Gene Trb (Sea Urchin)
Trb
Sequence
Protein domains of Trb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | Trb.AA | Trbl | 63-305 | 56 | 2.6e-168 | 535.8 | In-house | 1-256 (256) | Show / Hide |
Range on Protein: 63-305 Range on HMM: 1-256/256 Sequence Identity: 56% (144 aa) LLEEVD-PKVFKCVDTFNNQECICKVVDVHQYREAFAPTFHLGYHSRINHVEEVLQGHTQAYVIFPTT-------------HGDMHSYVRRKRKLREREA .|| . .|.. . .| ||| .. .| | .| | | |. |. . ||. | ..||. | | |||||||||....|.|.|| CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA AALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEERTDVVLDGIEEGHILATPEDDNLNDKHGCPAYVSPEILLTSGSYSGKAADMWSLGVILYTMLVGR |.|||||.|||||||.||.||||||||.||||.||||...|...|...|... |||.|.||||||||||||||.|.|||||||||||||||.|||||||| ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTG-EDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGR YPFHDSDPAALFTKIRLGQYNVPESLSTQAKSMIYSLMRVDPSERLTAEEVLEHPWF ||||||.|..||||||.||...||.||..|...|..|.|..||||.||...|.|||| YPFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF |
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| Kinase | Trb.AA | CAMK | 129-305 | 22 | 4.6e-66 | 211.6 | In-house | 143-425 (425) | Show / Hide |
Range on Protein: 129-305
Range on HMM: 143-425/425
Sequence Identity: 22% (63 aa)
THG----DMHSYVRRK---------------RKLREREAAALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEER---------------TDVVLDGIEE
. | |. .|.... ... ||||. .|.|...||..|| |..| ||||. . . .. .. .
SGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF
GHILATPE----------------------DDNLNDKHGCPAYVS-PEILLTSG------------SYSGKAADMWSLGVILYTMLVGRYPFHDS-----
.. | .. ... |.|.|.. ||.|. .| | |...||||.|||||.||.|..|| ..
ANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEI
--------DPAALFTKIRLGQYN-VPESLST-----------------------QAKSMIYSLMRVDPSERLTAEEVLEHPWF
.. || ||. |.|. |. .|. ..|..| ....|||..|.|.|..|.|||.
CEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | Trb.AA | SgK495 | 132-303 | 38 | 1.1e-45 | 139.38 | In-house | 1-171 (171) | Show / Hide |
Range on Protein: 132-303 Range on HMM: 1-171/171 Sequence Identity: 38% (67 aa) DMHSYVRRKRKLREREAAALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEERTDVVLDGIEEGHILATPEDDNLNDKHGCPAYVSPEILLTSGS-YSGK . .| . ..| |||. .|| .|. | | .| ||||| | . . . |. . | | | |. | |||.||..| || | || NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTHQITITNFCLGKHLVS--EHDLLKDQRGSPAYISPDVL--SGRPYRGK AADMWSLGVILYTMLVGRYPFHDSDPAALFTKIRLGQYNVPES--LSTQAKSMIYSLMRVDPSERLTAEEVLEHP .||| |||.|.||| | .|| || | || ||. | .|. | .| .|. .||..|||| .|.| PSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV |
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| Kinase | Trb.AA | MELK | 131-305 | 33 | 1.3e-39 | 132.9 | In-house | 82-254 (254) | Show / Hide |
Range on Protein: 131-305 Range on HMM: 82-254/254 Sequence Identity: 33% (58 aa) GDMHSYVRRKRKLREREAAALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEERTDVVLDGIEEGHILATPEDDNLNDKHGCPAYVSPEILLTSGSYSGK |.| |. |. .| | |. .| |.| |.|. | | |||| ..|. . . .. |. . ||. | ||| || |. .| | GEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPE-LIQGKQYIGS AADMWSLGVILYTMLVGRYPFHDSDPAALFTKIRLGQYNVPESLSTQAKSMIYSLMRVDPSERLTAEEVLEHPWF ||.||.|..||....| || | ... || | |..|. || ..| .. .. ||| |. ..|.||| EADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV |
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| Kinase | Trb.AA | MARK | 211-305 | 41 | 3.8e-38 | 122.4 | In-house | 167-262 (262) | Show / Hide |
Range on Protein: 211-305 Range on HMM: 167-262/262 Sequence Identity: 41% (40 aa) GCPAYVSPEILLTSGSYSGKAADMWSLGVILYTMLVGRYPFHDSD--PAALFTKIRLGQYNVPESLSTQAKSMIYSLMRVDPSERLTAEEVLEHPWF | |.| .|||.| . | |...|.|||||.||.|..|..|| ... |. ||. |.| .| .|......| .|. |.|.|| |.||...|||. GTPPYMAPEIFL-KKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | Trb.AA | CAMKL | 213-305 | 33 | 6.2e-37 | 115.3 | In-house | 197-297 (297) | Show / Hide |
Range on Protein: 213-305 Range on HMM: 197-297/297 Sequence Identity: 33% (35 aa) PAYVSPEILLT-SGSYSGKAADMWSLGVILYTMLVGRYPFHDSDPA-------ALFTKIRLGQYNVP--ESLSTQAKSMIYSLMRVDPSERLTAEEVLEH |.| .|||.. .| |...|.||.|||||.|..|..|| | . . |. ||. | |. | ..| .....| ... |.|..| |......| PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH PWF ||. PWM |
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| Kinase | Trb.AA | CAMK1 | 211-305 | 42 | 1.3e-36 | 103.93 | In-house | 175-276 (276) | Show / Hide |
Range on Protein: 211-305 Range on HMM: 175-276/276 Sequence Identity: 42% (44 aa) GCPAYVSPEILLT--SGSYSGKAADMWSLGVILYTMLVGRYPFHDSD-PAALFTKIRLGQYNVPES----LSTQ-AKSMIYSLMRVDPSERLTAEEVLEH | | || ||.| | .|| |||| |||.|..|.| || |.. . || || ..|. |. | | || | .. |||..|.|.|..|.| GTPGYVAPEVLECKKDKPY-DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNH PWF ||. PWI |
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| Kinase | Trb.AA | AMPK | 211-305 | 43 | 1.1e-34 | 100.48 | In-house | 161-254 (254) | Show / Hide |
Range on Protein: 211-305 Range on HMM: 161-254/254 Sequence Identity: 43% (41 aa) GCPAYVSPEILLTSGSYSGKAADMWSLGVILYTMLVGRYPFHDSDPAALFTKIRLGQYNVPESLSTQAKSMIYSLMRVDPSERLTAEEVLEHPWF | | | .||. .. | | | || ||||| || |. || |.. ..|. ||. |.| .|. ||..||..| .. .||| .|.| ... .|||| GSPCYAAPEM-ISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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| Kinase | Trb.AA | S_TKc | 64-305 | 25 | 1.1e-32 | 115.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 64-305 Range on HMM: 1-231/231 Sequence Identity: 25% (70 aa) LEEVDP-------KVFKCVDTFNNQECICKVVDVHQYREAFAPTFHLGYHSRINHVEEVLQGHTQAYVIFPTTHG---DMHSYVRRKRK------LRERE | ... ||.||... .... .|... | .|| | | . .| | . |... | |...| ..... . | . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H AAALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEERTDVVLDGIEEGHI------LATPEDDNLNDKHGCPAYVSPEILLTSGSYSGKAADMWSLGVIL |. ...|...|...|| ||.. |||| . . || ||. . | | |..||.| .|.....|.||.|.|| ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL YTMLVGRYPFHDSDPAALFTKIRLGQYNVPESLSTQAKSMIYSLMRVDPSERLTAEEVLE-------HPWF | ||.|. ||. .....| ||. | .||..| ....||..|.|| |.|. |||| YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | Trb.AA | TSSK | 214-305 | 30 | 6.8e-32 | 101.94 | In-house | 193-289 (289) | Show / Hide |
Range on Protein: 214-305 Range on HMM: 193-289/289 Sequence Identity: 30% (30 aa) AYVSPEILLTSGSYSGKAADMWSLGVILYTMLVGRYPFHD--SDPAALFTKIR--LGQYNV--PESLSTQAKSMIYSLMRVDPSERLTAEEVLEHPWF ||..||||. . |..|..| ||.|||||.|..|. || | |.. . .. .. ...|...|..|..... .|..|....|...|.| AYAAPEILR-GIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM |
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| Kinase | Trb.AA | RSK | 211-305 | 34 | 2e-31 | 110.76 | In-house | 170-278 (278) | Show / Hide |
Range on Protein: 211-305 Range on HMM: 170-278/278 Sequence Identity: 34% (38 aa) GCPAYVSPEILL---TSGSYSGKAADMWSLGVILYTMLVGRYPFHD---SDPAALFTKIRLGQ--YNVP--ESLSTQAKSMIYSLMRVDPSERLT----- . .|. ||.| | .. ||.| |||||..|.||.|. ||. .... ....|. |. . | ..||. ||. | .. .||. ||. YTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD AEEVLEHPWF |||...|||| AEEIKQHPWF |
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| Kinase | Trb.AA | Pkinase | 213-305 | 30 | 1.8e-28 | 101.74 | Pfam | 175-293 (293) | Show / Hide |
Range on Protein: 213-305 Range on HMM: 175-293/293 Sequence Identity: 30% (36 aa) PAYVSPEILLTSGSYSGKAADMWSLGVILYTMLVGRYPFHDS------DPAALFTKIRLGQYNVPESLS---------------------TQAKSMIYSL | |..||... .|.| |...||||.|.||| || || || .. |. ... .|. ... ... . .|. |... PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC MRVDPSERLTAEEVLEHPWF ..||..|.|||..|.|||| LCKDPKKRPTAEQILQHPWF |
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| Kinase | Trb.AA | MARK | 131-174 | 36 | 7.6e-14 | 41.81 | In-house | 87-132 (262) | Show / Hide |
Range on Protein: 131-174 Range on HMM: 87-132/262 Sequence Identity: 36% (17 aa) GDMHSYVRRK--RKLREREAAALFHQMVQAVAHCHTHGVVLRDLKL |....|.. . ..| |.|| ..|.|.| || || ...| ||.|. GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP |
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| Kinase | Trb.AA | CAMKL | 131-174 | 36 | 8.4e-14 | 40.28 | In-house | 106-155 (297) | Show / Hide |
Range on Protein: 131-174 Range on HMM: 106-155/297 Sequence Identity: 36% (18 aa) GD--MHSYVRRK----RKLREREAAALFHQMVQAVAHCHTHGVVLRDLKL |. .. |.... ... |.|| .| |.| ||..|| ||.| ||.|. GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP |
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| Kinase | Trb.AA | TSSK | 130-174 | 45 | 1.7e-13 | 40.64 | In-house | 101-151 (289) | Show / Hide |
Range on Protein: 130-174 Range on HMM: 101-151/289 Sequence Identity: 45% (23 aa) HGDMHSYVRRK------RKLREREAAALFHQMVQAVAHCHTHGVVLRDLKL |||. .|..|. . |.| .| ..|.||| ||..|| |.|| ||||. HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC |
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| Kinase | Trb.AA | AMPK | 131-174 | 40 | 2.8e-13 | 35.82 | In-house | 85-128 (254) | Show / Hide |
Range on Protein: 131-174 Range on HMM: 85-128/254 Sequence Identity: 40% (18 aa) GDMHSYVRRKRKLREREAAALFHQMVQAVAHCHTHGVVLRDLKL |. .|. ....| ||||. .| |.. .| || |..| ||||. GELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP |
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| Kinase | Trb.AA | Pkinase | 130-174 | 26 | 4.5e-09 | 33.17 | Pfam | 84-136 (293) | Show / Hide |
Range on Protein: 130-174 Range on HMM: 84-136/293 Sequence Identity: 26% (14 aa) HG----DMHSYVR--RKRKL--REREAAALFHQMVQAVAHCHTHGVVLRDLKL .| | ..|.. |.... |.|. . |.......|| .|.. ||||. GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP |
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| Kinase | Trb.AA | CAMK1 | 145-173 | 41 | 2.3e-07 | 17.41 | In-house | 107-135 (276) | Show / Hide |
Range on Protein: 145-173 Range on HMM: 107-135/276 Sequence Identity: 41% (12 aa) EREAAALFHQMVQAVAHCHTHGVVLRDLK |..|. . .| ..|| ..| .|.| |||| EKDARHIMKQILSAVEYMHSKGIVHRDLK |
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| Kinase | Trb.AA | RSK | 138-174 | 35 | 1.1e-05 | 17.15 | In-house | 94-132 (278) | Show / Hide |
Range on Protein: 138-174 Range on HMM: 94-132/278 Sequence Identity: 35% (14 aa) RRKRK--LREREAAALFHQMVQAVAHCHTHGVVLRDLKL ..|.. . |.||.. . . | || | |..|.. ||||. KEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP |
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| Kinase | Trb.AA | TyrKc | 64-305 | 15 | 0.000194 | -150.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 64-305 Range on HMM: 1-280/280 Sequence Identity: 15% (46 aa) LEEVDP-------KVFKCVDTFNNQECICKVVDVHQYREAF---APTFHLG--YHSRINHVEEVLQGH-------TQAYVIFP-TTHGDMHSYVRRKRK- .. . .|.|.. . ... |.. . ||.| | . | | | . . .... ||| ..| |..|. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LREREAAALFHQMVQAVAHCHTHGVVLRDLKLRKFVFKKEERTDVVLDGIEEGHI------LATPEDDN-------LNDKH----GCP-----AYVSPEI | .. .| . .. | .... ||| | ... .. |. .| .. |. .|| LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC LLTSGSYSGKAADMWSLGVILYTML-VGRYPFHD-----SDPAALFTKIRLGQYNVPESL-----STQAKSMIYSLMR----VDPSERLTAEEVLEHPWF . | .. . | || || .. .. | | . ... .. ... | . . . . . .|..|. ||..| | .|. | | I-NYGKFT-TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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