Gene CAMK2 (Sea Urchin)

CAMK2

Species: Sea Urchin
Alias: CAMK2, Spk091, SPU_004156
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: CAMK
Family: CAMK2

Sequence

Name Sequence Type Origin Length Description Download
CAMK2.AA Protein None 229 None Fasta, JSON
CAMK2.kin_dom Protein Kinase Domain None 106 None Fasta, JSON

Protein domain

Protein domains of CAMK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CAMK2.AA CAMK2 1-200 81 1.2e-146 493.45 In-house 59-259 (259) Show / Hide 
Range on Protein: 1-200
Range on HMM: 59-259/259
Sequence Identity: 81% (163 aa)

NVVRLHDSIAEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDNGEQ-W
|.||||||| |||||||||||||||||||||||||||||||||||||||||||.|||.| ||||||||||||||||.|||||||||||||||.....| |
NIVRLHDSIQEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW

YGFAGTPGYLSPEVLRKDPYGKPVDIWACGLFLFIKFVGFPCLWCEDQQLLYHQAITGLWQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPW
.|||||||||||||||||||||||||||||  |.|  ||.|  | |||  ||.|   | . |||||||||||||||||..|||.|| ||| | .||||||
FGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDYPSPEWDTVTPEAKNLINQMLTINPKKRITADEALKHPW

I
|
I
Kinase CAMK2.AA CAMK1 16-200 44 1.1e-91 266.82 In-house 84-276 (276) Show / Hide 
Range on Protein: 16-200
Range on HMM: 84-276/276
Sequence Identity: 44% (85 aa)

YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVK--LADFGLAIELDNGE-QWYGFAGTPGYLSPE
||| .||||||||. || ...|.| ||.|...|||. ||..|.. ||||||||||||...|  .. .|  .|||||.  .|..|   .   |||||  ||
YLVMELVTGGELFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPE

VLRK---DPYGKPVDIWACGLFLFIKFVGFPCLWCED-QQLLYHQAITGLWQYPSPEWDTVTPE-AKNLIDSMLTVNPGKRISACQALKHPWI
||     .||.|..|.| .|  ..|  .|.|  . |. .. |. . . . . .|||.|| .  . ||..|  ||.|.| ||... |.|.||||
VLECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CAMK2.AA CAMK 1-200 23 6.8e-83 266.81 In-house 99-425 (425) Show / Hide 
Range on Protein: 1-200
Range on HMM: 99-425/425
Sequence Identity: 23% (77 aa)

NVVRLHDSIAEEGF-------------------HYLVF---DLVTGGEL----FEDIVAREY---------------YSEADASHCIQQILESVEHCHKN
|...|.. .  . .                    |.|.   ....||||    |. ||....               ..|..|.....||.. |..||..
NIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

LIVHRDLKPENLLLASKLKG--------------AAVKLADFGLAIELDN------------------------GEQWYGFAGTPGYLS-PEVLRK----
 ||||||||||.|| .. ..              . .|..|||.|...|                         |.  . | |||.| . ||||..    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------DPYGKPVDIWACGLFLFIKFVGFPCLWCE-------------DQQLLYHQAITGLWQYPSPE------------WDTVTPE--------A
          ..||...|.|.||  |.|  .|.|  . .             ... |... ..| ...|.|.            || .. |        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KNLIDSMLTVNPGKRISACQALKHPWI
|.|| .||.|.| ||... |.|.|||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CAMK2.AA CDPK 14-200 39 9.5e-68 206.93 In-house 75-271 (271) Show / Hide 
Range on Protein: 14-200
Range on HMM: 75-271/271
Sequence Identity: 39% (78 aa)

FHYLVFD--LVTGGELFEDIVAREYYSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGA----AVKLADFGLAIELDN-----GEQWYGF
..|.|.   ..||||||. |... ...| .|.  ..|||  | .||.| ||||||||||.|. || ...     .|. |.|.. . |      ... . .
NYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQR

AGTPGYLSPEVLRKDPYGKPVDIWACGLFLFIKFVGFPCLWCEDQQLLYHQAITGLWQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWI
.||| |..||||.|  | . .||| ||  |.|  .| |  . . .|  . .   |  ..  |||| .. |||.||  ||...| ||.|| |||.|||.
CGTPYYIAPEVLQKK-YNEKCDIWSCGVILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CAMK2.AA DCAMKL 1-200 38 2e-65 202.29 In-house 76-279 (279) Show / Hide 
Range on Protein: 1-200
Range on HMM: 76-279/279
Sequence Identity: 38% (78 aa)

NVVRLHDSIAEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLAS-KLKGAAVKLADFGLAIELDN-GEQ
....|...   |   |||. .|.|| ||. |.    ..| ||.  . .. .  .. |   |||||.||||||.     .   .||.||||| . .     
HIIQLYEHWDTETHYYLVMEYVQGGDLFDAITENTKFTERDAAIMMTCLCKALKYLHEMNIVHRDIKPENLLVCKHEDGEKSLKLCDFGLACHVNGDFGP

WYGFAGTPGYLSPEVLRKDPYGKPVDIWACGLFLFIKFVGFPCLWCE--DQQLLYHQAITGLWQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALK
 |   ||| |  ||.|..  ||  ||||| |  | |  .|||    .  ||. |  | . |   .|.|.|| ..  ||.||  || |.| || .| | ..
LYTVCGTPTYVAPEILMETGYGCKVDIWAAGVILYILLCGFPPFRSPDNDQEELFDQIMQGKFEFPMPYWDNISDSAKDLISHMLQVDPEKRYTAEQIMQ

HPWI
|||.
HPWV
Kinase CAMK2.AA RAD53 1-200 31 3.4e-65 192.95 In-house 65-305 (305) Show / Hide 
Range on Protein: 1-200
Range on HMM: 65-305/305
Sequence Identity: 31% (75 aa)

NVVRLHDSIAE-EGFHYLVFDLVTGGELFEDIVAREY----YSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGA---------------
...|..|.. . .   |.|  |.||||||..||....    ..|...     |....|   | | |.|||||||| |.... ..                
CIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISF

AVKLADFGLAIELDNGEQWYGFAGTPGYLSPEVLRKD---------------PYGKPVDIWACGLFLFIKFVGFPCLWCE-DQ----QLLYHQAIT-GLW
..|..||||.  ...|.    . ||| |. |||...                 |.| ||.|  |  |.| . |.|    . .|      |..| .. |  
LIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKY

QYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWI
 .|.|.|| .. |||.||..||.|.| ||... .|| |||.
HFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase CAMK2.AA Pkinase 1-200 31 3.5e-63 221.02 Pfam 61-293 (293) Show / Hide 
Range on Protein: 1-200
Range on HMM: 61-293/293
Sequence Identity: 31% (75 aa)

NVVRLHDSIAEEGFHYLVFDLVTGG----ELFEDIV--AREYY--SEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLA-SKLKGAAVKLADFGLAI
|.|||.|.  ...  |.|.... ||    .||. |   ..  .  || .. ... |||. .|.||.. |.||||||||.|.      .| ||..||||| 
NIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK

E--LDNGEQWYGFAGTPGYLSPEVLR-KDPYGKPVDIWACGLFLFIKFVGFPCLWCE------DQQLLYHQAITGLWQYPSPEWDTVT------------
   . |..  ..|.|||.|..|||.|   .||..||.|.||. |.. . | |  . .      ||. .. .   . . ...|.|...             
QFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWT

-----PEAKNLIDSMLTVNPGKRISACQALKHPWI
     .|.| .|...|...| ||..| |.|.|||.
FHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CAMK2.AA PSK 16-200 38 1.7e-54 172.37 In-house 72-258 (258) Show / Hide 
Range on Protein: 16-200
Range on HMM: 72-258/258
Sequence Identity: 38% (72 aa)

YLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDNGEQWY--GFAGTPGYLSPEV
|.| .. ||||.|  |||.  ..| ||    | .|. .   |   | |||||||||| .   . . .   |||||     .. |      ||| | .|||
YMVMEMATGGEMFDRIVAKGRFTERDATRVLQMVLDGMRYLHALRITHRDLKPENLLYYHPGNESKIMITDFGLAYQRKKSNDWMMKTTCGTPEYIAPEV

LRKDPYGKPVDIWACGLFLFIKFVGFPCLWCEDQQLLYHQAITGLWQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWI
|   || . ||.|| |   .|   |.  .  . . .|| . .|| . |    |  | . ||. ||..|..|.|.|..| ||.||||.
LLRKPYTQSVDMWAVGVIAYILMSGIMPFDDDCRTRLYRHILTGKYNYYGQPWPSVSHLAKDFIDKLLEINQGERMTASQAMKHPWV
Kinase CAMK2.AA Ciliate-E2 1-200 23 3.4e-54 184.43 In-house 93-365 (365) Show / Hide 
Range on Protein: 1-200
Range on HMM: 93-365/365
Sequence Identity: 23% (67 aa)

