Gene VRK (Sea Urchin)
VRK
Sequence
Protein domains of VRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | VRK.AA | VRK | 30-297 | 51 | 2.2e-184 | 594.77 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 30-297 Range on HMM: 1-284/284 Sequence Identity: 51% (146 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYVIKIEP-HENGPLYTELHFYQRAAQVDQVAKWQKEHK------------LSHLGVPKLFGFGSHDSDG |||||||||||||.||.||.||......|..||.|||| ||||||.||.|||||||...|..||.|.|| |..||.|...|||.||..| WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG TKYRFLVMPLFGEDIWKKYL-ACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYKPDDKHRKYEEFPKKG .||||.||| ||.|..|.| .....|....|..||...||.||||||..|||.|||.||.||||. |....|.|.||||..||.|..|||.|.|.|... EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFE-KNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRC HNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLT--DLNYVMNQKIKYSKDISGLLKTCFS-SSYPNELKTFL ||||.||||.|||.|..||||.|..|||| |..||. .|||.|.| | ..|. .|.|. .| .....|| . . |. .. HNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM |
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Kinase | VRK.AA | CK1 | 30-314 | 26 | 8.5e-84 | 284.7 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 30-314 Range on HMM: 1-339/339 Sequence Identity: 26% (89 aa) WRLGKPIGQGGFG-MIYKASEN--TSGKTK---SDGTYVIKIEP-HENGPLYTELHFYQRAAQVDQVAKWQ-----KEHKLS-HLGVPKLFGFGSHDSDG |...|.||.|||| .|||.... .. |.. .. |..|.|| ...|........||. .. . .||. ..|... |.|.| .. | .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED TKYRFLVMPLFGEDIWKKYL---ACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSP------------KDKNKVFLADYGLVN-RYK .|...||.|.|..... ||.||. . .. .|||.|..|||.|.....| ||| .|...| .. .....|.. |.|.. .|. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR PDDKHR----------KYEEFP----KKGHNG-TPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTT--LPWED-KLTDL--NYVMNQKIKYSKDISGL ..|.|. .. ... |||. | |....||..|||. ..|| |. ..|... || | ||| . | . .. .| || . . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK LKTCFS-------SSYPNELKTFLDHAFKLKYDEEPDYNKL ..|.| ..| |. ..... .|||...||| .. MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | VRK.AA | CK1-A | 102-314 | 31 | 1.4e-31 | 108.82 | In-house | 56-261 (261) | Show / Hide |
Range on Protein: 102-314 Range on HMM: 56-261/261 Sequence Identity: 31% (67 aa) GVPKLFGFGSHDSDGTKYRFLVMPLFGEDIWKKYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYKP |.|.. .|. . | .|| | | . . |...|| | || |.. .||.|| |..| ||| | |.| . ||.|| |.|| .|. GIPHMRWYGC----EKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIG-RHCNKLFLIDFGLAKKYRD DDKHRKYEEFPKKGHNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPNELKTFLDHAF .. . | || . ||.||||. ||| |. .||||. . ..||| || | . . | .| |. .. .. SRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC--KGFPAEFCMYMNYCR KLKYDEEPDYNKL .|...|.||| | NLRFEEQPDYMYL |
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Kinase | VRK.AA | CK1-D | 101-314 | 31 | 5.5e-30 | 102.91 | In-house | 55-261 (261) | Show / Hide |
Range on Protein: 101-314 Range on HMM: 55-261/261 Sequence Identity: 31% (69 aa) LGVPKLFGFGSHDSDGTKYRFLVMPLFGEDIWKKYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYK .|.|.. .| ..| | .|| | | . . |..|| | || |.. .||.| |..| ||| | |.| | | |.. |.|| ||. IGIPEIRWCG---QEG-DYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLG-KRGNMVYIIDFGLAKRYR PDD--KHRKYEEFPKKGHNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPNELKTFLD .| | | .| || . || |.|. ||| |. ||||.. . .||| ..| | . . | . ||.| ..... DARTHQHIPYRE--NKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLC--KGYPSEFQQYMN HAFKLKYDEEPDYNKL .. .||.|. ||| | YCRNLKFDDKPDYCYL |
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Kinase | VRK.AA | CK1-G | 30-314 | 30 | 1.8e-26 | 86.66 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 30-314 Range on HMM: 1-266/266 Sequence Identity: 30% (88 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYV-IKIEP-HENGP-LYTELHFYQRAAQVDQVAKWQKEHKLSHLGVPKLFGFGSHDSDGTKYRFLVMPL .| || || | || .. || . .| ||.|| . . | | | ||. .. |.|. . || || .|| | YRVGKKIGCGNFGELFE------GKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCP-------------EGIPQVYYFGQC----GKYNIMVMDL FGEDIWKKYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLG-FSPKDKNKVFLADYGLVNRYKPDD--KHRKYEEFPKKGHNGTPEFT | . |. ||. | .|||... .||.|. . . |.| | | | | ||...... |.|. | . .| | | .| || . LGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYRE--HKSLTGTARYM SIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPNELKTFLDHAFKLKYDEEPDYNKL || ||| ||| |. || . . | ||| | | ||| | | . ..| .. |.| . .|...|.|||. | SINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | VRK.AA | CK1 | 30-256 | 32 | 1.5e-25 | 85.08 | In-house | 1-216 (271) | Show / Hide |
Range on Protein: 30-256 Range on HMM: 1-216/271 Sequence Identity: 32% (75 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYVIKIEPHENGP--LYTELHFYQRAAQ--VDQVAKWQKEHKLSHLGVPKLFGFGSHDSDGTKYRFLVMP |.|. |||| ||.||.. |.|. . . ||.|. . | | .|.. .| . |.|.. .| . .| ..|| YRVGRKIGQGSFGDIYLGINMTNGEE--N-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDN----------QCHGIPHMYWCGQEEQ--GDYNIMVMD LFGEDIWKKYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYK-PD-DKHRKYEEFPKKGHNGTPEFT | |.. . . ||.||. | .| |... .||.|. |..| ||| | | | . |....|.. |.|| ||. .. .| | | .|. || .. LLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRE--NKNLTGTARYA SIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPW || .|||. ||| | ||||.. | .||| SINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW |
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Kinase | VRK.AA | CK1-Unclassified | 138-256 | 41 | 8e-20 | 55.21 | In-house | 97-216 (244) | Show / Hide |
Range on Protein: 138-256 Range on HMM: 97-216/244 Sequence Identity: 41% (51 aa) CNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYK---PDDKHRKYEEFPKKGHNGTPEFTSIDAHLGVSPS ||.||. | .| |... .||||. |..| ||| | | | . | ...|.. |.|| ||. . || | | .|. || ..|| ||||. | CNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRE--NKNLTGTARYASINAHLGIEQS RRGDIQILGYVMLQWLCTTLPW || | ||||.. | .||| RRDDLESLGYVLIYFLKGSLPW |
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Kinase | VRK.AA | TTBKL | 118-318 | 24 | 7.2e-16 | 50.13 | In-house | 73-288 (288) | Show / Hide |
Range on Protein: 118-318 Range on HMM: 73-288/288 Sequence Identity: 24% (54 aa) KYRFLVMPLFGEDIWKKY-LACNKK-FTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFS---PKDKNKVFLADYGLVNRYKPDDK-------- .|.|.|| | |... . . .||| |..| . ..||.|..| ..|.. ..| |.| .| .|.. .. |.| |.|.. .|. .|. DYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHE ----HRKYEEF-PKKGHNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFS-SSYPNELKTFLD .|. .| .| . ||. ..|...|.. .| |. . |.. .| |||.. ..| .. | . . | | .. . | |. | NKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWTN-MEDKMEIEHMKKN--MKDEDLFKDMPRDHDCPSEFCKFMK HAFKLKYDEEPDYNKLRALC | |.| ..||| ..... HLRSLRYYDRPDYEMIYECF |
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Kinase | VRK.AA | S_TKc | 30-322 | 15 | 1.1e-13 | 23.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 30-322 Range on HMM: 1-231/231 Sequence Identity: 15% (49 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYVIKIEPHENGPLYTELHFYQRAAQVDQVAKWQKEHKLSHLGVPKLFGFGSHDSDGTKYRFLVMPLFGE ......||.|.|| ||. .. .. . ||| . .. . . |. | . ||... . .. ..|| . . YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----------------EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDG ---DIWKKYLACNKK-----FTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYKPDDKHRKYEEFPKKGHNGTPE | . .... |.. . .. ||.. |||.|... .| |.| .|.|| . ..| || .. . |||. DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--------------TTFCGTPW FTSIDAHLGVSPSR-RGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPNELKTFLDHAFKLKYDEEPDYNKLRA---- . . . .. . |. .| .. || |.. ..| .||. . |.| |... .. .. | .. . YMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD -LCRTVL | . IKCHPWF |
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Kinase | VRK.AA | Worm6 | 119-314 | 22 | 9.2e-13 | 42.4 | In-house | 77-279 (279) | Show / Hide |
Range on Protein: 119-314 Range on HMM: 77-279/279 Sequence Identity: 22% (47 aa) YRFLVMPLFGEDIW--KKYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGF----SPKDKNKVFLADYGLVN--RYKPDDKHRKYEE ....||.|.|.. | .| .. ..||. | .||| |...| || . ..| |.| .| | . .. .... |.|. .|. ... .. FNYIVMTLVGKNLWDLRKNRP-DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPR FPKKGHNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPN-ELKTFLDHAFKLKYDEEP .. | ||. . .. .| | .|. |. |.|. ... .||| ...| . | .| . .... ....| | |.. .| ...| ..| WTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWR-HMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRP DYNKL ||... DYKFI |
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Kinase | VRK.AA | TTBK | 118-199 | 30 | 9.1e-10 | 30.73 | In-house | 69-151 (257) | Show / Hide |
Range on Protein: 118-199 Range on HMM: 69-151/257 Sequence Identity: 30% (25 aa) KYRFLVMPLFGEDIWK-KYLACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRY |. ..|| | |. . .|. . | .|||.|.| |.. . | ||| | .| |. .|... |.|| .| KFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQY |
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Kinase | VRK.AA | TTBK | 215-314 | 35 | 1.6e-08 | 26.23 | In-house | 166-257 (257) | Show / Hide |
Range on Protein: 215-314 Range on HMM: 166-257/257 Sequence Identity: 35% (35 aa) GHNGTPEFTSIDAHLGVSPSRRGDIQILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIKYSKDISGLLKTCFSSSYPNELKTFLDHAFKLKYDEEPDYNKL | || . || ||. |. | | |.. . ||| |. | . | . | || | ||| | | |...|.|| |.| . ||| . GFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWR-KIKDKDQVGEMKEKY--DHRMLLKHC-----PHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | VRK.AA | CK1-Unclassified | 30-47 | 55 | 2.9e-07 | 17.53 | In-house | 1-18 (244) | Show / Hide |
Range on Protein: 30-47 Range on HMM: 1-18/244 Sequence Identity: 55% (10 aa) WRLGKPIGQGGFGMIYKA |... |||| ||.|||. YRVIEKIGQGSFGEIYKC |
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Kinase | VRK.AA | Pkinase | 118-178 | 25 | 1e-06 | 24.61 | Pfam | 73-141 (293) | Show / Hide |
Range on Protein: 118-178 Range on HMM: 73-141/293 Sequence Identity: 25% (18 aa) KYRFLVMPLFGE-----DIWKKYLA--CNKKF--TPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLL .. .||.. . | . |. ...| .. . . ||| |||.|.|. .| |.|..|.|. DHIYMVMEYCEGGLYVMDLF-DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI |
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Kinase | VRK.AA | Worm6 | 30-54 | 44 | 2e-06 | 19.52 | In-house | 1-25 (279) | Show / Hide |
Range on Protein: 30-54 Range on HMM: 1-25/279 Sequence Identity: 44% (11 aa) WRLGKPIGQGGFGMIYKASENTSGK | ..|.||.|||| .||... . .| WKVTKKIGEGGFGAVYKVEDKSDKK |
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Kinase | VRK.AA | CK1 | 289-312 | 37 | 2.5e-05 | 14.55 | In-house | 248-271 (271) | Show / Hide |
Range on Protein: 289-312 Range on HMM: 248-271/271 Sequence Identity: 37% (9 aa) YPNELKTFLDHAFKLKYDEEPDYN .|||. ..| .. .|...|.||| FPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | VRK.AA | TTBK | 30-49 | 55 | 3e-05 | 14.56 | In-house | 1-20 (257) | Show / Hide |
Range on Protein: 30-49 Range on HMM: 1-20/257 Sequence Identity: 55% (11 aa) WRLGKPIGQGGFGMIYKASE |. | ||.|||| || | . WKVVKKIGGGGFGEIYEAKD |
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Kinase | VRK.AA | TTBKL | 30-55 | 38 | 3.4e-05 | 13.59 | In-house | 1-26 (288) | Show / Hide |
Range on Protein: 30-55 Range on HMM: 1-26/288 Sequence Identity: 38% (10 aa) WRLGKPIGQGGFGMIYKASENTSGKT |. | ||.|||| .|... .. |. WMIVKMIGEGGFGQVYHVWDMKDKKD |
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Kinase | VRK.AA | TyrKc | 30-297 | 17 | 4.7e-05 | -140.95 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 30-297 Range on HMM: 1-280/280 Sequence Identity: 17% (58 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYVIKIEPHENGPLYTELHFYQRAAQVDQVAKWQKE----HKL--SHLGVPKLFGFGSHDSDGT---KYR .||| .| | || .||. . . .| .. .. .| .|| .| . .|.| .... . ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL FLVMPLFGEDIWKKYL-ACNKKFTPGLVFALAIQILDSLEYLHEMNYVHADIKSANLLLGFSPKDKNKVFLADYGLVNRYKPDDKHRKY----EEFPKKG ..|| . |.|| .. .|... ..|| . ||||..|..| |. | |.| | .| || . || . . ||. MIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDD---QQGESKDYYRKKE H-NGT---------PEFTSIDAH--------------------LGVSPSRRGDIQ--ILGYVMLQWLCTTLPWEDKLTDLNYVMNQKIK--------YSK | .| || .|. . .| .| |.|| . . ..... . | | | .. HKGGKTMLPIRWMAPE--CINYGKFTTKSDVWSFGVCMWEIFTYGQQP-YPGMIQQMMSNQEVIEYV-----------KQGYRMPQPPNDYPMSFVCCPD DISGLLKTCFSSSYPN-----ELKTFL .. . |.| . |.. .. EMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | VRK.AA | Pkinase | 30-70 | 29 | 7.7e-05 | 18.2 | Pfam | 1-36 (293) | Show / Hide |
Range on Protein: 30-70 Range on HMM: 1-36/293 Sequence Identity: 29% (12 aa) WRLGKPIGQGGFGMIYKASENTSGKTKSDGTYVIKIEPHEN ...|..||.|.|| ||. . .|| ....|| . .. YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRH |
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Kinase | VRK.AA | CK1-D | 30-53 | 37 | 0.001553 | 8.15 | In-house | 1-24 (261) | Show / Hide |
Range on Protein: 30-53 Range on HMM: 1-24/261 Sequence Identity: 37% (9 aa) WRLGKPIGQGGFGMIYKASENTSG .|.|. || | || || . ... YRIGRKIGSGSFGDIYHGTNIQTN |
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Kinase | VRK.AA | CK1-A | 30-54 | 44 | 0.011268 | 5.07 | In-house | 1-25 (261) | Show / Hide |
Range on Protein: 30-54 Range on HMM: 1-25/261 Sequence Identity: 44% (11 aa) WRLGKPIGQGGFGMIYKASENTSGK .|| ..|| | || || . . |.|. YRLVRKIGSGSFGDIYLGINITNGE |