Gene ATMa (Sea Urchin)
ATMa
Sequence
Protein domains of ATMa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FAT | ATMa.AA | FAT | 2046-2081 | 21 | 0.021873 | 8.22 | Pfam | 1-56 (408) | Show / Hide |
Range on Protein: 2046-2081 Range on HMM: 1-56/408 Sequence Identity: 21% (12 aa) LEYQYEAAWRNGLWDL-----DLESSV------------EGSK---GYHENVFRAL .. .|||||.| ||. ... |.|. ... ..|.|. APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAI |
|||||||||
| FAT | ATMa.AA | FAT | 2152-2230 | 12 | 0.605907 | 3.39 | Pfam | 199-277 (408) | Show / Hide |
Range on Protein: 2152-2230 Range on HMM: 199-277/408 Sequence Identity: 12% (10 aa) ARDAERFQVAERALVHLKELEQKQDQNTVLEGCSSSLEE--AQLFWAKNERTTALHLMKALID-KLSKSQDSSHYKIYATTL .| . |.|..|..|. | . .... . .. . ....||.... |. .. . .... ... . .. | CRKHGRMQLCEKTLKMLYTYDPSEEDWHP--RAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEIN-GL |
|||||||||
| FAT | ATMa.AA | FAT | 2271-2304 | 17 | 0.002998 | 11.11 | Pfam | 374-408 (408) | Show / Hide |
Range on Protein: 2271-2304 Range on HMM: 374-408/408 Sequence Identity: 17% (6 aa) EDRQTFLARAMECYLHCLEASDQ-SQDTRVFRLCS ....... |..|..|.. |. . . .||.. HMIIQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW |
|||||||||
| Kinase | ATMa.AA | ATM | 2450-2712 | 64 | 9.3e-148 | 475.51 | In-house | 1-259 (304) | Show / Hide |
Range on Protein: 2450-2712 Range on HMM: 1-259/304 Sequence Identity: 64% (170 aa) KKSETGKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPIGLYLIGDQKKDLGAHVSYRPGDWKTKTCRGKMHAAH .. |.||||||||||||| . | || . |||..||| | |||||| | | |||| || ||. .|| ||| ||| |. | || RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNED---GAHKRYRPNDFSAFQCQKKMMEV- QSGDNNQKFRDFTTVCRNFQPVFHHFFLERFLDPADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFEQGRNLPTPETVPF | |. | || |||||| | .|.||||| |||||| ||||||| |||||..|||||||||||| |||||||||.|||||. ||||||||| QKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF RLTRDLVDAMGVAGVEGVFRRCSEKTMEEMHNSREALLTVVEVLLYDPLYTWTMSPARALELQ |||||.|| ||. ||||||||| ||||| | || | |||.|||||||||. ||| | .|| || RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQ |
|||||||||
| Kinase | ATMa.AA | PIKK | 2455-2693 | 39 | 1.2e-95 | 324.09 | In-house | 37-290 (290) | Show / Hide |
Range on Protein: 2455-2693 Range on HMM: 37-290/290 Sequence Identity: 39% (101 aa) GKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPIGLYLIGDQKKDLGAHVSYRPGDWK----------------T |..|||||....|.|.|.| .| | .|. .|.|.||.|.|.|. |..||.||.... ... . ..| .| ...... GHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQK---KHIRHEQEAQMNYQTCMYRDWLKQMSYY KTCRGKMHAAHQSGDNNQKFRDFTTVCRN-FQPVFHHFFLERFLDPADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFE- |. .... |. .| | .. | ....|. .|...|.||..|.|.| .||||.|. ..|||. ||||||..||.|| |.|.||||.| .|| KHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFES QGRNLPTPETVPFRLTRDLVDAMGVAGVEGVFRRCSEKTMEEMHNSREALLTVVEVL ... ||.||.|||||||..|.|||. ||||||||| |..|. | ..|| |.||.||. AMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
|||||||||
| Kinase | ATMa.AA | PI3Kc | 2455-2742 | 27 | 1.2e-74 | 255.22 | SMART | 6-336 (336) | Show / Hide |
Range on Protein: 2455-2742 Range on HMM: 6-336/336 Sequence Identity: 27% (91 aa) GKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPIGLYL------------IGDQKKDLGAHV------SYRPGDW ..||||||. |.|.|.|.| ...| .|. ||.|..|.||..|. ...|..||. .... . .. .. . | .| ...| CGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEIQKNMY-MMIW KTKTCRGKMHAAHQSGDNNQKFRDFTTVCRNFQPVFHHFFLERFLDP-ADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAF ... | ..|.. | . ....|. . ..|....||....|.|.| || ||.| | .|||.| ..|.|. |.|||| .||..|..| ...|||.| .| HQQACHWMMMYQHMTHMEWLKYF-EGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGHIF EQGRNLPTP-----ETVPFRLTRDLVDAMG----VAGVEGVFRRCSEKTMEEMHNSREALLTVVEVLLYDPL-YTWTMS--------PARALE-LQALDR ..|. .|.. |.||||||.|.|..|| ..|..| ||.| ..... | .........|...|||. |.|. . |. | .. GHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDEEA TEMG--------DQSELNTTTDGHQDILHPTNGA ... ....... | ....| ... AQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
|||||||||
| Kinase | ATMa.AA | ATR | 2456-2693 | 33 | 1.5e-57 | 194.47 | In-house | 39-267 (267) | Show / Hide |
Range on Protein: 2456-2693 Range on HMM: 39-267/267 Sequence Identity: 33% (80 aa) KDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPIGLYLIGDQKKDLGAHVSYRPGDWKTKTCRGKMHAAHQSGDNN |||||.| ... |.|... | | .|| ...| | |.|| .. ...|| . |. .| | |. .. . . . .. . .| . KDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTA--TLRPILDKL--------WKEKKQYMQFYQLRQCMDKKSREEW QKFRDF-TTVCRNFQPVFHHFFLERFLDPADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFEQGRNLPTPETVPFRLTRD .| . | . |.|| .|. ||.|| .|. | | || | ..|||..|||||| .||||| . |.||.| . | .|. . ||.||||||. EKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHN LVDAMGVAGVEGVFRRCSEKTMEEMHNSREALLTVVEVL .| .|| . .|.||| | .| | . |. .. |.. MVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF |
|||||||||
| Kinase | ATMa.AA | PI3_PI4_kinase | 2565-2703 | 26 | 4.5e-40 | 144.25 | Pfam | 138-300 (300) | Show / Hide |
Range on Protein: 2565-2703 Range on HMM: 138-300/300 Sequence Identity: 26% (44 aa) CRNFQPVFHHFFLERFLDP-ADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILI--DCNTAELVHIDLGIAFE--QGRNLPTPETVPFRLTR------ . .. |.....|.. . |. .|.| | ..||.| ..|.|. |.|||| ||.. |. | .|.||| |..|. .. .. ||.||||.|. MKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKK DLVDAM------GVAGVEGVFRRCSEKTMEEMHNSREALLTVV-------EVLLYDPLYTWTM ..|.|| .. | .| ||.. ..... . ...... | ...|.| |.. PMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS |
|||||||||
| Kinase | ATMa.AA | FRAP | 2586-2703 | 47 | 3.5e-38 | 133.17 | In-house | 133-251 (251) | Show / Hide |
Range on Protein: 2586-2703 Range on HMM: 133-251/251 Sequence Identity: 47% (56 aa) WFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFEQG-RNLPTPETVPFRLTRDLVDAMGVAGVEGVFRRCSEKTMEEMHNSRE |||.| |||| || |..||. |||||| ||... | .|||| | || | || .|||||| || || ..|.|| .| .| |. . .| WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE ALLTVVEVLLYDPLYTWTM .. | | ||||. | . SVMAVLEAFVYDPLFYWRL |
|||||||||
| Kinase | ATMa.AA | SMG1 | 2583-2645 | 53 | 2.2e-23 | 74.22 | In-house | 180-242 (242) | Show / Hide |
Range on Protein: 2583-2645 Range on HMM: 180-242/242 Sequence Identity: 53% (34 aa) PADWFEKRLSYTRSVATGSIVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFEQGRNLPTPE | .|. || || | |.|||..||||||. |.||| | | |||| | ||.|. | || PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE |
|||||||||
| Kinase | ATMa.AA | DNAPK | 2602-2703 | 29 | 4.2e-18 | 62.34 | In-house | 199-301 (301) | Show / Hide |
Range on Protein: 2602-2703 Range on HMM: 199-301/301 Sequence Identity: 29% (30 aa) IVGYVVGLGDRHVQNILIDCNTAELVHIDLGIAFE-QGRNLPTPETVPFRLTRDLVDAMGVAGVEGVFRRCSEKTMEEMHNSREALLTVVEVLLYDPLYT | ... | |||| | .. . . . || | .| . || || |||||| . | .. |... | . | |. ..| ||. ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD WTM | WKN |
|||||||||
| Kinase | ATMa.AA | FRAP | 2455-2506 | 48 | 1.9e-16 | 57.08 | In-house | 8-59 (251) | Show / Hide |
Range on Protein: 2455-2506 Range on HMM: 8-59/251 Sequence Identity: 48% (25 aa) GKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEW |..|.||| | |||.|.|| .||... | |.|| ..|| ||||. | GHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW |
|||||||||
| Kinase | ATMa.AA | PI3_PI4_kinase | 2453-2513 | 21 | 5.9e-12 | 45.9 | Pfam | 1-91 (300) | Show / Hide |
Range on Protein: 2453-2513 Range on HMM: 1-91/300 Sequence Identity: 21% (20 aa) ET-----GKDDLR--QDAVMQQVF-----------------------GLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPI .. |.|||| ||. | | . .|.| ...| .. ||..|.. |...|. . |..|| . .... WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTF |
|||||||||
| Kinase | ATMa.AA | DNAPK | 2455-2510 | 35 | 7.4e-08 | 24.48 | In-house | 39-94 (301) | Show / Hide |
Range on Protein: 2455-2510 Range on HMM: 39-94/301 Sequence Identity: 35% (20 aa) GKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGT | ||||| | | | . | || | | ..|. ||.|| . | GIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNT |
|||||||||
| Kinase | ATMa.AA | SMG1 | 2455-2516 | 31 | 0.002922 | 6.48 | In-house | 29-91 (242) | Show / Hide |
Range on Protein: 2455-2516 Range on HMM: 29-91/242 Sequence Identity: 31% (20 aa) GKDDLRQDAVMQQVFGLVNQLLSKSTETKRRKLQIRRYKVVPLCQNTGLLEWCEGTMPI-GLY | .|| | . | .|| . . | | | || ||. | .| |. ||| GLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLY |
|||||||||
| Kinase | ATMa.AA | ATM | 2753-2766 | 71 | 0.000169 | 9.84 | In-house | 291-304 (304) | Show / Hide |
Range on Protein: 2753-2766 Range on HMM: 291-304/304 Sequence Identity: 71% (10 aa) NQVAERVLLRLRQK |.||||||.|| | NKVAERVLMRLQEK |
|||||||||
| FATC | ATMa.AA | FATC | 2774-2806 | 57 | 2.4e-18 | 61.81 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 2774-2806 Range on HMM: 1-33/33 Sequence Identity: 57% (19 aa) VTLSVAGQVSLLIQEARDPKNLSRLYPGWSPWL . ||| .||. ||||| ||.||...|.||.||. EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW |
|||||||||