Gene MAPKAPK5a (Sea Urchin)
MAPKAPK5a
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MAPKAPK5a.AA | Protein | None | 207 | None | Fasta, JSON |
| MAPKAPK5a.kin_dom | Protein Kinase Domain | None | 157 | None | Fasta, JSON |
Protein domains of MAPKAPK5a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MAPKAPK5a.AA | MAPKAPK | 19-191 | 58 | 7.29999999999e-116 | 391.22 | In-house | 1-177 (268) | Show / Hide |
Range on Protein: 19-191 Range on HMM: 1-177/268 Sequence Identity: 58% (104 aa) IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQ--KR . |.|.|| ||||.|..|.|||....||||.|.|.|.||.||.||..||||..||.||.|..|..|||.||.|...||.|||.|.|||||.||... .. QIWKQVLGIGINGKVMQCYHKRTQQKFALKVLRDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQERGDQH FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDG--TLMTPHFTPYYVAPQV ||||.|....|||..|| .|||.|||||||||||||.||.......||.||||||.... |||||..|||||||.| FTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEV |
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| Kinase | MAPKAPK5a.AA | MAPKAPK | 19-191 | 47 | 1.2e-107 | 334.41 | In-house | 1-185 (292) | Show / Hide |
Range on Protein: 19-191 Range on HMM: 1-185/292 Sequence Identity: 47% (90 aa) IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDK-----PGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISK . |...|| ||.|.|. |.|||.....|.|.|.|. . || ||.||..|.||.|||.||..|.|..|| ......|||.|.|||||..|.. KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQF------DKCFYLVMECMEGGELFQHIQQ --QKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKV-------DDG----TLMTPHFTPYYVAPQV .|.||||.|. ..|.|.||| ..||.|||||||||||.| .|.....||||.||||||. ... .||||..||||.||.| RGHKHFTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEV |
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| Kinase | MAPKAPK5a.AA | CAMK | 24-191 | 25 | 5.1e-60 | 191.76 | In-house | 1-291 (425) | Show / Hide |
Range on Protein: 24-191 Range on HMM: 1-291/425 Sequence Identity: 25% (75 aa) KLGTGINGPVRPCQHKRSE------------DRFALKLLL---------------------------------DKPGARAEVNLHSRCSG------HANI .||.| | |. |.||.. ..| | . |. | |........| | || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VKIIEVFSNEVQFP----------GEPAPKSRLLVVM---ELMDGGEL----FDRISKQ---------------KRFTERQAVILTKQIASAVLQCHSLN .|..||. .. .|. ..... || |...|||| ||.| .. .|||||.| . .||.||| |||.| IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IAHRDLKPENLLLKDNSEDSP--------------VKLSDFGFAKVDDG--------------------------TLMTPHFTPYYVA-PQV |.||||||||.|| ||..||. .|..|||||.. |. . |. ||.|.| | | IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV |
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| Kinase | MAPKAPK5a.AA | CAMK1 | 17-193 | 34 | 2.8e-53 | 153.22 | In-house | 1-186 (276) | Show / Hide |
Range on Protein: 17-193 Range on HMM: 1-186/276 Sequence Identity: 34% (68 aa) YTIDWTQKLGTGINGPVRPCQHKRS---EDRFALKLLL--DKPGA---------RAEVNLHSRCS--GHANIVKIIEVFSNEVQFPGEPAPKSRLLVVME | . . ..|.| . |. |.||.. .. .|.| . . . |.. . ..| | ||.|..|.. .. . ||| YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYES----------DNHFYLVME LMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVK--LSDFGFAKVDD-G--TLMTPHFTPYYVAPQVST |. |||||||| . . .||..|. . |||.||| .||..|.||||||||||..|..|||..| ..||| .| | . .. |. ||.|||| | . LVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLE |
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| Kinase | MAPKAPK5a.AA | Pkinase | 19-189 | 29 | 3.9e-40 | 142.99 | Pfam | 1-180 (293) | Show / Hide |
Range on Protein: 19-189 Range on HMM: 1-180/293 Sequence Identity: 29% (58 aa) IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARA----------EVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGG--- . .|.| | | |. |.|| .....|.| . . ... |. .. |. .| |||.....| . |... .|||...|| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----------KDHIYMVMEYCEGGLYV -ELFDRIS--KQKRF--TERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLK-DNSEDSPVKLSDFGFA----KVDDGTLMTPHFTPYYVAP .|||.|| ....| .|... .||.... ||| .| ||||||||.|.. .. |..||..|||.| .. ..|. ||.|.|| MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP |
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| Kinase | MAPKAPK5a.AA | CDPK | 97-191 | 43 | 4.4e-38 | 114.55 | In-house | 78-185 (271) | Show / Hide |
Range on Protein: 97-191 Range on HMM: 78-185/271 Sequence Identity: 43% (47 aa) VVME--LMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDS----PVKLSDFGFAKVDD-------GTLMTPHFT .||| . ||||||.| ...|||..| .|| ||| ||| || ||||||||.|.. ...|| ..|. |.| .| | .... | IVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGT PYYVAPQV |||.|| | PYYIAPEV |
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| Kinase | MAPKAPK5a.AA | RAD53 | 69-189 | 33 | 3.2e-35 | 102.0 | In-house | 63-195 (305) | Show / Hide |
Range on Protein: 69-189
Range on HMM: 63-195/305
Sequence Identity: 33% (47 aa)
HANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKR----FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDS----
| .|..|...| . . |.|||.|||||..| .|| |.| .. . .|. ||. |...|.|||||||| |.....|.
HPCIIRIYDIFDTP---------QKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQ
-----------PVKLSDFGFAK-VDDGTLMTPHF-TPYYVAP
.|..||| .| |..|..|. . || ||||
LGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAP
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| Kinase | MAPKAPK5a.AA | MSK | 19-191 | 30 | 1.9e-34 | 113.85 | In-house | 1-176 (277) | Show / Hide |
Range on Protein: 19-191 Range on HMM: 1-176/277 Sequence Identity: 30% (56 aa) IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLL-------DKPGAR--AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFD . ..| | . .| | |. .. .| | | | . .|. .| .| |||. ..|. .. . |||. ||||| LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQD----------QCHTYLVMEYCNGGELFT RISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGT----LMTPHFTPYYVAPQV .|.| ..|.| . . .. .|| . |.. | ||||||||.|. |.... .|||.|||||. . .| || | || . HIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEM |
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| Kinase | MAPKAPK5a.AA | DCAMKL | 69-189 | 37 | 6.2e-34 | 102.54 | In-house | 74-188 (279) | Show / Hide |
Range on Protein: 69-189 Range on HMM: 74-188/279 Sequence Identity: 37% (47 aa) HANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKD-NSEDSPVKLSDF | .|....|... | . . |||. || ||| |.. .||||.|.|.. ....| |..|| |||.||||||... . .|| || HPHIIQLYEHWDTETH----------YYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDF GFAKVDDG---TLMTPHFTPYYVAP | |.. .| | | || |||| GLACHVNGDFGPLYTVCGTPTYVAP |
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| Kinase | MAPKAPK5a.AA | RSK | 33-191 | 33 | 5.3e-33 | 115.95 | In-house | 15-179 (278) | Show / Hide |
Range on Protein: 33-191 Range on HMM: 15-179/278 Sequence Identity: 33% (59 aa) VRPCQHKRSEDRFALKLLLDK----PGAR------AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQKR---FTE .| |.|. .. .| | |.| . .. .|.| .|| .| .||. ..| | . | .||.. |||||....|.|. |.| CRKCTHHDTGQIYAMK-VLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTE----------GKLYLIMEYCRGGELFTHLQKEKHFGCFSE RQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSED-SPVKLSDFGFAKV---D-DGTLMTPHFTPYYVAPQV . | . .|..|| |.. | |||||||| |. | | . .||.||||.| | . .||. .| |.|| . DEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEM |
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| Kinase | MAPKAPK5a.AA | RSK | 20-189 | 33 | 2.2e-29 | 102.09 | In-house | 2-174 (271) | Show / Hide |
Range on Protein: 20-189 Range on HMM: 2-174/271 Sequence Identity: 33% (62 aa) DWTQKLGTGING---PVRPCQHKRSEDRFALKLLL-DKPGAR-----AEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDR . ...|.| . .. |||| ... .| | . .. .. |. | . |..||| .|| | . . .|..| ||.|||| ELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGK----------VYMIMDFMRGGDLFDR ISKQKRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDN-SEDSPVKLSDFGFAK---VDDGTLMTPHFTPYYVAP ..||| |.|| . . ||.|. ||. |.|||||||| |. | . . .|. |||||| ..| |||. | |.|| LLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAP |
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| Kinase | MAPKAPK5a.AA | S_TKc | 19-204 | 25 | 2.5e-18 | 68.12 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-204
Range on HMM: 1-231/231
Sequence Identity: 25% (65 aa)
IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDG--GELFDRISKQKR
. .|.| | | |. |.||.. ..|.| . .| |...... .| ||||...|| . ..| .|||..|| |.|||.| |..|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGR
------FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGTLMTPHFTPYYVAPQVSTSLTP-------------
|.| .| ...||..|. |||..| ||||||||.|| . .|..|||.|.. .| ||.|.|| | . ..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL----TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILY
-------------------------------------------IAQ-------LEYK
. | ..
EMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | MAPKAPK5a.AA | TyrKc | 19-207 | 15 | 5e-05 | -141.34 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 19-207
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)
IDWTQKLGTGINGPVRPCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNE-------VQFPGEPAPK-------SRLLVVMELMDG
| .||| | | |. .. | | | | . .. . . ... .. |.. | . |..|||.|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH
GELFDRISKQKR-FTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLLLKDNSEDSPVKLSDFGFAKVDDGT----------------LMT--------
| | |.. | .. .. .. . |||. || |. |||| | |...| || |||| .. .
GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM
----------------------------------PH-----FTPYYVAPQVSTS--LTPIAQ-------------------------------LEYKLHF
| ... | .| . . . . | . |
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | MAPKAPK5a.AA | CDPK | 19-48 | 34 | 0.226487 | 0.21 | In-house | 1-32 (271) | Show / Hide |
Range on Protein: 19-48 Range on HMM: 1-32/271 Sequence Identity: 34% (11 aa) IDWTQKLGTGINGPVRPCQHK-RS-EDRFALK .. .||.| | || ..|| . . |.| | YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMK |
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