Gene HUNKc (Sea Urchin)
HUNKc
Sequence
Protein domains of HUNKc.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | HUNKc.AA | HUNK | 14-158 | 63 | 1.3e-109 | 356.67 | In-house | 21-166 (433) | Show / Hide |
Range on Protein: 14-158 Range on HMM: 21-166/433 Sequence Identity: 63% (92 aa) RLDPRYVALKVIEKRKITKP-YVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIMEYVPGRDLLTLVRGQKGGRLKEGVARRFVRQLVSALHHMHE .|....||.|||.|.||.|. ||.|||.|||.||...||||||||||.......|.|.|||.||.||...|...|||||.||||||..||||||.||||. VLTGEKVAIKVIDKKKIKKDDYVHKNLRREAQIMQMMRHPNIVRLYEVMETDNNYYLVMEYCPGGDLMHKVCEKKGGRLEEGVARRYIRQLVSAVHHMHH HGIVHSLANISRLETYLSLSLSLSDVHTVKNYVAFRLDFGLSNQCG ||.||....|..|||||||||.|.|.|..||||||..||||||.|| HGVVHRDLKIENLETYLSLSLLLDDDHNIKNYVAFIIDFGLSNCCG |
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| Kinase | HUNKc.AA | HUNK | 159-268 | 58 | 1.2e-81 | 264.32 | In-house | 324-433 (433) | Show / Hide |
Range on Protein: 159-268 Range on HMM: 324-433/433 Sequence Identity: 58% (64 aa) PEELFKTHCGSPEYAAPELYVAGRDYGPEVDIWSLGVIMFAMVTGKLPFTTPHSENRRQHLLLQIKKGLKGVHDKEMAHLTDEDMALRLKVKPDKIQDVV .|..||||||||.|||||.|..|.||||.||.||.||.|.||.||.||||....|....||...|.||...||.|.|.||||.||.||.|..|||||.|. YEDFFKTHCGSPAYAAPEIYCRGKDYGPKVDVWSIGVNMYAMLTGTLPFTVEPPEFNMRHLHQKIMKGEMNVHPKQMTHLTDCDMFLRRKLEPDKIQRVN LENKLDDVSA |.||.|.... LQNKMDHRWM |
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| Kinase | HUNKc.AA | CAMKL | 20-117 | 39 | 3e-47 | 148.77 | In-house | 28-150 (297) | Show / Hide |
Range on Protein: 20-117 Range on HMM: 28-150/297 Sequence Identity: 39% (48 aa) VALKVIEKRKIT-KPYVKKN-----------LTREARIMSQLR---HPNIVRLYETITSPQL------YCLIMEYVPGRD--LLTLVRGQKG--GRLKEG || |.|.|.||. .|..||| ..||..||..|. ||||..|||.|. |. ..|.|||..| . |. .. ... ||..|. VAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEH VARRFVRQLVSALHHMHEHGIVH |||. ||.|||....|.||||| EARRYFRQIVSAVNYCHSHGIVH |
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| Kinase | HUNKc.AA | CAMK | 17-117 | 25 | 4.2e-41 | 129.71 | In-house | 31-202 (425) | Show / Hide |
Range on Protein: 17-117 Range on HMM: 31-202/425 Sequence Identity: 25% (43 aa) PRYVALKVIEKRKITK-------------------------PYVKKNLTREARIMSQ-------LRHPNIVRLYETITS-------------------PQ .. || |.|.|.|... |. .||. || .||.. |.||||..|||.. . .. GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDK LYCLIM---EYVPGR----DLLTLVRGQKG-------------GRLKEGVARRFVRQLVSALHHMHEHGIVH ....| ||..| ||. .. ... ||..| |||..||..||.|..|.|.||| HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH |
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| Kinase | HUNKc.AA | CAMKL | 150-278 | 29 | 3.7e-36 | 112.77 | In-house | 172-297 (297) | Show / Hide |
Range on Protein: 150-278 Range on HMM: 172-297/297 Sequence Identity: 29% (40 aa) DFGLSNQCGP-----EELFKTHCGSPEYAAPELYVA--GRDYGPEVDIWSLGVIMFAMVTGKLPFTTPHSENRRQHLLLQIKKGLKGVHDKEMAHLTDED |||.||.. | ....||.||||.|.|||.. . .||.|||||.|||..|||.|.||| .. . . |.|. . |.| . . .. DFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K------QGKDNI-YLYWKIMCG-YYPP MALRLKVKPDKIQDVVLENKLDDVSAIFNILMEEHL ... . |. . .. | .|.. . . IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | HUNKc.AA | MARK | 20-117 | 43 | 6.1e-36 | 115.09 | In-house | 27-127 (262) | Show / Hide |
Range on Protein: 20-117 Range on HMM: 27-127/262 Sequence Identity: 43% (44 aa) VALKVIEKRKITKPYVKKNLTREARIMSQLRHPNIVRLYETIT--SPQL-YCLIMEYVPGRDLLTLVRGQKGGRLKEGVARRFVRQLVSALHHMHEHGIV ||.|..|| |...| .||. ||..||..| ||||..|...| .| .|||||..| .|. .. . .|||.| |||. ||.|||.. .|...|| VAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIV H | H |
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| S_TKc | HUNKc.AA | S_TKc | 7-258 | 22 | 2.6e-33 | 117.91 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 7-258 Range on HMM: 1-231/231 Sequence Identity: 22% (64 aa) LKLMPPL-------------RLDPRYVALKVIEKRKITKPYVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIMEYVPG--RDLLTLVRGQKGGR- ... .. . . |.||.|.| ... || .|... .|||||.||... . . ....|||..| ||... . ..... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---LKEGVARRFVRQLVSALHHMHEHGIVHS---LANISRLETYLSLSLSLSDVHTVKNYVAFRLDFGLSNQCGPEELFKTHCGSPEYAAPELYVAGRDY . | .||....|...|| ..|.|||.| .|| | . ||||. | .| ||.|.| |||. | RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------HIKICDFGLARQL------TTFCGTPWYMAPEVL----GY GP-EVDIWSLGVIMFAMVTGKLPFTTPHSENRRQHLLLQIKKGLKGVHDKEMA----HLTDEDMALRLKVKPDKI-------QDVV |. ..|.||.|.|.. |..|. || .. . .|| . ..|. .. . | . |. . . GKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | HUNKc.AA | AMPK | 19-117 | 37 | 2.6e-31 | 90.26 | In-house | 26-123 (254) | Show / Hide |
Range on Protein: 19-117 Range on HMM: 26-123/254 Sequence Identity: 37% (38 aa) YVALKVIEKRKITKPYVKKNLTREARIMSQLRHPNIVRLYETI--TSPQLYCLIMEYVPGRDLLTLVRGQKGGRLKEGVARRFVRQLVSALHHMHEHGIV .||.|...|.||.. ... . || .|. .|||.|..||| | | ... ..||||.| .| . |||.| |.|| | .|.. .|.|.|| KVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIF-MVMEYVSGGELFDYIVKH--GRLQEREACRFFQQIISGVEYCHRHMIV H | H |
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| Kinase | HUNKc.AA | Pkinase | 14-117 | 28 | 8.8e-31 | 109.92 | Pfam | 21-131 (293) | Show / Hide |
Range on Protein: 14-117 Range on HMM: 21-131/293 Sequence Identity: 28% (32 aa) RLDPRYVALKVIEKRKITKPYVKKNLT-REARIMSQLRHPNIVRLYETITSPQLYCLIMEYVPGR----DLLTLVRGQKGGRL--KEGVARRFVRQLVSA . ... ||.|.|.||.. . . .. .|..|| |.||||||||.. .... ....|||..| || ........|.. | .......|.... KGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRG LHHMHEHGIVH | ..|..||.| LEYCHSMGIIH |
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| Kinase | HUNKc.AA | CAMK | 150-226 | 25 | 1.9e-30 | 94.78 | In-house | 239-362 (425) | Show / Hide |
Range on Protein: 150-226 Range on HMM: 239-362/425 Sequence Identity: 25% (32 aa) DFGLSNQCGP------------------------EELFKTHCGSPEYAA-PELYVA-------------GRDYGPEVDIWSLGVIMFAMVTGKLPFTTPH |||..|.. | ...|| ||.|||.| ||. . |||..|.||.|||...|..|..|| .. DFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDC SENRR---------QHLLLQIKKG .. . . |. .|.|| DNEICEDEWIGMNDYELFEKIMKG |
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| Kinase | HUNKc.AA | AMPK | 150-207 | 62 | 2.3e-29 | 84.38 | In-house | 143-200 (254) | Show / Hide |
Range on Protein: 150-207 Range on HMM: 143-200/254 Sequence Identity: 62% (37 aa) DFGLSNQCGPEELFKTHCGSPEYAAPELYVAGRDY-GPEVDIWSLGVIMFAMVTGKLPF |||||| . |. || |||| |||||. ..|. | |||||||| |||..||. |.||| DFGLSNMMKDGEFLKTACGSPCYAAPEM-ISGKLYCGPEVDIWSCGVILYAMLCGYLPF |
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| Kinase | HUNKc.AA | MARK | 150-207 | 47 | 4.3e-29 | 92.37 | In-house | 149-206 (262) | Show / Hide |
Range on Protein: 150-207 Range on HMM: 149-206/262 Sequence Identity: 47% (28 aa) DFGLSNQCGPEELFKTHCGSPEYAAPELYVAGRDYG-PEVDIWSLGVIMFAMVTGKLPF |||.|... |... .|.||.|.|.|||. . ...| |.||||||||....||.|..|| DFGFSICIPPGQKLNTFCGTPPYMAPEI-FLKKPYDGPKVDIWSLGVVLYFMVCGYFPF |
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| Kinase | HUNKc.AA | NuaK | 18-117 | 39 | 1.3e-26 | 66.49 | In-house | 25-122 (252) | Show / Hide |
Range on Protein: 18-117 Range on HMM: 25-122/252 Sequence Identity: 39% (39 aa) RYVALKVIEKRKITKPYVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIMEYVPGRDLLTLVRGQKGGRLKEGVARRFVRQLVSALHHMHEHGIVH | || | | | || . || .||| | ||.|. || . . ..||| | .| . . ..| |. ||.| || |||.| | |.|.| REVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYI--SECKSLPEREARHFFRQIVSAVHYCHKHRICH |
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| Kinase | HUNKc.AA | TSSK | 20-117 | 38 | 4.1e-26 | 82.68 | In-house | 43-146 (289) | Show / Hide |
Range on Protein: 20-117 Range on HMM: 43-146/289 Sequence Identity: 38% (41 aa) VALKVIEKRKITKPYVKKNLTREARIMSQ-LRHPNIVRLYETITSPQ-LYCLIMEYVPGRDLLTLVRGQKG------GRLKEGVARRFVRQLVSALHHMH || |.| ..| .. |..| | || || . |.||||...||.. . | ...||| . ||| . |. |.|.| ||.. ||.|||. ..| VAIKIIDRKKAPTDYLNKFLPREIQIMRKTLKHPNIIQFYEMFETCQGKIYMVMEYAEHGDLLEYI--QRRTQERCCGALHEEQARKWFRQMVSAVKYCH EHGIVH |..|| SHNVVH |
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| Kinase | HUNKc.AA | NuaK | 150-207 | 55 | 5.3e-26 | 64.89 | In-house | 142-199 (252) | Show / Hide |
Range on Protein: 150-207 Range on HMM: 142-199/252 Sequence Identity: 55% (33 aa) DFGLSNQCGPEELFKTHCGSPEYAAPELYVAGRDY-GPEVDIWSLGVIMFAMVTGKLPF |||||| ... .| |||| || || | |. | ||||| |||||....|| | .|| DFGLSNYYHDQKFLHTFCGSPLYASPEI-VNGQPYHGPEVDCWSLGVLLYTMVYGTMPF |
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| Kinase | HUNKc.AA | QIK | 150-220 | 50 | 4.4e-24 | 86.35 | In-house | 161-231 (272) | Show / Hide |
Range on Protein: 150-220 Range on HMM: 161-231/272 Sequence Identity: 50% (36 aa) DFGLSNQCGPEELFKTHCGSPEYAAPELYVAGRDY-GPEVDIWSLGVIMFAMVTGKLPFTTPHSENRRQHLL |||.|| ...| .| |||| |||||. |..| ||.|||||.||.....|.|.||| . .| || | DFGFSNWFKQGQLLMTWCGSPPYAAPEMF-EGKEYDGPKVDIWSMGVVLYVLVCGALPFDGKTLQNLRQRVL |
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| Kinase | HUNKc.AA | Pkinase | 150-226 | 34 | 4e-21 | 75.76 | Pfam | 155-233 (293) | Show / Hide |
Range on Protein: 150-226 Range on HMM: 155-233/293 Sequence Identity: 34% (28 aa) DFGLSNQ--CGPEELFKTHCGSPEYAAPELYVAGRDYGPEVDIWSLGVIMFAMVTGKLPFTTP---HSENRRQHLLLQIKKG ||||. | . . ..| ||.|.|.|||. |..|||.||.||.|.|.. |..|..|| .. .. .... .|... DFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGP |
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| Kinase | HUNKc.AA | Ciliate-E2 | 150-226 | 26 | 3e-20 | 66.18 | In-house | 199-303 (365) | Show / Hide |
Range on Protein: 150-226
Range on HMM: 199-303/365
Sequence Identity: 26% (31 aa)
DFGLSNQCGPE--------------------------------ELFKTHCGSPEYAAPELYV--------AGRDYGPEVDIWSLGVIMFAMVTGKLPFTT
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DFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--
PHSENRRQHLLLQIKKG
. |||..
----------QQQIKQC
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| Kinase | HUNKc.AA | RSK | 150-226 | 35 | 3.1e-20 | 70.92 | In-house | 150-230 (278) | Show / Hide |
Range on Protein: 150-226 Range on HMM: 150-230/278 Sequence Identity: 35% (29 aa) DFGLSNQ--CGPEELFKTHCGSPEYAAPELYV---AGRDYGPEVDIWSLGVIMFAMVTGKLPFTTPHSENRRQHLLLQIKKG |||.. | | ... .| |.. ||.|||. .. .. .|.|||||.|. | ||..||. | |. .. .|.|| DFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKG |
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| Kinase | HUNKc.AA | Ciliate-E2 | 19-117 | 21 | 5.1e-20 | 65.39 | In-house | 49-184 (365) | Show / Hide |
Range on Protein: 19-117 Range on HMM: 49-184/365 Sequence Identity: 21% (29 aa) YVALKVIEKRKITKPYVKKNLTREAR----------IMSQLRHPNIVRLYETIT--SPQLYCLIMEYVPGRDLLTLVRGQ----------KGGRLKEGVA ..|.|...|..| .... || . |..|| ||||...||. . . . |.|||. | ||. . . . . ....| . IYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEI RRFVRQLVS---------------ALHHMHEHG-IVH ... .|... ||...|. . |.| KYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH |
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| Kinase | HUNKc.AA | TSSK | 150-208 | 42 | 9e-18 | 54.89 | In-house | 166-230 (289) | Show / Hide |
Range on Protein: 150-208 Range on HMM: 166-230/289 Sequence Identity: 42% (28 aa) DFGLSNQCGPEE------LFKTHCGSPEYAAPELYVAGRDYGPEV-DIWSLGVIMFAMVTGKLPFT ||| .. . . . | || ||| ||||| . |. | |.. |.||.||| ..||.|..||. DFGFARYWPRDDPGRCCHLSKTFCGSYAYAAPEI-LRGIPYDPKWYDVWSMGVILYIMVCGCMPFD |
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| Kinase | HUNKc.AA | RSK | 21-117 | 32 | 4.9e-17 | 59.09 | In-house | 28-127 (278) | Show / Hide |
Range on Protein: 21-117 Range on HMM: 28-127/278 Sequence Identity: 32% (32 aa) ALKVIEKRKITKPYV-KKNLTREARIMSQLR-HPNIVRLYETITSPQLYCLIMEYVPGRDLLTLVRGQKG-GRLKEGVARRFVRQLVSALHHMHEHGIVH | ||..|.|| . . . .| .|.. . ||.||.|... .. |||||..| .|.| . .| | . | |. ...|.|. |.|..||.| AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIH |
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| Kinase | HUNKc.AA | QIK | 20-117 | 27 | 1.4e-16 | 60.78 | In-house | 27-141 (272) | Show / Hide |
Range on Protein: 20-117 Range on HMM: 27-141/272 Sequence Identity: 27% (33 aa) VALKVIEKRKITKPYVKKNLTREARIMSQLRHPNIVRLYETITSPQLYCLIMEYVPGRDLLTLVRGQKGGR--------------------LKEGVARRF || |.| | .... . .| . || || .|.||.|..||. . . . ...|| .. .. . | || ..| .||| VAIKIIDKSQLDEENLQK-CYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYL--CKHGRKGVKMVNSPDIGDQVLMGVPMAENEARRW VRQLVSALHHMHEHGIVH |..|| |. |...||| FWQICSAVHYCHKRNIVH |
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| Kinase | HUNKc.AA | Pkinase_Tyr | 20-117 | 29 | 1.3e-14 | 50.09 | Pfam | 31-134 (270) | Show / Hide |
Range on Protein: 20-117 Range on HMM: 31-134/270 Sequence Identity: 29% (31 aa) VALKVIEKRKITKPY-VKKNLTREARIMSQL-RHPNIVRLYETIT-SPQL--YCLIMEYVPGRDLLTLVRGQ--KGGRLKEGVARRFVRQLVSALHHMHE || |.. | . ... .. . |||.||.|| .|||||||| .| . ....|||.|. |||. | . ...|. . .| ... . .. VAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES HGIVH ....| KNCIH |
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| TyrKc | HUNKc.AA | TyrKc | 7-247 | 17 | 2.9e-08 | -88.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 7-247
Range on HMM: 1-280/280
Sequence Identity: 17% (57 aa)
LKLMPPL-----------RLDPRYVALKVIEKRKITKPYVKKNLTREARIMSQL--RHPNIVRLYETITSP-------QLYCLIMEYVPGRDLLTLVRGQ
..| | ... . || |.. . . .. . ||||||..| .|||||||| .|.. . ....|||.|. ||. |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
KGGRLKEGVARRFVRQLVSALHHMHEHGIVHSLANISRLETYLSLSLSLSDVHTVKNYV-----------AFRL-----DFGLSNQCGPE-------ELF
.. |. | | . . |.. |.. . .. ||||| . . .
RPK-LCMKDLLSFCWQIACGMEYLHSK-----------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYY
KTHC--GSPE-----YAAPELYVAGRDYGPEVDIWSLGVIMFAMVT-GKLPFTTP--HSENRRQHLLLQIKKG--LKGVHD----------KEMAHLTDE
.. |. ||| |. . .. |.|| || |. . | |. | . . |... ..|.| .. .. .|| . .
RKKEHKGGKTMLPIRWMAPECINYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQ
-------------DMALRL
. ..
CWHEDPEDRPTFSEIHECF
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