NVVRLHDSIA--EEGFHYLVFDLVTGGELFEDIV------------AREYYSEADASHCIQQILE---------------SVEHCHKNL-IVHRDLKPEN
|.......     .   |||.... ||.||. |             . .|..|  ... ..|||.                .|..|..  |.|||.||||
NIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPEN

LLLASKLKGAAVKLADFGLAIELDNG--------------------------------EQWYGFAGTPGYLSPEVLRKDP---------YGKPVDIWACG
.|.        .|..||||. ..|.                                 .. . ..|||||..||.|.. .         |.. .|||..|
ILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

LFLFIKFVG-FPCLWCEDQQLLYHQAITGLWQYPSPE--------------WDTVTPEAKNLIDS----MLTVNPGKRIS-ACQALKHPWI
  |..   | .|          . | . . ...|.||              |. ...|.|.||      || ..| |||. . |.|.|||.
VILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CAMK2.AA CAMK-Unique 16-200 24 6.3e-54 176.32 In-house 111-363 (363) Show / Hide 
Range on Protein: 16-200
Range on HMM: 111-363/363
Sequence Identity: 24% (61 aa)

YLVFDLVTGGELFEDIVA--------------------REYYSE--ADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLK-------------GA
|.| ....||.||. |..                    . ..||  .|..  .|..|. |.. |.. |||||||.||... . .|               
YIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNW

AVKLADFGLAIELDNGEQWY---GFAGTPGYLSP--------------EVLRKDPYGKPV----DIWACGLFLFIKFVGFPCLWCEDQQ--------LLY
 .||.||||. .... .       . ||| |..|              ||.  ..|. ..    |||..|  ... ..| |   ||.           ..
HIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIF

HQAITGLW-QYPSPEWDT---VTPEAKNLIDSMLTVNPGKRISACQALKHPWI
  .  |    .... |.    ...|||....  .|| | .|.|| ..|.|.||
ECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CAMK2.AA S_TKc 1-200 26 4.8e-46 160.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-200
Range on HMM: 1-231/231
Sequence Identity: 26% (71 aa)

N------------------------------------------------VVRLHDSIAEEGFHYLVFDLVTG--GELFEDIVAREY------YSEADASH
                                                 .|.|.|.. . .. |.|.... |  |.||. |. | .      ..| .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

CIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDNGEQWYGFAGTPGYLSPEVLRKDPYGK-PVDIWACGLFLFIKFVGFPCLW
 ..||.. .|.||.. |.||||||||.|| .      .|..||||| .|      . | ||| |..||||   .||| ..|.|.||  |.. ..| |  .
YMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP

CEDQQLLYHQAITGLWQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALK-------HPWI
  ..|.....                .||||..|. .|...| ||..| .||.       |||.
--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CAMK2.AA CAMKL 1-129 33 1.9e-44 139.68 In-house 76-223 (297) Show / Hide 
Range on Protein: 1-129
Range on HMM: 76-223/297
Sequence Identity: 33% (50 aa)

NVVRLHDSIAEEGF------HYLVFDLVTGGE--LFEDIVAREY----YSEADASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFG
|...|.. |  . .       |||  .. |||  ||. ||....     .| .| .  .||.. |..||.. |||||.||||.|| .. .   .|..|||
NIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFG

LAIELDN-----GEQWYGFAGTPGYLSPEVLRK--DPYG-KPVDIWACG
.... ..     |.    | |.| | .||.. .  .||  ..||||.||
FSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG
Kinase CAMK2.AA CAMKL 161-200 42 1e-14 43.23 In-house 259-297 (297) Show / Hide 
Range on Protein: 161-200
Range on HMM: 259-297/297
Sequence Identity: 42% (17 aa)

YPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWI
|  | |  |  ....|| .||.||| ||... | ..||| 
YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase CAMK2.AA TyrKc 3-200 12 2.4e-05 -136.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-200
Range on HMM: 1-280/280
Sequence Identity: 12% (36 aa)

VRLHD----------------------------------------SI--------------AEE-------GFHYLVFDLVTGGELFEDIVAREY-YSEA
..| .                                        ..               ..       . ...|. .. .| | . . ...   . .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

DASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDNG------EQWYGFA---GTPG-----YLSPEVLRKDPYGKPVDIW
|  .   || .  |. |.. ..||||   | |.....    || .||||. .....      .. |  .   |. .      ..||....  .    |.|
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

ACGLFLF--IKFVGFPCLW-----CEDQQLLYH-QAITGLWQYPSPEWD----TVTPEAKNLIDSMLTVNPGKRISACQALKHPWI
. |  ..    . . |        ...|... . ..   . | |...      . ..|  ... .    .| .| .  .   |  .
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF