Gene MELK (Sea Urchin)

MELK

Species: Sea Urchin
Alias: MELK, Spk105, SPU_002533
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: MELK

Sequence

Name Sequence Type Origin Length Description Download
MELK.AA Protein None 706 None Fasta, JSON
MELK.kin_dom Protein Kinase Domain None 99 None Fasta, JSON

Protein domain

Protein domains of MELK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MELK.AA MELK 1-169 71 2.4e-103 349.67 In-house 10-180 (254) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-180/254
Sequence Identity: 71% (123 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGDDLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDRLKEAEARGFFRQIIAA
|||||||||.|.| .|.||||||||..||.||||||||. |.|.| ||||| || ..||..|||||.|.|||||.||||. .|||.| |.| |||||..|
GGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSA

VAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKD-H-LETCCGSPAYAAPELVSGKEYIGSE
.|..| .|||||||||||||.|||  |||||||| ||.||.|| | |.|||||||||||||..||.|||||
IAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSE
Kinase MELK.AA CAMKL 1-169 43 1.4e-90 289.24 In-house 10-216 (297) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-216/297
Sequence Identity: 43% (91 aa)

GGFAKVKLATH-LLSGQKVAIKIMD--KHAL-------------GDDLPRVKTEIKAMKELV---HQHICTLYEVVETKNK------IFMVIEFCPGGE-
|.|.||||||| .. |.||||||.|  |  .              .|. |.. ||. || |    |..|. ||||.||...      |..| | |.||| 
GSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-LFDYIVAK----DRLKEAEARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQS--LKLIDFGLAAK--P--KGNKDHLETCCGSPAYAAPELVSG-
 ||||||..    .|..| ||| .||||..||...|. | .|||.||||.||||...  .|.||||....  |  .|. . |.|.||||.|.|||...| 
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGN

-KEYIGSE
 |.|.| .
NKPYDGPK
Kinase MELK.AA S_TKc 1-274 31 2.6e-90 307.27 SMART 10-231 (231) Show / Hide 
Range on Protein: 1-274
Range on HMM: 10-231/231
Sequence Identity: 31% (92 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGDDLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPG--GELFDYIVAKDR------LKEAEARG
|.|.||....|  .|..|||||..         ... ||. .|.  | .|..||.| .. ....|| |.|.|  |.|||||. . |      . | .|| 
GAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

FFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSGKEYIGSEGGMKDHLETCCGSPAYAAPELVS
...||. |....|. |  ||||||||.||||   .|..|||||..                                        |.||.| | |||.. 
YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------TTFCGTPWYMAPEVL-

GKEYIGS-EADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELII-------HPWV
     |  ..|.|| |..|| .|||  ||.  .. ....||.          | | |...|..||..|.||.   |.         |||.
---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MELK.AA AMPK 1-169 52 4.2e-90 267.68 In-house 10-180 (254) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-180/254
Sequence Identity: 52% (91 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGD--DLPRVKTEIKAMKELVHQHICTLYEVV-ETKNKIFMVIEFCPGGELFDYIVAKDRLKEAEARGFFRQI
| | |||..|| | |.||||||..|  . |  .  |.. ||. .| . |.||  ||||. ||.  ||||.|. .||||||||| ..||.| ||. || ||
GTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQI

IAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSGKEYIGSE
|..|  .|. . .||||||||||||.....|. ||||    | . . | |.|||| |||||..||| | | |
ISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG-EFLKTACGSPCYAAPEMISGKLYCGPE
Kinase MELK.AA CAMK 1-169 28 2.9e-79 254.9 In-house 5-314 (425) Show / Hide 
Range on Protein: 1-169
Range on HMM: 5-314/425
Sequence Identity: 28% (89 aa)

GGFAKVKLATHLLSG------------QKVAIKIMDKHALGD---------------------------DLPRVKTEIKAMKELV-------HQHICTLY
|.|.||||..| ...            |||||||.||  | |                           |. .|. ||. || |        | .|. ||
GSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLY

EVVE------------TKNK--------IFMVI---EFCPGGEL----FDYIVAK---------------DRLKEAEARGFFRQIIAAVAFIHNEGYAHR
|| |            | .|        ..||    |.|.||||    |||||..                |..|.||| .||||. ||...|. . .||
EVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHR

DLKPENLLLDEDQ-----------------SLKLIDFGLAAKPKGNK-----------------------DHLETCCGSPAYAA-PELVSG---------
||||||.|||..                   .|.||||.|.| ....                       . ..|.||.|.|.| ||...|         
DLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNA

----KEYIGSE
    |.|.| .
TDEEKPYYGPK
Kinase MELK.AA MARK 1-167 46 6.1e-75 244.42 In-house 10-184 (262) Show / Hide 
Range on Protein: 1-167
Range on HMM: 10-184/262
Sequence Identity: 46% (83 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGD--DLPRVKTEIKAMKELVHQHICTLYEVVE--TKNK-IFMVIEFCPGGELFDYIVAK--DRLKEAEARGF
|..||||||.|...|.||||||..|  | |   .  |. ||. || | | .|  |..|.|  |... |... | ..||||.|||.|.   ||.| ||| .
GSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRI

FRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQ--SLKLIDFGLAAK-PKGNKDHLETCCGSPAYAAPELVSGKEYIG
||||. || . |. . .|||.||||.|.||.     |.||||.... | |.|  |.|.||.|.|.|||....|.| |
FRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK--LNTFCGTPPYMAPEIFLKKPYDG
Kinase MELK.AA MELK 170-274 71 2.8e-72 246.25 In-house 149-254 (254) Show / Hide 
Range on Protein: 170-274
Range on HMM: 149-254/254
Sequence Identity: 71% (76 aa)

GGMKDH-LETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKEL
| .  | |.|||||||||||||..||.|||||||.||||.|||.|.||||||||||....|.||.||.||||.|||.|.|.||||||||.|.|||.||.|
GRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNL

IIHPWV
..||||
LNHPWV
Kinase MELK.AA NuaK 1-169 47 2e-71 186.83 In-house 10-179 (252) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-179/252
Sequence Identity: 47% (81 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGD--DLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDRLKEAEARGFFRQII
| . ||||||   .|..||||   | .  |  |. ..  ||. |  | | ||   ||| | |.|| .|.|.  ||||.|||  . .| |.||| |||||.
GTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPEREARHFFRQIV

AAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSGKEYIGSE
 ||.. | .. .||||| || |||..   |  ||||    . ... |.| |||| || || | |. | | |
SAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYH-DQKFLHTFCGSPLYASPEIVNGQPYHGPE
Kinase MELK.AA QIK 1-169 42 3.4e-65 222.89 In-house 10-198 (272) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-198/272
Sequence Identity: 42% (80 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHAL-GDDLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDR---------------
| || ||||.|    .||||||.|| .|  ..| ... |.. || | | ||  ||.| ||.. ...| |.|..||.|||.... |               
GNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKMVNSPDIGDQV

-----LKEAEARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSGKEYIGSE
     ..| |||  | ||..||.. |. . .||||| ||.|||..   |..|||.    |. .  |.|.||||.|||||.  |||| | .
LMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQ-LLMTWCGSPPYAAPEMFEGKEYDGPK
Kinase MELK.AA AMPK 174-274 58 7e-63 185.53 In-house 154-254 (254) Show / Hide 
Range on Protein: 174-274
Range on HMM: 154-254/254
Sequence Identity: 58% (59 aa)

DHLETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIHPW
. | |.|||| |||||..||| | | | |||| || |||.||| |||||.|.. ||.||..|.|. | .|| | |.|..|||||.|.|||. ...  |||
EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPW

V
 
F
Kinase MELK.AA CAMK1 1-165 38 7.5e-60 172.63 In-house 10-193 (276) Show / Hide 
Range on Protein: 1-165
Range on HMM: 10-193/276
Sequence Identity: 38% (70 aa)

