Gene DNAPK (Sea Urchin)
DNAPK
Sequence
Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| NUC194 | DNAPK.AA | NUC194 | 222-630 | 36 | 5.8e-153 | 519.26 | Pfam | 1-446 (446) | Show / Hide |
Range on Protein: 222-630
Range on HMM: 1-446/446
Sequence Identity: 36% (164 aa)
KEIRKAAIQRVCIPLLRQASRDATVTFYKGHIHDIISVLEARLTK--NPVPAFENQLVSKICYFELIEVLYSRLSKDDLNSKDSALNREYRHGNVE----
..| . . |.|..||. .| |. |.|.. || ||......| || . ..|| |...|.|.. .|||.||||.||...|.|. | .|.
NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA
--KGNEMSTALTKAALGARNEDC-RGETVAVELR--RQFHCAAFNCSAAIISCVQDNIKFYNAFLFSENHAKGQFLLDNLVDPKKEY---GFAIEMDAPV
.||| ..||.|.. .|. |. .|.....|.| |..||||.|| .|.|||.. |||..|||.|| |......||.| . .| | .| |.
PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM
ERKKRFVAIRTQAR-ETNTPEESGYVSGPAHYLSSQ--YLSDSSLSEDVNQFDFSSSVRHFGSSMESQR-----DGGSQGSQGSQRPGS-MASRQDSKPV
||||. |||| || . ... .. .||||| |. |||||... ||||| .| .. ||. ..|| .| ... |. ||
ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQD----
FSPGGEYLEMEEDALNQHECMAAMTGVLK-HMTNNKINPDI-----TKATKAE----EMPQWMSGLQKKLSSQSTEHNIKLFIVRLVINAQDVFQPYARF
. | | | .|||||||.|.|..| || |.| | . . . .|| ||. | .|| |.. || ||| ..|| ..|.|||.|
-----DVMELEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKF
WLSPLMQFLA-----GGQQG-GINYMVLDIMLVMLDWSTLAVPE-------DDEE
|..|||| .| | |..||| || | |...| | ||
WIGPLMQLIVKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH
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| MIT | DNAPK.AA | MIT | 1363-1394 | 33 | 0.000612 | 16.64 | Pfam | 1-33 (71) | Show / Hide |
Range on Protein: 1363-1394 Range on HMM: 1-33/71 Sequence Identity: 33% (11 aa) ALIKTKDVTQEAIQAES-RGDYESALELYSKAI .| | ... ..|..|. |.|| |...| .|| YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAI |
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| FAT | DNAPK.AA | FAT | 1457-1688 | 16 | 4.6e-08 | 27.22 | Pfam | 18-237 (408) | Show / Hide |
Range on Protein: 1457-1688 Range on HMM: 18-237/408 Sequence Identity: 16% (41 aa) YLPYMMRSKLKRLMEGSEDDSLLGFIDSSAKDQEKRVILESRYTEELAALSILKEDYN--RAKYYLANSTSSFLQEWSG-LGPLMLTSRLSKLQDIQKLT |.... ... | | | | | |||.. .|. . .. . ... .| ... .. .|..| . . ...||. | . ....... .| |. YMDEYISVMKK-LL-GE-DQ-L-TFIDEDSPDE---PTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLA EAEQFLQLANKPFSE------GLKSSATRLVSDWSRNLPDPKRDPISVWDDVTQYRCLYMD----KLCNLLGDSGGGGGGGGDSMETEDQKFDDLVRREK | | . | .. . . .. ... .| . ||. | ....||.. . |.... .. . | . .| ELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM---------------------NSFCYRGPHED VLLSMKMADSACQQANFCVAAKHLKSTHRGLVEFEDL----RPAWTHSY ..|.|... . .. .. |.||. .. . || | ||..| MWMWIKFANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAY |
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| FAT | DNAPK.AA | FAT | 1865-1884 | 28 | 0.653518 | 3.28 | Pfam | 388-408 (408) | Show / Hide |
Range on Protein: 1865-1884 Range on HMM: 388-408/408 Sequence Identity: 28% (6 aa) LQAMNLNSP-EARQHFPRLLQ ... |.. ..|| ..|||. FHSIALSQGSNSRQDTLRLLW |
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| Kinase | DNAPK.AA | DNAPK | 2139-2440 | 49 | 2.4e-158 | 532.32 | In-house | 1-301 (301) | Show / Hide |
Range on Protein: 2139-2440 Range on HMM: 1-301/301 Sequence Identity: 49% (149 aa) HVKIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDF ||.|||||| | . |||.|| | ||| || . ||..| .||||.|||||||| .|| |...| .|.|| | | || ..||| ||| .||| .| .||| HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI ITRSMTEAE-HKVYTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLC . | . . | | | | ||.. . . . |. .| ... ..||..| | | |..|| | .| ..|..| || ||.|..|| | LNNEMQQKMGKKEYISQDREPPCMYRDWLKQMDRKHD--VAEYHIMYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVIC ICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVFVKEPSLD | .||||||||| ||.| |.|. ..|||||||||||||||.||| ||| ||. ||||.|||| |.. . |.| ..|.|. .|.|..|||...||.| ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD WKC || WKN |
