Gene BCR (Sea Urchin)
BCR
Sequence
Protein domains of BCR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RhoGEF | BCR.AA | RhoGEF | 7-38 | 35 | 0.00034 | 16.01 | Pfam | 163-196 (196) | Show / Hide |
Range on Protein: 7-38 Range on HMM: 163-196/196 Sequence Identity: 35% (12 aa) DLLKHTPE-HHE-DHSILSQVLEKTRKFFKQVDE .||||||. |. |.. |.. ||. ... ....| ELLKHTPPCDHPKDYEDLQKALEAMKEVASHINE |
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| PH | BCR.AA | PH | 52-217 | 11 | 2.4e-07 | 31.63 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 52-217
Range on HMM: 1-82/82
Sequence Identity: 11% (19 aa)
LLRQGYLVEWTEGGRKLRRVLLWSDLIICASKKNTSGMFQRDRGQYDFQWYIPLTELSLTPNDRCEAEPDVVAKSDAELRQMKKDISELQEKIKRDKAAK
....|.| .. ..| | . | .| ... .| . . |||....... .
VIKEGWLYKKSK-RWKKRWFVLFNDCLYYYKDK-------------KPKGSIPLSDCTVRE-P-------------------------------------
QSNAIKKSIEQKRKQAAELEVGYVLESPNLPFHLYHHSGKTYTILMSSDYERSDWKDSILSAKREC
| ..| .. ||.. .|. |. .| ..| .| ...
------------------------------CFEIHH-DR-TYYFQCESEEEMQEWMQAIQKAIHNN
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| PH | BCR.AA | PH | 52-215 | 12 | 0.00058 | 16.94 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 52-215
Range on HMM: 1-92/92
Sequence Identity: 12% (21 aa)
LLRQGYLVEWT-EGGRKLRRVLLWSDLIICASKKNTSGMFQRDRGQYDFQWYIPLTELSLTPNDRCEAEPDVVAKSDAELRQMKKDISELQEKIKRDKAA
. ..|.| .. ...| | . | .. ... ... |. . .||| ....|. ..
VIKEGWLHKKGKRKSWKKRWFVLFNNCLYYYKDDK-----------YRPKGSIPLSDCQVTKVPDN----------------------------------
KQSNAIKKSIEQKRKQAAELEVGYVLESPNLPFHLYHHSGKTYTILMSSDYERSDWKDSILSAKR
. | . . ...||.. .|. |. || ..| || |
---------------------------KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQAIQSACR
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| C2 | BCR.AA | C2 | 260-355 | 18 | 5.4e-10 | 40.44 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 260-355 Range on HMM: 1-92/92 Sequence Identity: 18% (22 aa) MLHVTVKEARGLTVPSQLYCCLETDAYGIFSRMAKTRKTANTI---TPKWNE---EFALDVDGARTLRILCYDFTKGLDDEMYDKGAVS----------- |.|...|||.| |. .. ||. || |.||| .| .||. . ||. ..|. . . .. TLTVHIIEARNLP---DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHCCIPPNNPHWHQWDG ---LTKQNISSPGGMD |.. . . . CIHLSDIL-GYRH-WW |
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| C2 | BCR.AA | C2 | 261-335 | 27 | 4.1e-09 | 33.56 | Pfam | 1-86 (90) | Show / Hide |
Range on Protein: 261-335 Range on HMM: 1-86/90 Sequence Identity: 27% (24 aa) LHVTVKEARGLTV-------PSQLYCCLETDAYGIFSRMAKTRKTANTITPKWNEEFALD--VDGART-LRILCYDFTKGL-DDEM |.|.|.|||.| | |. .. . .. . ||. || |.|||.| .| .. ||. ..|. . || . LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFI |
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| C2_PKD | BCR.AA | C2_PKD | 301-325 | 36 | 0.000216 | 11.99 | In-house | 62-86 (183) | Show / Hide |
Range on Protein: 301-325 Range on HMM: 62-86/183 Sequence Identity: 36% (9 aa) TITPKWNEEFALDVDGARTLRILCY |..| ||..| .|. .| . |.|. TFYPEWNKCFDHHVYEGRHIQIVCM |
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| RhoGAP | BCR.AA | RhoGAP | 442-613 | 28 | 2.2e-58 | 201.19 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 442-613 Range on HMM: 1-193/193 Sequence Identity: 28% (57 aa) KNIPNIITLCVEEIDRRGVHEMGIYRISGSSADIQKLKKAFEQNRRNI-----------TAMLKQSDIHAVAGLLKSYLRELPEPLFTHVLYPQFVDGLQ ..|| |. |.|.|...| .. ||||..|.. ||.|..||... .. . |.|.|||.||.|.|||||||.|. ||..|.. . SHIPIIVRKCIEYIEKHGMDTEGIYRKCGNQSRIQELRNAFDRGPD-DLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK L--------------TDPVAKKKCFLSLLKNVVEPNRTIIFLIFNHLRRIAKEEEKNKMNLHNLSTVFGPTLLGPAATISATGKPDILAEIMGMSSV . |......... |.. ...| ... ||.|.|. ...||||.|||...|||||..| .... ..... |.. . . CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP--MMDMRHQNKCVEFLIEHYD |
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| RhoGAP | BCR.AA | RhoGAP | 445-598 | 35 | 4.2e-57 | 195.66 | Pfam | 1-156 (156) | Show / Hide |
Range on Protein: 445-598 Range on HMM: 1-156/156 Sequence Identity: 35% (56 aa) PNIITLCVEEIDRRGVHEMGIYRISGSSADIQKLKKAFEQNRRNITAMLKQSDIHAVAGLLKSYLRELPEPLFTHVLYPQFVD--GLQLTDPVAKKKCFL | |. |.|.|...| .. ||||.||... |..|..||... . ... |.|.||..|| |.|||||||||. ||. |.. .. |. ..... PMIVRKCIEYIEQHGLDTEGIYRVSGNKSRIKELREAFDRGPDVDLNDWEWHDVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMR SLLKNVVEPNRTIIFLIFNHLRRIAKEEEKNKMNLHNLSTVFGPTLLGPAATISAT |.. .||. . .. ||.|.|. ...|||| |||...|||.|. | .. |.. ELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDDDSMD |
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