Gene DYRK2 (Sea Urchin)

DYRK2

Species: Sea Urchin
Alias: Spk141, DYRK2, SPU_026899
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK2.AA Protein None 561 None Fasta, JSON
DYRK2.kin_dom Protein Kinase Domain None 314 None Fasta, JSON

Protein domain

Protein domains of DYRK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK2.AA DYRK2 193-506 68 1.3e-242 797.46 In-house 1-318 (318) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-318/318
Sequence Identity: 68% (220 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKNKFQGFS
||.|...||||||||||.|||||.||.|.||.||.||||.||.||||||.|.|.|||||.|| .||...| ||||.|||||||||||||.||||.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ-RIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYP
|||||.||||.||||. ||.|.|||||||||||||||..|||||||||||||.||| ||||||||||||||||||||||||.|||||.|||.|||.||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LLPGEDEGDQLACMIEVMGMPSQNLIDTS-----KRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDLVKALKGCDDPLFLDFLKRC
|.|||.|.||.|||.||.|||.....||.     .| |.|.||.....||  |...|...........|.. |.|||||.....||||.|..|.||.|||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LEWDPSSRMTPSQALRHSWL
.|||||.||||||||.| |.
FEWDPSERMTPSQALKHPWI
Kinase DYRK2.AA DYRK 193-506 57 2.7e-210 704.91 In-house 1-320 (320) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-320/320
Sequence Identity: 57% (188 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKNKFQGF-
||.|...||||||||||..|||||...|.|..||.||||||||.||.|||.|..||.|.... .||...| .||| ||.||||||||||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLQLVRKFAHSLLQCLEGLHRN-KIIHCDLKPENILLKQQ-GRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTG
||.||||||...|.||  ||.| .|||||||||||.|||. ..|.||||||||||.||||||||||||||||||||||..|...|||||||||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLLPGEDEGDQLACMIEVMGMPSQNLIDTS--KRSKNFINSKGQPRYCTVTTLPDGTT------VLNGGRSRRGKVRGPPGSKDLVKALKGCDDPLFLD
.||.|||.| |||||..||.|||....||..  .| ..|...   ..||.... ... .      .... ...| ..|.|||....  ... ||| .|.|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKRCLEWDPSSRMTPSQALRHSWL
|.|.||.|||..|.||||||.|.|.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase DYRK2.AA CMGC 193-506 22 5.1e-129 426.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-513/513
Sequence Identity: 22% (117 aa)

YEVLKILGKGSFGQVVKVYD--------------HKTNQHIAVKMVRNEKRFHRQAQ-------------EEIRILEHLR-KQDKDN-----------NM
||..| .|.|..|.|.| .|              |.||...|.| ..|.. ...||.              ||.||.||. ..|. |             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

NLIHMFESFSFRN-----------------HICITFELLSMNLYELIKKNK--------------------------FQGFSLQLVRKFAHSLLQCLE--
|.......| ..|                 |... ||.. ..||..||.|.                           . |.. ..| ... .|..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