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| Kinase | DNAPK.AA | PIKK | 2141-2430 | 36 | 1.1e-116 | 393.9 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 2141-2430 Range on HMM: 1-290/290 Sequence Identity: 36% (105 aa) KIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFIT |...|. | . ...||| |.||| |. ||.|.| .|||| |||..||| .|| .|..|..|..| |...|| |.||..|.|..||| ..|||.... RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK RSMTEAE-HKVYTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLCIC . . ... . . . . ||.. . .. . |.... .|. ..|||.. . | |.... |.. . .||.....| ...||.|| |. QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMS-YYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMV QYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVF ||||.||||..|... .||. |.||||..|.||.|.|| ||..||| ||...|.| ||...||. ....|.....||. | | ....|| GYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | DNAPK.AA | PI3_PI4_kinase | 2170-2440 | 23 | 4.8e-75 | 260.41 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 2170-2440 Range on HMM: 1-300/300 Sequence Identity: 23% (76 aa) DYPFLVKVGEDLR--MDQRIEQLF-----------------------CIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFITRSMT .|||..|.|.||| |.|..|.. ..|| .. .|... .| .....| ..|. |. |..|||...||.. . |. WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV EAEHKV--------YTSRTAGPGALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASP-EAFLTLRAHFARSHAV . .|| . .... . .. ... . |..|..| | . |.. |. . .. |.... | .|.||.|. KCKHKHFNKEHKMWMKMWPDWWHLM---------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAG LCICQYILGIGDRHLSNFLV--SLETGGMVGIDFGHSFG-SATQFLPIPELIPFRVTR------QIINLM------LPMKIDGVLQSTMVHTLRALRQNH .|. ||||.||||..|..| .|| ...|||||.|. ....... ||..||| |. .....| |.. .| ......|..||||... MCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHM ELLVNTM-------DVFVKEPSLDWKC .|..|.. . .|. ....|. NLCMNLLKKAVMRGECMVHDGLPMWRS |
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| Kinase | DNAPK.AA | PI3Kc | 2172-2491 | 24 | 2.6e-66 | 227.54 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 2172-2491 Range on HMM: 1-336/336 Sequence Identity: 24% (85 aa) PFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFITRSMTEAE------HKVY------TSRTAGPG ....|.|.||| |.|. |.| .|| |...|..|..| |....| ..|. |. |..|||. ..|| ..... . .. .. AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQ-K-NM ALFTTWLQKFCQNDGNIIKLFTEAYKKANETETIKAFREREAKLPWDLLRRGFMQLSASP-EAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLE . . |.|. |. |. .. .|..| |.. .. . . |. |.. . .| |.. . | .|.||.|. |. |||||||||..|... . Y-MMIWHQQACHW--------MMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMK TGGMVGIDFGHSFGSATQFLPIP-----ELIPFRVTRQIINLML----PMKIDGVLQSTMVHTLRALRQNHELLVNTMDVFVKEPS-LDWKCF-AVKQAD || ...||||| ||.. ...| . |. ||| |......| |.. .| ........||.|....|..|.. ..|. | .|. . .. TGHCFHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYL YQKLSED--SREDISWYPKK--KIKFAEMKLQGVNSTYITKAELEMGP |.. .| | |... | .. ..|. | ... ...... ... ... RQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | DNAPK.AA | ATR | 2285-2430 | 30 | 8.9e-26 | 84.47 | In-house | 123-267 (267) | Show / Hide |
Range on Protein: 2285-2430 Range on HMM: 123-267/267 Sequence Identity: 30% (45 aa) KKANETETIKAFREREAKLPWDLLRRGFMQLSASPEAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELI | ..| | |.||| . . | . |. . . | . || ||.|. ||.|.|||| | |. .| .| .|. |.| || .||.. KSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIV PFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVNTMDVF |||.|. ... | ||| .|. .. ... .|.. . .. .| | PFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
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| Kinase | DNAPK.AA | FRAP | 2316-2440 | 35 | 3.8e-25 | 89.38 | In-house | 127-251 (251) | Show / Hide |
Range on Protein: 2316-2440 Range on HMM: 127-251/251 Sequence Identity: 35% (44 aa) SASPEAFLTLRAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRA | . | . | . || |.. . ||||.||||.|| . || .| |||| | | . .||.|||| || ..| | |.| | .. SPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKV LRQNHELLVNTMDVFVKEPSLDWKC .| . | .. .. || | . |. IREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | DNAPK.AA | ATR | 2140-2249 | 33 | 3.1e-20 | 65.26 | In-house | 1-110 (267) | Show / Hide |
Range on Protein: 2140-2249 Range on HMM: 1-110/267 Sequence Identity: 33% (37 aa) VKIAGFDETVLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFI |||||. | |.||.||| |...| | | . | .||| | | . ..| .. .|. .| . . || |.|. . .|.||| | ||. . AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL TRSMTEAEHK .. | . . DKLWKEKKQY |
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| Kinase | DNAPK.AA | ATM | 2326-2457 | 34 | 2.1e-19 | 58.3 | In-house | 137-267 (304) | Show / Hide |
Range on Protein: 2326-2457 Range on HMM: 137-267/304 Sequence Identity: 34% (46 aa) RAHFARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDFGHSFGSATQFLPIPELIPFRVTRQIINLMLPMKIDGVLQSTMVHTLRALRQNHELLVN | . || | | ||||.|||| | |. .| || | | . || || .|||.|| |. | ..|| |. .| | |. RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLT TMDVFVKEPSLDWKCFAVKQADYQKLSEDSRE ..| . .| || .| |. || | IVEVLLYDPLFDWTMNPLKALYLQQRPEDETE |
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| Kinase | DNAPK.AA | FRAP | 2170-2239 | 32 | 1.7e-14 | 49.83 | In-house | 1-70 (251) | Show / Hide |
Range on Protein: 2170-2239 Range on HMM: 1-70/251 Sequence Identity: 32% (23 aa) DYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTLKDFI .| || | ||.| | |. ||| ..| .|. .. ...| .. | ..|. . |.. ||. ||. | EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILI |
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| Kinase | DNAPK.AA | ATM | 2174-2228 | 43 | 5.5e-13 | 37.42 | In-house | 3-57 (304) | Show / Hide |
Range on Protein: 2174-2228 Range on HMM: 3-57/304 Sequence Identity: 43% (24 aa) LVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEW ||| .||| | . | | . | .| .| ||. ||.|||. | |.||| LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW |
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| Kinase | DNAPK.AA | SMG1 | 2329-2367 | 51 | 7.4e-10 | 28.67 | In-house | 190-228 (242) | Show / Hide |
Range on Protein: 2329-2367 Range on HMM: 190-228/242 Sequence Identity: 51% (20 aa) FARSHAVLCICQYILGIGDRHLSNFLVSLETGGMVGIDF .||| ||. . ||.|.||||| | |. . || .| ||. YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | DNAPK.AA | SMG1 | 2149-2235 | 33 | 1.3e-09 | 27.89 | In-house | 1-87 (242) | Show / Hide |
Range on Protein: 2149-2235 Range on HMM: 1-87/242 Sequence Identity: 33% (29 aa) VLTLSSLRKPKCITIRGNDEMDYPFLVKVGEDLRMDQRIEQLFCIMNSILAQDAACSQRGLTLTTYQVVPMTPRLGILEWVKRTTTL . | ||| . | | ||.| | ||| .| || | |.| . | | | |. | |.. || | | ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL |
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| FATC | DNAPK.AA | FATC | 2523-2555 | 54 | 1.4e-16 | 56.1 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2523-2555 Range on HMM: 1-33/33 Sequence Identity: 54% (18 aa) KGLSVEDQVACLIDQATDPRILGKTYQGWEPWV ..||||.|| .||..||||. | . |.|| ||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
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