TRRAP

Species: Sea Urchin
Alias: Spk058, SPU_000865, TRRAP
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: TRRAP

Sequence

Name Sequence Type Origin Length Description Download
TRRAP.AA Protein None 3853 None Fasta, JSON

Protein domain

Protein domains of TRRAP.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TRRAP.AA PIKK 401-414 50 0.145334 1.92 In-house 277-290 (290) Show / Hide
Range on Protein: 401-414
Range on HMM: 277-290/290
Sequence Identity: 50% (7 aa)

ANAREILMRMLEVF
.. ||.||  .|||
RQHRETLMTVCEVF

FAT TRRAP.AA FAT 2818-3165 21 3.6e-98 328.95 Pfam 1-408 (408) Show / Hide
Range on Protein: 2818-3165
Range on HMM: 1-408/408
Sequence Identity: 21% (89 aa)

PQLVLESAWRVPNWGA--MKEALAQVE------------QSCPREMNWKVNLYRGFIAI--CHPDEKNLTLIERLVEMSSKQALEEWRR-LPHYVTQAHT
  | .|.|||...|    |.| ....             ...| |. |. ...... ..  .| .....   .|....  .  ..||.. ||. ....| 
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTACLPGESYNRHY

PLLQASQRIMELQEASQVHHGLQPTNLG-RNQSLHDMKAIVKTWRNRLPMV-SDDLSHWSDIFMWRQHHYQAIVQAYDNSSSTTQDNQQHNHTMLGVHAS
|...  | ..||.|..| . .. ..|.. .. |....|....||..|||..  .....|..|..||||....|.|.|             .. ..| |  
PVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM-----------NSFCYRGPHED

AQSIINYGKVARKHSLIGPALDSLSRIHT------------IPSVPV------------VDCFQKIRQQVKCYLQMA-GTMGKQELQEGL----EVIEST
.. .| . ...||| . . . ..|....|            .|.. .            ...||..|....|..|.  |.  ..|.. ||    |||..|
MWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GLTYNLEVINNT

NLKYFSREMTA-EFYALKGMFLAQV----------GRSDEANKTFSAAVQMHDTLVK-AWALWGDYLEQIFCKDK-------------QMSLGESAITCF
||.||.... | ..|...||....           ...||... ...|.. .... | ||. |. | ...| ...             .. .   |..||
NLEYFYTKLLAMRCYHKQGMWQWKLYEEQYMNWNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCF

LHACRHQNESKSRKYLAKVLW
.|.......|.||......||
FHSIALSQGSNSRQDTLRLLW

Kinase TRRAP.AA PIKK 3554-3831 24 1.7e-93 316.89 In-house 1-290 (290) Show / Hide
Range on Protein: 3554-3831
Range on HMM: 1-290/290
Sequence Identity: 24% (71 aa)

IARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLD
..|||. ...  .|.......||||..||.||||.       ..|...||.|.....|  | |..|. || |......|...|....|.|. .....| .
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCK---GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKE

IYKKWCSKQQVETDPPINR---------------YYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTSTDYFAFRKMMCGQLALLG
|||.||.| . . .... .               || ... .| .. |..... .......| ...|. ..|.|.. .||........|.. . ..|. .
IYKQWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMC

LAEFVLHLTRLNPEIIQIERNSGLLSVFYFRFDLDETSGELDANRPVPFRLTPNIAEFLTTVGVNGMLNACMISIARCLVQPSFQLPAILKAV
 ....|.| ...|| |.| . .| . . .|...     . |.....||||||.|. ..... ||.| . .|......|. |. . | ......
MVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF

Kinase TRRAP.AA TRRAP 3554-3599 76 2.6e-28 97.69 In-house 1-46 (46) Show / Hide
Range on Protein: 3554-3599
Range on HMM: 1-46/46
Sequence Identity: 76% (35 aa)

IARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRR
|||||| |||  ||||||||||||| |||||||||.||.   ..||
IARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDICKINARR

Kinase TRRAP.AA PI3_PI4_kinase 3597-3744 12 1.7e-09 36.84 Pfam 14-181 (300) Show / Hide
Range on Protein: 3597-3744
Range on HMM: 14-181/300
Sequence Identity: 12% (22 aa)

SRREERVLQVL-----------------------RMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLDIYKKWCSKQQVETDP-----
.|...|..| .                       |. |  . |.... .| .|.. .|... .|.....|..|.....  | .... |   . ..     
CRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMVKCKHKHFNKEHKM

PINRYYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTS-TDYFAFRKMMCGQLALLGLAEFVL
 . ....... .         .. . ...| .....|.  | .| ....|.  ......|.  . ..| .. . ..|
WMKMWPDWWHLM---------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYIL

Kinase TRRAP.AA PI3Kc 3597-3853 15 4.3e-07 -52.4 SMART 10-318 (336) Show / Hide
Range on Protein: 3597-3853
Range on HMM: 10-318/336
Sequence Identity: 15% (49 aa)

SRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLLDIYKKWCSKQQVETDPPINRYYERLAVVQLRGSQASHQVL----
 |...|..|..|. |. . | ||...| |... .......|.....|. |.. .|  | || . .. .. |  . ..  .| | . . . ..   .    
LRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQ-K-NMY-MMIWHQ

----------------RDILKEVQTNMVPRTLLKEWALDTFPTS-TDYFAFRKMMCGQLALLGLAEFVL----------HLTRLNPEIIQIE----RNSG
                . .. | .|....   |..| ...||..  |....|.  . ..|    . ..|          .|.. . ... |      ..|
QACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIFGHG

LLSVFYFR-FDLDETSGELDANRPVPFRLTPNIAEFLT----TVGVNGMLNACMISIARCLVQPSFQLPAILKAVLRDEM-IAWSKK-------------
  . . |. . .         .  ||||||... .         |. |    |. .. | . ..| .. ... . ..|.. . |...             
-PKKPGFKHH-H---------RERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRL

--TSLSLRAARV-----------K
  .|  ..| ..            
DHLSDEEAAQYFMQTMCTKLIEHS

Kinase TRRAP.AA ATR 3553-3831 18 4e-06 16.31 In-house 2-267 (267) Show / Hide
Range on Protein: 3553-3831
Range on HMM: 2-267/267
Sequence Identity: 18% (53 aa)

RIARFMPHVEITHKHNTAARRLYIRGSNGKIYPYLVVNDASMAESRREERVLQVLRMLNHYLGKRKETAKRQLQFTVPRVVAVSPQMRLVEDSPSSLSLL
 || |   |||        ... ..||.||.|  .      .   |.. |  ..  ..|  . |  |  .|...     |. .  |  ..|     ..| 
YIAGFDDMVEILASLQ-KPKKISLKGSDGKFYIMMCKPKDDL---RKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLR

DIYKK-WCSKQQVETDPPINRYYERLAVVQLRGSQASHQVLRDILKEVQTNMVPRTLLKEWALDTFPTSTDYFAFRKMMCGQLALLGLAEFVLHLTRLNP
 | .| |  |.|  .       . .|    .. |..  . .. ...|      |  . ..| . .|| ...... |.  |   | . .  ... |     
PILDKLWKEKKQYMQ-------FYQLRQCMDKKSREEWEKQK-VFREFLLPRHP-PIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHT

EIIQIERNSGLLSVFYFRFDLDETSGE-LDANRPVPFRLTPNIAEFLTTVGVNGMLNACMISIARCLVQPSFQLPAILKAV
. | |..  |   .    . .   ||| ..    |||||| |.   .  .. .|.    .. | .|. .   .. ..... 
DNILIDKING--ECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF

Kinase TRRAP.AA PI3_PI4_kinase 3783-3841 15 0.06274 8.83 Pfam 223-300 (300) Show / Hide
Range on Protein: 3783-3841
Range on HMM: 223-300/300
Sequence Identity: 15% (12 aa)

RPVPFRLTP------NIAEFL------TTVGVNGMLNACMISIARCLVQPSFQLPAIL-------KAVLRDEMIAWSK
..||||.|.      .. . .         |  |..  .. .. | | ...  . . |        . ..|... |..
ERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS