Gene MAPKAPK2 (Sea Urchin)
MAPKAPK2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| MAPKAPK2.AA | Protein | None | 240 | None | Fasta, JSON |
| MAPKAPK2.kin_dom | Protein Kinase Domain | None | 155 | None | Fasta, JSON |
Protein domains of MAPKAPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MAPKAPK2.AA | MAPKAPK | 6-168 | 80 | 1.6e-133 | 449.85 | In-house | 105-268 (268) | Show / Hide |
Range on Protein: 6-168 Range on HMM: 105-268/268 Sequence Identity: 80% (132 aa) EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETT-TTNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP |||.|...|.|||.|.| |||||||||||||||.|..||..||||||||||||| ...|.||||||||||||||||||||||||||||||||||.|||.| EAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTDFGFAKETTRHNTLMTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYIMLCGYP PFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV |||||||.|||||||.||.|||||||.||||.||||||.||.|||||||.|||.|.||||.||. PFYSNHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTERLTIEEFMNHPWI |
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| Kinase | MAPKAPK2.AA | MAPKAPK | 6-168 | 57 | 3.2e-133 | 415.0 | In-house | 104-292 (292) | Show / Hide |
Range on Protein: 6-168 Range on HMM: 104-292/292 Sequence Identity: 57% (109 aa) EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKE-------TT---TTNLQTPCYTPYYVAPEVLGPEK----YDKSCDMWS ||..|.. |..||..|| ||||||||||||.|..|...|. .||.||||||| || |..|.||||||||.||||.|..| ||||||||| EASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFKEAHTYDKSCDMWS LGVIMYILLCGFPPFYSNHG-MAISPG-----------MKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV |||||||.|||.||||||.| ...|.. |..||..|||||||.|||..||.||.||.||||.|| .||.|...||.||. LGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
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| Kinase | MAPKAPK2.AA | CAMK1 | 6-168 | 44 | 4.7e-90 | 261.96 | In-house | 109-276 (276) | Show / Hide |
Range on Protein: 6-168 Range on HMM: 109-276/276 Sequence Identity: 44% (76 aa) EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLK--LTDFGFAKETTTT--NLQTPCYTPYYVAPEVLGP---EKYDKSCDMWSLGVIMYI .|..|.. | .||...| ..|.|||||||||||.| ..| .| . ||| .| . ...|.| ||.||||||| . |||.||||| ||| || DARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYI LLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSED-AKNLIKKLLRTDPAERLSIQEFMNSPWV ||||.||||.. . . . . | ...|||| |.| .|. ||..||..| || .|...... | ||. LLCGYPPFYDENVDNE---LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | MAPKAPK2.AA | CAMK | 6-168 | 30 | 1.7e-83 | 268.8 | In-house | 180-425 (425) | Show / Hide |
Range on Protein: 6-168 Range on HMM: 180-425/425 Sequence Identity: 30% (76 aa) EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNS--------------LLKLTDFGFAKETTTTN-------------------------LQTP ||. ..| | .|||..| .||.||||||||.|. |. ..| .|..|||||.. . . ..|. EARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTF CYTPYYVA-PEVLGP--------------EKYDKSCDMWSLGVIMYILLCGFPPFYSNHGMAIS---------PGMKRRIRNGQYEFPDPE--------- | ||.|.| |||| . |...|||||.|||.||.|||.||||. ... | . ....|..|.|.||.|. CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG ---WSQVSED--------AKNLIKKLLRTDPAERLSIQEFMNSPWV |. .|.. .|.||.|.|..|| .|..|.. .| ||. PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | MAPKAPK2.AA | CDPK | 5-168 | 42 | 3.6e-67 | 205.11 | In-house | 103-271 (271) | Show / Hide |
Range on Protein: 5-168 Range on HMM: 103-271/271 Sequence Identity: 42% (74 aa) TEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNS----LLKLTDFGFAKETTT------TNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV .|||.|.| | .|| . | || ||||||||.|. ..| .|. |.| .|. . . | ||||.||||| |...|| ||.|| KEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGV IMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV |.|||||| |||| . | ...|.|.| .|||. .|..||.||.|.| .|| |.| |. .. ||. ILYILLCGYPPFYGKNDQEIM----EKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | MAPKAPK2.AA | RAD53 | 17-168 | 38 | 1.1e-65 | 194.47 | In-house | 121-305 (305) | Show / Hide |
Range on Protein: 17-168 Range on HMM: 121-305/305 Sequence Identity: 38% (71 aa) AVHHLHVMNIAHRDLKPENLLYR-DRTPN--------------SLLKLTDFGFAKETTTT-NLQTPCYTPYYVAPEVLGPE---------------KYDK || || ..|.|||||||| |. .. .. .|.|.|||| .| . . ..| | || ||||||. . | | AVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTK SCDMWSLGVIMYILLCGFPPFYSNHGMA--ISPGMKRRIRN-GQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV ..|.||.|.| ||.|||.||| | . . . .. |.| | |.|| |.|. .|| ||.|||..| || .|..| | .|.|| KVDCWSMGCILYICLCGYPPF-SDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM |
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| Kinase | MAPKAPK2.AA | Pkinase | 6-168 | 32 | 2.9e-61 | 214.65 | Pfam | 109-293 (293) | Show / Hide |
Range on Protein: 6-168 Range on HMM: 109-293/293 Sequence Identity: 32% (61 aa) EAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYR-DRTPNSLLKLTDFGFAK---ETTTTNLQTPCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILL |. ... | ... ..| |.| ||||||||.|. . .... .|..|||.|| . . ..|.| ||.|.||||. ..|....||||.|.|.|..| ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML CGFPPFYSNH----GMAISPGMKRRIRNGQYEFPDPEWSQVS-----------------EDAKNLIKKLLRTDPAERLSIQEFMNSPWV || |||. .| . . | .||. ....|. |.|. .| |..| .||..|. ||..|..... ...||. CGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | MAPKAPK2.AA | MSK | 3-168 | 37 | 4.4e-59 | 198.38 | In-house | 99-277 (277) | Show / Hide |
Range on Protein: 3-168 Range on HMM: 99-277/277 Sequence Identity: 37% (68 aa) RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETTTT---NLQTPCYTPYYVAPEVLG----PEK-YDKSCDMWSLGV ...|...|.|.. || |.| | ||||||||.|. |...| .||.|||||..... ...||.| | |||.| .. ||..||.||||| DESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV IMYILLCGFPPFY--SNHGM---AISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPWV |.| .| | || . . . . .||. |. || .|...|.|||.||..|| ||. ||. .. . | ILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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| Kinase | MAPKAPK2.AA | RSK | 5-168 | 41 | 7.9e-59 | 201.75 | In-house | 104-278 (278) | Show / Hide |
Range on Protein: 5-168 Range on HMM: 104-278/278 Sequence Identity: 41% (75 aa) TEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPN-SLLKLTDFGFAKE-TTT--TNLQTPCYTPYYVAPEVLG---PEK-YDKSCDMWSLGVIM .||... . | || ||| | |||||||| || |.. | .|||||||.|. ..|.||| |.|||.| ... .||.|| |||||.| DEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLM YILLCGFPPFYS---NHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLS-----IQEFMNSPWV | .| |.|||.. |. |. .||..|.. .. |.|. .|..||.||.|.| ||. ||. ..| ..|| YEMLTGCPPFQGPNDNNRKEIM----KRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | MAPKAPK2.AA | CAMK-Unique | 3-168 | 29 | 1.2e-58 | 192.17 | In-house | 155-363 (363) | Show / Hide |
Range on Protein: 3-168
Range on HMM: 155-363/363
Sequence Identity: 29% (61 aa)
RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTP-------------NSLLKLTDFGFAKETTTTNLQ----TPCYTPYYVAP----------
| .... |.... .|| ..| .| |||||.||.... . . |. .||.||| ... . | | ||.|.||
RCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQE
----EVLGPEKYDKSC----DMWSLGVIMYILLCGFPPFYSNHGM----AISPGMKRRIRNGQY-EFPDPEWSQ---VSEDAKNLIKKLLRTDPAERLSI
||.. .|| | | ||||||||..||| |||... . . ..|. |.| .|. . |. .|. ||...|... .||. |.|.
MTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSA
QEFMNSPWV
| ..|.
KELLEHQWI
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| Kinase | MAPKAPK2.AA | Ciliate-E2 | 10-168 | 29 | 1.5e-55 | 189.13 | In-house | 165-365 (365) | Show / Hide |
Range on Protein: 10-168 Range on HMM: 165-365/365 Sequence Identity: 29% (65 aa) IVRSIGQAVHHLHVMN-IAHRDLKPENLLYRDRTPNSLLKLTDFGFAK------------------------ETTTTNL---------QTPCYTPYYVAP ....| .|...|| | | |||.||||.|. .|..|||..| ..|.... .| |.||.|.|| YIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP EVLGPEK---------YDKSCDMWSLGVIMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPE--------------WSQVSEDAKNLIKK----L |.|. .| ||..||.||||||.|..|.| ||| . | .....|| || | ..|...|.|||| . EILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM LRTDPAERLS-IQEFMNSPWV | || .|.. ... .| || LQKDPEKRITGWEQILNHPWF |
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| S_TKc | MAPKAPK2.AA | S_TKc | 1-168 | 21 | 8.2e-23 | 83.02 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-168
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)
M------------------------------------------------------------------------------------------IRLTEAAEI
. .|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
VRSIGQAVHHLHVMNIAHRDLKPENLLYRDRTPNSLLKLTDFGFAKETTTTNLQTPCYTPYYVAPEVLGPEKYDK-SCDMWSLGVIMYILLCGFPPFYSN
.. | .|. ..| ..| ||||||||.| . .|..|||.|.. | | ||.|.||||| .|.| .||.||.|.|.|..||| |||.
MYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--
HGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMN-------SPWV
| ..|. |..||..|.|.|. ||..|... | .. ||.
----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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