Gene LATS (Sea Urchin)

LATS

Species: Sea Urchin
Alias: Spk011, SPU_009470, LATS
External Links: Sea Urchin Project Link ,
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: LATS

Sequence

Name Sequence Type Origin Length Description Download
LATS.AA Protein None 1219 None Fasta, JSON
LATS.kin_dom Protein Kinase Domain None 322 None Fasta, JSON

Protein domain

Protein domains of LATS.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LATS.AA NDR 781-1102 52 4e-232 724.26 In-house 1-350 (350) Show / Hide 
Range on Protein: 781-1102
Range on HMM: 1-350/350
Sequence Identity: 52% (190 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEAD--NEWVVKLYYSFQDKDNLYFVMDYIPGGDLMS---LLIRLEI
|..||..|.|||||| |.|| ||...||.|..|| .....||..||.|||||.||||  |.||||||||||||..||.||.|.||||.|.   ||....|
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

FEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLCTG---------------------FRWTHDSKYYQ-KSGHARQDSMEPFD
|.||.|||||||.|.|||||||| .|||||||||.|.|.||||||||||||||                     |.|||.|.||| ...|..||.|....
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

TM-DGEKCKCINHFAHKEKELDLSSLDKRPLKTLERRRKRQQERCKAHSLVGTPNYIAPEVLTR-TGYTQLCDWWSVGVILYEMLVGQPPFHADSPAETQ
 . . .||||..         .... .|...|.|..|...|. ||.|.|.||||.|.||||... |||.|.|||||.|.|.||||||.|||..|.| ||.
SNPMNQKCKCHT---------QMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETC

WKVINWKQCL-----HIPSQAKLSRDASDFILRLCT-GPEERLGKNG--VLDIKSHPFF
.|..||||..     |.|..|.||..| | | |||.  |..|||..|  | .|||||||
MKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase LATS.AA AGC 781-1102 30 1e-185 485.4 In-house 1-395 (395) Show / Hide 
Range on Protein: 781-1102
Range on HMM: 1-395/395
Sequence Identity: 30% (134 aa)

FKKIKTLGIGAFGEVALARKV------DTNALYAVKKLRKLD-VIQRN--QAGHVKAE------------RDILAEAD----------NEWVVK-LYYSF
|. .|..| |.||.| |.||.      ||. .||.|.|.| . .....  .  |...|            |.||....          . ..|| |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKDN--LYFVMDYIP--------GGDLMSLLIRLE-----IFEEDLARFYIAE-------LVLAIESVHK-MDFIHRD-IKPDNILVDRDGHIKLTDFG
||||.  |||||.|.|        ||.....|.  .     .|.|. ||||.||       .|||.|. |. |..|||| .||.||| |.||||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCTG----------------FRWTHDSKYYQKSGHARQDSMEPFDTMDGEKCKCINHFAHKEKELDLSSLDKRPLKTLERRRKRQQE-----------RC
||.                 |.| |..|| | ..     .|.  . .                            | .........            | 
LCKEGMNDGEKGQQSQSNMKFHW-HNKKY-Q-KS-----NMD--T-N----------------------------K-CNPNNWQRNNMSQEDDTTRKKRD

KAHSLVG--TPNYIAPEVLTRTGYTQLCDWWS--VGVILYEMLVGQPPFHADSPA----------ETQWKVI------NWKQCL------HIPSQAKLSR
......|  ||.|.|||.|    |.. |||||  .|...||||.|.|||..|.|           |.  |..      |||. .      ..| . ..| 
RTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSP

DASDFILRLCT-GPEERLGKN-------GVLDIKSHPFF
.| |.| .|..  ||.||| .       |. .||.||.|
EAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase LATS.AA DMPK 781-926 50 6.5e-105 260.11 In-house 1-147 (270) Show / Hide 
Range on Protein: 781-926
Range on HMM: 1-147/270
Sequence Identity: 50% (74 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLE-IFEED
|. .|  | |.||||.. |   ||  || |.. | . . | .   .. ||||.. .. .|...|.| |||...||.||.| ||||| .|. | |  ..||
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLC
.||||.||.|||| |.|.| ..||||||||.|.|| ||||| ||| |
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSC
Kinase LATS.AA S_TKc 781-1102 29 3.9e-99 336.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 781-1102
Range on HMM: 1-231/231
Sequence Identity: 29% (100 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPG--GDLMSLLIRLEI---
.......| ||||.| ..|...|. ..|.|...           |.. |..|| . . ...||||..||| |.||.||.|..|  |||.... .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLCTGFRWTHDSKYYQKSGHARQDSMEPFDTMDGEKCKCINHFAHKEKE
   | |  ||||......|.|  |.. .||||.||.|||.|.  |||..||||.. .                                           
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

LDLSSLDKRPLKTLERRRKRQQERCKAHSLVGTPNYIAPEVLTRTGYTQ-LCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINWKQCLHIPSQAKLSR
                           ....|||.|.|||||   ||.   |||||.|.||||||.|.|||.     .. .|.|              |.
---------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SP

DASDFILRLCT-GPEERLGKNGVLD----IKSHPFF
.| ||| ....  ||.|..   .|     ||.||.|
EAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LATS.AA RSK 784-1102 32 3.7e-96 325.76 In-house 1-278 (278) Show / Hide 
Range on Protein: 784-1102
Range on HMM: 1-278/278
Sequence Identity: 32% (112 aa)

IKTLGIGAFGEVALARKV---DTNALYAVKKLRKLDVIQRNQ-AGHVKAERDILAEAD-NEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEI---
.| || |..|.| | ||.   ||. .||.| |.|  ..||.  . |...||.||..      .|.|.|.||... || .|.|..||.|   | . ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDR---DGHIKLTDFGLCTGFRWTHDSKYYQKSGHARQDSMEPFDTMDGEKCKCINHFAHKEKE
| || |.||.||.|||.|  |. ..||||.||.||| |    .|||||||||.|  |                                           
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQF-------------------------------------------

LDLSSLDKRPLKTLERRRKRQQERCKAHSLVGTPNYIAPEVLT----RTGYTQLCDWWSVGVILYEMLVGQPPFHA---DSPAETQWKVINWKQCLHIPS
                   | ..  .... ..| .|.|||.|.    . |... ||||| ||..||||.|.|||..   ....|.  .. . |  | .| 
-------------------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN

QAKLSRDASDFILR-LCTGPEERLG--KNGVLDIKSHPFF
 ..||..| |.| . |.  |. |||  .... .||.||.|
WQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase LATS.AA AktR 781-1102 33 5.9e-95 321.77 In-house 1-268 (268) Show / Hide 
Range on Protein: 781-1102
Range on HMM: 1-268/268
Sequence Identity: 33% (112 aa)

FKKIKTLGIGAFGEVALARKV-DTNALYAVKKLRKLDVIQRNQAGHVKAERDILA-EADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEIFEE
|. .| || ||||.| |..|  |.. .|| | ..| . |.|||. |.  ||.|.. ....   |||.|.||.|..|.|.|.|.|||.| . | . . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DLARFYIAELVLAIESVHKM-DFIHRDIKPDNILVDRDGHIKLTDFGLCTGFRWTHDSKYYQKSGHARQDSMEPFDTMDGEKCKCINHFAHKEKELDLSS
. ||||.|. .||.|  |.  . | ||.||.||| | |||.|.|||||                                                    
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

LDKRPLKTLERRRKRQQERCKAHSLVGTPNYIAPEVLTR-TGYTQLCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINWKQC--LHIPSQAKLSRDAS
             .   .. ||.|..||| |.|||..|.  |..  .|||..|. .|||..|.||| ...   ....... | .  . .|  ...|  . 
-----------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKN---QNQMFQKIKIKQQNKFPYPSYFSSQCK

DFILR--LCTGPEERLG--KNGVLDIKSHPFF
|.| |  ||  |..|||  .||  .|||||.|
DLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase LATS.AA MAST 781-925 46 9.5e-80 243.18 In-house 170-317 (337) Show / Hide 
Range on Protein: 781-925
Range on HMM: 170-317/337
Sequence Identity: 46% (69 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQD--KDNLYFVMDYIPGGDLMSLLIRLE-IFE
|. || .. ||.| | |... .|| ..| |.... | | .||  .|..||.||....|..|||..||||   |. |..||.|  |||  |||  .   ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGL
|..|..||||.||..|  |... .|||.||||.| | .||||||||||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS.AA MAST 781-925 48 1.2e-77 249.77 In-house 166-310 (334) Show / Hide 
Range on Protein: 781-925
Range on HMM: 166-310/334
Sequence Identity: 48% (71 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEIFEEDL
|. || .. ||.| | |... .|| ..|.|...| | | .|.  .|..||.|||...|..|||..|||| |..|..||.|  |||. |||  .  |.|..
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGL
|..||||.||..|  |... .|||.||||.| | .||||||||||
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGL
Kinase LATS.AA Akt 781-926 54 2.8e-72 230.35 In-house 1-148 (264) Show / Hide 
Range on Protein: 781-926
Range on HMM: 1-148/264
Sequence Identity: 54% (80 aa)

FKKIKTLGIGAFGEVALARKVDTNALY-AVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEIFEED
|  .| || |.|| | |..| ||. .| | | |.|   ||.||  |.|.|| ||   ..  .|.|.||||..|.|||||||..||.| ..| | ..| ||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

LARFYIAELVLAIESVHKMDFIHRD-IKPDNILVDRDGHIKLTDFGLC
 ||||.||..||||  |... | ||  || |||.|.||||.|||||||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase LATS.AA ROCK 781-926 51 3.4e-61 207.12 In-house 1-145 (263) Show / Hide 
Range on Protein: 781-926
Range on HMM: 1-145/263
Sequence Identity: 51% (75 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLEIFEEDL
|. || .| |||||| | |.  ..  ||.| | | ..|.|  .     ||||.| |  ||.|.|.| |||.  || ||||.|||||..|.   ..  |  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDV-PEKW

ARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLC
|||| .|.|||....| | |||||.||||.|.|. ||.|| ||| |
ARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTC
Kinase LATS.AA GEK 781-926 50 1.7e-60 201.69 In-house 1-147 (269) Show / Hide 
Range on Protein: 781-926
Range on HMM: 1-147/269
Sequence Identity: 50% (74 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGGDLMSLLIRLE-IFEED
|  .| .| |||||||  .  .|. .||.| | | ....|  .   . |||.| . |. |. .| | ||| ..||.||||  ||||. || . |    ||
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLC
.|||||||.|.||.|||.. ..||||||||.|.|. |||.| ||| |
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSC
Kinase LATS.AA DMPK 1003-1102 50 1e-59 145.8 In-house 162-270 (270) Show / Hide 
Range on Protein: 1003-1102
Range on HMM: 162-270/270
Sequence Identity: 50% (55 aa)

VGTPNYIAPEVLT--RTG----YTQLCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINW-KQCLHIPSQAK--LSRDASDFILRLCTGPEERLGKNGV
|||| ||.||||.   ..    |   ||||||||..||||.|. ||.||| .||  |  |  | .|  |.. |  .| .| |.| .| . .|||||.||.
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGY

LDIKSHPFF
 |.| ||||
EDFKCHPFF
Kinase LATS.AA Pkinase 781-926 33 6e-44 156.47 Pfam 1-159 (293) Show / Hide 
Range on Protein: 781-926
Range on HMM: 1-159/293
Sequence Identity: 33% (54 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVK-AERDILAEADNEWVVKLYYSFQDKDNLYFVMDYIPGG----DLMSLLI--RL
.......| |.||.| ......|. ..|||...| .     .  |.. .|  |... . . .|.||..|.|||..|.||.| .||    ||....   | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EIF--EEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHI----KLTDFGLC
  |  .|. ..||. ... ..|  |.| .||||.||.|||.|..|||    |..||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase LATS.AA MAST 1003-1102 44 1.1e-41 124.71 In-house 229-337 (337) Show / Hide 
Range on Protein: 1003-1102
Range on HMM: 229-337/337
Sequence Identity: 44% (48 aa)

VGTPNYIAPEVLTRTG-YTQLCDWWSVGVILYEMLVGQPPFHADSPAE-TQWKVINWKQCLHIPSQ------AKLSRDASDFILR-LCTGPEERLGKNGV
.||| ||||||....| | .  ||||.|.|.|| ||| ||| .|.| | .  ..|| .  .  |.        ..| .| | | . |   | .||| ||.
CGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGA

LDIKSHPFF
 .||.||||
DEIKQHPFF
Kinase LATS.AA MAST 1001-1102 40 9.5e-38 119.04 In-house 223-334 (334) Show / Hide 
Range on Protein: 1001-1102
Range on HMM: 223-334/334
Sequence Identity: 40% (45 aa)

SLVGTPNYIAPEVLTRTG-YTQLCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINWKQC-LHIPSQ------AKLSRDASDFILRLCTG-PEERLGKN
...||| ||||||....| . .  ||||.|.|.|| ||| |||  |.| |.  ...| .     .|         ..| .| | | .| .  |..||| |
QCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGAN

-GVLDIKSHPFF
 |. ..|.||||
NGADEVKQHPFF
Kinase LATS.AA ROCK 1003-1102 51 2.2e-36 121.21 In-house 160-263 (263) Show / Hide 
Range on Protein: 1003-1102
Range on HMM: 160-263/263
Sequence Identity: 51% (54 aa)

VGTPNYIAPEVLTRTG----YTQLCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINWKQCLHIPSQAKLSRDASDFILRLCTGPEERLGKNGVLDIKS
|||| ||.||||   |    | . |||||||| .||||||. || |||   |  |... |. |. | ....|..| | | .  |  |.|||.||| ||| 
VGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQ

HPFF
|.||
HKFF
Kinase LATS.AA GEK 1003-1102 47 6.7e-36 117.7 In-house 162-269 (269) Show / Hide 
Range on Protein: 1003-1102
Range on HMM: 162-269/269
Sequence Identity: 47% (51 aa)

VGTPNYIAPEVLT-----RTGYTQLCDWWSVGVILYEMLVGQPPFHADSPAETQWKVINWKQCLHIPSQAK---LSRDASDFILRLCTGPEERLGKNGVL
|||| ||.||.|      .  | . |||||.||..|||| |. || |.| .||  |..|.|.....||| .   .| .| |.| .|   .|.|||.||. 
VGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQ

DIKSHPFF
| | ||||
DFKKHPFF
Kinase LATS.AA Akt 998-1045 44 6.7e-25 76.46 In-house 158-206 (264) Show / Hide 
Range on Protein: 998-1045
Range on HMM: 158-206/264
Sequence Identity: 44% (22 aa)

KAHSLVGTPNYIAPEVLTRTGYTQLCDWWS-VGVILYEMLVGQPPFHAD
|. .. ||| |.|||.|  .|.|. .|||. .|...|||. |.|||...
KTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQ
Kinase LATS.AA Pkinase 999-1102 26 1.3e-23 84.63 Pfam 168-293 (293) Show / Hide 
Range on Protein: 999-1102
Range on HMM: 168-293/293
Sequence Identity: 26% (34 aa)

AHSLVGTPNYIAPEVLT-RTGYTQLCDWWSVGVILYEMLVGQPPFHAD----SPAETQWKVINWKQCLHIPSQAKLS--------------------RDA
.....|||.|.||||.  ...|.. .|.||.|.|||||| |.|||  .    . .. .... . ...    .  ...                    ...
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

SDFILR-LCTGPEERLGKNGVLDIKSHPFF
 ||| . ||  |..|..     .|. ||.|
KDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase LATS.AA TyrKc 781-1026 15 5.6e-10 -61.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 781-1026
Range on HMM: 1-280/280
Sequence Identity: 15% (51 aa)

FKKIKTLGIGAFGEVALARKVDTNALYAVKKLRKLDVIQRNQAGHVKAERDILAEA--DNEWVVKLYYSFQDK-------DNLYFVMDYIPGGDLMSLLI
 ...|.|| |||||| ...        |||.|..              |  |. .   ... .|.||    ..       . |. || | |.||| . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RLEI-FEEDLARFYIAELVLAIESVHKMDFIHRDIKPDNILVDRDGHIKLTDFGLCTGFRWTHDS-------KYYQKSG--HAR-------------QDS
. .  .  .    .        |  |.. .||||.   |.||......| .||||.   |  .|        .|| |..  ...             ...
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS---RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

----------------------MEPFDT---------------MDGEKCKCINH----FAHKEKELDLSSLDKRPLKTLERRRKRQQERCKAHSLVGTPN
                      ..|                  ..|.  ..  .                                       . |. | 
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F-VCCPD

YI--------APEVLTRTGYTQLCDWW
 .        . .   |   ..... .
EMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase LATS.AA Akt 1061-1102 33 8.8e-10 27.37 In-house 220-264 (264) Show / Hide 
Range on Protein: 1061-1102
Range on HMM: 220-264/264
Sequence Identity: 33% (15 aa)

LHIPSQAKLSRDASDFILRLCT-GPEERLG--KNGVLDIKSHPFF
. .|   ..| .. |.| .|..  |..|||  .|.. .||.||.|
VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase LATS.AA Pkinase_Tyr 896-942 31 6e-06 20.72 Pfam 128-173 (270) Show / Hide 
Range on Protein: 896-942
Range on HMM: 128-173/270
Sequence Identity: 31% (15 aa)

HKMDFIHRDIKPDNILVDRDGHIKLTDFGLCTGFRWTHDSKY-YQKSG
. . .||||.   |.||......| .||||.     ..|. | ....|
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGG
Kinase LATS.AA Pkinase_C 1121-1175 25 9e-06 23.71 Pfam 1-46 (46) Show / Hide 
Range on Protein: 1121-1175
Range on HMM: 1-46/46
Sequence Identity: 25% (14 aa)

TVRHPTDTSNFDPVSPNKLGSDSSTDSWDSNPNEEENHRQQTDHAFFEFTFRRFF
.|..|||||||||   .   .|..        ....  ... ...|  ||.....
QVKSPTDTSNFDPEFTDEPPMDTP--------PDWR-MSSGDQEPFRGFTYVNPD
Kinase LATS.AA S_TK_X 1103-1173 25 5.9e-05 19.0 SMART 1-79 (79) Show / Hide 
Range on Protein: 1103-1173
Range on HMM: 1-79/79
Sequence Identity: 25% (21 aa)

QTIDLDSNI---RKMKAPYIPTVR----HPTDTSNFDPVSPNKLGSDSSTDS------WDSNPNEEENHRQQTDHAFFEFTFRR
  || |      .....|..|...    .|||||||||  ...  ... .|.      | .   |.|    . .  | .||...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNE-METE----IPPDPFRGFTYVF
Kinase LATS.AA Pkinase_Tyr 781-866 29 0.011751 9.62 Pfam 1-94 (270) Show / Hide 
Range on Protein: 781-866
Range on HMM: 1-94/270
Sequence Identity: 29% (28 aa)

FKKIKTLGIGAFGEVALARKV----DTNALYAVKKLRKLDVIQRN--QAGHVKAERDILAEA-DNEWVVKLYYSFQ-DKDN--LYFVMDYIPGGDL
 ...|.|| |||||| ...      .|.   |||.| | .  ...  ..   . |  |. .  ... .|.||     ...   .| || | |.|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL