Gene NIM1 (Sea Urchin)
NIM1
Sequence
Protein domains of NIM1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | NIM1.AA | NIM1 | 6-233 | 70 | 7e-222 | 658.54 | In-house | 25-258 (258) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-258/258 Sequence Identity: 70% (165 aa) KKVAIKILD--KTKLDQKTQRLLSREISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPGGELFTKISNEGKIAEAECKPIFAQVTSAVYHMHSKNIIHR .||||||.| |||.||||||.|||||.|||..|||||.|||||||||...|||||||.||||.|.|..|||..|..|||||||..|||.||||.||.|| EKVAIKIMDLDKTKMDQKTQRMLSREIQCMECMHHPNIVRLYEVVETLTRVHLVMEYARGGELYTHIHQEGKLREIHCKPIFAQIVSAVKHMHSRNIVHR DLKAENVFYAANGYVKVGDFGFSTYCKM----SDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADTVAKLKKCILDGQFTIP |.|||||.|..|..|||||||||.|||| ...||||||||||||||||.||.|||..||.|||||.|||||||||||||.||.|.|||||.||..|| DIKAENVMYTSNNCVKVGDFGFSCYCKMGTGANQMLNTFCGSPPYAAPELFQDEHYIGEYVDVWALGILLYFMMTGVMPFRAETVPKMKKCILKGQYQIP SYVSSNGQLLIRGVLKQPPPDRYTIDQIKSSQWL .|||.....||||.||..|..||||||....||. DYVSLPCHRLIRGMLKHIPTQRYTIDQMMNHQWM |
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Kinase | NIM1.AA | CAMKL | 5-233 | 37 | 3.7e-121 | 388.44 | In-house | 25-297 (297) | Show / Hide |
Range on Protein: 5-233 Range on HMM: 25-297/297 Sequence Identity: 37% (104 aa) EKKVAIKILD--KTKLDQKTQRL-----------LSREISCMERLH---HPNIIRLYEVVETLAK------LHLVMEYAPGGE--LFTKISNE----GKI ..||||||.| |...|..... . |||..|..|. |||||.||||.|| . ..|||||..||| || .| .. |.. GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRM AEAECKPIFAQVTSAVYHMHSKNIIHRDLKAENVFYAANG--YVKVGDFGFSTYCKM-----SDTLNTFCGSPPYAAPELFKD--ENYIGPPVDTWALGI | |.. .| |. |||...||..|.|||.|.||. || .|. |||||.... ..|.||||||||.|||.|.. . |.||.|| |..|. PEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGV MLYFMMTGVMPFRADTVA---------KLKKCILDGQFTIPSYVSSNGQLLIRGVLKQPPPDRYTIDQIKSSQWL .||.|..| .||..||.. ..|. .. ....|...|| . |||. |. | .|.||.||.. |. ILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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Kinase | NIM1.AA | MARK | 5-233 | 45 | 1.6e-104 | 342.52 | In-house | 24-262 (262) | Show / Hide |
Range on Protein: 5-233 Range on HMM: 24-262/262 Sequence Identity: 45% (109 aa) EKKVAIKILDKTKLDQ-KTQRLLSREISCMERLHHPNIIRLYEVVE--TLAK-LHLVMEYAPGGELFTKISNE--GKIAEAECKPIFAQVTSAVYHMHSK ..||||||..|.||. .. . . |||. | .|.|||||.|..|.| | . ..|.||||.||||. | . |.. | |.. || |. |||. .||| GRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSK NIIHRDLKAENVFYAANG--YVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADT--VAKLKKCILDG ||.|||.|.||. .|| .| |||||. ... ||||||.|||.|||.|. . | ||.||.|.||. |||| .| ||..|| .|.| || | NIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRG QFTIPSYVSSNGQLLIRGVLKQPPPDRYTIDQIKSSQWL ...||..|| . ||. .|. .| .| ||..| . |. KYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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Kinase | NIM1.AA | CAMK | 6-233 | 25 | 1.8e-104 | 337.59 | In-house | 32-425 (425) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 32-425/425 Sequence Identity: 25% (101 aa) KKVAIKILDKTKLD--------------------------QKTQRLLSREISCMER-------LHHPNIIRLYEVVE------------TLAK------- .||||||.||.||. .|... . |||..| . |.|||||.|||| | | | QKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDK -LHLVM---EYAPGGEL----FTKISNE---------------GKIAEAECKPIFAQVTSAVYHMHSKNIIHRDLKAENVFYAANG-------------- ...|| ||..|||| | .| |.. |.|.. .| |. ||| ..||.||.||||| ||. . |. HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDW --Y-VKVGDFGFSTYCKM------------------------SDTLNTFCGSPPYAA-PELFKD-------------ENYIGPPVDTWALGIMLYFMMTG . .|. ||||..... . ..||||.|.|.| ||... . |.||..| |..|..||.| .| NNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCG VMPFRAD-------------TVAKLKKCILDGQFT-IPSY---------------VSSN--------GQLLIRGVLKQPPPDRYTIDQIKSSQWL .||..| . .|.. |. |... .|.| .| . . |||. |. | .|.||.|... .|. YPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | NIM1.AA | AMPK | 6-233 | 42 | 1.1e-93 | 278.49 | In-house | 25-254 (254) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-254/254 Sequence Identity: 42% (97 aa) KKVAIKILDKTKL-DQKTQRLLSREISCMERLHHPNIIRLYEVV-ETLAKLHLVMEYAPGGELFTKISNEGKIAEAECKPIFAQVTSAVYHMHSKNIIHR .|||||||.|.|. ||... ..|||. . . ||.||.||||. || . .||||..||||| | |.. | | . |.|. |.| .| .| || EKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHR DLKAENVFYAANGYVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADTVAKLKKCILDGQFTIPSYVS ||| ||. .| .|. ||| | ..| ..| | |||| |||||. | || ||.| |. || |. | || . ...| | |..|...||...| DLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLS SNGQLLIRGVLKQPPPDRYTIDQIKSSQWL .. . ||.. |. | |.||..|. ..|. PEAKDLIKHMLQVDPMKRITIHDIRNHPWF |
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Kinase | NIM1.AA | QIK | 6-233 | 41 | 6.5e-93 | 314.98 | In-house | 25-272 (272) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-272/272 Sequence Identity: 41% (102 aa) KKVAIKILDKTKLDQKTQRLLSREISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPGGELFTKISNEGK--------------------IAEAECKPIF .||||||.||..||.. . ||. | .| ||.||.||.| || . .|.||...||.| . . |. .|| | . .| TKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRWF AQVTSAVYHMHSKNIIHRDLKAENVFYAANGYVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADTVA |. |||.. |..||.||||||||. .| .|. ||||| . | .|.|.||||||||||.|. ..| || || | .|. || . .| .|| .|. WQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQ KLKKCILDGQFTIPSYVSSNGQLLIRGVLKQPPPDRYTIDQIKSSQWL .|.. .| |.| || ..|. . ||| | | ||||.||. .|. NLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM |
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Kinase | NIM1.AA | NuaK | 6-233 | 41 | 3.2e-89 | 234.63 | In-house | 25-252 (252) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-252/252 Sequence Identity: 41% (96 aa) KKVAIKILDKTKLDQKTQ-RLLSREISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPGGELFTKISNEGKIAEAECKPIFAQVTSAVYHMHSKNIIHRD ..|||| | | . . . ||| | |.||.|| ||| | |. .||||| ||||. ||. ... |.| . .| |..|||. | .|.||| REVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRD LKAENVFYAANGYVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADTVAKLKKCILDGQFTIPSYVSS || ||. .|. .|. ||| | | . . |.|||||| || || . | || || |.||..|| | | ||| . .|.| | |.. | | LKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPCKPSD NGQLLIRGVLKQPPPDRYTIDQIKSSQWL . ||| |. | | || .| . |. ACM-LIRWMLMVNPRRRATIYDICHHWWV |
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Kinase | NIM1.AA | Pkinase | 6-233 | 31 | 3.8e-75 | 260.77 | Pfam | 25-293 (293) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-293/293 Sequence Identity: 31% (87 aa) KKVAIKILDKTKLDQKTQRLLSR--EISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPGG----ELFTKIS--NEGKI--AEAECKPIFAQVTSAVYHM |.||.||..| . . . .. . | ||. | ||.||||.|||...|. ....||||..|| .||. || ..|.. | ||| .. |. ...... KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYC HSKNIIHRDLKAENVFYAANGYV----KVGDFGFST---YCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRAD------ ||..||||||| ||... ||.. |..|||.. | . | ..||||.|.|.|||. .. .|.||.|| |..|..|| |..| ||. . HSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNH ----TVAKLKKCILDGQFTIPSYVS-----------------SNGQLLIRGVLKQPPPDRYTIDQIKSSQWL ... ....|. .. .. .| .... .|.. |.. | .|.|..||. . |. DQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | NIM1.AA | RSK | 9-233 | 34 | 2.5e-74 | 253.27 | In-house | 28-278 (278) | Show / Hide |
Range on Protein: 9-233 Range on HMM: 28-278/278 Sequence Identity: 34% (86 aa) AIKILDKTKLDQK--TQRLLSREISCMERLH-HPNIIRLYEVVETLAKLHLVMEYAPGGELFTKISNEGK---IAEAECKPIFAQVTSAVYHMHSKNIIH | |.|.| |..|. ..| .|....|| ||.|..|... .| ||.|.||| .||||||....|. . | |.. ..|....|| |.|.. ||| AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIH RDLKAENVFYAA---NGYVKVGDFGFSTY--CKMSDTLNTFCGSPPYAAPELFK----DENYIGPPVDTWALGIMLYFMMTGVMPFRA---DTVAKLKKC |||| ||. |. .| .|. ||||. . |... ..|||.. |.|||. | .. . . .| | ||. .| | || ||.. .. ... | RDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGH-DKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKR ILDGQ--FTIP--SYVSSNGQLLIRGVLKQPPPDRYT-----IDQIKSSQWL |. |. .|.| .|.| . . |||. |. | .|.. ...||...|. IQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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S_TKc | NIM1.AA | S_TKc | 1-233 | 27 | 5.5e-68 | 233.08 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 1-233 Range on HMM: 1-231/231 Sequence Identity: 27% (74 aa) MPTIE-------------------KKVAIKILDKTKLDQKTQRLLSREISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPG--GELFTKISNEGK---- .. ..|||||.. . . |||..... |||||..||.| .. .|..||||..| |.||. | . |. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --IAEAECKPIFAQVTSAVYHMHSKNIIHRDLKAENVFYAANGYVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGP-PVDTWALGIMLYFM . | ... ...|. .|. ..||..||||||| ||.. .|..|||... .||||.| | |||.. |. ..| |..|..|| | FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM MTGVMPFRADTVAKLKKCILDGQFTIPSYVSSNGQLLIRGVLKQPPPDRYTIDQIKS-------SQWL ..| ||. ..... | |. |. . .||. |. | .|.|. .. .|. LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | NIM1.AA | SNRK | 6-233 | 37 | 4.1e-65 | 212.08 | In-house | 25-254 (254) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 25-254/254 Sequence Identity: 37% (87 aa) KKVAIKILDKTKLDQKTQRLLSREISCMERLHHPNIIRLYEVVETLAKLHLVMEYAPGGELFTKI-SNEGKIAEAECKPIFAQVTSAVYHMHSKNIIHRD .|||.|..||||.|. .. | .|. || ||||.|||||..| ||.|..| |.... | | . | . |.|. |. | . ..||| EKVAVKVIDKTKMDEVSKAHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGYDMYDYIMKHEKGLCEDLARKYFCQIMHAIDYCHQLHVVHRD LKAENV-FYAANGYVKVGDFGFSTYCKMSDTLNTFCGSPPYAAPELFKDENYIGPPVDTWALGIMLYFMMTGVMPFRADTVAKLKKCILDGQFTIPSYVS || ||| |. | ||. ||||| . . |.|.||| |.|||. ..| | || |.||..|| .. | .||. . |.| ..|.|. || LKPENVVFFEKQGMVKLTDFGFSNKFMPGEKLETSCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFQEANDSETLTMIMDCKYTVPDHVS SNGQLLIRGVLKQPPPDRYTIDQIKSSQWL . . || .|.. | | ....|.|. |. DECRDLIQSMLVRDPKKRASLEEIVSHSWV |
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Kinase | NIM1.AA | Ciliate-E2 | 6-233 | 26 | 3.9e-63 | 215.55 | In-house | 48-365 (365) | Show / Hide |
Range on Protein: 6-233 Range on HMM: 48-365/365 Sequence Identity: 26% (86 aa) KKVAIKILDKTKLDQKTQ-RLLSREIS----------CMERLHHPNIIRLYEVVE--TLAKLHLVMEYAPGGELFTKISNE-----------GKIAEAEC |..|.||. | .. |. | . ||| .|.| |||||..||. . . .. |||||. ||.|| | | ... | |. KIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEI KPIFAQVTS---------------AVYHMHSKN-IIHRDLKAENVFYAANGYVKVGDFGFSTYCKMS--------------------------------D | |..|... |. ..|||| |||||.| ||... .|. |||.|.... . . KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQN TLNTFCGSPPYAAPELFKDENY--------IGPPVDTWALGIMLYFMMTGVMPFRADTVAKLKKCILDGQFT--------------IPSYVSSNGQLLIR . ||.||.|.| ||| .. ..| . .| |.||..||.|..| || . |.| .| .. .. ..| ... ||. MFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIK G----VLKQPPPDRYT-IDQIKSSQWL |. | |.| ..||. .|. KFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | NIM1.AA | Pkinase_Tyr | 5-124 | 32 | 3.2e-17 | 58.93 | Pfam | 28-156 (270) | Show / Hide |
Range on Protein: 5-124 Range on HMM: 28-156/270 Sequence Identity: 32% (42 aa) EKKVAIKILDKTKLDQKT--QRLLSREISCMERL-HHPNIIRLYEVVE-TLAK--LHLVMEYAPGGELFTKISN----EGKIAEAECKPIFAQVTSAVYH . .||.|.| | . ... .. . ||.. | | |||||.||| |. . .||||.|.| | . . .... . . .|. .. . KIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEY MHSKNIIHRDLKAENVFYAANGYVKVGDFG .|||.||||| | |. . |. ||..||| LESKNCIHRDLAARNCLVTENNVVKICDFG |
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TyrKc | NIM1.AA | TyrKc | 4-233 | 22 | 2.5e-13 | -7.21 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 4-233 Range on HMM: 1-280/280 Sequence Identity: 22% (64 aa) IEK-------------------KVAIKILDKTKLDQKTQRLLSREISCMERL--HHPNIIRLYEVVETL-------AKLHLVMEYAPGGELFTKI-SNEG |.. .||.| | . . .. . ||.. | .| |||||.||| |. . | .||||.|.| | . .... ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP KIAEAECKPIFAQVTSAVYHMHSKNIIHRDLKAENVFYAANGYVKVGDFGFSTYCKMS-------DTLNT-F--CGS--PPYA--APELFKDENYIGPPV |. .. . |. . . ||||.||||| | |. ...|. ||..||| | . . |. . .| |. ||| . ... . KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKS DTWALGIMLY-FMMTGVMPFRA-----DTVAKLKKCILDG-QFTIPSY--------VSSNGQLLIRGVLKQPPPDRYTIDQIKSSQWL | |. |.... . | .| . . . ... .| .| . .. ... . | || | .| . . DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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UBA_CAMKL | NIM1.AA | UBA_CAMKL | 260-297 | 17 | 2.6e-08 | 28.11 | In-house | 1-41 (41) | Show / Hide |
Range on Protein: 260-297 Range on HMM: 1-41/41 Sequence Identity: 17% (7 aa) EINVLDQLKAL--GIKDDQLESTRDQDSR-NSITGTYRIAL . ......... |.. ...... ..... | ||.||.. | DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL |