Gene DRAK (Sea Urchin)

DRAK

Species: Sea Urchin
Alias: SPU_028649, DRAK, Spk063
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: DAPK
Subfamily: DRAK

Sequence

Name Sequence Type Origin Length Description Download
DRAK.AA Protein None 518 None Fasta, JSON
DRAK.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of DRAK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DRAK.AA DAPK 13-271 63 8.8e-238 662.91 In-house 3-264 (264) Show / Hide 
Range on Protein: 13-271
Range on HMM: 3-264/264
Sequence Identity: 63% (166 aa)

QLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRD----CREDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFC
. || ||.|||||||.||....|.||||..||..|..    |||.|..||.|||........|.|||||||.|.|||.|||.|||||..||..|.|...|
EELG-RGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECLC

EKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQGEEIRDIQGTPDYVAPEILNYDPITLSTDMWSIGVLTYVMLT
|.|..|...|||||||||||.||.|||||||||.||.......|||.||||..|....|||.|||.|||.||||||.||.|..|.||||||||.||.||.
EEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIMLS

GISPFAGDTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
|||||.|||||||||||||.|.||.||.|||.|..|.|||..|.|.|.|||..|.|||.||||
GISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI
Kinase DRAK.AA DRAK 11-271 69 2.7e-213 670.01 In-house 1-259 (259) Show / Hide 
Range on Protein: 11-271
Range on HMM: 1-259/259
Sequence Identity: 69% (182 aa)

GVQLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFCEK
  . .| ||.|||||||.||....||||||..||..|.|||..||.||..|.........|.|||||||..|.|||||||.|||..||||||||..||||
TAKERG-RGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEK

DVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQGEEIRDIQGTPDYVAPEILNYDPITLSTDMWSIGVLTYVMLTGI
||.|...||||||||||..||.||||||||||||| |..|.|||..|||..||...|||.|.|.|||||||||||||||||..|||||||||||||||.|
DVQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTS-EYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHI

SPFAGDTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
|||.||.||||||||||.|||..||.||||||.|.|||||||||..|.|..|.|||||||.
SPFVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL
Kinase DRAK.AA MLCK 18-271 43 1.6e-127 338.13 In-house 9-257 (257) Show / Hide 
Range on Protein: 18-271
Range on HMM: 9-257/257
Sequence Identity: 43% (112 aa)

RGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFCEKDVVRLLQ
||.| .|..|  |.. . .||||.. ||     .|....|| |. |    ..|| .|. .||..|.....|| ||||| .. . | .. . | .|.. . 
RGKFGIVHRCIEKSTGKTWAAKFIKCRKPKD--KENVKNEIEIM-NQLHHPNLIQCHDAFETKNEMVMIMEYISGGELFER-IVDEDFHLTEREVIHYMR

QILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQGEE-IRDIQGTPDYVAPEILNYDPITLSTDMWSIGVLTYVMLTGISPFAGD
||.||||..|.|||.||||||.||.. ...   ..||.|||| || .. .|. ..   |||..||||. ||||....|||||.||..|..|.|.|||.||
QICEGVHHMHWQNIVHLDLKPENIMCQTRTS--HQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFMGD

TKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
. .||. |..  . || .| | . |.||.|||  | | | |||..|.|||.|||.
NDRETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL
Kinase DRAK.AA DAPK 19-271 48 2.9e-126 366.2 In-house 10-264 (264) Show / Hide 
Range on Protein: 19-271
Range on HMM: 10-264/264
Sequence Identity: 48% (125 aa)

GRFAVVRKCKHKESNRHFAAKFVRKRKMGRD----CREDILKEIRILENSVL-NQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFCEKDVV
| ||||.||. |     .||||..||..       .||||  |..||.  .. ..  | ||.|||. |.|.|.||  |||||  . ...||    |    
GQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILRE-IRGHPNIITLHDVYENKTDVVLILELVSGGELFDF-LCEKEC-LNEEEAT

RLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQGEEIRDIQGTPDYVAPEILNYDPITLSTDMWSIGVLTYVMLTGISPF
  . |||.|||..|| .|.|.|||| || |  . ...  ||.||||.|.    |.|...| ||| .||||| || |  | |||||||| ||..| | |||
QFIKQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILLSGASPF

AGDTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
 |||||||. ||.  | .| || |.  |  | |||  | | | .||.  .||| ||||
LGDTKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI
Kinase DRAK.AA CAMK 14-271 24 1.8e-111 360.58 In-house 1-425 (425) Show / Hide 
Range on Protein: 14-271
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

LLGVRGRFAVVRKCKHKESN------------RHFAAKFVRKRKMGRD--------------------------CREDILKEIRILENS------VLNQR
 || ||.|..|..|.||...            ...|.|.. |.|.  .                           |. ...||.|. .       .    
TLG-RGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

LIGLHEVYE------------TSTE--------VILVL---EYASGGELHQYC------------------VADKEDGFCEKDVVRLLQQILEGVHYLHS
.| |.||||            | .         ...|.   ||.||||| ...                  .. ..  |.|... |. .||...|||.||
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHS

QNIAHLDLKPQNILLTSKETSE-------------SDIKLIDFGIARYLNQ------------------------GEEIRDIQGTPDYVA-PEILNY---
.||.|.|||| ||||.......              .||.|||| |.....                        |.  ..  ||| |.| ||.||.   
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------DPITLSTDMWSIGVLTYVMLTGISPFAGD-------------TKQETFLNISQLNLDFAEEDFSCHS--------------------PE
           .... ..||||.||..|.||.| .|| ||             . .|.| .| . . || .. || .|                    .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

ARDFIQSLCVIDAEKRLSAKECLDHPWI
..|.|... . | |||.....||.|||.
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase DRAK.AA Trio 18-271 41 8.3e-110 282.63 In-house 9-258 (258) Show / Hide 
Range on Protein: 18-271
Range on HMM: 9-258/258
Sequence Identity: 41% (106 aa)

RGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILKEIRILENSVLN-QRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFCEKDVVRLL
||||.|||.| || . | .||||. .| |.   .|  ..| ..| .  |   ....||. ||| .  ||.|| ...|||   |.....   || .|   .
RGRFSVVRRCWHKATGRTCAAKFIPYRMMD---KEQVYHEYEMLQH--LQHPCVCSLHDTYETPRHYILILELCDDGELLC-CLMRWGS-YCESEVKTYM

QQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQG--EEIRDIQGTPDYVAPEILNYDPITLSTDMWSIGVLTYVMLTGISPFA
.|.||.|||||.. |.|||.|| |....     . .||..||| |  |...  | .    |.|  .||||.. .|. . || |||||||||||.|||||.
WQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEIIQGNPVSYGTDIWSIGVLTYVMLSGISPFY

GDTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
.. ..|| .||  .. .| |. |   | .|..||... . |  || .| ||| ||| 
DESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF
S_TKc DRAK.AA S_TKc 9-271 32 1.3e-85 291.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

LCGVQLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASG--GELHQYCVADKEDG
   ....| .| |..|.||.||...|..| | ..         |.|..||.||..      .. |..|... ... .|.||..|  |.|..| .  .  |
YEILRKIG-KGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FCEKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQGEEIRDIQGTPDYVAPEILNYDPITL-STDMWSIGV
    | | .. ....||.... |.||..| | ||||.||||..       ||..|||.|| |      . . |||.|.|||.|   . .  . |.||.|.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

LTYVMLTGISPFAGDTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLD-------HPWI
. | ||.|  ||   . |..| .|               ||||.|||. ... | |||..| |.|        |||.
ILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DRAK.AA CAMK1 18-271 35 1e-81 237.33 In-house 9-276 (276) Show / Hide 
Range on Protein: 18-271
Range on HMM: 9-276/276
Sequence Identity: 35% (95 aa)

RGRFAVVRKCKHKES---NRHFAAKFVR-KRKMGRDCR---EDILKEIRILENS--VLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDGFC
|| |..|..|.|||.   ....| |    |. |  . .   | ...|| |. ..     .  | ..|.||. ... ||.|. .||||    |  .   . 
RGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKG--NYT

EKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIK--LIDFGIARYLNQGE-EIRDIQGTPDYVAPEILNY---DPITLSTDMWSIGVL
||| ... .|||. |.|.||..|.| ||||.|.|. .|.  .|.||  ..|||........|    .  |||.|||||.|..   .|   . ||||||| 
EKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDE-DSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVI

TYVMLTGISPFAGDT-KQETFLNISQLNLDFAEEDFSCHSPE-ARDFIQSLCVIDAEKRLSAKECLDHPWI
||..|.| .|| ... ..| |  |.   ..| .  .   | . | |||  . . | .||.....||.||||
TYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase DRAK.AA Ciliate-E2a 19-271 35 7e-77 225.84 In-house 10-275 (275) Show / Hide 
Range on Protein: 19-271
Range on HMM: 10-275/275
Sequence Identity: 35% (96 aa)

GRFAVVRKCKHKESNRHFAAKFVRKRKMGRDC--REDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADK-EDGFCEKDVVRL
| |..|.. .||. . .||.| . | ||  .   .| . .|| |. . . .  .| |.||||. .   ||.|| .|||| .. . .| .. . .... ..
GNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQ-LDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEE-IQEICDI

LQQIL-EGVHYLHSQNIAHLDLKPQNILLT--SKET-SESDIKLIDFGIARYLNQGEE--IRDIQGTPDYVAPEILNYDPI------TLSTDMWSIGVLT
.||.| .|.||.|..|| | ||||.|||..  ||.    ||||.|||| |.. .. |.  .  . ||| |||||.||.  .      . . ||||.||  
MQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMWSCGVIF

YVMLTGISPFAGDTKQETFLNISQLNLDFAEED-FSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWI
| .|.| .|| | | .|.. .. . ..||   . ... | |. |... . . | .||..|...|.||| 
YILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Pkinase DRAK.AA Pkinase 9-271 28 2e-76 264.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 9-271
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

LCGVQLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILK--EIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGG----ELHQYCVAD
.. .. .| .| |..|.||.|| ... .| | ..||.   ....  ..  ||.|. .       . |....|..... .|.||. ||    .|. |  ..
YHIGRKIG-SGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KEDGF--CEKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIAR---YLNQGEEIRDIQGTPDYVAPEILN-YDPITLSTDM
.. .|   |... . . |||.|. |.||..| | ||||.|||. .. . ....|..|||.|.   | |..    .. |||.|.|||... . ... . ||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSIGVLTYVMLTGISPFAGD------TKQETFLNISQLNLDFAEEDFSCHS-----------------PEARDFIQSLCVIDAEKRLSAKECLDHPWI
||.|.. | ||.|  || |.      .... . .| .  |.| ..  .. |                 .|..||| ...  | .||..|...| |||.
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DRAK.AA Ciliate-E2 18-271 22 5.2e-68 232.25 In-house 9-365 (365) Show / Hide 
Range on Protein: 18-271
Range on HMM: 9-365/365
Sequence Identity: 22% (86 aa)

RGRFAVVRKCKHKESNRHFAAKFVRKRKMGRD---------------CREDILKEIRILENSVL--------------------NQRLIGLHEVYE--TS
.| |..|.|||... .. || |. . .|. ..               . .   .|.   |....                    .  .| ..|...  . 
QGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

TEVILVLEYASGGELHQYCVAD-KEDGFC--------EKDVVRLLQQILE---------------GVHYLHSQN-IAHLDLKPQNILLTSKETSESDIKL
. . ||.||..||.| .|.    |  ...        || . .. .|||.               ...||||.| | | |.||.|||.         ||.
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKI

IDFGIARYLNQGEEIRD--------------------------------IQGTPDYVAPEILNYDP---------ITLSTDMWSIGVLTYVMLTGISPFA
||||....... .. |                                 | ||| |.||||||. .          . . |.||.||. | ||.|  || 
IDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-

GDTKQETFLNISQLNLDFAEE--------------DFSCHSPEARDFIQS----LCVIDAEKRLS-AKECLDHPWI
       . .| | ..|| ..              ..  .|.|. |.|.     . . | |||.. ....|.|||.
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase DRAK.AA RSK 12-271 30 4.3e-64 219.23 In-house 1-278 (278) Show / Hide 
Range on Protein: 12-271
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

VQLL--GVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCR--EDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADKEDG-
...|  |  | . ..||| |. .....| | ..|.|. .  .  .. ..|..||| .   . .. ||....| ... |..|| .||||       |  | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FCEKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARY-LNQ-GEEIRDIQGTPDYVAPEILN---YDP-ITLSTDMWSIG
|.|...   . .|   | .||.| | | |||| |||..... .|  |||.||| ...  .. ..      .| .|.|||.|.    .   . . | || |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLTYVMLTGISPFAG---DTKQETFLNISQLNLDFAEEDFSCHSPEARDFIQSLCVIDAEKRLS-----AKECLDHPWI
|| | |||| .||.|   ....|.. .| . ....  .  .  |.||.|.|. .   | .|||.     |.| ..|||.
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
TyrKc DRAK.AA TyrKc 9-274 24 1.5e-13 -3.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 9-274
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

LCGVQLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMGRDCREDILKEIRILENS-VLNQRLIGLHEVYETS-------TEVILVLEYASGGELHQYCV
.   . || .| | .|.|.. |   .  | | ... .     |||...|.||. .    .. .. |. |  ..         . .|.||...| |..|  
ITLGKKLG-EGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

ADKEDGFCEKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARYLNQG-------EEIRDIQ--GTPD-----YVAPEILN
. ... .| || .    || .|  ||||.|. | ||   |.|....      .|  ||| .|..  .       . .|  .  |. .       ||| .|
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

YDPITLSTDMWSIGVLTYVMLT-GISPFAG-----DTKQETFLNISQLNLDFAEED-----FSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWIQKF
|   |  .| || ||. . ..| | .|  |      . || . .. | .     ..     | | ..|  . ... .  |.|.| . .|.     ...|
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF