Gene RSKR (Sea Urchin)

RSKR

Species: Sea Urchin
Alias: SPU_019117, RSKR, Spk024
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: RSKR

Sequence

Name Sequence Type Origin Length Description Download
RSKR.AA Protein None 375 None Fasta, JSON
RSKR.kin_dom Protein Kinase Domain None 180 None Fasta, JSON

Protein domain

Protein domains of RSKR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSKR.AA RSKR 137-314 54 1.2e-136 460.25 In-house 93-296 (296) Show / Hide 
Range on Protein: 137-314
Range on HMM: 93-296/296
Sequence Identity: 54% (112 aa)

VMEFAT-HGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNRASTICGTLQYMAPEILNEENY
..|... |||||.||...|.|.|||...|||||.|||.||.|||.||||.|||||||||.|||||||||||||||.|.|..||||||||||||||..|.|
MCEYPPCHGDLYSLWRQRGHFSEMAIRLFIAELAMALCYLHNAGIIYRDVKMENILLDQWGHIKLTDFGLSKWMKQGARTYTICGTLQYMAPEILCGEPY

THAVDWWSLGIIMYTLLTGGYP-----------IDGAKTHFTMYSRVLAKKYVLPSS--------------ISSEACDALDRLLRKDPNDRLQSLGEIVH
.|||||||||.||...|||.||           .|....||||...|....|.||.|              .|.|.||...|.|...||.||.||....|
NHAVDWWSLGVIMCQMLTGKYPNIKRHLLRRREYDNERDHFTMHASVAHIDYCLPDSDGDSEDFLPEEVQHCSHEFCDLMHRMLCQNPNHRLCSLHHLQH

LDFI
..|.
HPFF
Kinase RSKR.AA AGC 137-314 27 3.2e-98 253.9 In-house 111-395 (395) Show / Hide 
Range on Protein: 137-314
Range on HMM: 111-395/395
Sequence Identity: 27% (80 aa)

VMEFAT--------HGDLYTLWILEG-----VFTEMAVCIFIAE-------LSMALDYLQN-AGVIYRD-LKMENILLDQEGHIKLTDFGLSKWMKKGN-
|||..          |.. ....| |     .|.| ......||       . .||.|| .  |.|.|| || ||||||..||||||||||.|...... 
VMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGE

--------------------------------------------------RASTICG--TLQYMAPEILNEENYTHAVDWWS--LGIIMYTLLTGGYPID
                                                  |..|.||  | .|||||||    |..|.||||  ||..|| .|||  |  
KGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFY

GAK---------THFTMYSRVL------AKKYVLP----------SSISSEACDALDRLLRKDPNDRLQS---------LGEIVHLDFI
|           ... |. ...       .|  .|          ...|.|| | . .|| |||..|| .           ||    . 
GDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSKR.AA RSKR 28-136 67 3.7e-82 279.25 In-house 73-182 (296) Show / Hide 
Range on Protein: 28-136
Range on HMM: 73-182/296
Sequence Identity: 67% (74 aa)

HHPFIIQIYKSWQSKINLHIVMEFAT-HGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNRA
||||| . | .|| . .|....|... |||||.||...|.|.|||...|||||.|||.||.|||.||||.|||||||||.|||||||||||||||.|.|.
HHPFIHRQYDTWQNRHHLYMMCEYPPCHGDLYSLWRQRGHFSEMAIRLFIAELAMALCYLHNAGIIYRDVKMENILLDQWGHIKLTDFGLSKWMKQGART

STICGTLQYM
.|||||||||
YTICGTLQYM
Kinase RSKR.AA AGC 28-136 28 1.1e-65 167.87 In-house 88-274 (395) Show / Hide 
Range on Protein: 28-136
Range on HMM: 88-274/395
Sequence Identity: 28% (53 aa)

HHPFIIQ-IYKSWQSKIN--LHIVMEFAT--------HGDLYTLWILEG-----VFTEMAVCIFIAE-------LSMALDYLQN-AGVIYRD-LKMENIL
|||||..  . |.|.| .  |..|||..          |.. ....| |     .|.| ......||       . .||.|| .  |.|.|| || ||||
HHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL

LDQEGHIKLTDFGLSKWMKKGN---------------------------------------------------RASTICG--TLQYM
||..||||||||||.|......                                                   |..|.||  | .||
LDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYM
Kinase RSKR.AA SGK 135-313 38 8e-61 186.37 In-house 101-283 (283) Show / Hide 
Range on Protein: 135-313
Range on HMM: 101-283/283
Sequence Identity: 38% (70 aa)

YMVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSK-WMKKGNRASTICGTLQYMAPEILNEE
|.||...  |..      |. | |  . .  ||.  ||.||    .|||||| |||||| .||..||||||.|  .|. .  .|.|||. |.|||.|. .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

NYTHAVDWWSLGIIMYTLLTGGYPIDGAKTHFTMYSRVLAKKYVLPSSISSEACDALDRLLRKDPNDRLQSL---GEI-VHLDF
 .  .||||.||...| ...|  |    . . .||   . ..  .| ..|..|.| .  || ||| .|| .    .||  |  |
PHDRTVDWWCLGCVLYEMMYGLPPFY-SRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase RSKR.AA RSK 137-314 36 5.3e-59 202.33 In-house 79-278 (278) Show / Hide 
Range on Protein: 137-314
Range on HMM: 79-278/278
Sequence Identity: 36% (73 aa)

VMEFATHGDLYTLWILEGV---FTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQ---EGHIKLTDFGLSKWM--KKGNRASTICGTLQYMAPE
.||.   |.|.|    |.    |.|  .|. .||...|...|   |.|.|||| ||||.|.   ||||||||||..| .  ...... | |.|..|||||
IMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPE

ILN---EEN-YTHAVDWWSLGIIMYTLLTGGYPIDG---AKTHFTMYSRVLAKK--YVLP--SSISSEACDALDRLLRKDPNDRLQS----LGEIVHLDF
.|.    .. ...|.||||||..||..|||  |  |   .  . .|  |.. .|    .|  ...| || | . ..| .||..|| .    . ||    .
MLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMK-RIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPW

I
.
F
Kinase RSKR.AA Akt 135-302 40 2e-57 182.09 In-house 76-248 (264) Show / Hide 
Range on Protein: 135-302
Range on HMM: 76-248/264
Sequence Identity: 40% (70 aa)

YMVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRD-LKMENILLDQEGHIKLTDFGLSK-W-MKKGNRASTICGTLQYMAPEILN
|.||...  |.|...   ...|.|     ..||.. |...| . ..|||| || ||||.|..|||.||||||.|   .| . .. |.|||  |.||||||
YFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILN

EENYTHAVDWWS-LGIIMYTLLTGGYPIDGAKTHFTMYSRVLAKKYVLP--SSISSEACDALDRLLRKDPNDRL
   .| |||||. ||..|| ...|  |    . | .|.   . ...  |  . || |. | . .|| |||. ||
GNGHTKAVDWWGSLGCVMYEMMCGRPPFYN-QDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRL
Kinase RSKR.AA PKC 166-302 41 1.4e-55 178.54 In-house 107-243 (262) Show / Hide 
Range on Protein: 166-302
Range on HMM: 107-243/262
Sequence Identity: 41% (57 aa)

AELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKW-MKKGNRASTICGTLQYMAPEILNEENYTHAVDWWSLGIIMYTLLTGGYPIDGAKTH
|| ..|| .| . |.|||||| .|.|||.|||||..|||..|  | .|...|| |||  |.||||| .. |...||||..|. || .. |  | .|  . 
AEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGE-DE

FTMYSRVLAKKYVLPSSISSEACDALDRLLRKDPNDRL
 ..   .. .. . | ..| || . .  .. |.|..||
DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRL
Kinase RSKR.AA Pkinase 135-314 28 2.8e-53 188.11 Pfam 76-293 (293) Show / Hide 
Range on Protein: 135-314
Range on HMM: 76-293/293
Sequence Identity: 28% (64 aa)

YMVMEFATHG----DLYTLWI--LEGVF--TEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHI----KLTDFGLSK---WMKKGNRASTIC
|||||.. .|    ||...     .|.|  .|  .. .. ..  .|.|. . |.|.|||| ||||.|..|||    |..||||.|   . ...  ..|.|
YMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFC

GTLQYMAPEILN-EENYTHAVDWWSLGIIMYTLLTGGYPIDGA-----KTHFTMYSRVLAKKYVLPSSIS---------------------SEACDALDR
||. |||||...  . |...||.||.|.|.| .|.|  | .|.      ..  |. |.. ...  ... .                     .|..| ...
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLRKDPNDRLQSLGEIVHLDFI
.|.|||..|. .  .|.. ...
CLCKDPKKRP-TAEQILQHPWF
Kinase RSKR.AA MSK 137-302 37 2.4e-51 171.84 In-house 79-266 (277) Show / Hide 
Range on Protein: 137-302
Range on HMM: 79-266/277
Sequence Identity: 37% (70 aa)

VMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQE---GHIKLTDFGLSKWMKKG--NRASTICGTLQYMAPEILN
|||... | | |     . |.| .. . ..|| ||.|..   |.|.|||| ||||.| |   ||.||.|||...   ..   |. . |.||.|||||.|.
VMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLR

----EEN-YTHAVDWWSLGIIMYTLLTGGYPID----GAK----THFTMYSRVLAKKYVLP----SSISSEACDALDRLLRKDPNDRL
    ..  |  |.||||||.|.||.|||  |      ...    .|     |.. ..  .|    ...| .| | . .|| |||..||
RGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRL
Kinase RSKR.AA RSK 135-314 36 6.6e-50 172.12 In-house 77-271 (271) Show / Hide 
Range on Protein: 135-314
Range on HMM: 77-271/271
Sequence Identity: 36% (71 aa)

YMVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQE----GHIKLTDFGLSKWMKKGNR-ASTICGTLQYMAPEI
||.|.|.  ||| .    ...|.|  |..  ||.  |..||   |...|||| ||||.| |    ||||..|||..| ..  |  . | |.| .|||||.
YMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEV

LNEENYTHAVDWWSLGIIMYTLLTGGYPIDGAKTHFTMYSRVLAKKYVL-------PSSISSEACDALDRLLRKDPNDRLQS----LGEIVHLDFI
|.   ...|.||||.|..||. |||  |  . |.  |.    .  | ..       ...|| || | | ..|  ||. || .      .|   ...
LKRQGHDQACDWWSFGVLMYEMLTGCTPFQN-KPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSKR.AA p70 137-314 35 2.4e-49 170.28 In-house 106-299 (299) Show / Hide 
Range on Protein: 137-314
Range on HMM: 106-299/299
Sequence Identity: 35% (70 aa)

VMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKW-MKKGNR----------ASTICGTLQYM
. |.   | |...   .|.. |  .| . .| ..|| .|   |.|||||| ||..|.| ||..||||||.|  ...|              |.|||  ||
ILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIEYM

APEILNEENYTHAVDWWSLGIIMYTLLTGGYPIDGAKTHFTMYSRVLAKK--YVLPSSISSEACDALDRLLRKDPNDRLQ----SLGEIVHLDFI
|||||    . |||||||||. ||  |||| |   . ..      .|  |    ||   . |. | . .|| ..|  |.       ..|    | 
APEILMRCGHNHAVDWWSLGCLMYDMLTGGPPF-TGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSKR.AA S_TKc 61-314 26 5.5e-44 153.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 61-314
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

WIL-----EGVFTEMAVCIFIA-ELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNRASTICGTLQYMVMEFATH--GDLYTLWIL
. .     .| | .   |. .     .|.  .     |.| ...     . .  .|| |.  .              .  |||||.. .  |||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD--------------DHLYMVMEYCDGDLGDLFDYIKK

EGV------FTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNRASTICGTLQYMAPEILNEENYTH-AVDWWSLG
 |       |.|  .. .....  ||.|. . |.|.|||| ||||||.  |||..||||.. .      .|.|||. |||||.|    |.. ..||||.|
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

IIMYTLLTGGYPIDGAKTHFTMYSRVLAKKYVLPSSISSEACDALDRLLRKDPNDRLQSLGEIVH-------LDFI
.|.| .|.|  | .   ....|. ...          |.||.| ....|.|||..|. .  |. .         ..
CILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRP-TA-EALQDEWDIKCHPWF
Kinase RSKR.AA PKA 135-302 36 6e-44 152.33 In-house 76-247 (263) Show / Hide 
Range on Protein: 135-302
Range on HMM: 76-247/263
Sequence Identity: 36% (64 aa)

YMVMEFATHGDLYTLWILEGVFTEMAVCIFIA-ELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNRASTICGTLQYMAPEILNEE
|||||..  |.. .    .| |..   .. .| .   ||.|| .   |||||| ||||.|..||||.|||| .| ..   | .|.||| .|.||||.. .
YMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSK

-NYTHAVDWWSLGIIMYTLLTGGYPIDGA-KTHFTMYSRVLAKKYVLPSSISSEA---CDALDRLLRKDPNDRL
  .  .||||.|||. | .|.|  |     .. . .| . .. |.  |....| |    | ...|| .|.. |.
NGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRY
Kinase RSKR.AA RSK 24-136 38 4e-38 132.99 In-house 55-175 (278) Show / Hide 
Range on Protein: 24-136
Range on HMM: 55-175/278
Sequence Identity: 38% (46 aa)

AMVGHHPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGV---FTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQ---EGHIKLTDFGLS
.....||||.. . . | .  |...||.   |.|.|    |.    |.|  .|. .||...|...|   |.|.|||| ||||.|.   ||||||||||..
ERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFC

KWM--KKGNRASTICGTLQYM
| .  ...... | |.|..||
KQFRCDHNQWTMTFCYTIEYM
Kinase RSKR.AA Akt 29-132 40 5.8e-38 118.89 In-house 59-165 (264) Show / Hide 
Range on Protein: 29-132
Range on HMM: 59-165/264
Sequence Identity: 40% (43 aa)

HPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRD-LKMENILLDQEGHIKLTDFGLSK-W-MKKGNR
||||.. . | |.. .| .||...  |.|...   ...|.|     ..||.. |...| . ..|||| || ||||.|..|||.||||||.|   .| . .
HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDK

ASTICGT
. |.|||
TKTFCGT
Kinase RSKR.AA MSK 25-136 36 1.3e-33 111.04 In-house 56-172 (277) Show / Hide 
Range on Protein: 25-136
Range on HMM: 56-172/277
Sequence Identity: 36% (43 aa)

MVGHHPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQE---GHIKLTDFGLSKWMK
|.  ||.| . .   |..  ...|||... | | |     . |.| .. . ..|| ||.|..   |.|.|||| ||||.| |   ||.||.|||...   
MCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFP

KG--NRASTICGTLQYM
..   |. . |.||.||
QDEEWRMKSPCFTLHYM
Kinase RSKR.AA SGK 29-133 42 4.9e-33 99.0 In-house 84-189 (283) Show / Hide 
Range on Protein: 29-133
Range on HMM: 84-189/283
Sequence Identity: 42% (45 aa)

HPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSK-WMKKGNRAS
||||..   . | |  |  ||...  |..      |. | |  . .  ||.  ||.||    .|||||| |||||| .||..||||||.|  .|. .  .
HPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTF

TICGTL
|.|||.
TFCGTP
Kinase RSKR.AA RSK 27-132 38 6.5e-33 114.85 In-house 58-168 (271) Show / Hide 
Range on Protein: 27-132
Range on HMM: 58-168/271
Sequence Identity: 38% (43 aa)

GHHPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQE----GHIKLTDFGLSKWMKK
||||||.. . . |.  .. ..|.|.  ||| .    ...|.|  |..  ||.  |..||   |...|||| ||||.| |    ||||..|||..| .. 
GHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRD

GNR-ASTICGT
 |  . | |.|
ENGMLMTFCYT
Kinase RSKR.AA p70 29-136 36 1.5e-29 104.14 In-house 87-205 (299) Show / Hide 
Range on Protein: 29-136
Range on HMM: 87-205/299
Sequence Identity: 36% (43 aa)

HPFIIQIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKW-MKKGNR--
||||.    . |    |  . |.   | |...   .|.. |  .| . .| ..|| .|   |.|||||| ||..|.| ||..||||||.|  ...|    
HPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDE

--------ASTICGTLQYM
          |.|||  ||
EDPENVNATHTFCGTIEYM
Kinase RSKR.AA PKA 28-132 40 3.3e-29 103.35 In-house 57-161 (263) Show / Hide 
Range on Protein: 28-132
Range on HMM: 57-161/263
Sequence Identity: 40% (43 aa)

HHPFII-QIYKSWQSKINLHIVMEFATHGDLYTLWILEGVFTEMAVCIFIA-ELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKGNR
.||||. . | ..|   .|. |||..  |.. .    .| |..   .. .| .   ||.|| .   |||||| ||||.|..||||.|||| .| ..   |
KHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--R

ASTICGT
 .|.|||
TWTLCGT
Kinase RSKR.AA Pkinase 28-133 33 5.6e-29 103.54 Pfam 58-175 (293) Show / Hide 
Range on Protein: 28-133
Range on HMM: 58-175/293
Sequence Identity: 33% (40 aa)

HHPFIIQIYKSWQSKINLHIVMEFATHG----DLYTLWI--LEGVF--TEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHI----KLTDFG
.||.|...| ....| ....|||.. .|    ||...     .|.|  .|  .. .. ..  .|.|. . |.|.|||| ||||.|..|||    |..|||
NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG

LSK---WMKKGNRASTICGTL
|.|   . ...  ..|.|||.
LAKQFDY-NNS--MTTFCGTP
Kinase RSKR.AA PKC 77-136 54 2.4e-28 88.86 In-house 107-167 (262) Show / Hide 
Range on Protein: 77-136
Range on HMM: 107-167/262
Sequence Identity: 54% (33 aa)

AELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKW-MKKGNRASTICGTLQYM
|| ..|| .| . |.|||||| .|.|||.|||||..|||..|  | .|...|| |||  |.
AEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYI
Kinase RSKR.AA TyrKc 96-309 17 1.8e-08 -85.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 96-309
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

LKMENILLDQEGH-----------------IKLTDFGLSKWMKKGNRASTI------------CGTLQ----------YMVMEFATHGDLYTLW-ILEGV
.... .|   ||.                 .|     .   |.  .  . .            . | |          ..|||.. ||||       .. 
ITLGKKL--GEGAFGEVYKGTWKIQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

FTEMAVCIFIAELSMALDYLQNAGVIYRDLKMENILLDQEGHIKLTDFGLSKWMKKG---------NRAST--IC---GTLQYMAPEILNEENYTHAVDW
..    . |    .   .||   ..| |||   |.|.. ....| .|||||.  . .          |...   .     .  |||| .|.  .|.. | 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WSLGIIMYTLLTGGYPIDGA-----KTHFTMYSRVLAKKYVLPSSI---------SSEACDALDRLLRKDPNDRL--QSLGEIV
|| |. |. ..| | .         .. . .. .| . ..  .            ..|  .   .  . ||.||   . . |. 
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RSKR.AA PKC 29-57 37 0.001622 7.07 In-house 59-87 (262) Show / Hide 
Range on Protein: 29-57
Range on HMM: 59-87/262
Sequence Identity: 37% (11 aa)

HPFIIQIYKSWQSKINLHIVMEFATHGDL
|||  . . . |.. .|  |||.   |||
HPFLTHLHCCFQTMDRLFFVMEYVNGGDL
Kinase RSKR.AA Pkinase_Tyr 100-118 36 0.002651 11.81 Pfam 141-159 (270) Show / Hide 
Range on Protein: 100-118
Range on HMM: 141-159/270
Sequence Identity: 36% (7 aa)

NILLDQEGHIKLTDFGLSK
|.|.. ....| .||||..
NCLVTENNVVKICDFGLAR
Kinase RSKR.AA Pkinase_Tyr 189-207 36 0.002651 11.81 Pfam 141-159 (270) Show / Hide 
Range on Protein: 189-207
Range on HMM: 141-159/270
Sequence Identity: 36% (7 aa)

NILLDQEGHIKLTDFGLSK
|.|.. ....| .||||..
NCLVTENNVVKICDFGLAR
Kinase RSKR.AA Pkinase_Tyr 135-148 57 0.574119 3.9 Pfam 83-96 (270) Show / Hide 
Range on Protein: 135-148
Range on HMM: 83-96/270
Sequence Identity: 57% (8 aa)

YMVMEFATHGDLYT
|.|||.. ||||..
YIVMEYMPHGDLLD
Kinase RSKR.AA Pkinase_Tyr 225-249 44 0.758679 3.49 Pfam 181-205 (270) Show / Hide 
Range on Protein: 225-249
Range on HMM: 181-205/270
Sequence Identity: 44% (11 aa)

MAPEILNEENYTHAVDWWSLGIIMY
|||| .|.  .|.. | || |. |.
MAPECINYGKFTTKSDVWSFGVLMW
Kinase RSKR.AA Pkinase_Tyr 47-59 61 3.036419 1.45 Pfam 84-96 (270) Show / Hide 
Range on Protein: 47-59
Range on HMM: 84-96/270
Sequence Identity: 61% (8 aa)

IVMEFATHGDLYT
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IVMEYMPHGDLLD