Gene PKG2 (Sea Urchin)

PKG2

Species: Sea Urchin
Alias: Spk021, PKG2, SPU_004964
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: PKG

Sequence

Name Sequence Type Origin Length Description Download
PKG2.AA Protein None 646 None Fasta, JSON
PKG2.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of PKG2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CNMP PKG2.AA cNMP 21-134 27 6.2e-25 90.07 SMART 1-123 (123) Show / Hide 
Range on Protein: 21-134
Range on HMM: 1-123/123
Sequence Identity: 27% (34 aa)

FTKNFDSSQTREIVECMFPIDYKKGQIVINEGDSGAHFYVGATGTLEVSQG---------DRVLATMGPGKVFGELAILYNCTRTATITAV-TDAQVWAI
. || | .. ||....|.|  |..|.... .|| | |||.  .|...| .          . .....||| .|||||.| . .|||...|. .....| |
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL-RRPRTAAARACCECCTIWRI

DRKVFQLIMMKTGMQRHEEYFNFL
|.. |. .... ..   ..  ...
DFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG2.AA cNMP_binding 39-124 34 6.5e-23 81.32 Pfam 1-91 (91) Show / Hide 
Range on Protein: 39-124
Range on HMM: 1-91/91
Sequence Identity: 34% (32 aa)

PIDYKKGQIVINEGDSGAHFYVGATGTLEVSQGDRVLA-----TMGPGKVFGELAILYNC-TRTATITAVTDAQVWAIDRKVFQLIMMKTGM
.. ||||.... .|| . |||.  .|...|.. |         ..||| .|||.|...|. .||||..|.||...|.|.|..|. .|..   
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQILGFLGPGDFFGEMALFTNQNPRTATVVALTDCECWRIPREDFRQLMQQHPE
CNMP PKG2.AA cNMP 139-262 32 1.8e-27 98.52 SMART 1-123 (123) Show / Hide 
Range on Protein: 139-262
Range on HMM: 1-123/123
Sequence Identity: 32% (41 aa)

LLKDLSSDNLFKLANSLEVDFFHEGEYIIVEGSRGDTFYIISKGEVRITQS---VQGQREPQEVRSLQKGDFFGEKALLGEDVRTANVLASKGGCECLAV
..|.|. . | .|....|. ..  ||||. .| .||.||||..|.||...    . .. . |.|. |..|||||| |||    |.... | .  ||| ..
MFKNLDEQELRELCDHMEPRHYPAGEYIFRQGDPGDHFYIIVSGWVRVYKTRVQHMEDGREQIVGFLGPGDFFGELALL----RRPRTAAARACCECCTI

DRQSFNELIGNMQALQDKNYGDKERGA
.| .|.......|. ... | . .. |
WRIDFQHFMQQLQQHPQHMYRMLQQLA
CNMP_binding PKG2.AA cNMP_binding 157-249 35 9.5e-23 80.75 Pfam 1-91 (91) Show / Hide 
Range on Protein: 157-249
Range on HMM: 1-91/91
Sequence Identity: 35% (33 aa)

VDFFHEGEYIIVEGSRGDTFYIISKGEVRITQSVQGQREPQEVRSLQKGDFFGEKALLGED-VRTANVLASKGGCECLAVDRQSFNELIGNMQA
|  ...||.|. .| ..| |||. .|.|....  .. ||   .. |..|||||| ||....  |||.| |  . |||....|..|..|. .  .
VRHYKKGEVIFHQGDPCDHFYIVLSGKVKVYK-DEDGREQ-ILGFLGPGDFFGEMALFTNQNPRTATVVA-LTDCECWRIPREDFRQLMQQHPE
Kinase PKG2.AA PKG 337-595 79 3e-228 764.57 In-house 1-260 (260) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-260/260
Sequence Identity: 79% (207 aa)

LDIIATLGVGGFGRVELVQLAGDK-RTFALKCLKKHHIVETRQQEHIFSEKKIMMESSSPFIVKLFKTFRDQKYIYMLMEVCLGGELWTILRDKGHFDDR
|.|||||||||||||||||....| |||||||.||.|||.|||||||.|||.||||....|||.|..|||||||.|||||.|.||||||||||.|||||.
LKIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDK

TARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSCDYWSLGILIFELLTGNPPFT
|.|| .|||||||.|||...|.|||||||||.|||.||.||||||||||||.|||||||||||||||||||||||||.|.|||.||||..|||||||||.
TTRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFS

ANDPMKTYNVILKGIDMVEFPRKIPRSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
..|||||||.|||||||.||||||.|.| |.||.||||||.||.|||||||.||||||||
GSDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PKG2.AA AGC 337-595 29 1.4e-166 434.75 In-house 1-395 (395) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-395/395
Sequence Identity: 29% (118 aa)

LDIIATLGVGGFGRVELVQLA------GDKRTFALKCLKKHH-IVETR--QQEHIFSE------------KKIMMESS----------SPFIVK-LFKTF
 ... ..| |.||.| ||.        . .. .|.|.||| | ||...  ..||. .|            ..|... .          .||||| |. .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RDQKY--IYMLMEVCL---------GG-ELWTILR---DKGHFDDRTARFSTAC-------VVEAFHYLHS-RGIVYRD-LKPENLLLDNKGYVKLVDFG
 |...  .|..|| .          || ||...|.   ..|.||  .||| .|.       .| |..|||| .||..|| |||||.|||..|..||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKIGFGR---------------------------------------------------KTWTFCG--TPEYVAPEIILNKGHDLSCDYWS--LGILIF
..|..  ..                                                   .||||||  ||||.||||.    .. .||.||  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLTGNPPFTAN----------DPMKTYNVILKGI----DMVEFP----------RKIPRSAGNLIKRLCRDNPGERIGYQKN-----GISDIKKHKWF
|.||| |||...          .||.... |..|.    . |.||          |..   | .|||.|.  .| .|.|...|     |...||.|.||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKG2.AA PKA 337-595 48 1.6e-121 409.99 In-house 1-263 (263) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-263/263
Sequence Identity: 48% (130 aa)

LDIIATLGVGGFGRVELVQLAGDKRTFALKCLKKHHIVETRQQEHIFSEKKIMMESSSPFIV-KLFKTFRDQKYIYMLMEVCLGGELWTILRDKGHFDDR
 .||.||| | ||||.|..  .... .|.|.|||. || ..|.||. .||.|... ..|||| |.  || | .|.||.|| . |||. . || .|.|.  
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

TARFSTA-CVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNK-GHDLSCDYWSLGILIFELLTGNPP
.|.|  |  .| |. ||||  |.||||||||.|.|..|..|. |||||||.     ||| |||||| |||||..| ||  | | |.|||||.|.|.| ||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPP

FTAN--DPMKTYNVILKGIDMVEFPRKIPRSA---GNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
|...  |||..|. |..|   ..||| .   |     |||.|   .. .|.| .|||. |||.||||
FYDHNRDPMQIYEKICNGK--IKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PKG2.AA AktR 338-595 40 9.1e-102 344.39 In-house 2-268 (268) Show / Hide 
Range on Protein: 338-595
Range on HMM: 2-268/268
Sequence Identity: 40% (108 aa)

DIIATLGVGGFGRVELVQLA-GDKRTFALKCLKKHHIVETRQQEHIFSEKKIMM-ESSSPFIVKLFKTFRDQKYIYMLMEVCLGGELWTILRDKGHFDDR
.... || |.||.| |||    ... .|.| .||..|.| .|..|.  |..||  ... ||||||...| ...... .|| | |||| ..|. |..|.  
HVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEE

TARFSTACVVEAFHYLHSR-GIVYRDLKPENLLLDNKGYVKLVDFGFAK---KIGFGRKTWTFCGTPEYVAPEIILN-KGHDLSCDYWSLGILIFELLTG
.|||  | .. |. |||..  |.||||||||.|||  |.||..||| .|   ..    |. .|||||||.|||.|.. |||. |.|.|..||.|.|..||
QARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTG

NPPFTANDPMKTYNVILKGIDM---VEFPRKIPRSAGNLIK-RLCRDNPGERIGYQKNGISDIKKHKWF
.|||....  ........ | .   ...| ..   . .||. .|  .|| .|.||..||...||.|.||
CPPFYHKN--QNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PKG2.AA RSK 340-595 37 5.9e-94 318.45 In-house 1-278 (278) Show / Hide 
Range on Protein: 340-595
Range on HMM: 1-278/278
Sequence Identity: 37% (104 aa)

IATLGVGGFGRVELVQLA---GDKRTFALKCLKKHHIVETRQ-QEHIFSEKKIMMESS-SPFIVKLFKTFRDQKYIYMLMEVCLGGELWTILRDKGH---
.  || ||.| | |..       .. .| | |||. || .   ..| . | .|....  .||||.|. .|......|. || | |||| | |. ..|   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDDRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDN---KGYVKLVDFGFAKK--IGFGRKTWTFCGTPEYVAPEIIL----NKGHDLSCDYWSLGI
|. ..|.|  | .| |  .||..||..||||||| |.|.    | .||.||||.|.  . .. .| |||.| ||.|||..     ..||| .||.||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIFELLTGNPPFTA---NDPMKTYNVILKGIDMVEFP--RKIPRSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
|..|.|||.|||..   |.. .. . |.||   ...|   .. . | .||...   .|  |.|. ......||.|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PKG2.AA Pkinase 337-595 30 4.8e-92 316.89 Pfam 1-293 (293) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

LDIIATLGVGGFGRVELVQLAGDKRTFALKCLKKHHIVETRQQEHIF-SEKKIMMESSSPFIVKLFKTFRDQKYIYMLMEVCLGG----ELWTILR--DK
. |. ..| |.||.| . .  |. ...|.|..||.|. .  .|.|.  || .|| . ..|.||.|. .|.| ..||| || | ||    .|.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GHF--DDRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYV----KLVDFGFAKK--IGFGRKTWTFCGTPEYVAPEIIL-NKGHDLSCDYWSL
| |  ......|    ....  |.||.||..|||||||.|.||.|..    |. |||.||.  .  .. ..||||||.|.|||.|. ..... ..| ||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GILIFELLTGNPPFTAN------DPMKTYNVILKGIDMVEFPRKIP-------------------RSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
|....|.|.|.|||         |.|. .. |.... . ..| ...                   ...  .||.... .| .|..     . .|..|.||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PKG2.AA Akt 338-595 40 6.4e-91 290.88 In-house 2-264 (264) Show / Hide 
Range on Protein: 338-595
Range on HMM: 2-264/264
Sequence Identity: 40% (106 aa)

DIIATLGVGGFGRVELVQLAGDKRTF-ALKCLKKHHIVETRQQEHIFSEKKIMMESSSPFIVKLFKTFRDQKYIYMLMEVCLGGELWTILRDKGHFDDRT
|..  || | ||.| ||.   ... . |.| ||| .|.. .| ||.. |..|     .||||.|   | .|...|. |. | |||| . |. |. |.  .
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

ARFSTACVVEAFHYLHSRGIVYRD-LKPENLLLDNKGYVKLVDFGFAK-K-IGFGRKTWTFCGTPEYVAPEIILNKGHDLSCDYWS-LGILIFELLTGNP
|||  | .. |  .|||..|.||| |||||.|.|..|...| ||| .|   |  . || |||||||| ||||....||. ..| |. ||....|...|.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRP

PFTANDPMKTYNVILKGIDMVEFP--RKIPRSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
|| . |  . .  |. .   |.||  ..|   . .||..|.  .| .| |. .|.. .|| | ||
PFYNQDHHQMFKKIKNQ--PVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PKG2.AA S_TKc 337-595 32 1.8e-90 307.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

LDIIATLGVGGFGRVELVQLAGDKRTFALKCLKKHHIVETRQQEHIFSEKKIMMESSSPFIVKLFKTFRDQKYIYMLMEVCLG--GELWTILRDKGH---
 .|. ..| |.||.| ...  ...| .|.|..|          ||| .| .|...   |.||||. .|.| ...|| || | |  |.| ......|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDDRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAKKIGFGRKTWTFCGTPEYVAPEIILNKGHDL-SCDYWSLGILIFEL
   |.  .||| .. ...|  |.||.||..|||||||.|||.   .|. |||.|...       ||||||.|.|||..   |..  .|| ||.|....|.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTGNPPFTANDPMKTYNVILKGIDMVEFPRKIPRSAGNLIKRLCRDNPGERIGYQKNGI--SDIKKHKWF
|.| |||   ........|.            ...| ..|..... .| .|..  .     .|||.| ||
LCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKG2.AA Ciliate-E2b 337-595 34 3e-89 271.33 In-house 1-272 (272) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-272/272
Sequence Identity: 34% (94 aa)

LDIIATLGVGGFGRVELVQL-AGDKRTFALKCLKKHHIVETRQQEHIFSEKKIMMESSSPFIVKLFKTFRDQKYIYMLMEVCLGGELWTILRDKG--HFD
...|  || | || | ||.    .|. .|.|| .|  |...    |. .||...     |||.|....|.| ...|..|| | |.|| ...|. |   . 
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLS

DRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAKKIGFGRK----TWTFCGTPEYVAPEIIL-----NKGHDLSCDYWSLGILI
   ..| .| .. .. |||...|.|||.|||| ..|.|||.||.|.| || .         | | .|||.| |||||      .||   . | ||.||  
TYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICL

FELLTGNPPFT--ANDPMKTYNVILKGIDMVEFPRKIPRSAG--NLIKRLCRDNPGERIGYQKNGISDIKKHKWF
.|.. | .|..  . ||   |  |.|. | ..||  .       .|. ..   .|  | |     .|  | |.||
YEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGS---YSWLKSHPWF
Kinase PKG2.AA SGK 338-595 35 4.6e-86 265.7 In-house 2-283 (283) Show / Hide 
Range on Protein: 338-595
Range on HMM: 2-283/283
Sequence Identity: 35% (100 aa)

DIIATLGVGGFGRVELVQLAGD------------------KRTFALKCLKKHHIV-------ETRQQEHIFSEK-KIMMESSSPFIVKLFKTFRDQKYIY
|.. ..| |.||.| .|.  .|                  .  .|.| |.| ||.          .| || .|. .|.   ..||||.|   |  ... |
DFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKLY

MLMEVCLGGELWTILRDKGHFDDRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAK-KIGFGRKTWTFCGTPEYVAPEIILNKG
. |.   |||.   |.  .||    ||| .| .| |  ||||  |.||||||||.||| .|...| ||| .| .|    .| |||||||| |||... ..
FVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQP

HDLSCDYWSLGILIFELLTGNPPFTANDPMKTYNVILKGIDMVEFPRKIPRSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWF
|| . | |.||.. .|...| |||  ..    |  |...     .|. .  .|  ||. |   .| .| |  |..  .||.| .|
HDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQ--PLQIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase PKG2.AA Ciliate-E2 337-595 24 1.8e-78 267.03 In-house 1-365 (365) Show / Hide 
Range on Protein: 337-595
Range on HMM: 1-365/365
Sequence Identity: 24% (92 aa)

LDIIATLGVGGFGRVELVQLAGDKR-----------------------TFALKCLKKHHIVETRQQEHIF----------SEKKIMMESSSPFIVKLFKT
 ..|  .| |.|| | ...   ...                        .|.|..||  | .. | .||.           ||.|. . ..|.|.|.. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FR--DQKYIYMLMEVCLGGELWTILR------------DKGHFDDRTAR---------------FSTACVVEAFHYLHSRG-IVYRDLKPENLLLDNKGY
|   |...||. || | ||.|. ...            | . |... ..               |  ||...|..||||.. |..||.||||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKLVDFGFAKKIGFG--------------------------------RKTWTFCGTPEYVAPEIILNKG---------HDLSCDYWSLGILIFELLTGNP
.|..|||..||.                                     ..|.||||.|.||||. .|.         .| .||.||||....|.|.|.|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTANDPMKTYNVILKGIDMVEFPR----------------KIPRSAGNLIKR----LCRDNPGERIGYQKNGISDIKKHKWF
||        .. |...     .|                 |.. .. .|||.    .   .| .||.    |...|..|.||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PKG2.AA Ciliate-E2-Unclassified 338-595 28 4.8e-78 265.6 In-house 2-352 (352) Show / Hide 
Range on Protein: 338-595
Range on HMM: 2-352/352
Sequence Identity: 28% (101 aa)

DIIATLGVGGFGRVELVQLAGDKRTFALKCLKKHHIVETRQQEH---------IFSEKK-------------IMMESSSPFIVKLFKTFRDQKYIYMLME
 || ..| |||| | ..|   .|  .|.| .||..|.  .|...         .  .||             |.  . .|||||.| .|.|...||. ||
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

VCLGGELWTILRDKGH-----------------FDDRTAR-----FSTACVVEAFHYLHSRG-IVYRDLKPENLLLDNKG---YVKLVDFGFAKKIGFG-
 | ||.|| .......                 |... |.     | .|...... |||. . |..||.||||.|.||.|   |.|. |||..||..   
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNN

---------------RKTWTFCGTPEYV----APEIILNKGHDLS----CDYWSLGILIFELLTGNPPFTANDPMK----------------TYNVILKG
                ..|||||||.|     |||.. ....| |    ||.||||....|.|.|..|| .|.  .                 |. |...
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

-IDMVEFP-----RKIPRSAGNLIK----RLCRDNPGERIGYQKNGISDIKKHKWF
 |.  .||      ... .| ..|.    ..   ||..||     ....|..| ||
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-----TFEQILNHPWF
Kinase PKG2.AA TyrKc 337-589 20 2.5e-11 -39.47 SMART 1-280 (280) Show / Hide 
Range on Protein: 337-589
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

LDIIATLGVGGFGRVELVQLAGDKRTFALKCLKKHHIVETRQQEHIFSEKKIMMES--SSPFIVKLFKTFRDQ-------KYIYMLMEVCLGGELWTILR
.  . .|| | ||.| . ..    .. | |.||...      .| . .| .||..   . | ||.|.   ..|       . ....|| . .| |   ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DKGHFDDRTARFSTACVV-------EAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFAKKIGFG-----RKTWTFC----GTPE-----YVAPEII
....       ....  .       .   ||||.... |||   | |..... ||  ||| ...|. .     .|         |.         ||| |
KHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LNKGHDLSCDYWSLGILIFELLT-GNPPFTA-----NDPMKTYNVILKGIDMVEFPRK--------IPRSAGNLIKRLCRDNPGERIGYQKNGISDI
  .      | || |....|..| | .|         ..   .. . .| .. . |           |    ...|. .. .| .|   .   ....
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase PKG2.AA S_TK_X 596-646 24 8.9e-09 36.41 SMART 1-79 (79) Show / Hide 
Range on Protein: 596-646
Range on HMM: 1-79/79
Sequence Identity: 24% (19 aa)

QGFDWEGLRK--QEIAAPLPPKVK----GSSDCSNFD-SYPK--DVDIPADE-------------------TSGWDEHF
 |.||..|..  .|| .|  ||.|    .  | ||||  ...  ... |.|.                     |..  |
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF