Gene GPRK (Sea Urchin)
GPRK
Sequence
Protein domains of GPRK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GPRK.AA | GRK | 1-202 | 72 | 1.9e-169 | 538.53 | In-house | 65-272 (272) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 65-272/272 Sequence Identity: 72% (151 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGS--PGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPEND-TIR |..|||.| |.|||||.||||||||..||.|||. |||.|||.|||||||.||||..||.||||||.|||||||||||||||||||||.||||.. .|. VCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNEPGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIH GRVGTVGYMAPEVVKNER-YTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYSQKFSTEAQDICKKLLQKDPALRMGFENG--TAQ |||||.|||||||..||| |.||||.|.|||.|||||||..|||..||||||||||||||||..||..|||.||.|||..||||||. |.|...| .|| GRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEMIEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTCGAQ TVKDHSFF .||.|.|| EVKEHPFF |
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| Kinase | GPRK.AA | GRK | 1-202 | 79 | 7e-168 | 564.03 | In-house | 62-265 (265) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 62-265/265 Sequence Identity: 79% (163 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMG-SPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPENDTIRGR ||||||.| |.|||||.||||||||||||.||| .|||.||||.||||||.||||.|||.|||||||||||||||||||.|||||||||||||...|||| VSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFDEERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGR VGTVGYMAPEVVKNERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYS-QKFSTEAQDICKKLLQKDPALRMGFENGTAQTVKD ||||||||||||||||||||||.||||||||||||||.|||.|||||||||||||||||.|||| .|||.||.|||..||.|||. |.|........|.. VGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSPFRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREEGCDEVRQ HSFF |.|| HPFF |
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| Kinase | GPRK.AA | AGC | 1-202 | 28 | 4.3e-115 | 298.56 | In-house | 93-395 (395) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 93-395/395 Sequence Identity: 28% (87 aa) VS-LAYAFEMKEA--LCLVLTIMN---------GG-DLKFHIHNM-GSPGFEEERARFYAAE-------ILCGLEDLHR-LRIVYRD-MKPENILLDDHG |. | |.|. |. |..|. |. || .| .|.... .. |.|||||||||| |...|| ||. . |..|| .||||||||..| VKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDG HVRISDLGLAVEIP---------------------------------------------------ENDTIRGRVG--TVGYMAPEVVKNERYTFSPDYWG |....| ||. |.. ..|. .| | |||||.. |... |.|. HIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWS --LGCLIYEMIEGRAPFRA------------RKEKVKREEVDRRVKEDDEKYS----------QKFSTEAQDICKKLLQKDPALRMGFENGT-----AQT ||||.|||. |. ||.. ..|. .. . .|.......|. ..|| ||.|..||||.|||. | | ... |. FGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEE VKDHSFF .|.| .| IKNHPWF |
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| Kinase | GPRK.AA | RSK | 1-202 | 34 | 4.5e-64 | 219.17 | In-house | 64-278 (278) | Show / Hide |
Range on Protein: 1-202
Range on HMM: 64-278/278
Sequence Identity: 34% (75 aa)
VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGSPG-FEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDD---HGHVRISDLGLAVE-IPE-ND
|.| |||. .. | |.. ..||.| |. . .. | | |..|.||.||| . .| || . |..|| ||||||.|| .||....| |.. . .. |
VTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQ
TIRGRVGTVGYMAPEVVK---NER-YTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDD--EKYS--QKFSTEAQDICKKLLQKDPALRM
..|. |||||..| .. .. . |.| ||.|.||| |. ||.. .. |.|. .|... . . |. |.||.|. .|.|..||. |
WTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRL
GFENGTAQTVKDHSFF
| . |. .|.|..|
GCGPQDAEEIKQHPWF
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| Kinase | GPRK.AA | BARK | 1-202 | 46 | 1.1e-60 | 207.09 | In-house | 66-264 (264) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 66-264/264 Sequence Identity: 46% (95 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPENDTIRGRV | ..|||. . || .| .|||||| .|. | | |. |||||||. ||| .|. .||||.|| |||||..||||||||||| . | VCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGV--FSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDF-SKKKPHASV GTVGYMAPEVV-KNERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYSQKFSTEAQDICKKLLQKDPALRMGFENGTAQTVKDH || |||||||. | | | |.. |||..| .. | .||| | | | .|.|| . . ..|| | .|. . |||.| . |.| . . || ||.| GTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLRGHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCMGRGAQEVKEH SFF .|| PFF |
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| Kinase | GPRK.AA | AktR | 1-202 | 36 | 8.3e-60 | 205.0 | In-house | 64-268 (268) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 64-268/268 Sequence Identity: 36% (78 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRL-RIVYRDMKPENILLDDHGHVRISDLGLAV-EIP--ENDTI | | |.|. || | ... .. ||.| .|. . . |.||.||||.|.|| .|| || |.|||.|||||||| .|||.|.| ||. .. .... VKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKK--FSEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKA RGRVGTVGYMAPEVVKN-ERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKED--DEKYSQKFSTEAQDICK-KLLQKDPALRMG-FENG . .||. |||||.... . ...| |.| .|..||||. | || . . ....... ... .|. .|| ...|... |||.|.| | | . || YSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPFYHKN---QNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNG TAQTVKDHSFF . . .|.| .| WEE-IKSHPWF |
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| Kinase | GPRK.AA | PKC | 21-202 | 40 | 2.3e-58 | 187.69 | In-house | 83-262 (262) | Show / Hide |
Range on Protein: 21-202 Range on HMM: 83-262/262 Sequence Identity: 40% (75 aa) NGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLA-VEIPENDTIRGRVGTVGYMAPEVVKNERYTFS ||||| ||| ... |.||.||||||||.|.| ||. |.||| | .|.||| ||..| | |.. .. . || . || |.|||... . |..| NGGDLMFHIQQQRR--FKEEHARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKS PDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYSQKFSTEAQDICKKLLQKDPALRMGFENGT---AQTVKDHSFF |.| .| | ||| |..|| . | .|. . . .|. | .| || .|||....|.|. |.| . . .| ...| || VDWWAFGVLMYEMMAGQSPFHGEDE----DELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF |
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| Kinase | GPRK.AA | SGK | 1-202 | 40 | 6.8e-58 | 177.16 | In-house | 88-283 (283) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 88-283/283 Sequence Identity: 40% (82 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAV-EIPENDTIRGR |.| ||| |. | .|. .|||.. .|. .. | | ||||||||| | || || . |.||| ||||||||. ||... | ||. .| .||| VNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKH--FPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTF VGTVGYMAPEVVKNERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYSQKFSTEAQDICKKLLQKDPALRMGFENGTAQTVKDH ||. |.|||| . . . . | | |||. |||. | || . ... . . . .| .| |. . |||||| | | .. .. .|.| CGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPF----YSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME-IKNH SFF || PFF |
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| Kinase | GPRK.AA | Delta | 6-202 | 38 | 6.1e-55 | 188.84 | In-house | 68-259 (259) | Show / Hide |
Range on Protein: 6-202 Range on HMM: 68-259/259 Sequence Identity: 38% (77 aa) AFEMKEALCLVLTIMNGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLA-VEIPENDTIRGRVGTVG .| || | |. .||||| .|| ... |.|.||||||.||.|||. ||. |.|||.| .|.||| ||..| | |.. .. . . || TFQTKEHLFFVMEYLNGGDLMYHIQQCHR--FDEKRARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPD YMAPEVVKNERYTFSPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEKYSQKFSTEAQDICKKLLQKDPALRMGFENGTAQTVKDHSFF |.|||..| ..|..| |.| | |.|||. | .|| . | .|. . . .| | . . ||.|. |||...|| |.| .. . ...| || YIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPFHGEDE----DELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF |
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| Kinase | GPRK.AA | Pkinase | 1-202 | 29 | 2.2e-53 | 188.44 | Pfam | 63-293 (293) | Show / Hide |
Range on Protein: 1-202
Range on HMM: 63-293/293
Sequence Identity: 29% (71 aa)
VSLAYAFEMKEALCLVLTIMNGG----DLKFHIHNMGSPGF--EEERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHV----RISDLGLAVE-
| | ..|| | ...|. ..|| ||. .|. . . .| .|. ..||. .||.||| .|. .|..||.||||||.|..||. .|.| |||
VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF
-IPENDTIRGRVGTVGYMAPEVVK-NERYTFSPDYWGLGCLIYEMIEGRAPFRAR---KEKVKREEVDRRVKEDDEKYSQKFS-----------------
. | ...|| .||||||.. .. |. . | |..||..|||. || ||. . .. . .. .|... . ... .
DY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF
----TEAQDICKKLLQKDPALRMGFENGTAQTVKDHSFF
|..|..|..|.|||. | . |. .. | .|
HNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
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| Kinase | GPRK.AA | Akt | 1-139 | 43 | 3.3e-50 | 158.65 | In-house | 63-203 (264) | Show / Hide |
Range on Protein: 1-139 Range on HMM: 63-203/264 Sequence Identity: 43% (62 aa) VSLAYAFEMKEALCLVLTIMNGGDLKFHIHNMGSPGFEEERARFYAAEILCGLEDLHRLRIVYRD-MKPENILLDDHGHVRISDLGLAV-E-IPENDTIR |.| |.| .. |..|. .|||.| .|.. . | |.|||||.||| ...| || |.||| .||||||.| .||... | ||. . | ..|. VNLHYSFQTQDKLYFVMDYCNGGELFYHLQR--KRRFSEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTK GRVGTVGYMAPEVVKNERYTFSPDYWG-LGCLIYEMIEGRAPF || |.|||. .. .| . | || |||..|||. || || TFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF |
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| Kinase | GPRK.AA | S_TKc | 1-202 | 29 | 8.5e-41 | 142.78 | SMART | 19-231 (231) | Show / Hide |
Range on Protein: 1-202
Range on HMM: 19-231/231
Sequence Identity: 29% (71 aa)
VSLA--------------------------------YAFEMKEALCLVLTIMNG--GDLKFHIHNMGSPG----FEEERARFYAAEILCGLEDLHRLRIV
. ..|. . |..|. ..| |||. .|...|..| | | .||||...|.|.|| .|...|.
RHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII
YRDMKPENILLDDHGHVRISDLGLAVEIPENDTIRGRVGTVGYMAPEVVKNERYTF-SPDYWGLGCLIYEMIEGRAPFRARKEKVKREEVDRRVKEDDEK
.|| ||||||||. |. |.| ||| .. . .|| ||||||. |.. . | | .||..|||. |. ||. ... . .
HRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------
YSQKFSTEAQDICKKLLQKDPALRMGFENGTA--QTVKDHSFF
| || |. .|.|||||. |.. . . .| | .|
-----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | GPRK.AA | Akt | 165-202 | 39 | 2.4e-11 | 32.45 | In-house | 227-264 (264) | Show / Hide |
Range on Protein: 165-202 Range on HMM: 227-264/264 Sequence Identity: 39% (15 aa) KFSTEAQDICKKLLQKDPALRMGFENGTAQTVKDHSFF ..| |..|. ..||.||| .| | ...|| .|.| .| WISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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| Kinase | GPRK.AA | TyrKc | 1-202 | 17 | 5e-09 | -76.69 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-202 Range on HMM: 1-280/280 Sequence Identity: 17% (51 aa) VSL------------------------------------------AY-------------AFEMK------EALCLVLTIMNGGDLKFHIHNMGSPGFEE ..| . . . . | |..|. | .|||| .... . . ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM ERARFYAAEILCGLEDLHRLRIVYRDMKPENILLDDHGHVRISDLGLAVEIPEN-------DTIR------GR-VGTVGYMAPEVVKNERYTFSPDYWGL . .. | || | ||. ... || |.|... ..|.||| ||. .| . |..| |. . . ||||. . ..|. | | KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSF GCLIYEMIEGRAPFRARKEK--VKREEVDRRVKED--DEKYSQ-------KFSTEAQDICKKLLQKDPALRMGFENGTAQTVKDHSFF | ...|. .. .. .. .|| ..||. .. ..| .| |. . ||. | |.. |..| GVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-------HECF |
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| Kinase | GPRK.AA | S_TK_X | 203-282 | 20 | 3.6e-08 | 34.37 | SMART | 1-79 (79) | Show / Hide |
Range on Protein: 203-282 Range on HMM: 1-79/79 Sequence Identity: 20% (18 aa) NSISFSRLEA--GKLDPPFEPDKRAVYAKDVLDIEQFS--TVKGVNLDQNDDRFYTKFNSGSVAIPWQMEMIETQ----VFLELNVFG .| . .|.. ... ||| |. ..||| . |...| ... .| ........ || | .|| |.... . RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF |
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| Kinase | GPRK.AA | Pkinase_Tyr | 70-139 | 29 | 0.00012 | 16.36 | Pfam | 141-216 (270) | Show / Hide |
Range on Protein: 70-139 Range on HMM: 141-216/270 Sequence Identity: 29% (23 aa) NILLDDHGHVRISDLGLAVEIPENDTIRGRVGT-----VGYMAPEVVKNERYTFSPDYWGLGCLIYEMIE-GRAP-F |.|... ..|.|.| ||| | . |. |... . ||||. .. ..| | | | |..|.. |. | . NCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY |
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