Gene PKG1 (Sea Urchin)

PKG1

Species: Sea Urchin
Alias: Spk020, SPU_016494, SpPRKG1, PKG1
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
PKG1.AA Protein None 292 None Fasta, JSON
PKG1.kin_dom Protein Kinase Domain None 231 None Fasta, JSON

Protein domain

Protein domains of PKG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PKG1.AA PKG 6-240 76 6.8e-198 663.72 In-house 18-260 (260) Show / Hide 
Range on Protein: 6-240
Range on HMM: 18-260/260
Sequence Identity: 76% (185 aa)

VRLDG-SNQTYALKQLKKRHIVETRQQEHIMSEKNIMLEARCDFIVRLYCTFKDNKYLYMLLEACLGGEL-------GSFDDSTTRFYTACVTEALAYLH
|.. . ...|.|||..||||||.||||||||||||||.|.|||||||||.||.|.||.|||.|||.||||       |.|||.|||||.|||.||..|||
VQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKTTRFYCACVVEAFDYLH

NKGIVYRDLKPENILLDNKGYGKLVDFGFAKRIGHGRKTWTFCGTPEYVAPEIILNRGHDLSADYWSLGILMFELLTGSPPFTGSDPMKTYNIILKGMDM
.|.|.||||||||..|||.|| |||||||||.||.|||||||||||||||||||||.|||.|.|||.|||||.|||||.|||.||||||||||||||.||
RKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFSGSDPMKTYNIILKGIDM

IEFPRKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
.||||||||.|.|||||||.|||||||||||.|..||.|||||
WEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKG1.AA AGC 9-240 29 1.2e-147 384.71 In-house 27-395 (395) Show / Hide 
Range on Protein: 9-240
Range on HMM: 27-395/395
Sequence Identity: 29% (110 aa)

DGSNQTYALKQLKKRH-IVETR--QQEHIMSE------------KNIMLEAR----------CDFIVR-LYCTFKDNKY--LYMLLEACL---------G
..... ||.| |||.| ||...  ..||.|.|            .||. ...          ..|||. |...|.|...  ||...| .          |
KDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGG

G-EL----------GSFDDSTTRFYTAC-------VTEALAYLHN-KGIVYRD-LKPENILLDNKGYGKLVDFGFAKRIGHGR-----------------
| ||          |.|| ...|||.|.       .. || |||. .||..|| |||||||||..|. ||.|||..|..  ..                 
GCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNK

----------------------------------KTWTFCG--TPEYVAPEIILNRGHDLSADYWS--LGILMFELLTGSPPFTGS----------DPMK
                                  .||||||  ||||.||||.    .. ..|.||  ||.||.|.||| |||.|           .||.
KYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPME

TYNIILKG----MDMIEFP----------RKITRNAANMIKKLCKDNPTERLGYQKS-----GLKDIQKHKWF
... |..|    .. ..||          |... .| . ||||.. .|..|||....     | ..|..|.||
MFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKG1.AA PKA 6-240 46 1.2e-102 347.29 In-house 18-263 (263) Show / Hide 
Range on Protein: 6-240
Range on HMM: 18-263/263
Sequence Identity: 46% (117 aa)

VRLDGSNQTYALKQLKKRHIVETRQQEHIMSEKNIMLEARCDFIVR-LYCTFKDNKYLYMLLEACLGGEL-------GSFDDSTTRFYTA-CVTEALAYL
.|  .| . ||.|.|||. || ..|.||...||||... .  |||. .| ||.|..||||..| . |||.       |.|. ....|| |  .. || ||
CRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNPHAKFYAASQIVLALEYL

HNKGIVYRDLKPENILLDNKGYGKLVDFGFAKRIGHGRKTWTFCGTPEYVAPEIILNR-GHDLSADYWSLGILMFELLTGSPPFTGS--DPMKTYNIILK
|.. |.||||||||||.|..|. |. ||||||..     ||| |||||| |||||... ||  | | |.|||| .|.|.| |||. .  |||..|. |..
HSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICN

GMDMIEFPRKITRNA---ANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
|   |.||| .. .|      ||||   ..|.|.| .|.|  || .||||
G--KIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKG1.AA RSK 11-240 38 1.5e-85 290.57 In-house 23-278 (278) Show / Hide 
Range on Protein: 11-240
Range on HMM: 23-278/278
Sequence Identity: 38% (98 aa)

SNQTYALKQLKKRHIVETRQ-QEHIMSEKNIMLEAR-CDFIVRLYCTFKDNKYLYMLLEACLGGELGS----------FDDSTTRFYTACVTEALAYLHN
..| || |.|||. || .   ..| | | ||... . . |||.|. .|.....||. .| | ||||.           |. .. .|| | .. |. .|| 
TGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQ

KGIVYRDLKPENILLDN---KGYGKLVDFGFAKR--IGHGRKTWTFCGTPEYVAPEIIL----NRGHDLSADYWSLGILMFELLTGSPPFTG---SDPMK
.||..|||||||||.|.    |  ||.||||.|   . |. .| |||.| ||.|||..     ..||| ..|.||||.||.|.||| |||.|   ... .
QGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKE

TYNIILKGMDMIEFP--RKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
. . |.||    ..|   .....| . |.|. . .|  |||. ......|..|.||
IMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKG1.AA Akt 15-240 39 8.5e-82 261.25 In-house 27-264 (264) Show / Hide 
Range on Protein: 15-240
Range on HMM: 27-264/264
Sequence Identity: 39% (94 aa)

Y-ALKQLKKRHIVETRQQEHIMSEKNIMLEARCDFIVRLYCTFKDNKYLYMLLEACLGGELGS-------FDDSTTRFYTACVTEALAYLHNKGIVYRD-
| |.| |||..|.. .| ||.. |.||    .. ||| |.  | ....||. .. | |||| .       |. ...||| | .  |. .||.|.|.||| 
YYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFYCAEIILAIEHLHSKNIIYRDY

LKPENILLDNKGYGKLVDFGFAK-R-IGHGRKTWTFCGTPEYVAPEIILNRGHDLSADYWS-LGILMFELLTGSPPFTGSDPMKTYNIILKGMDMIEFP-
|||||||.|..|. .| ||| .|   | .. || |||||||| ||||... ||. ..| |. ||..|.|...| |||   |  . .  |.  .  ..|| 
LKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIK--NQPVKFPD

-RKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
 ..|  .. . |..|.. .|..|||. ......|. | ||
KDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKG1.AA AktR 11-240 38 1.7e-79 270.37 In-house 24-268 (268) Show / Hide 
Range on Protein: 11-240
Range on HMM: 24-268/268
Sequence Identity: 38% (95 aa)

SNQTYALKQLKKRHIVETRQQEHIMSEKNIML-EARCDFIVRLYCTFKDNKYLYMLLEACLGGELGS-------FDDSTTRFYTACVTEALAYLHNK-GI
... ||.| .|| .|.| .|..|.  |.|||  ...  |||.|. .|.....|. ..| | |||| .       |. ...||| | .  || |||..  |
NQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQARFYFAQILLALEYLHQHMNI

VYRDLKPENILLDNKGYGKLVDFGFAK-RIG--HGRKTWTFCGTPEYVAPEIILN-RGHDLSADYWSLGILMFELLTGSPPFTGSDPMKTYNIILKGM-D
.||||||||||||  |. |..||| .|  .      |. .|||||||.|||.|..  ||. |.|.|..||. .|..|| |||. ..    .  |.. .  
IYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQN

MIEFPRKITRNAANMIK-KLCKDNPTERLGYQKSGLKDIQKHKWF
 ...| ... .. . |. || ..||..||||...| ..| .|.||
KFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKG1.AA SGK 15-240 37 3.1e-76 234.81 In-house 45-283 (283) Show / Hide 
Range on Protein: 15-240
Range on HMM: 45-283/283
Sequence Identity: 37% (90 aa)

YALKQLKKRHIV-------ETRQQEHIMSEK-NIMLEARCDFIVRLYCTFKDNKYLYMLLEACLGGELG-------SFDDSTTRFYTACVTEALAYLHNK
||.| |.| ||.          .| |||.|. .|.   .  ||| |   |   ..||. ..   |||..       .|  .  |||.| .  || ||| .
YAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQ

GIVYRDLKPENILLDNKGYGKLVDFGFAK-RIGHGRKTWTFCGTPEYVAPEIILNRGHDLSADYWSLGILMFELLTGSPPFTGSDPMKTYNIILKGMDMI
 |.|||||||||||| .|. .| ||| .|  | .  .| |||||||| |||... ..|| . | |.||....|...| |||   .    |  |...   .
DIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQ--PL

EFPRKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
 .|. ..  |  .|. | . .|..|||  | .  .|..| .|
QIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase PKG1.AA Pkinase 7-240 30 8e-76 263.0 Pfam 19-293 (293) Show / Hide 
Range on Protein: 7-240
Range on HMM: 19-293/293
Sequence Identity: 30% (87 aa)

RLDGSNQTYALKQLKKRHIVETRQQEHIM-SEKNIMLEARCDFIVRLYCTFKDNKYLYMLLEACLGG----ELG---------SF--DDSTTRFYTACVT
.  |.....|.|..||||. .  .|.|.  ||  ||.. ....|||||..| |....|| .| | ||    .|          .|  .. . .||   . 
HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQIL

EALAYLHNKGIVYRDLKPENILLDNKGYG----KLVDFGFAKR--IGHGRKTWTFCGTPEYVAPEIIL-NRGHDLSADYWSLGILMFELLTGSPPFTGS-
..|.|.|..||..|||||||||.||.|.     |. |||.||   . ... ..||||||.|.|||.|. ..... ..| ||.|....|.|.| ||| |. 
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC

-----DPMKTYNIILKGMDMIEFPRKIT-------------------RNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
     |.|. .. |...  . ..| ...                   ...   ||.... .|..|..      ..| .|.||
WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PKG1.AA p70 11-240 37 4.6e-73 249.04 In-house 26-299 (299) Show / Hide 
Range on Protein: 11-240
Range on HMM: 26-299/299
Sequence Identity: 37% (103 aa)

SNQTYALKQLKKRHIVETRQQ-EHIM-------------------------SEKNIMLEARCDFIVRLYCTFKDNKYLYMLLEACLGGEL-------GSF
... || |.|.|. || .    .|                            | ||  |    ||. |   |..|  || .||   ||||       | .
TGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIW

DDSTTRFYTACVTEALAYLHNKGIVYRDLKPENILLDNKGYGKLVDFGFAK-RIGHGRK----------TWTFCGTPEYVAPEIILNRGHDLSADYWSLG
.  |..|| . .. || .|| .||.||||||||..|. .|  .| |||  |  |  | .          |.|||||.|| ||||..  ||.   |.||||
MEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLG

ILMFELLTGSPPFTGSDPMKTYNIILKGMDMIEFPRKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWF
.||.  |||.|||||. . || . ||||   .. | . |  .  .|||| | .||.|.|   .  .|||.|..|
CLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase PKG1.AA Ciliate-E2 12-240 25 8.3e-70 238.22 In-house 47-365 (365) Show / Hide 
Range on Protein: 12-240
Range on HMM: 47-365/365
Sequence Identity: 25% (84 aa)

NQTYALKQLKKRHIVETRQQEHIM----------SEKNIMLEARCDFIVRLYCTFK--DNKYLYMLLEACLGGELGS------------------FDDST
.. ||.|..||. | .. | .|||           ||||. .  ...|...| .|.  |....|. .| | ||.| .                  |..  
IKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKE

TR---------------FYTACVTEALAYLHNKG-IVYRDLKPENILLDNKGYGKLVDFGFAKRIGHG--------------------------------
 .               || ||. .|| |||.|. |..||.||||||.      |..|||..|..                                   
IKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQ

RKTWTFCGTPEYVAPEIILNRG---------HDLSADYWSLGILMFELLTGSPPFTGSDPMKTYNIILKGMDMIEFPR----------------KITRNA
  ..|.||||.|.||||. . .         .| ..|.||||....|.|.| |||        ...|...   . .|                 |.. ..
NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQEC

ANMIKK----LCKDNPTERLGYQKSGLKDIQKHKWF
 ..|||    . . .| .|..    | ..| .|.||
KDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKG1.AA S_TKc 6-240 32 8.5e-69 235.78 SMART 18-231 (231) Show / Hide 
Range on Protein: 6-240
Range on HMM: 18-231/231
Sequence Identity: 32% (81 aa)

VRLDGSNQTYALKQLKKRHIVETRQQEHIMSEKNIMLEARCDFIVRLYCTFKDNKYLYMLLEACLG--GELGS-------------FDDSTTRFYTACVT
.|  .... .|.|..|          |||..| .|. . ....||.|| .| | ..||| .| | |  |.| .             |.  ..|||.. . 
CRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQIC

EALAYLHNKGIVYRDLKPENILLDNKGYGKLVDFGFAKRIGHGRKTWTFCGTPEYVAPEIILNRGHDL-SADYWSLGILMFELLTGSPPFTGSDPMKTYN
.||.|.|..||..|||||||||||.    |. |||.|...       ||||||.|.|||..   |..  ..| ||.|....|.|.| |||   .......
CALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFK

IILKGMDMIEFPRKITRNAANMIKKLCKDNPTERLGYQKSGL--KDIQKHKWF
.|.            .. | ..|.|... .|..|..  .      || .| ||
KIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKG1.AA MAST 11-128 32 3.3e-41 123.2 In-house 23-150 (337) Show / Hide 
Range on Protein: 11-128
Range on HMM: 23-150/337
Sequence Identity: 32% (42 aa)

SNQTYALKQLKKRHIVETRQQEHIMSEKNIMLEARCDFIVRLYCTFKD--NKYLYMLLEACLGG-------ELG-SFDDSTTRFYTACVTEALAYLHNKG
.|...|.| .... .    |......|.||  .. ..|.| ....|     |||.| .|   ||        .| ... . ...|.|    .| |||..|
TNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMPEWMAKMYIAETVLCLEYLHSYG

IVYRDLKPENILLDNKGYGKLVDFGFAK
|| |||||.|.|.| .|  ||.|||..|
IVHRDLKPDNMLIDSNGHIKLTDFGLSK
Kinase PKG1.AA MAST 140-240 38 3.6e-40 119.96 In-house 229-337 (337) Show / Hide 
Range on Protein: 140-240
Range on HMM: 229-337/337
Sequence Identity: 38% (43 aa)

CGTPEYVAPEIILNRG-HDLSADYWSLGILMFELLTGSPPFTGSDPMK-TYNIILKGMDMIEFPRK--------ITRNAANMIKKLCKDNPTERLGYQKS
||||.| |||.|| .| .  ..|.||.|| |.|.|.|.||| |. | . . . |..  ..||.| .        ..  |   ||||   || .||| .  
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGAN--

GLKDIQKHKWF
| ..| .|. |
GADEIKQHPFF
Kinase PKG1.AA S_TK_X 241-292 19 6.3e-12 46.86 SMART 1-79 (79) Show / Hide 
Range on Protein: 241-292
Range on HMM: 1-79/79
Sequence Identity: 19% (16 aa)

DGFNWEGLRK--RSLTPPIVPTVR----SNSDASNFD-DYPP---DHEAAPEDD-------------------TSGWDKDF
.|..|..|..  . ..||..|...    |  |.|||| ...    .  . | |.                     |....|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
TyrKc PKG1.AA TyrKc 2-234 19 2e-09 -70.37 SMART 19-280 (280) Show / Hide 
Range on Protein: 2-234
Range on HMM: 19-280/280
Sequence Identity: 19% (54 aa)

KWNWVRLDGSNQTYALKQLKKRHIVETRQQEHIMSEKNIMLEA--RCDFIVRLYCTFKDN-------KYLYMLLEACLGGELGS--------FDDSTTRF
.|.        .. | | ||. .      .| .|.| .|| .   . . |||||    .        . |....| . .| | .        .  ..   
TWK--------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLS

YTACVTEALAYLHNKGIVYRDLKPENILLDNKGYGKLVDFGFAKRIGHG-----RKTWTFC----GTPE-----YVAPEIILNRGHDLSADYWSLGILMF
.   . .  .||| |... |||   |.|.....  |  ||| .. |...     .|         |.         ||| |  .      | || |..|.
FCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMW

ELLT-GSPPFTG-----SDPMKTYNIILKGMDMIEFPRK--------ITRNAANMIKKLCKDNPTERLGYQKSGLKDI
|..| | .|  |      ..   .. . .|. . . |           .    ...|. .. .| .|   .    ...
EIFTYGQQPYPGMIQQMMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF