 
Range on Protein: 1-34
Range on HMM: 58-91/318
Sequence Identity: 38% (13 aa)

DDDYNSVAMYNNFPHKFHSCIIIELLERNVYDLL
|  .| | | . |    | ||  |||  |.|...
DNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYI