Gene CDK2 (Sea Urchin)

CDK2

Species: Sea Urchin
Alias: CDK2, Spk126, SPU_007655
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK2

Sequence

Name Sequence Type Origin Length Description Download
CDK2.AA Protein None 299 None Fasta, JSON
CDK2.kin_dom Protein Kinase Domain None 283 None Fasta, JSON

Protein domain

Protein domains of CDK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CDK2.AA CDC2 4-286 65 2e-232 722.47 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 65% (197 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEG--VPSTAIREIALLKELD-HKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMD-VAPP-SG
..|||||||||||||||..|..... ||||||||..|.||  ||||||||| .||||. |.||||||||.|. .|||.|||....|||||||   |. . 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYT--HEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEM
.|| |||||. |.|||..|||..|..||||||||.|||..|.||.||||||||||.|.||||  |||||||||||||||||..|||.||.||.|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPM---------LNKDGKDLLKSMLCYEPDKRISAKTGLSHP
   .|...||.|||||||||.|||..|||.|. |||||.|||||..||||.|||..||.|.         |...| |||..||.|.| ||||||. |.||
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHP

YF
||
YF
Kinase CDK2.AA CDK 4-286 54 9.80000000001e-197 635.17 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 54% (175 aa)

FEKIEKIGEGTYGVVYKARDLKSG-----KTVALKKIRLDT-----ESEGVPSTAIREIALLKELDHKNIVKLHDVVHSD-----------KKLYLVFEF
.||.||||||||||||||||...|     . |||||||...     | ||.|.||||||.||||| |.||||||||.|..           .|||.|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MNQDLKKYMDVAPPSGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGR-----IKLADFGLARAFGV------PVRTYTHEVVTLWYRAP
| .|||||||           .|.|..|||.|...|| ....||||||||.||. .|      .|.||||||||||.      |.|||||||||||||||
MDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

EILLGCRYYS--TAVDIWSLGCIFVEMIT---RRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSM
|.|||.. ||  |..|.||.||||.||.|   |..||||||||||||.|||..|||.|. |||||.||||                        ||| .|
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKM

LCYEPDKRISAKTGLSHPYF
|||.|.|||||.  |.||||
LCYDPKKRISAEQALQHPYF
Kinase CDK2.AA CDK5 4-286 61 1.3e-188 601.64 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 61% (178 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMDVAPPSGLPPGL
.||.|||||||||.|||||. ...  ||||..||| | |||||||||||.||||| ||||| ||||.||.||| |||||. ||||||||     .. . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG-EMDMHI

VKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMI-TRRAL
.||.. |||.|.||||.|.|||||||||||||   |  ||||||||||||.|||.|.|||||||||.| .|.| . ||| .|.|| |||| ||. . | |
IKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPL

FPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYK---TSFPRWTPQD-FTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
||| .. |||.|||. |||| |  ||..| |||||   . .| . ..  . .||| |.. | |||. || ..|..||||| .| ||||
FPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase CDK2.AA CMGC 4-286 29 1.1e-159 529.14 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 29% (150 aa)

FEKIEKIGEGTYGVVYKARD--------------LKSGKTVALKKIRLDT---------ESEGVPSTAIREIALLKEL-----------------DHKNI
.|.|.||||||||||||.||               .... ||.|||...          | .|.|..|.||| .||.|                 .|.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLHDVVHSDK-----------------KLYLVFEFMNQDLKKYMDVAP-------PSGLPPGL------------VKSYL------QQLLQGIA--FCH
|||.|......                 .||||||.| .||..|..  .       | .|..              .|...      .|.|.|..  .||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

AHR--VLHRDLKPQNLLIDAD--------------------GRIKLADFGLARAFGVP---------------------VRTYTHEVVTLWYRAPEILLG
 |.  ..||||||.|.||. .                    ||.|..||||||.....                     .|.|||.|||.||||||||||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

CRYYS---------TAVDIWSLGCIFVEMITR--------RALFPGDSE-----------IDQLFRIFRTMGTPD---------------EKLWPGVTSL
...|.         |..|.||.|||| ||.|.        . ||||.||           |||||.||...|||.               |. ||....|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PDYKT--------------S------------FPRWTPQDFTKIVPM-----------------------------------LNKDGKDLLKSMLCYEPD
|.|..              |            ||.| |.......|                                    ..... |||| ||.|.||
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRISAKTGLSHPYF
|||.|.  |.||||
KRITAEQALQHPYF
Kinase CDK2.AA CDK7 4-286 45 7.79999999999e-151 405.17 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-288/288
Sequence Identity: 45% (133 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIR-LDTESE---GVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLK---KYMDVAPP
.|||..||||....||||.|...|. || |||. |   ||   |.  |||||| .|.|. | |.. | |.      ..|||.||  ||    |   .   
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSII--

SGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEM
  | |  .|.|  ..|||. .||.. .||||||| |||.. .|..|.|||||||..| | | ||| ||| |||||| | | | | |.||.|| |||| | 
--LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAEL

ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTP---QDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
. |   .||||.|||| |||.|.||| |. ||......|| . |  ...     . .|      |  ||.. |.  .| ||...   |..|||
MLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIK-FKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase CDK2.AA PCTAIRE 4-286 52 5.4e-135 454.77 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 52% (155 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMDVAPPSGLPPGL
. |..| |||||  ||| |    .  |||| |||. | || | |||||. |||.| | ||| |||..| .. | ||||.|..|||.|||    ...    
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDC-GNIMNMHN

VKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMITRRALF
|| .| ||| | |.||  ..||||||||||||. .|  ||||||||||  || .|| ||||||||| |..|.|   ||| .|.|  |||| || | |.||
VKLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLF

PGDS------EIDQLFRIFRTMGTPDEKLWPGVTSLPDYKT-SFPRWTPQDFTKIVPMLN---KDGKDLLKSMLCYEPDKRISAKTGLSHPYF
||          |||  ||| .|||||| ||||.|.....| .|||. .| .    |.|    |.. |||...| ||. .|.||   ..||||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase CDK2.AA PFTAIRE 4-286 51 6.00000000001e-135 454.62 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 51% (149 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMDVAPPSGLPPGL
.||.|| |||.|  |||..    .. |||| |||. | ||.| |||||  |||.| | ||| |||..| .. | .|||... ||..|||   | |. |  
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQE-EGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKH-PGGMHPNN

VKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEMITRRALF
|. .| ||| | ..||  |||||||||||||| . |  ||||||||||  || .|| ||||||||| | .|||   ||| .|.|  |||||||.. ...|
VRLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAF

PGD-SEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPR---WTPQDFTKIVPMLN--KDGKDLLKSMLCYEPDKRISAKTGLSHPYF
||     ||| .||...||| |  ||||..|| ||    |    .|.   ...| .    .. ||.. || .|| .|.||.  ..||||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase CDK2.AA CDK4 4-286 50 6.8e-129 434.51 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 50% (148 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESE--GVPSTAIREIALLKEL---DHKNIVKLHDVVH---SDK---KLYLVFEFMNQDLKKYMD
....  |||| || ||.||||..|. ||||..|  .. |  |.|   ||||.... |   .| ||||| || |    |    |. .|||   .||. |.|
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

VAPPSGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCI
 .||.|.||  .|    ||| |. | |.||. ||||||||.|.  ||..||||||||| ..      |  ||||||||||.||   || | ||.||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

FVEMITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
| ||  ||.||.| || ||| .||  ||.| |. ||   |||    .||   |. | ...| . | |.|||. ||||...||.||  .|.||||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP--WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase CDK2.AA PITSLRE 4-286 46 9.40000000001e-127 427.39 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 46% (138 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLD--TESEGVPSTAIREIA-LLKELDHKNIVKLHDVV--HSDKKLYLVFEFMNQDLKKYMDVAP--P
|... .|.||||||||.|.| . .  ||||.. ..   | || | |..|||  .|..| | |||..  .|      | |.|.|..  |||  |..     
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

SGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWSLGCIFVEM
    || .|. .|||| |... | . ..|||||  |||.   |  |..|||||| .| |.. ||  ||||||||||.||||. |||.||.|| |||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYK--TSFPRWTPQDFTKIVP---MLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
|| . ||.|.|||||. .||  |||| || |||.|.||  |  ..||   .    |..|    ..  | |||  ||.| | .||.|  .| ||.|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase CDK2.AA Pkinase 4-286 35 1.1e-113 388.81 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIR--EIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQDLKKYMDVA------P
.....|||.|..|.|||... ..||.||.|.|....|..... |..|  ||...|.|.|.|||.|.|........|.|.|... .|.  || .       
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

PSGL--PPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRI----KLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLGCRYYSTAVDIWS
  ..  ..  .|.|. |.|.|...||.....||||||.|.||| .| |    |..|||||. |   . . .|. ..|.||.|||...|..||...||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCIFVEMITRRALFPGD----SEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHP
.|||. ||...| .|||.    . .||...|.|.||.| .  ||   | ....  .. | .. ...  . .....||..|..||. | ||..|.  | ||
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

YF
.|
WF
Kinase CDK2.AA S_TKc 4-286 30 7.79999999999e-113 382.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 30% (92 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKELDHKNIVKLHDVVHSDKKLYLVFEFMNQ---DLKKYMDVAPP----
.|...|||.|..|.|||.|. |.|. ||.|.|.          ...|||..||. .|.|||||.|| .. ..||.|.|....   ||..|..  ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

SGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCRYYST-AVDIWSLGCIFVE
...|.  ...|..|.......|| |...||||||.|.|.|   .||..|||||| .       |. ..|.||.|||.|     |.. ..|.||.|||. |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

MITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLS-------HPYF
|.... .||      |....|. .|                                    ...||... .|...|.||..|   |        ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CDK2.AA CRK7 4-286 36 1e-109 370.83 In-house 1-343 (343) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-343/343
Sequence Identity: 36% (124 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTE---SEGVPSTAIREIALLKELDHKNIVKLHDVVHS--------DKK--LYLVFEFMNQDLKKY
.|.|. ||||||| ||||.... |. |||||.|.| |    || | |||||| .|..|.|.|||.|...| .        ..|   |.||| |  ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MDVAPPSGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVPV--RTYTHEVVTLWYRAPEILLGCRYY--------
..        .. .|... ||| |.. ||   .||||.|  |.|..  | .|.||||||| .      | ||  |.|||||.|| |||   |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STAVDIWSLGCIFVEMITRRALFPGDSEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKT-----SFPRWTP
                               ...|.|| |||..|  |....|.|  |..||  |.. .|.|    || |. || ..|      . |   
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

QDFT--KIVPMLNKDGKDLLKSMLCYEPDKRISAKTGLSHPYF
 .|   |   .. |.  |||  |||. |.||..|.  | |..|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase CDK2.AA Pkinase_Tyr 4-151 27 2.2e-24 83.18 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-151
Range on HMM: 1-160/270
Sequence Identity: 27% (46 aa)

FEKIEKIGEGTYGVVYKARDL----KSGKTVALKKIRLDTESEGVPSTA------IREIALLKEL-DHKNIVKLHDVVH-SDKK--LYLVFEFMNQ-DLK
 ....|.||| .|.|||..      . . .|| |...     ||  . .      .||....|.| .|.|||.|. |.   ..   .|.|.|.|   ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYMDVA--PPSGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARA
.|      ..  |..    .. .|  .| .. ....  ||||   | |.. .. .| .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase CDK2.AA TyrKc 4-286 21 9.2e-16 32.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

FEKIEKIGEGTYGVVYKARDLKSGKTVALKKIRLDTESEGVPSTAIREIALLKEL--DHKNIVKLHDVVHSD-------KKLYLVFEFMNQ-DLKKYMDV
 ....|.||| .|.|||..      .|| |... |.         .||. ....|  .|.|||.|. |. ..       . |..|.|.|   |||.|   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

APPSGLPPGLVKSYLQQLLQGIAFCHAHRVLHRDLKPQNLLIDADGRIKLADFGLARAFGVP------VRTYT-----HEV--VTLWYRAPEILLGCRYY
  |  |..    |.  |  .| .. | ... ||||   | |.......| .||||.|. .          .|.     ..   . .   ||| .  .. .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK-F

STAVDIWSLGCIFVEMITRRALFPGD--------SEIDQLFRIFRTMGTPDEKLWPGVTSLPDYKTSFPRWTPQDFTKIVPMLNKDGKDLLKSMLCYEPD
.|. |.|| |    |. |. .  . .        .|. .. .  . |  |.. . | .                 |    .   ..  .. |.   ..|.
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----------------F----VCCPDEMYQIMKQCWHEDPE

KRISAKTGLSHPYF
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DRPTFSEI--HECF
Kinase CDK2.AA Pkinase_Tyr 167-190 37 0.917762 3.21 Pfam 180-201 (270) Show / Hide 
Range on Protein: 167-190
Range on HMM: 180-201/270
Sequence Identity: 37% (9 aa)

WYRAPEILLGCRYYSTAVDIWSLG
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WM-APECINYGK-FTTKSDVWSFG