Gene 5755 (Tetrahymena)

5755

Species: Tetrahymena
Alias: 5755, PreTt05755, TTHERM_00578620, 329, 3733.m00022, 78.m00127
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: TKL
Family: TKL-ciliate2

Sequence

Name Sequence Type Origin Length Description Download
5755.AA Protein None 1037 None Fasta, JSON
5755.kin_dom Protein Kinase Domain None 270 None Fasta, JSON
5755.NA RNA None 3114 None Fasta, JSON

Protein domain

Protein domains of 5755.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RCC1 5755.AA RCC1 162-182 30 0.001042 14.92 Pfam 31-52 (52) Show / Hide 
Range on Protein: 162-182
Range on HMM: 31-52/52
Sequence Identity: 30% (7 aa)

IQAFGN--RVISVSAGENHTMII
.. . .  ||..|..| .|||..
VEFL-GNVRVVQVACGWQHTMAL
RCC1 5755.AA RCC1 185-254 26 4.7e-11 38.76 Pfam 1-52 (52) Show / Hide 
Range on Protein: 185-254
Range on HMM: 1-52/52
Sequence Identity: 26% (19 aa)

KQELYACGSNAYGQLG--IEGVSYLNKPTPIPVNICFPQYNIIFYQYFYFQKGLKDVKISMVSCGSDHTFAL
. ..|..|.| |||||       . ..|..| |..                     |....|.||..||.||
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQI-VEFL-G-----------------NVRVVQVACGWQHTMAL
RCC1 5755.AA RCC1 257-285 43 1.2e-08 30.93 Pfam 1-31 (52) Show / Hide 
Range on Protein: 257-285
Range on HMM: 1-31/52
Sequence Identity: 43% (14 aa)

QGEVYAWGLNLKGQLG--IGNFENQFSPVL-V
.|.||.|| |  ||||   |.  |.. |.. |
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIV
RCC1 5755.AA RCC1 377-444 14 1.4e-05 20.99 Pfam 1-52 (52) Show / Hide 
Range on Protein: 377-444
Range on HMM: 1-52/52
Sequence Identity: 14% (10 aa)

KNRLFSCGYGETYALG--HGEKSTLNEFKL-ISTIKSQQQQYGMNRGALDASPRLEKIEKLSCGLSHTTCV
. |....|... . ||  || .   .  .. ...  .                  ... . .|| .|| ..
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-G-----------------NVRVVQVACGWQHTMAL
RCC1 5755.AA RCC1 500-547 27 1.2e-10 37.43 Pfam 1-52 (52) Show / Hide 
Range on Protein: 500-547
Range on HMM: 1-52/52
Sequence Identity: 27% (15 aa)

KGDVYALGENTEGQLC--SEYNSPYEYPQR-INSLPS---ISQVAVGKNYCLVI
.|.||. | |..|||      .    .||. ...| .   ..||| | ......
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 5755.AA RCC1 554-603 26 0.000287 16.74 Pfam 4-52 (52) Show / Hide 
Range on Protein: 554-603
Range on HMM: 4-52/52
Sequence Identity: 26% (14 aa)

IFGWGSNAFGQITG-RLTSSPVLCQPVK-VQTINPENKDIKLI-CGSYHTIML
...||.| .||  |  ....   . |.. |..    |. .. . ||..||. |
VYTWGCNDYGQ-LGRIHGDT-NCHVPQQIVEFL-G-NVRVVQVACGWQHTMAL
Kinase 5755.AA TKL-ciliate2 760-1029 83 3.7e-229 767.57 In-house 1-273 (273) Show / Hide 
Range on Protein: 760-1029
Range on HMM: 1-273/273
Sequence Identity: 83% (229 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKFKMVHDEN-TVRDFLSECHAMEALRHPNIVMFLGACTKSPNFCIILEYCQKGSLWGLLQS-DVRLSWEDRR
|....||.||||||||||||||..||||||||.||.. ..|||..||||||||||||||||||||||.||||||.||||.||||.|||. ||||.|||||
LEIQNKITEGGYGIIYKAKWREIVVAVKKFKMDHDNQQQIRDFVNECHAMEALRHPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRR

RIALDAARGVHYLHSSNPPILHRDLKRQIKHKEKNLINIITLIKINSLNLLLDDNLRCKLADFGWTRVK-DDNYMTAKIGTYQWMAPEVISSNIYTEKAD
|||||.||||||||||||||.||||||||||||||||||||||||||||.|.|||.||||.|||||||| .|||||.|||||||||||||....||||||
RIALDIARGVHYLHSSNPPIIHRDLKRQIKHKEKNLINIITLIKINSLNVLVDDNFRCKLTDFGWTRVKPQDNYMTNKIGTYQWMAPEVIKAFYYTEKAD