GLHRNK--IIHCDLKPENILLKQQGRS------------------GIKVIDFGSSCYEHQR------------------------IYTYIQSRFYRAPEV
 .|...  |||.||||||||. .....                   .|..|||.....|..                        ...|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGGK----------YGMPIDMWSLGCILAELLTG--------YPLLPGEDE-----------GDQLACMIEVMGMPSQNLIDTSK-------RSKNFIN
.|| |          |. ||||||.|||.||..||        .|| ||..|            |||.....|.|.|. ..|...|       ......|
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGQPRYCT---------VTTLPDGTTVLNGGRSRRGKVRGPPGSKDLVKALKG-------------------------------CDDPLFLDFLKRCLE
 .. |.| .         .|.  .    .   . .| . . |.  |.|.. ..                                |.||...|.||..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPSSRMTPSQALRHSWL
.||. |.|..|||.| ..
YDPDKRITAEQALQHPYF
Kinase DYRK2.AA DYRK1 193-506 46 2.6e-113 382.75 In-house 1-321 (321) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-321/321
Sequence Identity: 46% (149 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKNKFQGFS
||.   .|||||||||| |||.. ...|.|...| | |  ||| |||.|| . |.||..  ...|. . | ||||.|. ||||| |||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LQLVRKFAHSLLQCLEGLHRN--KIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGY
| |.||||. ... |  .     .|||||||||||||    || ||.|||||||   |||| ||||||||.|||.|| .| | |||||||||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLLPGEDEGDQLACMIEVMGMPSQNLIDTSKRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRR-----GKVRGPPGSKDLVKALKGCDDPL-FLDFLK
||  | .| ||.  ..||.||| ...|| . ... . . . .  .    |  |.    .  . |.     |   | ||.. .  .     |.| | | .|
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTR-DKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIK

RCLEWDPSSRMTPSQALRHSWL
| |..|| .|.|| .||.||..
RMLQYDPKQRITPYYALQHSFF
Kinase DYRK2.AA YAK 193-426 46 2.1e-99 336.55 In-house 1-238 (347) Show / Hide 
Range on Protein: 193-426
Range on HMM: 1-238/347
Sequence Identity: 46% (111 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMN----LIHMFESFSFRNHICITFELLSMNLYELIKKNKF
| || .||.| ||||||     ||  .||| . |   .  ||  ||.||. | .|   || |    .. |  .| ..|| |. ||.||.||||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLT
 ||| ||.| .  . |  .  |   .|||||||||||.|..  .  ||.|||||||.| . .|||||.|.||.||.|..  |   |||||||||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLLPGEDEGDQLACMIEVMGMPSQNLIDTSKRSKNF
| |. ||  | .|.   |.. | |   .||  . .  .
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKY
Kinase DYRK2.AA S_TKc 193-506 26 2.8e-95 323.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-231/231
Sequence Identity: 26% (86 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSM---NLYELIKKNKFQ
||.|...|||.||.| |....||... |.|...      .... ||.||..       .  |.......|   .|... .|...    .|...|||.. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGM-PIDMWSLGCILA
|    |.   .|.... ... || .|...|||.||||||||| .     ||..|||...      .|.. ...|.||||.   .||  ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGYPLLPGEDEGDQLACMIEVMGMPSQNLIDTSKRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDLVKALKGCDDPLFLDFLK
|.|.|||. |      |.. |....|                                                                 .| ..||..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

RCLEWDPSSRMTPSQALR-------HSWL
.||..||. |.|  .||.       | |.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DYRK2.AA HIPK 193-435 40 8.3e-75 234.9 In-house 1-245 (329) Show / Hide 
Range on Protein: 193-435
Range on HMM: 1-245/329
Sequence Identity: 40% (100 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKNKFQGFS
|||| .||.| ||||||   . ||  .|.|. .|.  . || | |..||. |.... | ..... ..| |  .||.|. ||.|  |||.  |.|||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRIY-TYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTG
|. .|      |  |  |    .|| |||||||.|  . |    .|||||||  .  . .  ||.|||.|||||.||| ..   .|||||||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLLPGEDEGDQLACMIEVMGMPSQNLIDTSKRSKNFINSKGQPRY
 || || || ||   ...  . | . |.    ... | . . | ..
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKF
Kinase DYRK2.AA Pkinase 193-506 26 7.4e-71 246.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-293/293
Sequence Identity: 26% (90 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQE-----EIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSM-----NLYEL
|......|.||||.| | ....|..  ||| .. ... . . |.     ||.|. .|.        | . ....|  ..||.. .|.. .      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---KNKFQGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSG--IKVIDFGSSC---YEHQRIYTYIQSRFYRAPEVIL-GGKYGMP
|.   ...|  || . .....  .|. || .|...|||.||||||||....|  .  .|..|||...   | ... .|.  ...|.|||||. | .|| .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELLTGYPLLPGE----DEGDQLACMIEVMG--MPSQNLIDTSKRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDL
.||||.||||.|.|.|.|. ||.    .  ||.... ..||   ...   . |..  . ..    .                                  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------------------------

VKALKGCDD---PLFLDFLKRCLEWDPSSRMTPSQALRHSWL
 . ..   .   . ..||.|.||..||..| |. |.| | |.
-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DYRK2.AA DyrkP 193-389 41 4.2e-58 189.67 In-house 1-201 (323) Show / Hide 
Range on Protein: 193-389
Range on HMM: 1-201/323
Sequence Identity: 41% (83 aa)

YEVLKILGKGSFGQVVKVYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKNK----F
| ..  ||   | . ..  | .||| . .|.. | | .  |. .||..|  .         | ..... |  . |. |  |||  ||||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLT
. | .  . |    .|  |. .|  ..|||||||||||.| . .  .|.|||||||. |  .  |.||| |||||||.| ||   ||||||||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

G
|
G
Kinase DYRK2.AA PRP4 193-395 39 8e-57 195.1 In-house 1-207 (320) Show / Hide 
Range on Protein: 193-395
Range on HMM: 1-207/320
Sequence Identity: 39% (83 aa)

YEVLKILGKGSFGQVVKVY-DHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHLRKQ--DKDNNMNLIHMFESFSFRNHICITFELLSMNLYELIKKN-KF
|.|    |.| |. |..     ..|. .|.| .||    |.    |. ||  |  .  ||.     . ||..|..|.|.|. || .|||| |..||  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGS-SCYEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELL
 |..|  || .|  |.  |  | ...|.| |.|| |||     .. .| .|||| |  . . |  | .||||||||.|.| .|   ||||| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLLPG
||  . ||
TGKIMFPG
Kinase DYRK2.AA Ciliate-E2-Unclassified 193-506 21 1e-55 191.43 In-house 1-352 (352) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-352/352
Sequence Identity: 21% (86 aa)

YEVLKILGKGSFGQVVKVYDHKTNQH-----IAVKMVRNEKRFHRQAQEEIRILEHLRKQDKDNNMN-----------------LIHMFESFSFRNHICI
|...|..|.|.||.| |... |..|      . ...... |   ..  |........ .. | ....                 ...||. |  ...|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

TFELLSM-NLYELIKKNKF---------------QGFSLQLVR-----KFAHSLLQCLEGLHRNK-IIHCDLKPENILLKQQGR-SGIKVIDFGSS----
  |..   .| . |||.|.               . |. | ..     ...  .||.|| ||... ||| |.||||||....|.   ||.||||.|    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

--------------CYEHQRIYTYIQSRFYR----APEVILGGKYG----MPIDMWSLGCILAELLTGYPLLPGEDEGD----------------QLACM
               . .|...| ...  |     ||||. | .|.      .|.||||.|| |.|.||.  ..... .                ..   
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

IEV-MGMPSQNL----IDTSKRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRRGKVRGPPGSKDLVKALKGCDDPLFLDFLKRCLEWDPSSRMTPSQA
..     |...      . |.  |.|||                                                    |.|...|...|..|.|..|.
KQKNIQFPKFPWQQIPKHWSPEAKDFIN----------------------------------------------------DLLQKMLKKNPNKRITFEQI

LRHSWL
| | |.
LNHPWF
Kinase DYRK2.AA CLK 193-327 32 2.7e-55 163.87 In-house 1-147 (350) Show / Hide 
Range on Protein: 193-327
Range on HMM: 1-147/350
Sequence Identity: 32% (48 aa)

YEVLKILGKGSFGQVVKVYDHKT-NQHIAVKMVRNEKRFHRQAQEEIR-ILEHLRKQ-DKDNNMN--LIHMFESFSF-RNHICITFELLSMNLYELIKKN
||... || | || ||.. |||  ....|.| .|| ...  .|. ||. |.... .  |..|      ..|...| .  .|||| |||.  ..|...|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILL
.      .... .. .|..|. |.. .. || .|..| |||||||..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK2.AA CLK 335-412 49 3.7e-27 77.89 In-house 186-266 (350) Show / Hide 
Range on Protein: 335-412
Range on HMM: 186-266/350
Sequence Identity: 49% (40 aa)

IKVIDFGSSC---YEHQRIYTYIQSRFYRAPEVILGGKYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEVMGMP
|.||||||     ..|   .| ...| |||||||||  .  | | || |||| || ||. | .. |. . || | ..||||
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMP
Kinase DYRK2.AA TyrKc 193-506 18 3.8e-11 -42.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 193-506
Range on HMM: 1-280/280
Sequence Identity: 18% (63 aa)

YEVLKILGKGSFGQVVK-VYDHKTNQHIAVKMVRNEKRFHRQAQEEIRILEHL-RKQDKDNNMNLIHMFESFSFR-------NHICITFELLSM-NLYEL
 . .|.|| | ||.|.| ...    .  ||||.....  ..   .|.||. .|       .. |.. ..   .           ..| .|. .  .| . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKKNKFQGFSLQLVRKFAHSLLQCLEGLHRNKIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQR-------IYTYI----QSR-----FYRAPEVIL
..|.. . ....   .|..   .  | ||....|| ||   |.|.. ..   .|. ||| | . .          |       ...        |||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GGKYGMPIDMWSLGCILAELLT-GYPLLPGE----DEGDQLACMIEVMGMPSQNLI----DTSKRSKNFINSKGQPRYCTVTTLPDGTTVLNGGRSRRGK
 ||.    | || |  . |..| | .  ||.     . ...   ..  ... |                                               
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------------

VRGPPGSKDLVKALKGCDDPLFLDFLKRCLEWDPSSRMTPSQALRHSWL
               .| | ..    |.| . ||..| | |.   |. .
------------F-VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase DYRK2.AA CLK 479-506 39 3.4e-09 22.97 In-house 323-350 (350) Show / Hide 
Range on Protein: 479-506
Range on HMM: 323-350/350
Sequence Identity: 39% (11 aa)

FLDFLKRCLEWDPSSRMTPSQALRHSWL
. | ....|| ||| |.| ..|| | . 
LFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK2.AA DyrkP 475-506 43 6.4e-08 21.44 In-house 292-323 (323) Show / Hide 
Range on Protein: 475-506
Range on HMM: 292-323/323
Sequence Identity: 43% (14 aa)

DDPLFLDFLKRCLEWDPSSRMTPSQALRHSWL
|| .|.|| ..||  |   | |   ||.| |.
DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK2.AA PRP4 479-506 42 1.3e-07 24.03 In-house 293-320 (320) Show / Hide 
Range on Protein: 479-506
Range on HMM: 293-320/320
Sequence Identity: 42% (12 aa)

FLDFLKRCLEWDPSSRMTPSQALRHSWL
| |.| .||  ||. | |. .||.|. .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK2.AA HIPK 479-506 39 4.4e-07 17.82 In-house 302-329 (329) Show / Hide 
Range on Protein: 479-506
Range on HMM: 302-329/329
Sequence Identity: 39% (11 aa)

FLDFLKRCLEWDPSSRMTPSQALRHSWL
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FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK2.AA YAK 478-506 34 4e-06 16.41 In-house 319-347 (347) Show / Hide 
Range on Protein: 478-506
Range on HMM: 319-347/347
Sequence Identity: 34% (10 aa)

LFLDFLKRCLEWDPSSRMTPSQALRHSWL
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CFIDFINQLLQLNPRERWKPMQAMQHPFI