GGFAKVKLATHLLS---GQKVAIKIMD-KHALGDD----LPRVKTEIKAMK---ELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDRLKEAE
| |..|.|.||  .   |...|||..| | ..  .    . ....||  ||   .. |..|  .||. |..|.. .| | . |||||| || |.   | .
GAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGNYTEKD

ARGFFRQIIAAVAFIHNEGYAHRDLKPENLLL---DEDQSLK--LIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSG---KEY
||   .||. || ..|  | .||||||||||.   |||  .|  ..||||. . ... . ..|.||.| | ||| . .   | |
ARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY
Kinase MELK.AA CAMKL 176-274 49 1.1e-57 182.62 In-house 190-297 (297) Show / Hide 
Range on Protein: 176-274
Range on HMM: 190-297/297
Sequence Identity: 49% (54 aa)

LETCCGSPAYAAPELVSG--KEYIGSEADIWSMGVLLYALLCGFLPFDDD--------NVSLLYRKILSGVYEEPPWLSV-ETKELLRHMLQVNPTKRIK
|.|.||||.|.|||...|  |.|.| ..||||.||.|||..|| ||||||        |. .||.|| .| |..|.|..| . . |.|.||||||.||..
LKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPT

MKELIIHPWV
....  |||.
IHQIMNHPWM
Kinase MELK.AA Pkinase 1-169 36 5.2e-56 197.18 Pfam 10-192 (293) Show / Hide 
Range on Protein: 1-169
Range on HMM: 10-192/293
Sequence Identity: 36% (67 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGDDLPRVKT---EIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGG----ELFDYIV--AKDRL--KEAE
|.|..|....|  .|..||.||..|.   .. .. ..   ||. ||.| | .|..||...|.|..| || |.|.||    .|||||   .. ..   | |
GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE

ARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSL----KLIDFGLAAKP-KGNKDHLETCCGSPAYAAPELVSGKEYIGSE
.. ...||. .....|..|  ||||||||.|.|..  .    |..|||||..    |.  . | ||.| |.|||.. | .|.|..
CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK
Kinase MELK.AA BRSK 5-165 48 1.6e-54 184.16 In-house 14-176 (254) Show / Hide 
Range on Protein: 5-165
Range on HMM: 14-176/254
Sequence Identity: 48% (79 aa)

KVKLATHLLSGQKVAIKIMDKHALG---DDLPRVKTEIKAMKELVHQHICTLYEVVETKNKIFMVIEFCPGGELFDYIVAKDRLKEAEARGFFRQIIAAV
.||| .|  .|.||||||  |  |      | .|  ||  ||   | |.  .|.| |.|   ... |.  ||||||| | | ||.  ||| |||||| |.
LVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISAL

AFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLETCCGSPAYAAPELVSGKEY
 | |     |||||||||||||..  |  |||.|    .    |.| |||| || || ..| .|
DFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDM-MLHTSCGSPHYACPEVIRGEKY
Kinase MELK.AA CAMK 176-274 32 2.2e-53 169.99 In-house 276-425 (425) Show / Hide 
Range on Protein: 176-274
Range on HMM: 276-425/425
Sequence Identity: 32% (48 aa)

LETCCGSPAYAA-PELVSG-------------KEYIGSEADIWSMGVLLYALLCGFLPFDDD-------------NVSLLYRKILSGVYE-EPPWLSV--
..|.||.|.|.| ||...|             |.|.| ..|.||.||.||..|||..||..|             | . |..||..| |. .||..|   
MKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPIS

---------------------ETKELLRHMLQVNPTKRIKMKELIIHPWV
                     | | |.|.||||.|.||.. ..   |||.
CNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MELK.AA TSSK 1-165 37 2.3e-50 163.48 In-house 10-205 (289) Show / Hide 
Range on Protein: 1-165
Range on HMM: 10-205/289
Sequence Identity: 37% (74 aa)

GGFAKVKLATHLLSGQK----------------VAIKIMDKHALGDD-----LPRVKTEIKAMKE-LVHQHICTLYEVVETKN-KIFMVIEFCPGGELFD
| .|||..|..     |                ||||| |.    .|     |||   ||..|.  | | .|...||  || . ||.|| |.. .| |..
GSYAKVYCAYSKKHKCKHNPRLRDDLRIKRHTHVAIKIIDRKKAPTDYLNKFLPR---EIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAEHGDLLE

YIVAK------DRLKEAEARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAA-KPKGNKDHL----ETCCGSPAYAAPELVSGKEY
|| ..       .|.| .|| .|||...||...|. . .||||| ||.|||..  .||.||| |   |..  ..     .| ||| |||||| . |..|
YIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKCENILLDKHWNIKLTDFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEILRGIPY
Kinase MELK.AA MARK 176-274 45 1e-46 150.86 In-house 162-262 (262) Show / Hide 
Range on Protein: 176-274
Range on HMM: 162-262/262
Sequence Identity: 45% (46 aa)

LETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDN--VSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIHPW
|.|.||.|.|.|||....|.| | ..||||.||.||...|| .|||.|.     ||.|||.|.|. |. .|.| . |.. .|.||| .|....|.  |||
LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPW

V
.
M
Kinase MELK.AA QIK 173-274 46 4.8e-45 155.97 In-house 170-272 (272) Show / Hide 
Range on Protein: 173-274
Range on HMM: 170-272/272
Sequence Identity: 46% (48 aa)

KDH-LETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIH
... |.|.||||.|||||.  |||| | ..|||||||.||.| || |||| ...  | ...||| .  |...|..  .| |||| |.|..|. ..  . |
QGQLLMTWCGSPPYAAPEMFEGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQH

PWV
.| 
RWM
Kinase MELK.AA NuaK 173-274 44 1.4e-43 112.1 In-house 152-252 (252) Show / Hide 
Range on Protein: 173-274
Range on HMM: 152-252/252
Sequence Identity: 44% (45 aa)

KDHLETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIHP
.. |.| |||| || || | |. | | | | ||.|||||..  | .||| ..   | . | .| | ||.  |.   .| |.||.|||..|  . .   |.
QKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFDGHDFKHLVKQISQGAYYEPCKPSDAC-MLIRWMLMVNPRRRATIYDICHHW

WV
||
WV
Kinase MELK.AA BRSK 176-274 51 2e-42 142.36 In-house 156-254 (254) Show / Hide 
Range on Protein: 176-274
Range on HMM: 156-254/254
Sequence Identity: 51% (51 aa)

LETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIHPWV
|.| |||| || || ..| .| |  ||.|| || ||||| | |||||||.  |  |.  ||.  |..      .||| |. |.| ||| .||   |||.
LHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase MELK.AA CAMK1 176-274 38 8.5e-39 110.37 In-house 170-276 (276) Show / Hide 
Range on Protein: 176-274
Range on HMM: 170-276/276
Sequence Identity: 38% (42 aa)

LETCCGSPAYAAPELVSG---KEYIGSEADIWSMGVLLYALLCGFLPFDDDN-VSLLYRKILSGVYE--EPPWLS-VET--KELLRHMLQVNPTKRIKMK
..|.||.| | ||| . .   | | . . |.|| || .| ||||. || |.|  . |..||... ||  .| | . ..   |....||| |.|.||.  .
MKTACGTPGYVAPEVLECKKDKPY-DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCE

ELIIHPWV
. . |||.
QCLNHPWI
Kinase MELK.AA TSSK 176-274 40 1.1e-34 111.22 In-house 185-289 (289) Show / Hide 
Range on Protein: 176-274
Range on HMM: 185-289/289
Sequence Identity: 40% (43 aa)

LETCCGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDD--DNVSLLYRKIL-SGV-YEE--PPWLSVETKELLRHMLQVNPTKRIKMKELI
..| ||| |||||| . |..| .  .|.||||| ||...|| .||||   |.  . . .   .| . .   .|.| | | |.||||| .|..|....| .
SKTFCGSYAYAAPEILRGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEIC

IHPWV
 |.|.
HHCWM
Kinase MELK.AA Pkinase 180-274 25 3.4e-28 100.76 Pfam 172-293 (293) Show / Hide 
Range on Protein: 180-274
Range on HMM: 172-293/293
Sequence Identity: 25% (31 aa)

CGSPAYAAPELVSGKEYIGSEADIWSMGVLLYALLCGFLPFDDD------NVSLLYRKILSGVYEEPPWLS---------------------VETKELLR
||.| |.|||.. | .|.|...|.||.|..|| .||| .||...      .   ....|... .... . .                      | |....
CGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

HMLQVNPTKRIKMKELIIHPWV
 .|...|.||.  ...  |||.
WCLCKDPKKRPTAEQILQHPWF
Kinase MELK.AA TyrKc 1-278 20 2.5e-13 -7.22 SMART 10-280 (280) Show / Hide 
Range on Protein: 1-278
Range on HMM: 10-280/280
Sequence Identity: 20% (62 aa)

GGFAKVKLATHLLSGQKVAIKIMDKHALGDDLPRVKTEIKAMKEL--VHQHICTLYEVVETK-------NKIFMVIEFCPGGELFDYIVAKDR-LKEAEA
| | .| ..|     ..||.| . ..|    .     |.. |..|   |..|  || |. ..         ...| |..|.| | ||. .. . |. .. 
GAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDL

RGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLAAKPKGNKDHLET-CCGSPAYAAPELVSGKEYIGSEGGMKDHLETCCGSPAYAAPE
  |  || .  ...|  .. ||||   | |..|..  |  ||||.      .|. .  ..|         .|.. |  .|.. .. .          |||
LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS------RDIYDDDQQG---------ESKDYYRKKEHKGGKTMLPI----RWMAPE

LVSGKEYIGSEADIWSMGVLLYALL-CGFLPFDD-----DNVSLLYRKILSGVYEEPPWL---------SVETKELLRHMLQVNPTKRIKMKELIIHPWV
    ...  .. |.|| ||... ..  |  |  .      . . ..... .| . ..|           . |  .. .   . .| .|  ..|.      
CINYGKF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------

VQAF
.. |
HECF
Kinase MELK.AA Pkinase_Tyr 3-135 28 2.3e-10 35.74 Pfam 12-158 (270) Show / Hide 
Range on Protein: 3-135
Range on HMM: 12-158/270
Sequence Identity: 28% (42 aa)

FAKVKLATHL----LSGQKVAIKIMDKHALGDD---LPRVKTEIKAMKEL-VHQHICTLYEVVE-TKNK--IFMVIEFCPGGELFDYIVA----KDRLKE
| .|...|        ...||.|.. |.   ..   .     |.| ||.|  |..|  || |.   .    |..| |..|.| | ||  .    |..|. 
FGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTM

AEARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDEDQSLKLIDFGLA
 .  .. .|| .. .. .. .. ||||   | |..|.   |  |||||
KDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
UBA_CAMKL MELK.AA UBA_CAMKL 294-332 36 2.9e-14 49.25 In-house 1-41 (41) Show / Hide 
Range on Protein: 294-332
Range on HMM: 1-41/41
Sequence Identity: 36% (15 aa)

NLDCITEMAMHY-GKSKKDITSTLKQWKY-DHMTATYFILL
. ..| ||. .. | ....|...|...|| .|.||||..||
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL
KA1 MELK.AA KA1 660-706 35 3.4e-17 60.86 Pfam 1-48 (48) Show / Hide 
Range on Protein: 660-706
Range on HMM: 1-48/48
Sequence Identity: 35% (17 aa)

GKTVLSFDMEVCRLP-QMEMVGIRRKRLKGDTWEYKRMCQTILEHSRL
...|. | ..||..|  ....|...||..|..| || .|  ||.  ||
EPEVVKFEIQVCKVPGRLGLYGVDFKRVSGNQWQYKDLCTKILKEMRL