Gene MSK (Sea Urchin)

MSK

Species: Sea Urchin
Alias: SPU_024721, MSK, SPU_024930, Spk026
External Links: Sea Urchin Project Link
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: MSKb,

Classification

Group: AGC
Family: RSK
Subfamily: MSK

Sequence

Name Sequence Type Origin Length Description Download
MSK.AA Protein None 801 None Fasta, JSON
MSK.kin_dom Protein Kinase Domain None 116 None Fasta, JSON
MSK.kin_dom2 Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of MSK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MSK.AA MSK 1-111 56 1.5e-69 234.26 In-house 8-118 (277) Show / Hide 
Range on Protein: 1-111
Range on HMM: 8-118/277
Sequence Identity: 56% (63 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREHFRESEVRIYI
.|||.|..||...|..|||||||.|.|||.|||.||||||.||||.||.....|..|.||||||......|...|.||||||||...||||.|||.|...
GYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDESECRMIM

AEIIIALDCLH
.|...|.|..|
RELVMAVDHMH
Kinase MSK.AA AGC 1-111 37 6.7e-68 173.7 In-house 11-170 (395) Show / Hide 
Range on Protein: 1-111
Range on HMM: 11-170/395
Sequence Identity: 37% (60 aa)

AYGKVFLVRKVGNH---NQGKLYAMKVLKKAT-IVQKAK-TAEHTMTE------------RQVLEAVRS---------CPFLVT-LHYAFQTDSK--LNL
..|||.||||....     ||.||||||||.. ||.| | . ||||||            |..|| ...         .||.|  |||.||....  | .
SFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYF

ILD----YVN-----GG-ELFTHLY---QREHFRESEVRIYIAE-------IIIALDCLH
...    |||     || |||.||.   .. .| |...|.|.||       |. ||. ||
VMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLH
Kinase MSK.AA RSK 1-111 57 9.1e-63 214.84 In-house 8-121 (278) Show / Hide 
Range on Protein: 1-111
Range on HMM: 8-121/278
Sequence Identity: 57% (66 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH---FRESEVR
.||||||.||...|..|..|||||||||.|||..|...||||||..||.....||.|||||||||..|| ||..|..||||||||....|   | |.|..
GYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEAC

IYIAEIIIALDCLH
.|.|||. |...||
FYMAEIVLAVEHLH
Kinase MSK.AA RSK 1-111 37 3e-33 116.08 In-house 11-118 (271) Show / Hide 
Range on Protein: 1-111
Range on HMM: 11-118/271
Sequence Identity: 37% (42 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREHFRESEVRIYI
...||....|.     ...||||..||||.. | .    . .|| .|. . . || |.|||.||.  |. .|.|   ||.||..|     | |.||..| 
SFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--VCWEEERIILRYGHH-PFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSEREVKFYM

AEIIIALDCLH
|||  |...||
AEIALAMEYLH
Kinase MSK.AA AGC 112-158 34 8.6e-26 62.3 In-house 326-395 (395) Show / Hide 
Range on Protein: 112-158
Range on HMM: 326-395/395
Sequence Identity: 34% (24 aa)

RIL------TSHPPMP----------NTFSKEVKDFINKLLVKDPTKRLGCN-------GVKDIKSHSFF
.|.      .  ...|            ||.| ||.|.|||.|||.|||||.       |...||.| .|
KIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MSK.AA CAMK 1-111 15 1.7e-18 55.58 In-house 6-196 (425) Show / Hide 
Range on Protein: 1-111
Range on HMM: 6-196/425
Sequence Identity: 15% (30 aa)

AYGKVFLVRKV-GN---------HNQGKLYAMKVLKKATIVQ------------------------KAKTAEHTMTERQVLEAVR------SCPFLVTLH
..|||.|..    .          | |. .|.|...|  .                          ..|. .  . | ...  ..      . | .. |.
SFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLY

YAFQ------------TDSK--------LNLIL---DYVNGGEL----FTHLYQREH---------------FRESEVRIYIAEIIIALDCLH
 ...            | ||        . ...   .|. ||||    | .. ....               | |.|.| |.  |. |.. .|
EVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH
Kinase MSK.AA Ciliate-E2 1-111 24 7.1e-18 57.92 In-house 11-177 (365) Show / Hide 
Range on Protein: 1-111
Range on HMM: 11-177/365
Sequence Identity: 24% (41 aa)

AYGKVFLV--RKVGNH------------------NQGKLYAMKVLKKATIVQKAKTAEHTM----------TERQVLEAVRSCPFLVTLHYAFQ--TDSK
..|.|...  .||..                   ...|.||||..||  | |. |  .| |           |...||   ..|... ....||  .|..
NFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQI-KQEIHIMREINCFYKKINEKNILE-QLNHPNIIKMYECFQEKDDNN

LNLILDYVNGGELFTHLYQREHFR-----------ESEVR---------------IYIAEIIIALDCLH
. |...|..||.|| ..... ..|           | |..                |||.|| ||  ||
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH
Kinase MSK.AA RSK 112-158 41 7.1e-16 54.81 In-house 226-278 (278) Show / Hide 
Range on Protein: 112-158
Range on HMM: 226-278/278
Sequence Identity: 41% (22 aa)

RILTSH--PPMP--NTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIKSHSFF
||.. .  ..||  .. |.| ||.|.|.| .|| |||||.  ....||.|..|
RIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK.AA Pkinase 1-108 22 3.7e-15 54.66 Pfam 11-122 (293) Show / Hide 
Range on Protein: 1-108
Range on HMM: 11-122/293
Sequence Identity: 22% (26 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQ-KAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGG----ELFTHLY--QREHF--
..|.|.. ...|.     ..|.|..|| ..   | .|. .. .| |..  . ..|. |.|...|...... ....|..||    .||...   ..  |  
SFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYF

RESEVRIYIAEIIIALD
 | |.. |. .|. .|.
SEWECKFYMYQILRGLE
Kinase MSK.AA S_TK_X 159-221 28 1.2e-14 55.88 SMART 1-79 (79) Show / Hide 
Range on Protein: 159-221
Range on HMM: 1-79/79
Sequence Identity: 28% (23 aa)

KGLNWDDVAA--KRVSPPFRPHIN----GELDTSNFAEEFTSLVPADSPADI--PKTADARV---------FRVGYSFIA
.|..||.. .  |.. |||.| |.    .. ||||| .|||. .| ..|.|    ......          || |.....
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFR-GFTYVF
Kinase MSK.AA S_TKc 1-158 22 6.3e-14 27.27 SMART 11-231 (231) Show / Hide 
Range on Protein: 1-158
Range on HMM: 11-231/231
Sequence Identity: 22% (54 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNG--GELFTHLYQREH------FR
|.|||...|...    |...|.|..|           ||.. |.|.|.    .|..|.|...||. ..| ....|..|  |.||... .| .      | 
AFGKVYKCRHKK---TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

ESEVRIYIAEIIIALDCLHR---------------------------------------------------------------ILTSHPPMPNTFSK---
| ..| |...|. ||. .|.                                                                |.  || | .  .   
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFK

-----EVKDFINKLLVKDPTKRLGCNGVKD----IKSHSFF
     |.||||.|.|.|||.||...  .      ||.| .|
KIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK.AA RSK 119-158 40 3.4e-12 40.01 In-house 230-271 (271) Show / Hide 
Range on Protein: 119-158
Range on HMM: 230-271/271
Sequence Identity: 40% (17 aa)

PMPNTFSKEVKDFINKLLVKDPTKRLGC--NGVKDIKSHSFF
. ... |.| || . ..|  ||..|||.  |||..||.|..|
GNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MSK.AA Ciliate-E2 121-158 38 5.6e-12 37.38 In-house 326-365 (365) Show / Hide 
Range on Protein: 121-158
Range on HMM: 326-365/365
Sequence Identity: 38% (16 aa)

PNTFSKEVKDFINK----LLVKDPTKRLGCNGVKDIKSHSFF
..  |.|.||.|.|    .|.||| ||..  | ..|. | .|
WKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase MSK.AA MSK 112-153 37 5.8e-12 36.73 In-house 230-277 (277) Show / Hide 
Range on Protein: 112-153
Range on HMM: 230-277/277
Sequence Identity: 37% (18 aa)

RILTSHPPMP----NTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIK
||... .. |    ...|.. ||.| .|| ||| ||||.|  ..  .|
RICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK.AA CAMK1 1-111 22 7.1e-12 30.74 In-house 11-125 (276) Show / Hide 
Range on Protein: 1-111
Range on HMM: 11-125/276
Sequence Identity: 22% (27 aa)

AYGKVFLVRKVGN-HNQGKLYAMKVLKKATIVQKAKTAEHTM-------TERQVLEAV--RSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH
| ..|.|. .  .    || ||.|...|     |  .....|       .| ...  |   ..|. . ..  ...|... |....|.|||||    ....
AFSEVYLCTHKETQT-NGKQYAIKCIDK-----KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKGN

FRESEVRIYIAEIIIALDCLH
. | . |  . .|. |.  .|
YTEKDARHIMKQILSAVEYMH
Kinase MSK.AA CAMKL 1-112 21 2.8e-09 25.63 In-house 11-145 (297) Show / Hide 
Range on Protein: 1-112
Range on HMM: 11-145/297
Sequence Identity: 21% (29 aa)

AYGKVFLVRKVGNHNQGKLYAMKVLKKATIVQKAKTAEH-----------TMTERQVLEAVR--SCPFLVTLHYAFQTDSK------LNLILDYVNGGE-
..||| | . . .   |. .|.|...|  |  . ..  .              | | .. ..    |  . |.  ..|...      ..|.. |. ||| 
SFGKVKLATHIRTT--GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEM

-LFTHLYQREH----FRESEVRIYIAEIIIALDCLHR
 || .. ...|    . |.| | |   |. |.. .|.
DLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHS
Kinase MSK.AA CAMK 121-158 31 1e-08 23.44 In-house 392-425 (425) Show / Hide 
Range on Protein: 121-158
Range on HMM: 392-425/425
Sequence Identity: 31% (12 aa)

PNTFSKEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
. ..|.|.||.|.|.|..||.||. .   .....| ..
H-FVSQECKDLIRKMLQVDPEKRMTI---EQCLNHPWM
Kinase MSK.AA Pkinase_C 178-223 31 2.8e-08 32.42 Pfam 1-46 (46) Show / Hide 
Range on Protein: 178-223
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

HINGELDTSNFAEEFTSLVPADSP--ADIPKTADARVFRVGYSFIAPS
......||||| .|||.  | |.|   .    .| . | .|... .|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPF-RGFTYVNPD
Kinase MSK.AA Pkinase 110-158 25 3.7e-08 29.92 Pfam 231-293 (293) Show / Hide 
Range on Protein: 110-158
Range on HMM: 231-293/293
Sequence Identity: 25% (17 aa)

LHRILTSHPPMPNTFS-----------------KEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
....| .. | ... |                 .| ||||...| |||.||..    ..|. | .|
MGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase MSK.AA CAMK1 125-144 47 4.9e-08 19.38 In-house 245-265 (276) Show / Hide 
Range on Protein: 125-144
Range on HMM: 245-265/276
Sequence Identity: 47% (10 aa)

SKE-VKDFINKLLVKDPTKRL
|.. .||||...|..||.||.
SDQEAKDFIKHMLEVDPKKRY
Kinase MSK.AA CAMKL 117-158 28 9.7e-08 20.62 In-house 260-297 (297) Show / Hide 
Range on Protein: 117-158
Range on HMM: 260-297/297
Sequence Identity: 28% (12 aa)

HPPMPNTFSKEVKDFINKLLVKDPTKRLGCNGVKDIKSHSFF
.|| ..  | ...|.| |.|...|.||  .   ..|..| ..
YPPIWYHVS-DCRDLIRKMLQVNPEKRPTI---HQIMNHPWM
Kinase MSK.AA MAPKAPK 8-113 27 5.3e-07 17.24 In-house 15-122 (292) Show / Hide 
Range on Protein: 8-113
Range on HMM: 15-122/292
Sequence Identity: 27% (31 aa)

VRKVGNHNQGKLYAMKVLKKA--TIVQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQT----DSKLNLILDYVNGGELFTHLYQ--REHFRESEVRIY
|..  .   |. || |.|..    . |||        |   .  .  .|  | ..  |      |... |..   .||||| |  |  . || | |..  
VQTCVHKRTGQEYAVKILEDQPGHSRQKA------RREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHFTEREASQI

IAEIIIALDCLHRI
. .|  |.| ||..
MKDICSAVDFLHSM
Kinase MSK.AA CDPK 125-144 55 6e-06 14.4 In-house 241-260 (271) Show / Hide 
Range on Protein: 125-144
Range on HMM: 241-260/271
Sequence Identity: 55% (11 aa)

SKEVKDFINKLLVKDPTKRL
|.| || |.|.|..|| ||.
SDEAKDLIRKMLCYDPKKRM
Kinase MSK.AA MAPKAPK 125-144 65 9e-06 13.31 In-house 262-281 (292) Show / Hide 
Range on Protein: 125-144
Range on HMM: 262-281/292
Sequence Identity: 65% (13 aa)

SKEVKDFINKLLVKDPTKRL
|.|.|| | |||..|||.||
SEEAKDLIRKLLRRDPTQRL
Kinase MSK.AA MSK 269-530 53 2.4e-173 582.16 In-house 1-277 (277) Show / Hide 
Range on Protein: 269-530
Range on HMM: 1-277/277
Sequence Identity: 53% (147 aa)

MKSA-PIGDGSFSICRRCTHRKTEKEYAVKIVS-------RRVACT--QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKHFDE
.|.. ..|.|.|.|||.|.|..|.|.||.||.|       |..|..  .|...|..||.|||||.|...|.|..|||..||.|.||||...|||..||||
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

LEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSN--QPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLGVIL
 |..||||.||.|||.||..||.|||||||||||.|..|....|.|||||||.....  ...|.|||.||..|||.|.|.|.|||.||..||.|||||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YTMLSGRVPFQ--DPSIS-KSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWI
||||.|.||||  ..... ..||...|||||..|.|||.|..|...|..|||||..|||.||..||...||...||.
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase MSK.AA RSK 269-530 39 7.79999999999e-147 494.1 In-house 1-278 (278) Show / Hide 
Range on Protein: 269-530
Range on HMM: 1-278/278
Sequence Identity: 39% (113 aa)

MKSA-PIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACT---------QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKH---
.| . ..| |....||.|||..|...||.|.........         .|.. |..||.||.||.|.. |......|.|||.|.||||. ...|.||   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDD-AELKIIDFGFARI-TNS-NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSL
|.| ||...|...|.||...|..||.||||||||||..|.| . ...|..||||...  .. ||...|.|......|||.||||. |.| .|..||.|||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GVILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLT-----TDDLLQNEWI
||..|.||.|..|||  . .  |....|||||..|.||.....|...|..|||||...|..||..||.     .....|..|.
GVLMYEMLTGCPPFQG-PND--NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MSK.AA CAMK1 265-530 37 3.6e-120 351.03 In-house 1-276 (276) Show / Hide 
Range on Protein: 265-530
Range on HMM: 1-276/276
Sequence Identity: 37% (108 aa)

YELDMKSAPIGDGSFSICRRCTHRKT---EKEYAVKIVS-RRVACT----------QEITTLQLCQ--KHPNIVHLKEEFKDKLHTYIIMELCKGGELLG
||.. .   || |.||. ..|||..|   .|.||.|. . ...  .          .||  .. .   .||||. ..| . .. | |..|||..||||. 
YEFGKE---IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

RIRKKKHFDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELK--IIDFGFARITNSNQ-PLKTPCFSLHFAAPEVLKRAYEQDGEYDA
|| .|... | .|. ||....||| ||||.|||||||||||.|. | ..|...|  |.||| ..|....   .||.| .. . |||||..    |  || 
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK--DKPYDK

SCDVWSLGVILYTMLSGRVPFQDPS-ISKSNSASDIMKRIKHGNFSFDGEEWNSVSTP-AKDLIKGLLTVDPSRRLTTDDLLQNEWI
.||.|| |||.|..| |  ||.| . ...      ... || . . |.  .|...|   |||.||..|.|||. |.| .. |.  ||
ACDMWSIGVITYILLCGYPPFYDENVDNE------LFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MSK.AA CAMK 273-530 25 2.4e-114 369.99 In-house 1-425 (425) Show / Hide 
Range on Protein: 273-530
Range on HMM: 1-425/425
Sequence Identity: 25% (109 aa)

PIGDGSFSICRRCTHRKTE------------KEYAVKIVSRR---------------------------------VACTQEITTLQLCQK------HPNI
 .| |||.. ..|.|..|             ...|.||....                                     .||  ....|.      ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHLKEEFKD-------------------KLHTYIIM---ELCKGGEL----LGRIRKKKH---------------FDELEASMIMRKLVSAVDYMHSRGI
..| | . |                   . | |..|   |.| ||||    . .|.....               |.| ||. ..| ..|||.|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILFTDDSDD--------------AELKIIDFGFARITNS------------------------NQPLKTPCFSLHFAA-PEVLKR------
|||||||||||..|..||              . .||||||||.. ..                        .|..||.| .....| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

---AYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKSN-------SASDIMKRIKHGNFSFD-----------GEEWNS---------VSTPAKD
    .|.   |. .||.||.|||||.||.|. ||.... .          . ......|. |...|.           |.|| .         ||. .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKGLLTVDPSRRLTTDDLLQNEWI
||...|.|||..|.| .. |. .|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MSK.AA MAPKAPK 268-530 38 4.7e-105 326.24 In-house 1-292 (292) Show / Hide 
Range on Protein: 268-530
Range on HMM: 1-292/292
Sequence Identity: 38% (112 aa)

DMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRR-----VACTQEITTLQLCQKHPNIVHLKEEFKD----KLHTYIIMELCKGGELLGRIRK--KKHF
 . .  .| |.    ..|.|..|..||||||.  .         .|  ..  || |||||.. . |..    .   |..||. .||||. .| .  .|||
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF

DELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARI-------TNS--NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASC
 | ||| ||.   ||||..||..| ||||||||||.|| .... .|. |||||         | .  .. |.|||..  ..||||. .   .   || ||
TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSC

DVWSLGVILYTMLSGRVPFQ----DPSISKS------NSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWI
| ||||||.| ||.|  ||.    |  .|..          .  .||. | ..|  |||  .|  |||||. || .||. |||. ..... ||
DMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase MSK.AA AGC 273-530 23 1e-104 271.08 In-house 6-395 (395) Show / Hide 
Range on Protein: 273-530
Range on HMM: 6-395/395
Sequence Identity: 23% (93 aa)

PIGDGSFSICRRCTHR------KTEKEYAVKIVSRRV----------ACTQ-E------------ITTLQLCQK---------HPNIVH-LKEEFKDKLH
.|| |||. .. . ..       |.| ||.|... ..          ..|. |               |..|..         ||.||. |.  |.|| |
VIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDH

--TYIIMELCK---------GG-ELLGRIR---KKKHFDELEASMIMRK-------LVSAVDYMHS-RGIVHRD-LKPENILFTDDSDDAELKIIDFGFA
   |..||...         || ||. ...   |...||| .|  ..         .|.|..|.|| .||.||| |||||||...|     .|. |||..
TYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLTDFGLC

RITNS------------------------------------------------------NQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWS--LG
 . ..                                                      .. .  || . .. |||.|         |. .|| ||  ||
KEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL---------YGKACDWWSFGLG

VILYTMLSGRVPFQDPSIS----KSNSASDIMKRIKHGN-FSFDGEEWN-----------SVSTPAKDLIKGLLTVDPSRRLT----------TDDLLQN
...| ||.|. ||.. .      . ..  .....|..|. |........           ..|  ||||||.||..||..||.          .... . 
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

EWI
.| 
PWF
Kinase MSK.AA S_TKc 268-530 34 3.8e-98 333.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 268-530
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

DMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACTQEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKG--GELLGRIRKKKH------FDEL
  .  .|| |.|. ...|.|.|| ...|.||..      .||  |.   .|||||.|.. | |  | |..||.| |  |.|. .|.|...      |.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYDA-SCDVWSLGVILYT
.|  .|. ...|..|.||.||.||||||||||...     ..||.|||.||.       .| | .... |||||         |.  .||.||.|.||| 
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYE

MLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQ-------NEWI
||.|. ||.            ..|.|.              | .|||.|...|..||..|.|  ..||        .|.
MLCGYPPFP--------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MSK.AA CDPK 318-530 41 2.2e-94 289.88 In-house 60-271 (271) Show / Hide 
Range on Protein: 318-530
Range on HMM: 60-271/271
Sequence Identity: 41% (93 aa)

HPNIVHLKEEFKDKLHTYIIME--LCKGGELLGRIRKKKHFDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDA----ELKIIDFGFARI
||||. . | . |. . ||.||  .|.||||. .|  |.||.| ||. |||...||| |.||..|||||||||||||. ..||.    ..|.||.| ...
HPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKK

TNSN-----QPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDL
 ..|     . ... |   .  |||||.      . |. .||.||.|||||..|.|. ||         . ..||. .| |..||.|.||...|  ||||
FDQNQKIEDKKMSQRCGTPYYIAPEVLQ------KKYNEKCDIWSCGVILYILLCGYPPFY------GKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDL

IKGLLTVDPSRRLTTDDLLQNEWI
|. .|..||  |.. .. ||  |.
IRKMLCYDPKKRMSAQQALQHPWF
Kinase MSK.AA RSK 265-530 40 4.7e-94 318.76 In-house 1-271 (271) Show / Hide 
Range on Protein: 265-530
Range on HMM: 1-271/271
Sequence Identity: 40% (113 aa)

YELDMKSAPIGDGSFS---ICRRCTHRKTEKEYAVKIV---SRRVA---CTQEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGGELLGRIRKKKH
|||  .   || ||||   .|..|.|. |...||.||.   .| |.   |. |.  .     ||.|| |.. | |  . |.||....||.|..|. |.| 
YELHEC---IGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKM

FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAE-LKIIDFGFA-RITNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYDASCDVWSLG
| | |.. .|. . .|..| || |||||||||||||. |.| ... .|| |||||      |  |.|.| .  . |||||||     | .|..||.||.|
FSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQ----G-HDQACDWWSFG

VILYTMLSGRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTT-----DDLLQNEWI
|..|.||.|. |||       ..  .| .||| | ||. .  |...| .||||. ..|..|| .||..      . .|  |.
VLMYEMLTGCTPFQN---KPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MSK.AA Pkinase 265-530 33 5.1e-89 306.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 265-530
Range on HMM: 1-293/293
Sequence Identity: 33% (103 aa)

YELDMKSAPIGDGSFSICRRCTHRKTEKEYAVKIVSRRVACT---------QEITTLQLCQKHPNIVHLKEEFKDKLHTYIIMELCKGG----ELLGRIR
|..  |   || |||. ...|.|..|.|..||||...| .           .||  .. . .||||| |.. | || | |..||.| ||    .|  .|.
YHIGRK---IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--KKKHF--DELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFT-DDSDDAELKIIDFGFARI--TNSNQPLKTPCFSLHFAAPEVLKRAYEQDGEYD
  ... |  .| |. ..|. ......|.||.||.||||||||||.  ..  || .||.|||.|.   . .|. ..|.| .....||||..     . .|.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYG

ASCDVWSLGVILYTMLSGRVPFQDP-SISKSNSASDIMKRIKHGNFSFDGEEWNSVS-----------------TPAKDLIKGLLTVDPSRRLTTDDLLQ
 ..|.||.|.||| ||.|| ||..     . ..   ...||... ..|| ..|.|.|                  ..||.||..|..||..|.| ...||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

NEWI
 .|.
HPWF
Kinase MSK.AA CAMKL 267-530 32 4.2e-87 278.01 In-house 1-297 (297) Show / Hide 
Range on Protein: 267-530
Range on HMM: 1-297/297
Sequence Identity: 32% (100 aa)

LDMKSAPIGDGSFSICRRCTH-RKTEKEYAVKIVSRRVAC--------------------TQEITTLQLCQ--KHPNIVHLKEEFKDKLH------TYII
 ..    .| |||.  . .|| | |....|.||. .. ..                    ..||  ... .  |||||..| | . .. |       |..
YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MELCKGGE--LLGRIRKKKH----FDELEASMIMRKLVSAVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARI-----TNSNQPLKTPCFSLH
||.| |||  |. .|.|..|    ..| ||  . | .||||.|.||.||||||.||||||.... .   .|||||||. .      ...| ||| | |..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

FAAPEVLKR-AYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSIS--KSNSASDIMKRIKHGNFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDD
..|||....   . ||      |.||.|||||.|. |..|| |....  . .     ...|. | . ..   |..|| ...|||...|.|.|..| | ..
YMAPEIFQGNNKPYDGPK---VDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQ

LLQNEWI
... .| 
IMNHPWM
Kinase MSK.AA Ciliate-E2 274-530 25 3.1e-77 262.89 In-house 7-365 (365) Show / Hide 
Range on Protein: 274-530
Range on HMM: 7-365/365
Sequence Identity: 25% (97 aa)

IGDGSFSICRRCTHRKTE-----------------------KEYAVKIVSRR--VACTQEITTL--------QLCQ--------KHPNIVHLKEEFK--D
|| |.|.. ..|...|.                        |.||.||.. .   .  |||  .        .. .        .||||. ..| |.  |
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKD

KLHTYIIMELCKGGELLGRIRKKKH-----------FDELEASMIMRKLVS---------------AVDYMHSRG-IVHRDLKPENILFTDDSDDAELKI
. . |..||.|.||.|. .|...|.           |.| |.. ||.....               |. |.||.. |.|||.|||||||        .||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKI

IDFGFARITNSNQP---------LKTPCF------------------------SLHFAAPEVLK-RAYE--QDGE-YDASCDVWSLGVILYTMLSGRVPF
||||.... . ..          ...  .                        .... |||.|.   |.  |... || .||.|||||||| ||.|. ||
IDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

QDPSISKSNSASDIMKRIKHGNFSFDGEE--------------WNSVSTPAKDLIKG----LLTVDPSRRLT-TDDLLQNEWI
              .. || ....|. .|              |...|  .|||||     .| .||. |.|  ...|...|.
--------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MSK.AA TyrKc 268-529 20 2.2e-12 -22.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 268-529
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

DMKSAPIGDGSFSICRRCTHR-----KTEKEYAVKIVSRRVACTQEITTLQLC-QKHPNIVHLKEEFKDK-------LHTYIIMELCKGGELLGRIRKKK
  .   .| | | . ...| .     |. ||.|      | .  .|.  .     .||||| |     ..          .|.||....| |. ..||..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

HFDELEASMIMRKLVS-------AVDYMHSRGIVHRDLKPENILFTDDSDDAELKIIDFGFARITNSN------QPLKTP-----C---FSLHFAAPEVL
.         |..|.|         .| ||....||||   |.| ...      || ||| .|   .       .  ...     .   . .   |||..
PK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KRAYEQDGEYDASCDVWSLGVILYTMLS-GRVPFQDPSISKSNSASDIMKRIKHGNFSFDGEE-----WNSVSTPAK--DLIKGLLTVDPSRRLTTDDLL
     ..|..    |||| || .. ... |  |  ..      |........|.|.     ..        |  |..  ...|     ||. | |  .. 
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI-

QNEW
  ..
HECF
Kinase MSK.AA APH 378-411 22 9.3e-05 17.11 Pfam 170-204 (248) Show / Hide 
Range on Protein: 378-411
Range on HMM: 170-204/248
Sequence Identity: 22% (8 aa)

RGIVHRDLKPENILFTDDSDDAELK--IIDFGFARI
....|.|..| |.....  .| .    .||...|..
PCWCHGDFHPGNVMWDP-RPDGGRVTGVIDWDDACW
Kinase MSK.AA Pkinase_Tyr 333-385 28 0.000109 16.5 Pfam 81-137 (270) Show / Hide 
Range on Protein: 333-385
Range on HMM: 81-137/270
Sequence Identity: 28% (16 aa)

HTYIIMELCKGGELLGRIRK----KKHFDELEASMIMRKLVSAVDYMHSRGIVHRDL
. ||.||....| ||   ||    |....  .   . .   .. .| .|....||||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase MSK.AA CDPK 269-300 34 0.000598 8.24 In-house 1-35 (271) Show / Hide 
Range on Protein: 269-300
Range on HMM: 1-35/271
Sequence Identity: 34% (12 aa)

MKS-APIGDGSFSICRRCTHR-KTEKEY-AVKIVS
.|   ..| |.|.  |...|. ||  |  |.||..
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIP