Gene CDK10 (Sea Urchin)

CDK10

Species: Sea Urchin
Alias: Spk137, CDK10, SPU_026319
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK10

Sequence

Name Sequence Type Origin Length Description Download
CDK10.AA Protein None 397 None Fasta, JSON
CDK10.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of CDK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK10.AA CDK10 59-343 85 5.3e-232 777.03 In-house 1-285 (285) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-285/285
Sequence Identity: 85% (244 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDGLPISGLREIHLLINLRHENVVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPSPFTET
|||||||||||||||||||||.|.||||||||||.||||||||||||||.|||..||||.||||||||||||||||||||||||||||||||||.|||||
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

QVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDMWAAGCILGELLVNKPL
||||..|||||||.||||||.|||||||||||..|.||.|.|||||||.||.||.||||..|||||||||||.|...|||||||||.|||||||||.|||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

MPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
|||.||.|||..||||||||...||||||.||||||||||||||||||.||.||||||.||||||.||||||||||||.||||||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase CDK10.AA CDK 59-343 41 7.4e-161 518.51 In-house 1-284 (284) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-284/284
Sequence Identity: 41% (133 aa)

FEKLNRVGEGTYGIVYRARDMKSK-----EIVALKKVRMEK-----EKDGLPISGLREIHLLINLRHENVVELHEVVVGQHLD---------SIFLVMQY
.|||...||||||.||.|||....     .||||||.|||.     ||.|.||. .||| || .| |.|.| ||.|... ..|         ....|. |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CEQDLASLLDNMPSPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGC-----LKIADFGLARRYGL------PVRPMTPRVVTLWYRAPE
...||....|          .||. .|.|||| |.|.|...||||| .|.|. .||.     |||||||||| .|       |.|..|..||||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLFGSLEQT--TAIDMWAAGCILGELLV---NKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLKAKFTWLSQSGLRLLNFL
||.|| . .  |.||||..|||..|..    .|||.|| ||..|. .|....|||.. .|||...||                            ||| .
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

LMYNPKKRATAEESLESSYF
|.|.|||| .||. |.. ||
LCYDPKKRISAEQALQHPYF
Kinase CDK10.AA PITSLRE 59-343 51 1.2e-160 539.94 In-house 1-295 (295) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-295/295
Sequence Identity: 51% (151 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRME--KEKDGLPISGLREIH-LLINLRHENVVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMP---
|..|||..|||||.||||.| .  ||||||.. ||  |||.| ||  ||||  .|  |.|.|.| . |.|.|  .|.|..|| | | ||.||..||    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

SPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDMWAAGCILGEL
 ||.. ..||| .| |||  ..||| ..||||| ||||.  .|.|||.||||||.|| |..| || |||||||||||| |. . .|..|||  |||..|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFT-LKKQPYNNLKAKFT---WLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
.  |||..| ||. ||| |  ..|||.  ||||..||| . ... ....|||||. .|     .|. |. ||| .| ||||.| ||.. |   .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK10.AA CMGC 59-343 25 6.6e-133 439.47 In-house 1-513 (513) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

FEKLNRVGEGTYGIVYRARD--------------MKSKEIVALKKVR---MEK------EKDGLPISGLREIHLLINLR-----------------HENV
.|.....||||||.||..||              ....||||.||..   .|       ||||.||. |||| .| .|.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VELHEVVVGQHLD---------------SIFLVMQYCEQDLASLLDNMPS--------PFTETQ------------VKCLA------LQMLRGLR--YLH
| |.....  . |               ...||. |...||. ...|..         |..| .            .|..        |.||||   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

DNF--VIHRDLKVSNLLLADN--------------------GCLKIADFGLARRYGLP---------------------VRPMTPRVVTLWYRAPELLFG
 .   .|||||| .|.|. .|                    |.|||.|||||| |. .                     .||.|..|||.||||||.|.|
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

SLEQT---------TAIDMWAAGCILGELLVN--------KPLMPGASE-----------LHQINHIIDLLGTPN---------------DTIWPGFSEL
. . |         |.||||..|||..|.. .        ||| || ||           ..|...|...||||.               . .||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PMVQNFT-------------------------LKKQPYNNLKAKFTW-----------------------------------LSQSGLRLLNFLLMYNPK
|  ..|                          ....|....| .| |                                   ... .. ||. .| |.|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRATAEESLESSYF
|| |||. |.  ||
KRITAEQALQHPYF
Kinase CDK10.AA CDK7 59-343 39 5.69999999999e-130 348.46 In-house 1-288 (288) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-288/288
Sequence Identity: 39% (114 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVR----MEKEKDGLPISGLREIHLLINLRHENVVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPSP
.||.  .|||... ||.|.| .. .||| ||..     .  |||.  . .||| .|  ..|.||..|  .    |...| ||. . . ||          
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFM--HKSNIQLVFDFMDWDLEVVIKDKSII

FTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDMWAAGCILGELLV
.|   .|  ....|.|| |.| |.. |||||  |||.  || |||||||||| || | |  |. ||| ||||||||||    .|..|||. |||. ||. 
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

NKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPY---NNLKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
  | .|| |.. |.  |   ||||..  ||. ....     ..|..|      |.  ||  |.  | |.  ..  || || |. ..|.. ||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMM--DYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK10.AA CDC2 59-343 40 1.7e-119 369.05 In-house 1-301 (301) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-301/301
Sequence Identity: 40% (124 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDG--LPISGLREIHLLINLR-HENVVELHEVVVGQHLDSIFLVMQYCEQDLASLLD-NMP--
..|....||||||.||...||....||||||.| | | .|   | . .||| .| .|. |.|.| ||.|..     ....|  |...||  ..|   |  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

SPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPR--VVTLWYRAPELLFGSLEQTTAIDMWAAGCILG
.....  || .. |.|.|. ..| . ..||||| .|.|. ..| .|||||||||  | |.|. |.   ||||||||||.|.|.   .|..|||. |||. 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELP-------MVQNFTLKKQPYNNLKAK-FTWLSQSGLRLLNFLLMYNPKKRATAEESLE
|.     .||| .| ||  |.  |   |||||. .||| ..||       . .   |.|. .||.| | .. | . |. ||. .| |.| || .|.| |.
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

SSYF
  ||
HPYF
Kinase CDK10.AA CDK5 59-343 41 7.2e-114 361.28 In-house 1-287 (287) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-287/287
Sequence Identity: 41% (119 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDGLPISGLREIHLLINLRHENVVELHEVVVGQHLDS-IFLVMQYCEQDLASLLDNMPSPFTE
.||....||||||.||.||. ...||||||.||.. |  | | . .||| ||  |.|.|.| || |.   | .  . ||  .| |||   .|..      
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI---HSEKKLTLVFEFCDQDLKKYMDSCNGEMDM

TQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDMWAAGCILGELL-VNK
  .| . .|.|.|| . |.. | |||||  |||   || || ||||||| .| |||  .  |||||||.|  |.||   .| |||| .|||. |.    .
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQ--NFTLKKQPYNN-LKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
|| ||...  |   | ...|||.   ||. ..||  .     . . | .  ..     |.. |. ||. .|..||..| .|.. |.  ||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK10.AA CRK7 59-343 37 7.89999999999e-107 361.21 In-house 1-343 (343) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-343/343
Sequence Identity: 37% (127 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKE---KDGLPISGLREIHLLINLRHENVVELHEVVVG--------QHLDSIFLVMQYCEQDLASL
.|... .|||||| || |.. . .|.||||||||. |   |.| ||   ||| .|  | |.|.| |.|.|.         .|  |...|  |   ||. |
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDNM-PSPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPV--RPMTPRVVTLWYRAPELLFGSLEQ--------
|..     | . |.||.  |.| |. |.|.. ..|||.| ||.|.  .| .||||||||| |      || | ||.|||||.|||| |  .         
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TTAIDMWAAGCILGELLVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLK
                              ...||||  |||||||.. ||. .|  |. |.  |  . |.||   ||   .||  . .  |.|    | 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

AKFT------WLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
  |        ...  | ||  .| ..|||| |||| |.. .|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK10.AA S_TKc 59-343 27 4.1e-89 303.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDGLPISGLREIHLLINLRHENVVELHEVVVGQHLDSIFLVMQYCEQ---DLASLLDNMPSP-
.|.|. .|.|..| ||..|. |...|||.|...         .. .||| .| . .|.|.| |..| .    |....|| ||..   || ......... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTT-AIDMWAAGCIL
    |.| ...... |....| |.|.. .|||||| .|.|| .  ..||.||||||..       |  ..|.||.|||.|      .. ..|.|. ||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESLE-------SSY
 |.|. .|. |      |.. .....|                                    |.... ... .| ..|.|| || | |.         .
YEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase CDK10.AA CDK4 59-343 38 1.3e-88 300.75 In-house 1-290 (290) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-290/290
Sequence Identity: 38% (114 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKD--GLPISGLREIHLLINLR---HENVVELHEVVVGQHLDS----IFLVMQYCEQDLASLLD
..... .||| ||.||||||...  .||||.||   . .  |.|.| .||| ..  |    | |.| | .|      |     | .|.  |..||. .||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NMPSP-FTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDMWAAGCI
..| |   . ..| .  |.|||. .|| . .||||||  |.|.. .| .|.||||||| |.     .|| |||||||||| |  |   |. .|||..|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLLQSYYNTP-VDMWSVGCI

LGELLVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESLESSYF
  |.   .|| .| ||  |   | |. |.|    ||  . ||  . |  ...   ..|   . ....|. ||.  | ||..|| .|.. |. .||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPW-DHFPQRHP--RPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK10.AA CDK-Unclassified 59-343 29 6.5e-86 282.62 In-house 1-324 (324) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-324/324
Sequence Identity: 29% (97 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKD----------GLPISGLREIHLLINLRHENVVELHEVVVGQHLDS-----------IFLVM
 . .  .||||.|.|. |.|.    .|| ||.    .|.            .|. .||| .| |. |.|. .. ...    ..|           ...||
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM

QYCEQDLASLLDNMPSPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNG-----CLKIADFGLARRYG------------LPVRPMTPRVV
 |  ...   |.|   .    |..  ..||| |. ||| |  .|||.| .|... .|.      |||||||.|. |              | .  .. |.
EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS

TLWYRAPELLFGSLEQTTAIDMWAAGCILGELLVNKPLMPGASELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLK-KQPYNNLKAKFTWLSQSGLRL
| ||||||||||| . .|..|.|..|||. |..  ||. .| .|. |. ||...||||..  ||  . .|     . | ||. ..       .. |.. .
TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASENNC

LNFLLMYNPKKRATAEESLESSYF
.  ..||.|..| ...| | ...|
EFQMVMYQPYNRWKCMEILQHPWF
Kinase CDK10.AA Pkinase 59-343 30 4e-78 270.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 59-343
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDGLPISGLR--EIHLLINLRHENVVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNM-----
.... ..|.|..| ||.... .. .|||.|... ..||.. ... .|  ||... .|.|.|.|.|....     |.| .|| ||| .|  ..| .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--PSPF--TETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCL----KIADFGLARRY-GLPVRPMTPRVVTLWYRAPELLFGSLEQTTAIDM
    .|  .| ..|. ..|.|||| |.|.. .|||||| .|.|. .|| .    ||.|||||. .   . . || ...|.||.|||.. |. . ....||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAAGCILGELLVNKPLMPGA----SELHQINHIIDLLGTPNDTIWPGFSELPMVQNFTLKKQPYNNLKAKFTWLSQSGLRLLNFLLMYNPKKRATAEESL
|..|||| |.|  .|. ||.    . . |.  |   .|.|..  ||  .. .    |.  . .   .. . . .|.... ... .| ..|||| |||. |
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

ESSYF
.. .|
QHPWF
Kinase CDK10.AA Pkinase_Tyr 59-206 29 9.2e-21 70.94 Pfam 1-159 (270) Show / Hide 
Range on Protein: 59-206
Range on HMM: 1-159/270
Sequence Identity: 29% (49 aa)

FEKLNRVGEGTYGIVYRARDM----KSKEIVALKKV---RMEKE--KDGLPISGLREIHLLINL-RHENVVELHEVVV--GQHLDSIFLVMQYCEQ-DLA
 ...   ||| .| ||...      . |  || |..    |...  .. .    .||. .. .| .|.|.| |. |..  |..  .|..|| |..  || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLL

SLLDNM---PSPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLAR
. | .    . |.|  .  . ..|  .|. ||...  |||||   | |...|.. ||.||||||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase CDK10.AA TyrKc 59-295 21 4.6e-13 -11.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 59-295
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FEKLNRVGEGTYGIVYRARDMKSKEIVALKKVRMEKEKDGLPISGLREIHLLINL--RHENVVELHEVVVGQ-----HLDSIFLVMQYCEQ-DLASLLDN
 ...   ||| .|.||... .|  . || |... ..         .||. .. .|  .|.|.| |. |.. |       . ...|| |..  || . | .
ITLGKKLGEGAFGEVYKGT-WK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MPSPFTETQVKCLALQMLRGLRYLHDNFVIHRDLKVSNLLLADNGCLKIADFGLARRYGLP---------VRP----MTPRVVTLWYRAPELLFGSLEQ-
    ..  .    ..|  .| .|||.. .|||||   | |...|.. ||.||||.|  .            |.     .  .. .   ||| .    .  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGK

-TTAIDMWAAGCILGELL----VNKPLM----PGASELHQINHIIDLLGTPND------------------TIWPG-------FSELPMVQNF
 ||. | |. |  . |..       | |      ..|...     . .  | .                  . |         |||.  .. |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF