Gene HIPKa (Sea Urchin)
HIPKa
Sequence
Protein domains of HIPKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | HIPKa.AA | HIPK | 143-420 | 63 | 9.20000000001e-151 | 478.37 | In-house | 1-278 (329) | Show / Hide |
Range on Protein: 143-420 Range on HMM: 1-278/329 Sequence Identity: 63% (177 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAENADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLPL |||||||||||||||||||||||||.||||||||||.||||||||||||..|| ||||....|||||.|.||||||||||.|| |||||.|| || |||| YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL KHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRCVKFLLSITLIEIVCMKSLSCVQTTFYVGW ||||| ||||| ||.||| ||||||||||||||||||.|.|||||||||||||||||.||.||||||||| .| . ..| . | || || . || KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW YMYVSFCIHVNVRYIIQVVALPGLSHLNLKNKSADFSIRGTTMSSSTWLLKACSKRPSETGV*SDSRSNYLFNTINDM | .|||.| || . |. |. | | . .. . | || .|.| | | || . || PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDM |
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| Kinase | HIPKa.AA | DYRK | 143-312 | 49 | 9.20000000001e-105 | 354.35 | In-house | 1-171 (320) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-171/320 Sequence Identity: 49% (86 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAE-NADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPL- ||.||..|.|.||||||||...|||.|||||..|.....||.|||..|| .|. . . | .. |..|.||.|.||.|.|||||. |||.|||. .|... YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF PLKHIRPTLQQVLVALLKLKTL-GLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR .|...|. .||.|..|..|... .||.|||||||||..| |.....|||||||...... ...||.|||.|| SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYR |
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| Kinase | HIPKa.AA | CMGC | 143-312 | 23 | 1.2e-61 | 200.98 | In-house | 1-292 (513) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-292/513 Sequence Identity: 23% (68 aa) YEVLEFLGRGTFGQVVKCWK--------------RGTNEIVAIKILKNHPSYARQGQ-------------IEVSILARLS------------AENADDFN ||... .|.||.|.|.||. . ||||||||..|| . | .|.. |..|| .|. .| .. | YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN LVRAYEYFQHKN-----------------HTCLVFELLEKNLYDFLKQSKF-------RPLPLKH------------IRPTL------QQVLVALL--KL .|. |..|.||| | .||||.....||...|. .| .||. | |. . .|.| .| . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC KTLG--LIHADLKPENIMLVDPVRQP----------------YRVKVIDFGSASHVSKA-----------------------VCSTYLQSRYYR . || |||||||.. . . . .|.|..|||.| .... ..| ..|.|| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYR |
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| Kinase | HIPKa.AA | YAK | 143-312 | 45 | 4.6e-60 | 202.61 | In-house | 1-172 (347) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-172/347 Sequence Identity: 45% (80 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL-SAENADDFN----LVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKF | || ||.||||||||| . .|||..|.|..|| . | |. |. || | . .. | ..| | .| |||| |||||.|. |||..||| || YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF RPLPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR . . || . |.| .. |. .|| ||||||||| . .| .|.|||||. | | || |.|.|| CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCK-PNKP-EIKIIDFGSSCQEKKMVY-TYIQQRHYR |
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| Kinase | HIPKa.AA | DYRK2 | 143-312 | 40 | 5.1e-56 | 180.5 | In-house | 1-169 (318) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-169/318 Sequence Identity: 40% (70 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAENADD-FNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLP ||.||..|.| ||||||| |.. ||||.. | ...| ..|. || ... . | .| |. .|| ||.|..|||| |||...|. .| . YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS LKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR |. .|. ...| .| |. .||.|||||||.| . | .||||||| . || |||.|| LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRS--GIKVIDFGSSCFEHQYRIYTYIQSRFYR |
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| Kinase | HIPKa.AA | DYRK1 | 143-364 | 37 | 1.5e-49 | 170.92 | In-house | 1-222 (321) | Show / Hide |
Range on Protein: 143-364 Range on HMM: 1-222/321 Sequence Identity: 37% (85 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAENADD-FNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQSKFRPLP ||. .|.| |||||| . . . | |||||.|| .. | |||. .| . .. ... ...|. . | ..|| ||||||| |||| |. .|| YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS LKHIRPTLQQVLVALLKLKT--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRCVKFLLSITLIEIVCMKSLSCVQTTFY | .| ||.. ||| . | | .|| |||||||.|. | | .|.|||||. .. . . |.|||.|| || | . | || |. LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIY-QYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH VGWYMYVSFCIHVNVRYIIQVVALP .| .. . |. |. .| TGEPLFSGSNEVDQMNKIVEVLGMP |
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| Kinase | HIPKa.AA | CLK | 143-279 | 33 | 1.9e-49 | 146.01 | In-house | 1-150 (350) | Show / Hide |
Range on Protein: 143-279 Range on HMM: 1-150/350 Sequence Identity: 33% (50 aa) YEVLEFLGRGTFGQVVKCWKRGT-NEIVAIKILKNHPSYARQGQIEVS-ILARLSAE-NADDFNL---VRAYEYFQH-KNHTCLVFELLEKNLYDFLKQS ||.. || |||| ||.|| . . ||.|| .|. | . ..|.. |. . . ... .. .. ...| . ..| |.||||. ...|||.| YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN K------FRPLPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDP . ..|.|. ||| | . |. .| ..|.| ||||||| .||. NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDS |
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| Kinase | HIPKa.AA | PRP4 | 143-312 | 38 | 3.4e-37 | 129.87 | In-house | 1-172 (320) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-172/320 Sequence Identity: 38% (68 aa) YEVLEFLGRGTFGQVVKCW-KRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAE---NADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLKQ-SKF |.| . | | |. |..| . .|| |||||. | .. . | |. || .|. | | || .. |.|..| ||||| . || . ||. | YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD RPLPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR | || .| || ..|| || .. .|||.|| ||. | .|||||||.. ||.||.|| VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNE---SKNTLKMCDFGSASHIHENEITPYLVSRFYR |
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| Kinase | HIPKa.AA | DyrkP | 143-312 | 36 | 7.7e-33 | 104.98 | In-house | 1-172 (323) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-172/323 Sequence Identity: 36% (63 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAE-NADDFNLVRAYEYFQHKNHTCLVFELLEKNLYDFLK----QSKF | ..|.|| | . ..| . || .. .||. | | | |. .| . |. | .| |.|| || | .. |||. |||.| | . YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ RPLPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR | . . ||.|.|| . | ||| |||||||.. . .||.|||||. . . | | ||| || RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKC--QVKIIDFGSSCFIHDHLSS-YVQSRSYR |
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| Kinase | HIPKa.AA | Pkinase | 143-312 | 29 | 2.5e-31 | 111.84 | Pfam | 1-178 (293) | Show / Hide |
Range on Protein: 143-312 Range on HMM: 1-178/293 Sequence Identity: 29% (54 aa) YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQI-----EVSILARLSAENADDFNLVRAYEYFQHKNHTCLVFELLEK-----NLYDFL |.... .|.|.||.| || ..||..|||.||.| . . |. |..|..||. .| || |..|. |.| ..|.|..|. |.|.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI KQSKFRPL--PLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLV-DPVRQPYRVKVIDFGSAS---HVSKAVCSTYLQSRYYR . .. ... . .... . |.| .| . | || |||||||... ... . .||..|||.| . .. ..|. ...|. STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYM |
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| Kinase | HIPKa.AA | S_TKc | 143-442 | 19 | 1.5e-29 | 105.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 143-442
Range on HMM: 1-231/231
Sequence Identity: 19% (63 aa)
YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSAENADDFNLVRAYEYFQHKNHTCLVFELLEK---NLYDFLKQSKFRP
||.|. .|.|.||.| ||....|..||||||.| .. . |..|| . . |.|. |..||. .| ..|.|... .|.|..|. . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----LPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYR---CVKFLLS---------ITLI
.| |.| ..|.. || . .| || |||||||.| . ..|..|||.| .. .|. ...|. . ..|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILY
EIVCMKSLSCVQTTFYVGWYMYVSFCIHVNVRYIIQVVALPGLSHLNLKNKSADFSIRGTTMSSSTWLLKACSKRPSETGV*SDSRSNYLFNTINDMLHL
| .| . . . .. ..... |..
EMLCGYPPFP-------------------QMQMMFKKIG---------------------------------------------------SPEAKDFIRK
FICK--SDRTCSLNYHT-------HESL
.| ..| . |. .
CLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | HIPKa.AA | CAMK | 148-299 | 18 | 2.6e-27 | 84.45 | In-house | 1-248 (425) | Show / Hide |
Range on Protein: 148-299 Range on HMM: 1-248/425 Sequence Identity: 18% (46 aa) FLGRGTFGQVVKCWKRGTN------------EIVAIKILKN-----------------------------HPSYARQGQIEVSILARLSAEN--ADDFNL ||||.||.| .| . |. . |||||.. |. .. . |..|. .|.. . | |. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRAYEYFQH-------------------KNHTCLVF---ELLEKN-----LYDFLKQSKF-------------RPLPLKHIRPTLQQVLVALLKLKTLGL .. ||... ..| ..|. |. . |.|.... . . .. . | .|.. |. . .. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI IHADLKPENIMLVDPVRQP-------------YRVKVIDFGSASHVSK .| |||||||.|.| . . .|.|||| | .. . VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDP |
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| Kinase | HIPKa.AA | TyrKc | 143-361 | 15 | 4e-06 | -122.96 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 143-361
Range on HMM: 1-280/280
Sequence Identity: 15% (47 aa)
YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARL--SAENADDFNLVRAYEYFQHK-------NHTCLVFELLEK-NLYDFL
. .. ||.| ||.|.|. . . ||.| ||.. . | .|. .| . . |.|| | . .. ..|.|. .. .| |.|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL
KQSKFRPLPLKHIRPTLQQVLVALLKLKTLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA-VC----STYL-----QSR-------------
. .. . |..|. |. | ..|| || |... .. .||. ||| . . . ..| ...
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI
----------------------------YYRCVK-FLLSITLIEIVCMK-SLSCVQT-------TFYVGWYMYVSFCIHV------NVRYIIQVV
|. .. .. . .|| | . . . . |. . | | . . |..
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | HIPKa.AA | Pkinase_Tyr | 143-177 | 33 | 6e-06 | 20.82 | Pfam | 1-39 (270) | Show / Hide |
Range on Protein: 143-177 Range on HMM: 1-39/270 Sequence Identity: 33% (13 aa) YEVLEFLGRGTFGQVVKCWKR----GTNEIVAIKILKNH . .. ||.| ||.|.|. . .|. ||.|.||.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG |
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| Kinase | HIPKa.AA | CLK | 286-294 | 77 | 0.051046 | 1.03 | In-house | 186-194 (350) | Show / Hide |
Range on Protein: 286-294 Range on HMM: 186-194/350 Sequence Identity: 77% (7 aa) VKVIDFGSA ..||||||| ICVIDFGSA |
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