Gene CASK (Sea Urchin)
CASK
Sequence
Protein domains of CASK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CASK.AA | CASK | 1-119 | 50 | 8.8e-86 | 278.36 | In-house | 117-291 (330) | Show / Hide |
Range on Protein: 1-119
Range on HMM: 117-291/330
Sequence Identity: 50% (88 aa)
SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKEN-------------------------------------SAPVKLGGFGIAIPLPSS---------
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CHYMRQILEALMYCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAIQLSHKFTSFYSDPN
----------GLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNM
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TKHITDFADEDPMACGRVGCPHFMAPEVVRREPYGCPCDIWGCGVMLFILLSGCLPFFGTKDRLFEMIMKGRYDM
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| Kinase | CASK.AA | CASK | 120-222 | 73 | 6.7e-78 | 252.34 | In-house | 129-231 (330) | Show / Hide |
Range on Protein: 120-222 Range on HMM: 129-231/330 Sequence Identity: 73% (76 aa) KPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFNARRKLKGAVLAAVASHKFTSFYSDPNTKHITDFADEDP ...|||||..|.....|.|.|.|.|||||||||||||||||||||||||||||||||||||.|..||.|...|...|||||||||||||||||||||||| YCHQWDHIHRDVRPHCRVMASKDNRQRITVEEALAHPWLRERDKFAPKVHLLETVEELKKFSAPVKLCGFGVAIQLSHKFTSFYSDPNTKHITDFADEDP TSS ... MAC |
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| Kinase | CASK.AA | CAMK | 1-158 | 28 | 3.9e-74 | 238.07 | In-house | 182-425 (425) | Show / Hide |
Range on Protein: 1-158 Range on HMM: 182-425/425 Sequence Identity: 28% (70 aa) SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENS--------------APVKLGGFGIAIPLPSS-----------------------GLIAGGRIG ..|.||| .|..|||...|.|||.|| .|| ..... ...|. || |. .... | . | RRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCG TPHFMA-PEVVRR--------------EPYGKPVDIWGCGVMLFILLSGSLPFFG--------------TKDRLFDMITKGRYNMKPRQ----------- ||..|| |||... ..||...|.| |||.|.|.|.| .|| | . .|| .|.||.|.. | . TPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPE -WDHISGD--------AKELIRSMLSVDPRQRITVEEALAHPWL ||.|| . .| |||.|| ||| .|.|.|..|.|||. WWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | CASK.AA | CAMK1 | 1-158 | 37 | 2.1e-65 | 189.06 | In-house | 111-276 (276) | Show / Hide |
Range on Protein: 1-158 Range on HMM: 111-276/276 Sequence Identity: 37% (63 aa) SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVK--LGGFGIAIPLPSSGL-IAGGRIGTPHFMAPEVVRR---EPYGKPVDIWGCGVMLFIL .| |.|| .|. |.|...| |||.|| |...|.. ...| . ||.. . ... . . ||| ..||||. . .||.|..|.|..|| ..|| RHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIF-DHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYIL LSGSLPFFGTK-D-RLFDMITKGRYNMKPRQWDHISGD-AKELIRSMLSVDPRQRITVEEALAHPWL | | ||.. | ||..|.|. |.. .||.|| ||..|. || ||| .|.|.|..|.|||. LCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | CASK.AA | CDPK | 3-158 | 39 | 3.4e-59 | 180.29 | In-house | 108-271 (271) | Show / Hide |
Range on Protein: 3-158 Range on HMM: 108-271/271 Sequence Identity: 39% (65 aa) YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSA----PVKLGGFGIAIPLPSS----GLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFIL .||||. |. |||.| |.|||.|| .|. .|.... ..|. .|.. ... . |.|||. .|||| .. | . .||| ||| |.|| IMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKK-YNEKCDIWSCGVILYIL LSGSLPFFGT-KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL |.|. ||.| .... ||.|... ..||||| .|| ||| || .|| .|.. ..||.||| LCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
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| Kinase | CASK.AA | CAMK2 | 1-158 | 47 | 1.9e-56 | 190.07 | In-house | 101-259 (259) | Show / Hide |
Range on Protein: 1-158 Range on HMM: 101-259/259 Sequence Identity: 47% (76 aa) SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIAIPLPSSGLIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLP || ..||.|.. .|| |.|.|||.|| .||| | | ||| ||.|| . | ||| ...|||.|..||||||||| |||.|.||| | | SHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPP FFGT-KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL |. . ||. | | |. || . .||.|| .|| ..|..||| .||| |||. FWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPWI |
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| Kinase | CASK.AA | CAMK-Unique | 3-158 | 25 | 2.1e-51 | 167.88 | In-house | 162-363 (363) | Show / Hide |
Range on Protein: 3-158 Range on HMM: 162-363/363 Sequence Identity: 25% (51 aa) YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKEN-------------SAPVKLGGFGIAIPLPSSGLIA--GGRIGTPHFMAP--------------EVV .|... .|. | |..||.|||.|. ... . .. .|| ||.. . .. . ..||| .||| ||. IMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI RREPYGKPV----DIWGCGVMLFILLSGSLPFFGTKDR---------LFDMITKGRY-NMKPRQWDH---ISGDAKELIRSMLSVDPRQRITVEEALAHP . .|. .. ||| .||.....|.|..|| .. . .|. |.||.| | . ..|. || || .. . ||| .|.. .|.| |. NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQ WL |. WI |
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| Kinase | CASK.AA | Pkinase | 2-158 | 32 | 3.2e-50 | 177.96 | Pfam | 112-293 (293) | Show / Hide |
Range on Protein: 2-158 Range on HMM: 112-293/293 Sequence Identity: 32% (60 aa) HYMRQIMEALRYCHDNDIIHRDIKPHCVLLA-TKENSAPVKLGGFGIAIPL-PSSGLIAGGRIGTPHFMAPEVVR-REPYGKPVDIWGCGVMLFILLSGS .||.|| ..| |||.. |||||.|| .|. . ...|.||.. ||.| . .. . .. |||..|||||.| ...||..||.|.||..|...|.| FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR LPFFGT-------KDRLFDMITKGRYNMKPRQWDHIS-----------------GDAKELIRSMLSVDPRQRITVEEALAHPWL .|| | .. ....| .... .|. || ..|..|...| .|| .|.| |..| |||. PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | CASK.AA | Ciliate-E2 | 2-158 | 24 | 3.2e-49 | 167.12 | In-house | 164-365 (365) | Show / Hide |
Range on Protein: 2-158 Range on HMM: 164-365/365 Sequence Identity: 24% (54 aa) HYMRQIMEALRYCHDND-IIHRDIKPHCVLLATKENSAPVKLGGFGIAI----------------PLPSSG----------------LIAGGRIGTPHFM .|...|..||.|.| . |||||||| .|. .|. ||.. .. . .. .|||..| FYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYM APEVVRREP---------YGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNMKPR--------------QWDHISGDAKELIRS----MLSV |||...... |.. .||| .||.|...|.| .|| .. | .. .. . |...| ..| ||. || . APEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQK DPRQRIT-VEEALAHPWL || .||| |..| |||. DPEKRITGWEQILNHPWF |
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| Kinase | CASK.AA | CAMKL | 2-158 | 36 | 1.8e-48 | 152.75 | In-house | 131-297 (297) | Show / Hide |
Range on Protein: 2-158 Range on HMM: 131-297/297 Sequence Identity: 36% (64 aa) HYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIA---IPL-PSSGLIAGGRIGTPHFMAPEVVRR--EPYG-KPVDIWGCGVMLFIL .| |||..|. |||...|.|||||| .|| . |. .|. || . .| .| . |.|..||||.. . .|| ..|||| |||.|. . RYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAM LSGSLPFFGT---------KDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWL . | ||| . . .|. .| .| | .|. | |.| |.. |||.|| |.| .|.|... . |||. VCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-Y--YPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | CASK.AA | RSK | 1-158 | 30 | 4.4e-45 | 156.08 | In-house | 107-278 (278) | Show / Hide |
Range on Protein: 1-158 Range on HMM: 107-278/278 Sequence Identity: 30% (52 aa) SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENS-APVKLGGFGIAIPLPSS-GLIAGGRIGTPHFMAPEVVR---REP-YGKPVDIWGCGVMLFIL . ||..| |... |. .|||||.|| .|.. .. . . .|| || . .. . . . ..| ..||||... .. ..| .|.| || .. . CFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEM LSGSLPFFG----TKDRLFDMITKGRYNMKPRQWDHISGDAKELIRSMLSVDPRQRIT-----VEEALAHPWL |.| .|| | ... ... | ||..... |. .| .||.||| || .|| .|.. .|| ..|||. LTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | CASK.AA | RAD53 | 63-158 | 38 | 6e-41 | 119.35 | In-house | 188-305 (305) | Show / Hide |
Range on Protein: 63-158 Range on HMM: 188-305/305 Sequence Identity: 38% (45 aa) GTPHFMAPEVVR---R------------EPYGKPVDIWGCGVMLFILLSGSLPFF-GTK-----DRLFDMITK-GRYNMKPRQWDHISGDAKELIRSMLS ||| . ||||.. . . |.| ||.| |. |.|.|.| .|| . . . ||. |.. |.|. . .|| || || ||..|| GTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLC VDPRQRITVEEALAHPWL ||| |.|..||| |||. VDPEKRYTIDEALNHPWM |
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| Kinase | CASK.AA | S_TKc | 1-158 | 25 | 9e-16 | 54.38 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-158
Range on HMM: 19-231/231
Sequence Identity: 25% (62 aa)
SH------------------------------------------------------------------------------YMRQIMEALRYCHDNDIIHR
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RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHR
DIKPHCVLLATKENSAPVKLGGFGIAIPLPSSGLIAGGRIGTPHFMAPEVVRREPYGK-PVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKGRYNMKP
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DLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------
RQWDHISGDAKELIRSMLSVDPRQRITVEEALA-------HPWL
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------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | CASK.AA | RAD53 | 3-35 | 42 | 2.8e-10 | 26.29 | In-house | 114-146 (305) | Show / Hide |
Range on Protein: 3-35 Range on HMM: 114-146/305 Sequence Identity: 42% (14 aa) YMRQIMEALRYCHDNDIIHRDIKPHCVLLATKE | .|. .|..| ||| |.|||.|| .|..... YFYQMCDAVKYLHDNGICHRDLKPENILCNHQD |
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| L27 | CASK.AA | L27 | 296-350 | 32 | 6.7e-10 | 40.13 | SMART | 1-62 (62) | Show / Hide |
Range on Protein: 296-350 Range on HMM: 1-62/62 Sequence Identity: 32% (20 aa) VHVTTEQVLELFRQHNQDS----QDAYELQAILSD---PYFRALLQAHDVVAHEVYSDHAIR . ..||| ..| |.. .|. ||. ||.. | |.|||..||.||...| .. .. AVQRVYEVLEELQSHLQHHEDMQEDLQELRQILQSMFMPHFHALLKIHDKVACTKYQPPPPP |
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| L27 | CASK.AA | L27 | 292-350 | 37 | 4.5e-07 | 29.57 | Pfam | 1-56 (56) | Show / Hide |
Range on Protein: 292-350 Range on HMM: 1-56/56 Sequence Identity: 37% (22 aa) SLQSVHVTTEQVLELFRQHNQDSQDAYELQAILSDPYFRALLQAHDVVAHEVYSDHAIR .| | ..|| .| .| .|. ||| ||..| ...|||.||.||..|| . . . AVQRVLELLEQLQSLSEHH---PEDLQELQQILQSPHMHSLLQVHDKVACKVYDPPSPE |
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| PDZ | CASK.AA | PDZ | 385-463 | 25 | 1.7e-22 | 79.68 | Pfam | 1-86 (86) | Show / Hide |
Range on Protein: 385-463 Range on HMM: 1-86/86 Sequence Identity: 25% (22 aa) LVQFQKN-SEEPLGITLKMNEDR----RCIVARIMHG-GMIHRQATLHVGDEIREINNASVANQTVDQLQKLLRELKG-SITFKIV .|...|. . ..||...|...| ......|.| |...|. .|.|| | .||. ...| |.|. ...... || ... .| QVTLEKQDKRGGLGFSIKGGNDQRHDQGIYISEVMPGSGAAERGGRIHEGDQIISINGQDIRNMTHDRAVQAIKGSKGGEVHLTIQ |
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| PDZ | CASK.AA | PDZ | 394-466 | 20 | 1.2e-13 | 52.61 | SMART | 1-80 (80) | Show / Hide |
Range on Protein: 394-466 Range on HMM: 1-80/80 Sequence Identity: 20% (17 aa) EPLGITLKMNEDRRCIVARIMHGGMIHRQAT-----LHVGDEIREINN-ASVANQTVDQLQKLLRELKG-----SITFKIVPSY ..||.... ........|| .. . |..||.| |.|. .| | | .| ...|.. .| ..|..... GGLGFSIVG----GIFISSVVPGGPAEKAGRNTRGHLRPGDRILEVNGQQPVENMTHEQAVDMLKQCGGGGIGDKVTLTVQRPG |
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| SH3 | CASK.AA | SH3 | 475-542 | 33 | 1.6e-15 | 58.79 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 475-542 Range on HMM: 1-58/58 Sequence Identity: 33% (23 aa) IYVRAQFDYDPGQDDLIPCQQAGLSFRCGDILQIISKDDHNWWQARKEGEPLNGTAGLIPSPELQEWR ||||..||.. .. |||. |||.....||| .||..|. . .| |..|| ..| . PYVRALYDYQA-------QNPDELSFKKGDIITVLEKDDDGWWKGRCNR---TGQEGWFPSNYVEEID |
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| SH3_2 | CASK.AA | SH3_2 | 476-541 | 26 | 7.7e-13 | 47.86 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 476-541 Range on HMM: 1-68/68 Sequence Identity: 26% (20 aa) YVRAQFDYDP-GQDDLIPCQQAGLSFRCGDILQII---SKDDHNWWQA-RK--EGEPLNGTA--GLIPSPELQEW |.|. .||.| . .. ..|.|. ||.. .| .||..|||.. .. . |.. |..|| ..|. YYRVHCDYVPATYCNENH--EPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWG-----GRRMRGWFPSQWVEEC |
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| SH3_1 | CASK.AA | SH3_1 | 498-535 | 41 | 4.1e-08 | 30.47 | Pfam | 14-49 (49) | Show / Hide |
Range on Protein: 498-535 Range on HMM: 14-49/49 Sequence Identity: 41% (16 aa) LSFRCGDILQIISKDDH-NWWQARKEGEPLNGTAGLIPS |||. |||...|.|.| .|| .| . | |..|| LSFKKGDIIHVIEKSDDWDWWKGRCNNT---GQEGWFPS |
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| SH3_1 | CASK.AA | SH3_1 | 478-489 | 41 | 3.0158 | 4.09 | Pfam | 1-12 (49) | Show / Hide |
Range on Protein: 478-489 Range on HMM: 1-12/49 Sequence Identity: 41% (5 aa) RAQFDYDPGQDD .| .||.. |.| VALYDYQAQQPD |
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| Guanylate_kin | CASK.AA | Guanylate_kin | 599-775 | 35 | 2.9e-75 | 259.0 | Pfam | 1-198 (198) | Show / Hide |
Range on Protein: 599-775 Range on HMM: 1-198/198 Sequence Identity: 35% (70 aa) MRKTLVLLGAHGVG---RRHIKNTLITSHPNKY-A-YPIPHTTRRCKSDEENGKNYFFV-SHEEMMNDIANNKYLEYGT-HEDAMYGTKLDTIREIHNRS .....||.|..||| ..|||..|...||.| . |..||||| .|..|| |.|| |.|||.|.|.|....|... ... ||||.. |||.|| QMRPIVLSGPSGVGYEVKSHIKKALWDEHPHKFDGRYCVPHTTRPPRPGEVDGKHYHFVSSREEMWNMIQNHEFIEWAQVFNGNMYGTSKETIRQIHEQG LI---AILDVE-PQALKVLRCA-EFAPFVVFIAAPTLTGMNDV----HDSSLERLAKESELLRQAYGHF-----FDLTIVNNDIDDTIRTLENAMEEI | .|||.. .|..|.|| . |..|..|||..|..... . ....| ..|..| ..|...| ||. |||.|.|... |. ..|. KIMQLCILDIDTWQGVKQLRKTYELHPIMVFIKPPSMQELQRRLRCRNTEQEEKINKRMEAAEQEMQHYDEPGMFDYIIVNDDFDKAYWHLKEILEAE |
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| GuKc | CASK.AA | GuKc | 599-776 | 32 | 9.1e-67 | 229.04 | SMART | 1-203 (203) | Show / Hide |
Range on Protein: 599-776 Range on HMM: 1-203/203 Sequence Identity: 32% (66 aa) MRKTLVLLGAHGVGRRHIKNTLITSHPN--KYAYPIPHTTRRCKSDEENG--KNYFFVS-HEEMMNDIANNKYLEYGTHEDA-MYGTKLDTIREIHNRSL .|...||.|..|||....|..|. .|. |.....||||| .. |.|| . |.||| .|||...|..||.||.|..... .|||...|.|..|.. HRRPIVLSGPSGVGKSTLKHMLMQEYPDYPKFEFSVPHTTRPPRPGEVNGCVVDYHFVSLKEEMEQMIKHNKFLEWGEYHGNLYYGTSKETVRQVHEQGK IAILDVEPQALKVLRCA----EFAPFVVFIAAPT----LTGMND---VHDSSLERLAKESEL-LRQAYGHF------FDLTIVNNDIDDTI-RTLENAME ..|||..||....|| | .| |.|.||..|. .. .. ....||..|... .. ..| ||..|||.|..|.. . | ..|| HCILDIDPQGVRQLRYARRYSYFYPIVIFIKPPSMEELEERLRQPCQRGTETEERIQKRLAHQAQKEMQHYPKCHHEFDYVIVNDDLEDACYKELKEIME EIC . . QEQ |
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