Gene CRIK (Sea Urchin)

CRIK

Species: Sea Urchin
Alias: Spk333, SPU_011918, CRIK
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: CRIK

Sequence

Name Sequence Type Origin Length Description Download
CRIK.AA Protein None 1862 None Fasta, JSON
CRIK.kin_dom Protein Kinase Domain None 263 None Fasta, JSON

Protein domain

Protein domains of CRIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CRIK.AA DMPK 54-316 57 7.50000000001e-271 679.79 In-house 1-270 (270) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-270/270
Sequence Identity: 57% (155 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEEN
||...||||||||.|||||.| ||||||||...|.|.|.....|.|.||.|||....|.|.|.|.|||||...||..||..||||||.|..|..|...|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNGS-LASYGTECDWWSLGIVAYEM
||||||||.|.||||.|.||||||||||||.||||.||||||||||..|......|.||..||||||..|||||....   ..||.||||||.|...|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

MVGKTPFSDDSMVITYSNIMDF-QRKLSFPTSSP--LTPRATSLIKQLLCDRSARIG---YEQLGYHEFF
..|.|||..||.| ||..||.. ...||||....  ....|..||.||||||..|.|   ||.. .|.||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase CRIK.AA CRIK 54-316 69 1.2e-243 785.27 In-house 1-272 (272) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-272/272
Sequence Identity: 69% (188 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEEN
|||||.||.||||||||||||.|||.|||||.||...||.|.|.|||||.|||.|..||||..|||||||.||||||||.|||||||||..|.||.|.||
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNG---SLASYGTECDWWSLGIVAY
|||||||||..|.||||.||||||||||.|.|.||||||||||||||||....|.|.||||||||||.||||||..||   |...||..|||||.||.||
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMMVGKTPFSDDSMVITYSNIMD------FQRKLSFPTSSPLTPRATSLIKQLLCDRSARIGYEQLGYHEFF
|||.|||||..|.|..||||||.      |||.||||......|....||..|||..|.|..||||..|.||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRLKYEQLCCHPFF
Kinase CRIK.AA AGC 54-316 28 2.3e-157 410.38 In-house 1-395 (395) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-395/395
Sequence Identity: 28% (115 aa)

FEVKDVIGRGHFGQVQVVREK------VTNDVYAMKVLHKAE--------TLAKENVAF-------FEEEKDIMARAS----------SPWLTK-LQYAF
||.. |||.|.||.|  ||.|       |...|||||| |..        .... ....       . ||..|.....          .|...| | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDDDN--LYLMMEFHP---------GG-DLLSLLA-R-FDDVFEENMARFYLAE-------LVAAIHSLHT-MGYVHRD-IKPDNVLLDRTGHIKLADFG
||.|.  ||. ||..|         || .|.. |  |    .|.|..||||.||       .| |...||  ||..||| .||.|.|||. |||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SAAKLGDKN-------------------------------------------------TVSSKMPVG--TPDYVAPEVLQSLNGSLASYGTECDWWS--L
.. .. ...                                                 ..  .  .|  ||.|.|||.|         || .|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GIVAYEMMVGKTPFSDDSMV----------ITYSNIM----DFQRKLSFPTS--------SPLTPRATSLIKQLLC-DRSARIG----------YEQLGY
|.. |||..|..||..|. .           .. .||     .. |. ||          . ..| | .|||.||| |.. |.|          .|..  
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HEFF
|..|
HPWF
Kinase CRIK.AA GEK 54-316 49 2.7e-120 405.74 In-house 1-269 (269) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-269/269
Sequence Identity: 49% (133 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEEN
||.  ||||| || | ||. | |..|||||.|.| | | .  .| | ||.|.. .  . |.|.| |||||...|||.|..  ||||| ||..|.|   |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNGSLASYGTECDWWSLGIVAYEMM
|||||.||.| ||.|.| ..||||||||||||||. |||.||||||  .. . ..| |.. ||||||..||.|| ...   .||.||||||||...|||.
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

VGKTPFSDDSMVITYSNIMDFQRKLSFPTSSP---LTPRATSLIKQLLCDRSARIGYEQLG---YHEFF
 |.|||  .|.| ||. ||... ...||       .   |  ||.||.| . .|.| . ..    | ||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase CRIK.AA ROCK 54-316 50 4.1e-113 382.1 In-house 1-263 (263) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-263/263
Sequence Identity: 50% (133 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEEN
|..  ||||| || ||.||.| .. |||||.| | | . .   ||| ||.|||| | |.|. .|.||||||  ||..|.. ||||| .|.. .|    | 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNGSLASYGTECDWWSLGIVAYEMM
 |||| .|.| |. ..| ||..|||.||||.|||. ||.||||||   |.. .  | .   ||||||..||||.|  |  . || |||||| |.  |||.
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKS-QGQDGEYGRECDWWSVGVFIYEML

VGKTPFSDDSMVITYSNIMDFQRKLSFPTSSPLTPRATSLIKQLLCDRSARIGY---EQLGYHEFF
|| |||  ||.| |||.||| .  |.||    .  .|  ||.. | ||  |.|    ...  |.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase CRIK.AA S_TKc 54-316 31 2e-91 310.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPG--GDLLSLLARFDDV--
.|. ..||.| ||.|  .|.| |. ..|.|...            .. | .|. .   |.. || ..||| |.||. ||. .|  |||.... .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FEENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNGSLASYGT-ECDWWSL
   | | .||||..... |.  .| .| .|||.||.|.|||.  |||..|||.|..|        .  .|||.|.|||||        .||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GIVAYEMMVGKTPFSDDSMVITYSNIMDFQRKLSFPTSSPLTPRATSLIKQLLC-DRSARIGYEQLGY-------HEFF
|.. |||..|..||.   |  .. .|.              .| | ..|...|. | . |..  ..         |..|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CRIK.AA NDR 54-198 54 1e-84 261.11 In-house 1-149 (350) Show / Hide 
Range on Protein: 54-198
Range on HMM: 1-149/350
Sequence Identity: 54% (82 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARAS--SPWLTKLQYAFQDDDNLYLMMEFHPGGDLLS---LLARFDD
||.  .||.| ||.| .||.| |...||||.. |.| . |..||    |.|||| |.  .|| .|| |.|||...||| ||.|||||. .   || .. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

VFEENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFG
.|.|..|||| ||.| ||.|.| |||.|||||||| |.|. ||||| |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase CRIK.AA RSK 56-316 32 1.9e-77 263.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 56-316
Range on HMM: 1-278/278
Sequence Identity: 32% (92 aa)

VKDV--IGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKEN-VAFFEEEKDIMARAS-SPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDV--
.|.   .| | . ... .. . |. .||||||.||.  ...  ..   .| .|..|   .| . .| ||||... ||| ||. .||.|.  | .      
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FEENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDR---TGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQSLNGSLASYGTECDWWSLG
| |. |.||.||.| |.  ||. | .|||.||.|.|.|     ||||| ||| . ..  ...   . ...| .|.|||.|   |     ..  |||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

IVAYEMMVGKTPFSD---DSMVITYSNIMDFQRKLSFPTSSPLTPRATSLIKQLLC-DRSARIG-----YEQLGYHEFF
.. ||| .|..||     ..   .  .|.  .  |..|  . |.. | .||...|. | . |.|      |..  |..|
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CRIK.AA SGK 54-316 34 5.6e-75 230.87 In-house 1-283 (283) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-283/283
Sequence Identity: 34% (100 aa)

FEVKDVIGRGHFGQVQVVREKVT------------------NDVYAMKVLHKAETL-------AKENVAFFEEEK-DIMARASSPWLTKLQYAFQDDDNL
|. . ||| | || |  |. | .                   ..|||||| |.  .       .|. . .   |. .|.   ..| . .| |||| .. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLMMEFHPGGDLLSLLARFDDVFEENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTVSSKMPVGTPDYVAPEVLQ
|. |..  ||.. . | |    | |  |||| ||.| |.  ||    ..|| ||.|.|||  ||..| |||  .|.| | .   .   ||| | |||||.
YFVMDYVNGGEMFYHLQR-EKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFG-LCKEGIKTNDTTFTFCGTPEYLAPEVLR

SLNGSLASYGTECDWWSLGIVAYEMMVGKTPFSDDSMVITYSNIMDFQRKLSFPTSSPLTPRATSLIKQLLC-DRSARIGYE----QLGYHEFF
      . .. . |||.||.| ||||.|. || .    . | ||.    .| .|..   .. | .||..||  |.. | |      .   | ||
K-----QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNII--NQPLQIPPQ--MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase CRIK.AA Pkinase 54-316 28 2.5e-70 244.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFE-EEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGG----DLLSLLA-RFD
.... .||.| ||.|   ..| |....|.|.. | ..  ..... .   |  ||.| ..|   .| ..|.|.|..|. ||...||    || ...  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DVF--EENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHI----KLADFGSAAKL-GDKNTVSSKMPVGTPDYVAPEVLQSLNGSLASYGTEC
 .|  .|. ..||. ... ..  .| || .|||.||.|.|.|..|||    |..|||.|...   .|.   . ..|||.|.||||..    .   ||...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGIVAYEMMVGKTPFSDD------SMVITYSNIMDFQRKLSFPTSSPLT-----------------PRATSLIKQLLC-DRSARIGYEQLGYHEFF
|.||.|.. |||. |..||...      ..   . .||. . . ..|....                   . . ..|| .|| | . |.. ||.  |..|
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CRIK.AA MAST 54-198 42 2.9e-55 166.95 In-house 1-147 (337) Show / Hide 
Range on Protein: 54-198
Range on HMM: 1-147/337
Sequence Identity: 42% (62 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQD--DDNLYLMMEFHPGGDLLSLLARFDDVFE
|| . .|..| .|.|  |. | ||| .||||. .  |. |  |     |..| . .. |.  |. |.||   .. |.. ||.  |||  |||  .   ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFG
|.||..|.||.| ..  || .| ||||.||||.|.| .|||||.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase CRIK.AA MAST 54-198 44 9.1e-55 174.82 In-house 1-144 (334) Show / Hide 
Range on Protein: 54-198
Range on HMM: 1-144/334
Sequence Identity: 44% (64 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARASSPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEEN
|| . .|..| .|.|  |. | ||| .||||. |.... |  |     |..| | ...|.  |. |.|| ...|.. ||.  |||. |||  .   |.|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFG
||..|.||.| ..  || .| ||||.||||.|.| .|||||.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase CRIK.AA NDR 215-316 40 2.9e-38 115.18 In-house 242-350 (350) Show / Hide 
Range on Protein: 215-316
Range on HMM: 242-350/350
Sequence Identity: 40% (46 aa)

VGTPDYVAPEVLQSLNGSLASYGTECDWWSLGIVAYEMMVGKTPFSDDSMVITYSNIMDFQRKL-----SFPTSSPLTPRATSLIKQLLC-DRSARIG--
|||||| ||||.|  .|    |. .||||||| . ||| || .|| .|.   |. .||...  .     .||.  .|.|.|  ||..|.| |.. |.|  
VGTPDYMAPEVFQQKTG----YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

---YEQLGYHEFF
    ..   | ||
GKGVDEIKSHPFF
Kinase CRIK.AA MAST 215-316 35 6.8e-23 66.2 In-house 229-337 (337) Show / Hide 
Range on Protein: 215-316
Range on HMM: 229-337/337
Sequence Identity: 35% (41 aa)

VGTPDYVAPEVLQSLNGSLAS-YGTECDWWSLGIVAYEMMVGKTPFSDDSMV-ITYSNIMDFQRKLSFPTS------SPLTPRATSLIKQLL-CDRSARI
.||||| ||||   ..|   . ||   ||||.||. ||  || .|| .|.   .. .||   .|....|         ...| |  |||.||  . . |.
CGTPDYIAPEV---ILG--QGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRL

GYE---QLGYHEFF
|     .   |.||
GANGADEIKQHPFF
Kinase CRIK.AA MAST 215-316 33 1.2e-20 62.95 In-house 225-334 (334) Show / Hide 
Range on Protein: 215-316
Range on HMM: 225-334/334
Sequence Identity: 33% (39 aa)

VGTPDYVAPEVLQSLNGSLAS-YGTECDWWSLGIVAYEMMVGKTPFSDDSMVITYSNIMDFQRK-LSFPTS------SPLTPRATSLIKQLL-CDRSARI
.||||| ||||.        . .|   ||||.||. || .|| .|| ||.  ....||    .   ..|        . ..| |  ||..|| .| . |.
CGTPDYIAPEVILG-----QGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRL

GYE----QLGYHEFF
|      .   |.||
GANNGADEVKQHPFF
Kinase CRIK.AA TyrKc 54-316 19 1.3e-12 -18.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 54-316
Range on HMM: 1-280/280
Sequence Identity: 19% (59 aa)

FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARA--SSPWLTKLQYAFQDD-------DNLYLMMEFHPGGDLLSLLA
 . ....|.|.||.|   . |   .| | |.|..        .. | .|  || .   . | . .|  .  ..       . |.. ||. |.|||.. | 
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RFDDVFEENMARFYLAELVAAIHSLHTMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDK---------NTV----SSK--MPVGTPDYVAPEVLQSL
.  . .       .     .    || ....|||.   |.|... ...| .||| . ...|.          ..    ..|  .|.      |||..   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---WMAPECI---

NGSLASYGTECDWWSLGIVAYEMM-VGKTPFSD-----DSMVITYSNIMDFQRKLSFPT----SSPLTPRATSLIKQLLC-----DRSARIGYEQLGYHE
      . |. | || |.. .|..  |..| ..      |    . ....  |    |     |.   ..... . |.       | . |   ...  ||
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

FF
.|
CF
Kinase CRIK.AA S_TK_X 317-381 27 5e-11 43.88 SMART 1-79 (79) Show / Hide 
Range on Protein: 317-381
Range on HMM: 1-79/79
Sequence Identity: 27% (23 aa)

TGLEWATLR----DGKPPFVPTVS----SVDDVSNFD-EFDPIEPMKHNASILMRC-KGGFSGHDLP----------FVGFTYSK
 |. | .|.      .|||.|...    |  |.|||| ||.  .||      |. . .. ..... .          | ||||. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase CRIK.AA Pkinase_C 334-383 33 2.5e-07 29.1 Pfam 1-46 (46) Show / Hide 
Range on Protein: 334-383
Range on HMM: 1-46/46
Sequence Identity: 33% (17 aa)

TVSSVDDVSNFD-EFDPIEPMKHNASILMRCKGGFSGHDLPFVGFTYSKTS
.|.| .|.|||| ||   . .... .  ...   .||...||.||||.  .
QVKSPTDTSNFDPEF---TDEPPMDTPPDWR--MSSGDQEPFRGFTYVNPD
Kinase CRIK.AA Pkinase_Tyr 169-198 33 4.3e-05 17.87 Pfam 127-156 (270) Show / Hide 
Range on Protein: 169-198
Range on HMM: 127-156/270
Sequence Identity: 33% (10 aa)

LHTMGYVHRDIKPDNVLLDRTGHIKLADFG
|. ....|||.   |.|.......| .|||
LESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase CRIK.AA Pkinase_Tyr 54-143 25 0.039148 7.85 Pfam 1-98 (270) Show / Hide 
Range on Protein: 54-143
Range on HMM: 1-98/270
Sequence Identity: 25% (26 aa)

FEVKDVIGRGHFGQVQVVREK-----VTNDVYAMKVLHKAETLAKE--NVAFFEEEKDIMARA-SSPWLTKLQYAFQ-DDDN--LYLMMEFHPGGDLLSL
 .   ..|.|.||.|   . |      . .| | |.| |  .  ..    .|.. |  ||    . | . .|  .   ...   .|. ||. |.||||. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

L
|
L
C1 CRIK.AA C1 1172-1220 22 2.4e-09 38.28 SMART 1-61 (61) Show / Hide 
Range on Protein: 1172-1220
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

HRFTIGLSMRGTKCSACADTIHFG------RQVAKCIECHLICHPKCAHCLPH-------TC
|.. ..   ..|.|. | ..| ..      .|  .|..|.. || ||....|        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 CRIK.AA C1_1 1172-1223 29 3.9e-07 29.84 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1172-1223
Range on HMM: 1-55/55
Sequence Identity: 29% (16 aa)

HRFTIG-LSMRGTKCSACADTI-H-FGRQVAKCIECHLICHPKCAHCLPHTCGLP
|..  .    . |.|. |.. . . .|.|  || .||. || .|.. .|  ||. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
PH CRIK.AA PH 1274-1396 15 2.5e-09 38.22 SMART 1-82 (82) Show / Hide 
Range on Protein: 1274-1396
Range on HMM: 1-82/82
Sequence Identity: 15% (19 aa)

NQIQGWMKTPRFSRMNKQGWEKKWCCLEGTMLSLFDKENLDTGKQPTDEYSLCPEDAIVTVHAGVSATELPNTASSDLPFVFHLESRPVTTCWPDTKTLY
 ...||..        | .| |.|..| . .|......               |   |   .. |.  .           .| . .           |.|
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK--------------KPKGSIPLSDCTVRE-P-----------CFEIHH-DR--------TYY

LMAPSFQDKQQWMVGLEVASIRG
. ..| ...|.||  .. |. . 
FQCESEEEMQEWMQAIQKAIHNN
PH CRIK.AA PH 1274-1394 15 4.3e-07 28.23 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1274-1394
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)

NQIQGWMKTPRFSRMNKQGWEKKWCCLEGTMLSLFDKENLDTGKQPTDEYSLCPEDAIVTVHAGVSATELPNTASSDLPFVFHLESRPVTTCWPDTKTLY
  ..||..        . .| | |..| .. |.......              |   |   .. |  .. .     . |..| . .          .|.|
VIKEGWLHKKG----KRKSWKKRWFVLFNNCLYYYKDDK------------YRPKGSIPLSDCQVTKVPDN-----KRPHCFQIRT-DR-------RTYY

LMAPSFQDKQQWMVGLEVASI
. |.| .....||  .. |. 
FQAESEEEMNDWMQAIQSACR
CNH CRIK.AA CNH 1429-1689 17 7e-44 156.9 Pfam 1-312 (336) Show / Hide 
Range on Protein: 1429-1689
Range on HMM: 1-312/336
Sequence Identity: 17% (56 aa)

CTLLISDNVLLIG-AEEGLYTMLL------MDRKKPLSQIGGVSSVFQMHIITQLMMLLIF--AGPERNLCIVDLKHLRTMS---SQAQMPAP-------
..  .... ||.| ..||||.. .      ..... .. . .   | |...| .. .|..   .. ...|.  .| .|   .   .|...|..       
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSR--RVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIE

-----GLFSPSIFYLIQSCHLFA--CGKVDGSFYLCAAMPT-----KISILKYSEGLSKF-------------CVRKE-IQTA----EPSSCLLFT---E
     .   .        ||.|.    .. .. .||.|...     .| .... . ..||             .  .| ...     .........   .
RIMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEK

ASILAG-TDRFYEIELK-DFKIDEFLESTDTSLAFAVYGASQLDSFPIAAIQVAPDGEPQEFLLCFHEFGIFVDSKGR-RSR--PDDMKWSRLPLAFTYR
 ..  | .. |. . |    .. ...   |.|. .. . |.    .||.....  | |  |||||..|....|.. |. |||  .....|.  | .|...
PKLCVGCQKGFHIVNLDGTGQPWWLHDPADHSV-QQDFMARRENCKPICMHRINDD-E--EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACC

QPYLYMAHFNSVEVCEIK
.|||.  | |..|.  ..
YPYLLAFHPNFIEIRHVE
CNH CRIK.AA CNH 1425-1725 17 1.8e-38 135.03 SMART 1-375 (375) Show / Hide 
Range on Protein: 1425-1725
Range on HMM: 1-375/375
Sequence Identity: 17% (65 aa)

LDINCTLLISDN-----VLLIGAEEGLYTMLLMDR-KKP----LSQIGGVSSVFQMHIITQLMMLLIFAGP---ERNLCIVDL----------KH-LRTM
......  |..      .||.|.|.|.|.  . .   ..    ...| .  .|..| ..  .  |.  .|    .. ...|.|          .| .  |
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

SSQAQMPAPGLFSPSIFYLI-QSCHLFAC-GKVDG--SFYLCAAMPTKISIL--KYSEGLSKFCVR------------------KEIQTAEPSSCLLFTE
....  | .   .. | ..    ||...  ..  .  . .||.||.... |.   |   ....|..                  .|| .... .|.....
CNHHLVPRKNVWTTKIPDTKGN-CHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDS

A---SILAGTDR----FYEIELKDFKID----------EFLESTDTSLAFAVYGAS--QL--DSFPIAAIQVAPDGEPQEFLLCFHEFGIFVDSKG---R
    .|. |.|     .|..  ...  .          ...   |.||.|..  .|  |.  .....  .|  . |   ..|||...||.||.. |   |
FERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWR

RSRPDDMKWSRLPLAFTYRQPYLYMAHFNSVEVCEIKHTAE--TPSRERTFLSQANPRFVGP-AITPGAVYIASLG
|.|... .|.. | .| |..||..  ..|.... .|| .    .  ..|  .   ..|.... .. .......|  
RWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP