Gene MAST1 (Sea Urchin)

MAST1

Species: Sea Urchin
Alias: SPU_011838, MAST1, Spk008
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: MAST
Subfamily: MASTL

Sequence

Name Sequence Type Origin Length Description Download
MAST1.AA Protein None 725 None Fasta, JSON
MAST1.kin_dom Protein Kinase Domain None 96 None Fasta, JSON

Protein domain

Protein domains of MAST1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAST1.AA MAST 562-678 46 1.9e-68 219.69 In-house 206-334 (334) Show / Hide 
Range on Protein: 562-678
Range on HMM: 206-334/334
Sequence Identity: 46% (60 aa)

KSCKRRPQQAACGQPQEERILGTPDYLAPELLLQQP-HGIGVDWWALGVCLYEFLIGIPPFCDSEPDLVFQNILSRD---LSWPEG-----DEAISVIAQ
. |.. . .   .  | ....|||||.|||..|.|. ||. ||||..|...||||.|.|||.|..|...|||||.|.    .||||     |||.|. ||
PQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQ

DLIEKLLTLAPEDRPTAT----DVKQHEFL
|||||||.. |..|..|.    .||||.|.
DLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase MAST1.AA MASTL 579-678 54 1e-59 203.14 In-house 162-283 (283) Show / Hide 
Range on Protein: 579-678
Range on HMM: 162-283/283
Sequence Identity: 54% (67 aa)

ERILGTPDYLAPELLLQQPHGIGVDWWA-LGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSWPEGDEAIS---------------------VIAQDLIE
..||||||||.||...||.||..||||| ||||.|||..|||||||..|..||||||||||.||.|||..|                     |....|||
MDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVPVMCLIE

KLLTLAPEDRPTATDVKQHEFL
.||...|.|||.||||.||.|.
NLLQMRPRDRPSATDVQQHTFI
Kinase MAST1.AA AGC 581-678 30 3e-54 137.58 In-house 265-395 (395) Show / Hide 
Range on Protein: 581-678
Range on HMM: 265-395/395
Sequence Identity: 30% (41 aa)

ILG--TPDYLAPELLLQQPHGIGVDWWA--LGVCLYEFLIGIPPFCDSEPD----------LVFQNILSR------DLSWP-------EGDEAISVIAQD
. |  ||.|.||| |    .|  .|||.  ||...||.|.|.|||.. .|.           .||.|...      .. .|       ..|. .|. |.|
FCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKD

LIEKLLTLAPEDRPT----------ATDVKQHEFL
||.|||.  ||.|..          | ..|.|.. 
LIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase MAST1.AA MAST 562-678 40 5.8e-54 162.91 In-house 209-337 (337) Show / Hide 
Range on Protein: 562-678
Range on HMM: 209-337/337
Sequence Identity: 40% (52 aa)

KSCKRRPQQAACGQPQEERILGTPDYLAPELLLQQP-HGIGVDWWALGVCLYEFLIGIPPFCDSEPDL-VFQNILS--RDLSWPEG-----DEAISVIAQ
. |.. ...   .  |  ...|||||.||| .| |. .|  ||||..|. .||||.|.||| ...|   .||||..  |...|||.     |...|  ||
PQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQ

DLIEKLLTLAPEDRPTAT---DVKQHEFL
|||.|||.. | .|  |    ..|||.| 
DLIKKLLQPNPKKRLGANGADEIKQHPFF
Kinase MAST1.AA SGK 583-678 41 6.7e-35 104.87 In-house 187-283 (283) Show / Hide 
Range on Protein: 583-678
Range on HMM: 187-283/283
Sequence Identity: 41% (41 aa)

GTPDYLAPELLLQQPHGIGVDWWALGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSWPEGDEAISVIAQDLIEKLLTLAPEDRPTAT----DVKQHEFL
||| ||||| |. |||.  |||| ||  |||...|.||| .    . ..||.. .|  | .   .|. | |||. ||.  |..|  .     ..|.| | 
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase MAST1.AA NDR 583-678 35 6.7e-33 98.3 In-house 243-350 (350) Show / Hide 
Range on Protein: 583-678
Range on HMM: 243-350/350
Sequence Identity: 35% (38 aa)

GTPDYLAPELLLQ-QPHGIGVDWWALGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSW-----PEGDEA-ISVIAQDLIEKLLTLAPEDRPT-----AT
|||||.||| ..| . ..  .||| ||. .||.|.|.||||...|. ....|..    |       . || .|. |.|||..|..  |. |       . 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

DVKQHEFL
..|.| | 
EIKSHPFF
Kinase MAST1.AA Akt 583-678 36 2.3e-30 94.18 In-house 164-264 (264) Show / Hide 
Range on Protein: 583-678
Range on HMM: 164-264/264
Sequence Identity: 36% (37 aa)

GTPDYLAPELLLQQPHGIGVDWWA-LGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSWPEGDEAISVIAQDLIEKLLTLAPEDRP-----TATDVKQHE
||| ||||| |... |.  ||||. ||. .||.. | ||| .   .  |..|.. ..  |.  ..||  ..|||..||.  |. |.     .| ..|.|.
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHP

FL
..
WF
Kinase MAST1.AA RSK 583-678 34 1.1e-28 101.65 In-house 170-278 (278) Show / Hide 
Range on Protein: 583-678
Range on HMM: 170-278/278
Sequence Identity: 34% (38 aa)

GTPDYLAPELLL---QQP-HGIGVDWWALGVCLYEFLIGIPPFCD---SEPDLVFQNILSRD--LSWPEGDEAISVIAQDLIEKLLTLAPEDRPT-----
.| .|.|||.|    ||  |.  .||| ||| .|| | | |||     . .. ....|.. .  |. |. .. .|  |.||| |.|.  |..|..     
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPN-WQYLSQEAKDLIRKMLHRDPHKRLGCGPQD

ATDVKQHEFL
| ..|||...
AEEIKQHPWF
Kinase MAST1.AA Pkinase 583-678 28 1.3e-28 102.2 Pfam 173-293 (293) Show / Hide 
Range on Protein: 583-678
Range on HMM: 173-293/293
Sequence Identity: 28% (34 aa)

GTPDYLAPELLL-QQPHGIGVDWWALGVCLYEFLIGIPPFCDS------EPDLVFQNILSRDLSWPEGDE------------------AISVIAQDLIEK
|||.|.|||... .|..|  ||.|..|. |||.| | |||...      ... ....|....|....  .                  ..|  ..|.|..
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLTLAPEDRPTATDVKQHEFL
.|.. |..||||....||...
CLCKDPKKRPTAEQILQHPWF
Kinase MAST1.AA PKC 583-678 35 1.4e-27 86.32 In-house 162-262 (262) Show / Hide 
Range on Protein: 583-678
Range on HMM: 162-262/262
Sequence Identity: 35% (37 aa)

GTPDYLAPELLLQQPHGIGVDWWALGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSWPEGDEAISVIAQDLIEKLLTLAPEDRPTA--------TDVKQ
|||||.||| |  |. |  |||||.|| .||...| .||     | .||.|. .. . |     .|. | .......|  ||.|  .         |...
GTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPFHGEDEDELFQSIMHDNPHYP---RWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIRE

HEFL
| | 
HPFF
Kinase MAST1.AA PKA 583-678 36 9.3e-26 91.89 In-house 160-263 (263) Show / Hide 
Range on Protein: 583-678
Range on HMM: 160-263/263
Sequence Identity: 36% (39 aa)

GTPDYLAPELLLQQ-PHGIGVDWWALGVCLYEFLIGIPPFCDS--EPDLVFQNILSRDLSWPEGDEAISVIA---QDLIEKLLTLAPEDRP---TA--TD
|||.||||| ..   .|| .|||||||.  ||.| |.||| |.  .|   .. |.. .. .|.    ... |    |||.|||.  .. |     .   |
GTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYEKICNGKIKFPRH---FDSDANYFKDLIKKLLQVDLTKRYGNMKNGVND

VKQHEFL
.| |.. 
IKNHKWF
Kinase MAST1.AA S_TKc 308-678 11 2.3e-09 -39.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 308-678
Range on HMM: 1-231/231
Sequence Identity: 11% (51 aa)

SRLSGGVAEGGSSS--FCLDHGDSSLSGLDLDASRSSAADPAEKEAVKVRRSSGKKNVSFDLDVSMDCKSEASDVKMPG-----DMSESCH---------
 ..   . .|. ..   | ...                    .. |.|. .               . ..| .  |. .      . ....         
YEILRKIGKGAFGKVYKCRHKK------------------TGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVME

--DD--DDLSRKGQLEPSP-----MGDGRSQS---------------------------LVSNQSESSMKSCDLQERSALSELTNFSPDDTTRMNIKPRN
  |    || .  .  ...     .   . ..                           |...      | ||      |                    
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------------

ASTPGPQGTRHTPLRIAFRTPGQLPYVTPARIRYKTPGRGTLITPGPTPLRTPKSCKRRPQQAACGQPQEERILGTPDYLAPELLLQQPHGRGTLITPGP
                                                                                                    
----------------------------------------------------------------------------------------------------

TPLRTPKSCKRRPQQAACGQPQEERILGTPDYLAPELLLQQPHGI-GVDWWALGVCLYEFLIGIPPFCDSEPDLVFQNILSRDLSWPEGDEAISVIAQDL
                         . |||.|.|||.|   ..|   .|||..|..|||.| | |||.  .....|..|.             |  | |.
-----------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDF

IEKLLTLAPEDRPTATDVKQ-------HEFL
|.|.|.  ||.|||| .. |       |...
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAST1.AA MASTL 526-548 60 2.4e-09 27.88 In-house 162-184 (283) Show / Hide 
Range on Protein: 526-548
Range on HMM: 162-184/283
Sequence Identity: 60% (14 aa)

ERILGTPDYLAPELLLQQPHGRG
..||||||||.||...||.|| .
MDILGTPDYLKPEQDYQQTHGQV
Kinase MAST1.AA SGK 530-547 72 2.5e-07 18.18 In-house 187-204 (283) Show / Hide 
Range on Protein: 530-547
Range on HMM: 187-204/283
Sequence Identity: 72% (13 aa)

GTPDYLAPELLLQQPHGR
||| ||||| |. |||.|
GTPEYLAPEVLRKQPHDR
Kinase MAST1.AA MAST 33-546 3 3e-06 15.86 In-house 162-243 (334) Show / Hide 
Range on Protein: 33-546
Range on HMM: 162-243/334
Sequence Identity: 3% (17 aa)

TSVNRQGLPRPSSLGDLLSDLNRDKRPHASSHDDASRHGRDSISVALADRILSAASEGSQASSRGRPQEDAGSGCQRSARFGRSATRQGGRERDVVFETP
|..|                                                                                                
TPPNI-----------------------------------------------------------------------------------------------

VGRAPVSRPSIHLSFSDERRQSGPEAAQQTSNEGQSMASSPTEDVALLGSGSEVRGRKRHLSQVEMSPISLRASKGCVRMLGSGSHSGLTTEIQGLSLKL
                                                                                                    
----------------------------------------------------------------------------------------------------

FVADGEGEEEEEESNTGCHRNRLSDADSLDSSLSIEDMESIRAKSFEGVDTQGSKDVGMVDSEGRSIRDSCYGSGSRLSGGVAEGGSSSFCLDHGDSSLS
                                                                                                    
----------------------------------------------------------------------------------------------------

GLDLDASRSSAADPAEKEAVKVRRSSGKKNVSFDLDVSMDCKSEASDVKMPGDMSESCHDDDDLSRKGQLEPSPMGDGRSQSLVSNQSESSMKSCDLQER
                                                                                                    
----------------------------------------------------------------------------------------------------

SALSELTNFSPDDTTRMNIKPRNASTPGPQGTRHTPLRIAFRTPGQLPYVTPARIRYKTPGRGTLITPGPTPLRTPKS----------------------
                                                              .  ..| ... . ...                      
-------------------------------------------------------------FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQQQQEQ

--CKRRPQQAACGQPQEERILGTPDYLAPELLLQQP-HG
  |.. . .   .  | ....|||||.|||..|.|. ||
PQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHG
Kinase MAST1.AA S_TK_X 679-713 18 0.000117 16.27 SMART 1-79 (79) Show / Hide 
Range on Protein: 679-713
Range on HMM: 1-79/79
Sequence Identity: 18% (15 aa)

HDLDWDHVR----EMEPPFVPAPD----DETDTTYFD------------------------------------GWKAEK
...|||...    |.||||.| .     ..||| .||                                    |. .  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase MAST1.AA PKA 530-548 50 0.000202 16.83 In-house 160-179 (263) Show / Hide 
Range on Protein: 530-548
Range on HMM: 160-179/263
Sequence Identity: 50% (10 aa)

GTPDYLAPELLLQQ-PHGRG
|||.||||| ..   .||..
GTPEYLAPEIIQSKNGHGKS
Kinase MAST1.AA Akt 530-547 55 0.000383 9.05 In-house 164-181 (264) Show / Hide 
Range on Protein: 530-547
Range on HMM: 164-181/264
Sequence Identity: 55% (10 aa)

GTPDYLAPELLLQQPHGR
||| ||||| |... |..
GTPEYLAPEILNGNGHTK
Kinase MAST1.AA PKC 530-546 64 0.000454 8.89 In-house 162-178 (262) Show / Hide 
Range on Protein: 530-546
Range on HMM: 162-178/262
Sequence Identity: 64% (11 aa)

GTPDYLAPELLLQQPHG
|||||.||| |  |. |
GTPDYIAPEILQYQEYG
Kinase MAST1.AA NDR 530-543 60 0.00108 6.54 In-house 243-257 (350) Show / Hide 
Range on Protein: 530-543
Range on HMM: 243-257/350
Sequence Identity: 60% (9 aa)

GTPDYLAPELLLQ-Q
|||||.||| ..| .
GTPDYMAPEVFQQKT
Kinase MAST1.AA MAST 33-546 3 0.001192 6.3 In-house 165-247 (337) Show / Hide 
Range on Protein: 33-546
Range on HMM: 165-247/337
Sequence Identity: 3% (17 aa)

TSVNRQGLPRPSSLGDLLSDLNRDKRPHASSHDDASRHGRDSISVALADRILSAASEGSQASSRGRPQEDAGSGCQRSARFGRSATRQGGRERDVVFETP
...|  |                                                                                             
FNTNIFGK--------------------------------------------------------------------------------------------

VGRAPVSRPSIHLSFSDERRQSGPEAAQQTSNEGQSMASSPTEDVALLGSGSEVRGRKRHLSQVEMSPISLRASKGCVRMLGSGSHSGLTTEIQGLSLKL
                                                                                                    
----------------------------------------------------------------------------------------------------

FVADGEGEEEEEESNTGCHRNRLSDADSLDSSLSIEDMESIRAKSFEGVDTQGSKDVGMVDSEGRSIRDSCYGSGSRLSGGVAEGGSSSFCLDHGDSSLS
                                                                                                    
----------------------------------------------------------------------------------------------------

GLDLDASRSSAADPAEKEAVKVRRSSGKKNVSFDLDVSMDCKSEASDVKMPGDMSESCHDDDDLSRKGQLEPSPMGDGRSQSLVSNQSESSMKSCDLQER
        .  .....|.. . . .                                                                           
-------NHFNEYHIQKNYQQFQQD---------------------------------------------------------------------------

SALSELTNFSPDDTTRMNIKPRNASTPGPQGTRHTPLRIAFRTPGQLPYVTPARIRYKTPGRGTLITPGPT---------PLRTPKSCKRRPQQAACGQP
                                                                   .| .          .   . |.. ...   .  
-------------------------------------------------------------------FGINGNTNKNQIQQQQEQPQCQQQNEMRPHNIH

QEERILGTPDYLAPELLLQQP-HG
|  ...|||||.||| .| |. .|
QNKQCCGTPDYIAPEVILGQGTYG
Kinase MAST1.AA Pkinase 530-547 47 0.01104 10.57 Pfam 173-191 (293) Show / Hide 
Range on Protein: 530-547
Range on HMM: 173-191/293
Sequence Identity: 47% (9 aa)

GTPDYLAPELLL-QQPHGR
|||.|.|||... .|..|.
GTPWYMAPEVIRGGQYYGP
Kinase MAST1.AA RSK 530-547 40 0.03711 4.13 In-house 170-191 (278) Show / Hide 
Range on Protein: 530-547
Range on HMM: 170-191/278
Sequence Identity: 40% (9 aa)

GTPDYLAPELLL---QQP-HGR
.| .|.|||.|    ||  |..
YTIEYMAPEMLKRANQQGGHDK