Gene eEF2K (Sea Urchin)

eEF2K

Species: Sea Urchin
Alias: eEF2K, Spk035, SPU_011641
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Atypical
Family: Alpha
Subfamily: eEF2K

Sequence

Name Sequence Type Origin Length Description Download
eEF2K.AA Protein None 683 None Fasta, JSON

Protein domain

Protein domains of eEF2K.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase eEF2K.AA Alpha 117-308 31 4.6e-100 285.42 In-house 1-215 (215) Show / Hide 
Range on Protein: 117-308
Range on HMM: 1-215/215
Sequence Identity: 31% (68 aa)

DEVQVKMGSESFAHGAMR------ECFRMKKKSNFSKHHQWKNSGNFVAKRYMETVERDVYFQDVRLQMDAKIWGEEFNRHN------PPKKVDIFQMAV
... ..|.|  |. ||||      .|.. .| ...    |||.  . |.... . |||........... .. |..| ..|.      |.| ......  
QCTKIQMSSYPFMEGAMRYAMHAWDCWLHQKMVKKQHKKQWKSF-KYVWHHWIKDVERQMVCHHCVREFNQRLWEQEYTTHFNQMKPQPIKQFVHCYIYE

LEFMNRPGKPLFHLESYIEGKYIKYNSNSGFVR----DEALRKTPQAFSHFTFERSGHKLIVVDIQ-GVG-DLYTDPQIHT----STGTEYNEGNLGMRG
|.   .........|.|.||.|.|||.|.|.|.    |  .....|||||.|...|.. |.|||.| ||| ...||||||.    ..|. .  ||.|..|
LIHCHNHNIKYYSVENYMEGEYQKYNNNAGWVDFLTDDNEFNQLMQAFSHWTWQYSNGQLMVVDLQWGVGEWKLTDPQIHCPAKLDQGMKFGDGNCGYEG

MALFFATH--ACNEIC
|. ||.||  .||..|
MFRFFYTHHVQCNHYC
Alpha_kinase eEF2K.AA Alpha_kinase 111-308 35 1.5e-99 337.94 SMART 1-255 (255) Show / Hide 
Range on Protein: 111-308
Range on HMM: 1-255/255
Sequence Identity: 35% (90 aa)

EKTWVQDEVQVKM-GSESFAHGAMRECFRMKKKSNFSK--HHQWKNSGNFVAKRYMETVERDVYFQ--------DVRLQMDAKIWGEEFNR---HNP-PK
.. |...|..||.  . .||.||||.|..... |...    |.|.   . ..|.|..|. ...||         ||..|| .| |..|||.   ||| ||
DNKWTCQETCVKIKEPKPFAKGAMRWCYWGCDWSEHMHCFCHGWECVAKYFKKEYKRTWDEERYFHETLHLCLRDVEMQMMCKHWANEFNQEAQHNPCPK

KVDIFQMAVLEFM-------NRPGKPL----------------FHLESYIEGKYIKYNSNSGFVRDEALRKT-----------PQAFSHFTFERSGHKLI
|.|. ...|..|        .|.....                ||.| ..||...|||.|.|.|.|.. . |           .|||||.|.|.|.| ..
KIDFIPCYVFHFPRRIPAEYDRNIPYWFSYRTTDQMMVMCCCIFHMEPFMEGEFVKYNNNNGWVNDCMRWTTTSQRRTEMFEYCQAFSHWTYEWSNHQML

VVDIQGV----GD--LYTDPQIHTST--GTEYNEGNLGMRGMALFFATHACNEIC
|.|||||    ||  .||||||||    |. . .||||..|.. ||.|| ||.||
VCDIQGVIHKNGDLYYYTDPQIHTEDQNGYGFGMGNLGQEGIEKFFQTHQCNQIC
Kinase eEF2K.AA Alpha_kinase 128-308 36 3.7e-78 270.76 Pfam 1-225 (225) Show / Hide 
Range on Protein: 128-308
Range on HMM: 1-225/225
Sequence Identity: 36% (84 aa)

FAHGAMRECFRMKKKSNFSKHHQWKNSGNFVAKRYME----TVE------RDVYFQDVRLQMDAKIWGEEFNRH-----NPPKKVDIFQMA-VLEFMNRP
||.||||.||||.. .    ...|.|  |.|||.| .    ..       .| ||||.. || .. | |.||.      |||..... ... |.|. ...
FAQGAMRWCFRMFDTW----DPNWRNNQNCVAKWYKKIKNYNQKQSIYVEEDYYFQDCKMQMICQQWMEKFNQKLQEHNNPPPPIEFYDCCIVYELEDHN

G---------------KPLFHLESYIEG-KYIKYNSNSGFVRDEALRKTP-----QAFSHFTFERSGHKLIVVDIQGVG--D---LYTDPQIHTSTGTE-
.               ......|.|||| ...|||.|.|.|.|.  | .|     |||||||..||.....|.||||||  .   ..|||||||  |   
KPDCYQGFFSYRTDWGGKYWYMEPYIEGCEFVKYNNNYGWVYDNMDRNDPWNQYMQAFSHFTYHRSNGQMMVCDIQGVGYNNKCYYLTDPQIHTKDGNYE

--YNEG--NLGMRGMALFFA-THACNEIC
  . ||  ||| .|.  ||. .| ||.||
MDFDEGMGNLGQEGIEKFFQNQHKCNHIC
Kinase eEF2K.AA VWL 219-313 45 2.2e-36 106.02 In-house 108-206 (206) Show / Hide 
Range on Protein: 219-313
Range on HMM: 108-206/206
Sequence Identity: 45% (45 aa)

ESYIEGKYIKYNSNSGFV--RDEALRKTPQAFSHFTFERSGHKLIVVDIQGVG-DLYTDPQIHTSTG-TEYNEGNLGMRGMALFFATHACNEICDHLEL
| |||| | ||| |.|..  .|.   .  |||||||.  |   . .||.||..  . ||||||.      . .||||  ||  || || ||..|  | |
ENYIEGDYQKYNNNAGWCNQTDMEYNQLSQAFSHFTWQYSQGYCMIVDLQGNEDGMLTDPQIHCLDQSHKFGQGNLGYEGMLRFFMTHQCNKYCQKLQL
Kinase eEF2K.AA Alpha-Unclassified 149-308 31 6.5e-32 101.24 In-house 36-215 (215) Show / Hide 
Range on Protein: 149-308
Range on HMM: 36-215/215
Sequence Identity: 31% (57 aa)

HQWKNSGNFVAKRYMETVERDVYFQDVRLQMDAKIWGEEFNRHNPPKKV--DIFQMAVLEFMNRPGK--P-LFHLESYIEGKYIKYNSNSG----FVR--
||    | .| | | |       | ||  || |. .  |||.    . .  .||       . |. |  . .  .|.|..| . ||..|.|    ||.  
HQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPPIFLIHREDKNIKGCISVEPYLIGEFVKYSNNTGKEINFVKWE

DEALRKTPQAFSHFTFERSGHKLIVVDIQG-VG------DLYTDPQIHTSTGTEYN--EGNLGMRGMALFFATH--ACNEIC
.||  .  ....|.|.. ..|..||.| || |.         |||||||     |    .| |||..  .|. |   ||..|
YEAYQYC-CTYQHWTYQWTNHCDIVCDLQGWVDENDKKTWKMTDPQIHTIR-QRYQGFKTNCGMRFIDYWFNNHHVQCNHYC
Kinase eEF2K.AA ChaK 216-308 35 1.1e-11 42.47 In-house 120-219 (219) Show / Hide 
Range on Protein: 216-308
Range on HMM: 120-219/219
Sequence Identity: 35% (35 aa)

FHLESYIEGKYIKYNSNSG--FVRDEALRKTPQAFSHFTFERSGHKLIVVDIQGVGDLYTDPQI-----HTSTGTEYNEGNLGMRGMALFFATHACNEIC
| .| .. | . ||| | |   .    |     ||||.|.|     |.|.|.||||.  ||| .       | .  .   |||   .  | | | ||  |
FTIEKCMTGEFRKYNNNNGDEIIPTNTLEEIMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVIKPEEKQSCDMVFGPANLGEDAIRNFRAKHHCNSCC