VFSYGIILWEIASREPPYRNKSGTAVSVEVVKNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
||||.||||||||||||||||.|..|...|..|||||||||||||||||||||||||||||||||||||||||
VFSYSIILWEIASREPPYRNKKGDVVAEKVMCNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKELE
Kinase 5755.AA TKL 766-1028 30 1.4e-107 363.71 In-house 1-364 (364) Show / Hide 
Range on Protein: 766-1028
Range on HMM: 1-364/364
Sequence Identity: 30% (120 aa)

ISEGGYGIIYKAKWRE----------TTVAVKKFKMVH-------------------------DENTVRDFLSECH-AMEALRHPNIVMFLGACTKSPN-
| .||.|..||.|||           ..|||||||. .                         .    |.|. |    |  ||||||| |.|.|. .|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCIILEYCQKGSLWGLLQSDVRLSWEDRRRIALDAARGVHYLHSSN------PPILHRDLKRQIKHKEKNLINIITLIKINSLNLLLD
            .||. |||..|||. .|.      |. | |.|||.|||..||||.|      |||.|||||                    | |.|.|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK--------------------SKNILVD

DNLR--------------CKLADFGWTRVKD---DNYMTA------------------KIGTYQWMAPEVISSN----------------IYTEKADVFS
.|..              ||..|||  |...   .. .|.                  ..||..||||||.  .                 |.||.||.|
ENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS

YGIILWEIASREPPYR--NKSGTAVS-------VEVVKNNLRPTIP------------KNCPPQFADLMQRCWDNNQNLRPSFNEIIKEL
.||.||||..|..||.  . .   ..       . |....|||.||            ..|||....|||.||| . . ||||.||.|.|
FGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 5755.AA TyrKc 760-1028 28 4.4e-64 220.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 760-1028
Range on HMM: 1-280/280
Sequence Identity: 28% (89 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKFKMVHDENTVRDFLSECHAMEAL--RHPNIVMFLGACTKS-------PNFCIILEYCQKGSLWGLLQSDVR
.| . |. || .|..||..|. ..||||. |  .    ..||..|   |  |  .||||| ..|.||..       .  .|..||. .|.|   |..  .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LSWEDRRRIALDAARGVHYLHSSNPPILHRDLKRQIKHKEKNLINIITLIKINSLNLLLDDNLRCKLADFGWTRVKDDN--------YMTA-----KI-
 |...|   .....|.|  ||||   .. ||||                       | |...|...| .||| .|  .|         | ..     .  
KLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLA--------------------ARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-GTYQWMAPEVISSNIYTEKADVFSYGIILWEIASR-EPPYRN-----KSGTAVSVEVVKNNLRPTIPKN--------CPPQFADLMQRCWDNNQNLRPS
   . |||||.|  ...|.| ||.|.|. .||| .. ..|| .     .| . | .| ||.  |. .|.|        ||.   ..|..||. . . ||.
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV-IEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FNEIIKEL
|.||....
FSEIHECF
Kinase 5755.AA MLK 902-1028 38 6e-52 178.47 In-house 153-291 (291) Show / Hide 
Range on Protein: 902-1028
Range on HMM: 153-291/291
Sequence Identity: 38% (54 aa)

INSLNLLLDD------NLRCKLADFGWTRVKDDN-Y-MTAKIGTYQWMAPEVI---SSNIYTEKADVFSYGIILWEIASREPPYR-NKSGTAVSVEVVKN
..| |.|.|.      .. .| .|||  | . ..   |. ..||| |||||||    .. |.||.||.|.|..|||. .|| ||.   .. |.  .|. |
LKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYN

NLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKEL
.|||.||..||. .. ||..||. . . |||| .|...|
GLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase 5755.AA Dicty4 760-883 41 2.1e-51 169.8 In-house 1-141 (277) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-141/277
Sequence Identity: 41% (58 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKF---KMVHDENTVRDFLSECHAMEALRHPNIVMFLGACT----KSPNFCIILEYCQKGSLWGLLQS-----
...| .| .|..|  ||..|| . |||||.   . . |||.  .|. | | |  .|||||. |.||||    ... .||  ||. ||.|  || .     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

--DVRLSWEDRRR---IALDAARGVHYLHSSNPPILHRDLK
   . |.|....|   .|.|||||. .||..|| |.|||||
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLK
Kinase 5755.AA Dicty4 906-1030 43 4.6e-51 168.62 In-house 144-277 (277) Show / Hide 
Range on Protein: 906-1030
Range on HMM: 144-277/277
Sequence Identity: 43% (58 aa)

NLLLDDNLRCKLADFGWTR----VKDDNY-MTAKIGTYQWMAPEVISSNIYTEKADVFSYGIILWEIASREPPYR--NKSGTAVSVEVVKNNLRPTIPKN
||| |.|.| | .|||  .    ..| .  ... .||  ||||||  .. |.|||||.|.||.||||. |. ||    ..   .   |.   ||| ||..
NLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDW

CPPQFADLMQRCWDNNQNLRPSFNEIIKE--LEK
||| ...|.|.|||.. . ||||.|||..  || 
CPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase 5755.AA TKL-Unique 904-1028 37 1.4e-48 167.7 In-house 140-290 (290) Show / Hide 
Range on Protein: 904-1028
Range on HMM: 140-290/290
Sequence Identity: 37% (56 aa)

SLNLLLDDN-----LRCKLADFGWTRVKD-DNYMTAK----------IGTYQWMAPEVISS--NIYTEKADVFSYGIILWEIASREP------PYRNKSG
|.|.|.| |     .. |..|||  .... .| ||..          .|...||||||...  . |.||.||.|.||.|||||.|.       ||.. . 
SSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQ

TAVS--VEVVKNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKEL
...   | ... |.||.|| .||... ||.|.||. .   ||||.|||..|
EQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase 5755.AA S_TKc 760-1034 22 2.9e-45 157.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 760-1034
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LTTETKISEGGYGIIYKAKWRE--TTVAVKKFKMVHDENTVRDFLSECHAMEALRHPNIVMFLGACTKSPNFCIILEYCQK--GSLWGLLQSDVR-----
 .   || .|..|  ||.....    ||.|. |        .....|   ..  .||||| .....    ......|||    |.|  ....  |     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSWEDRRRIALDAARGVHYLHSSNPPILHRDLKRQIKHKEKNLINIITLIKINSLNLLLDDNLRCKLADFGWTRVKDDNYMTAKIGTYQWMAPEVISSN
 ..  . |...   .... |.|| .  |.||||| .                    |.|||.  . |..|||  |.      |  .||  .|||||.   
PFPE-HARFYMYQICCALEYCHSHG--IIHRDLKPE--------------------NILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---

IYTE-KADVFSYGIILWEIASREPPYRNKSGTAVSVEVVKNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIK---ELEKMNFS
 |.  |.|. | |.||.| ....||..        .... ....       .|.. |....|.. . . ||.  |. .   .  .. . 
GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5755.AA DRK 906-1030 38 1.7e-44 148.59 In-house 130-258 (258) Show / Hide 
Range on Protein: 906-1030
Range on HMM: 130-258/258
Sequence Identity: 38% (50 aa)

NLLLDDNLRCKLADFGWTR----VKDDNYMTAKIGTYQWMAPEVISSNIYTEKADVFSYGIILWEIASREPPYRNKSGTAVSVEVVKNNLRPTIPKNCPP
||| |.. . | ||||       .|.       .||  | ||||  .  |||||||.|..|.|||.. |. ||  .    |   | .  .|| .|..|||
NLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPP

QFADLMQRCWDNNQNLRPSFNEIIKELEK
 .. ||..||. .   |||. |... || 
KYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase 5755.AA DRK 760-883 39 7.8e-42 139.48 In-house 1-127 (258) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-127/258
Sequence Identity: 39% (50 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKFKM--VHDENTVRDFLSECHAMEALRHPNIVMFLGACTKSPNFCIILEYCQKGSLWG-LLQSDVRLSWEDR
      |  |.|| ..   || | ||||. .   . ||| . .|  |   |  ||||||. |.|.|. .|  ||. ||  .|||   |.   . ..|  .
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLM

RRIALDAARGVHYLHSSNPPILHRDLK
 ....|.|.|. |||..|| |.|||||
KQMMFDCAKGMIYLHCCNPIIIHRDLK
Kinase 5755.AA MLK 760-883 33 8.5e-40 135.75 In-house 1-154 (291) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-154/291
Sequence Identity: 33% (52 aa)

LTTETKISEGGYGIIYKAKWRETT-----VAVKKFK-----MVHDENTVRDFLSECHAMEALRHPN----IVMFLGACTKSPN-FCIILEYCQKGSLWGL
......| .|..|  .|..|| ..     ||||...     ..  .   .||  ||     |.|||    |. |.|.|...|. |||..|||..|||  .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L---Q-----------SDVRLSWEDRRRIALDAARGVHYLHSSNP-PILHRDLK
|   .           .|.. . .   ..||. |||.|||||  | || |||||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLK
Kinase 5755.AA LRRK 915-1030 34 9.7e-40 138.25 In-house 217-351 (351) Show / Hide 
Range on Protein: 915-1030
Range on HMM: 217-351/351
Sequence Identity: 34% (46 aa)

CKLADFGWTR--VKDDNY-MTAKIGTYQWMAPEVISSN---IYTEKADVFSYGIILWEIASRE-PPYRNKS----G--TAVSVEVVKNNLRPTIPKN-CP
.|.|||| .|    . .     . |. .|||||..  |    ||||.|..|.|.||||. .|. .|... .    .  .    . ... |||||| . ||
AKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCP

P-----QFADLMQRCWDNNQNLRPSFNEIIKELEK
|      . ||.| ||... . ||.|..|.| |. 
PCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase 5755.AA TKL-Unique 762-883 40 1.1e-38 134.14 In-house 1-139 (290) Show / Hide 
Range on Protein: 762-883
Range on HMM: 1-139/290
Sequence Identity: 40% (56 aa)

TETKISEGGYGIIYKAKWRETTVAVKKFKM-VHDENTVRD-FLSECHAMEALR-HPNIVMFLGACT----KSPNFCIILEYCQKGSLWGLLQ--------
   || ||||| .||.||| . ||.|.|.     .|.... | .|   |. |. ||||| . |.|.    . ||.||..|||. |||  .|.        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--SDVRLSWEDRRRIALDAARGVHYLHSSNPPILHRDLK
  .   |... | ..|.|.|.| .|||...|||.|||||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLK
Kinase 5755.AA Pkinase_Tyr 906-1028 35 1.2e-36 124.71 Pfam 141-270 (270) Show / Hide 
Range on Protein: 906-1028
Range on HMM: 141-270/270
Sequence Identity: 35% (46 aa)

NLLLDDNLRCKLADFGWTRVK--DDNY---MTAKIGTYQWMAPEVISSNIYTEKADVFSYGIILWEIASRE-PP-YRNKSGTAVSVEVVKNNLRPTIPKN
| |...|. .| .||| .|    ||.|    .       |||||.|. ...|.| || |.|. .||| ..   | | . | . |   . ... |  .|.|
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN

CPPQFADLMQRCWDNNQNLRPSFNEIIKEL
||.   |||..||. . . ||.| ||. .|
CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase 5755.AA TK 906-1028 20 2.6e-34 111.86 In-house 270-486 (486) Show / Hide 
Range on Protein: 906-1028
Range on HMM: 270-486/486
Sequence Identity: 20% (44 aa)

NLLLDDNLR-----------CKLADFGWT------RVKDDN---YMTAKIGTYQ---------------------------WMAPEVISSNI--------
| |...|..           ||.|||| .      . .|..   . ..| . .                            |||||.. ...        
NCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYG

-YTEKADVFSYGIILWEIAS--REPPYRNKSG--------TAVSVEVVKNN--------------LRPTIPKNCP--------------PQFADLMQRCW
 .|.| ||.|.|. .||| .  .||.| . |          .  .| ...               .|.  |..||              . ..||||.||
KFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCW

DNNQNLRPSFNEIIKEL
. . . ||.| .. ..|
HYDPEDRPTFSQLHEQL
Kinase 5755.AA Shk 906-1033 42 2.5e-33 116.69 In-house 133-269 (269) Show / Hide 
Range on Protein: 906-1033
Range on HMM: 133-269/269
Sequence Identity: 42% (58 aa)

NLLLDDNLRCKLADFGWTR-VKDDN----YMTAKIGTYQWMAPEVISSNIYTEKADVFSYGIILWEIASREPPYR-NKSGTAVSVE-VVKNNLRPTIPKN
||| | |.| | .|||     | .        .  ||  ||||||   . | |||||.| |||||||. .. ||    |     .| ..   .|| ||  
NLLVDQNWRVKVCDFGFSQYMKKHEMLKDKQKGAKGTPLWMAPEVMMNHPYNEKADVYSFGIILWEILTCQEPYPKHHSEYDKFYEAICNKKERPPIPDD

CPPQFADLMQRCWDNNQNLRPSFNEIIKE--LEKMNF
||.   .| |.||| | . ||||||||..  |.    
CPKSLKHLIQKCWDHNPQRRPSFNEIIQRRILNHILI
Kinase 5755.AA Pkinase_Tyr 760-882 31 1.3e-32 111.04 Pfam 1-137 (270) Show / Hide 
Range on Protein: 760-882
Range on HMM: 1-137/270
Sequence Identity: 31% (44 aa)

LTTETKISEGGYGIIYKAKWR------ETTVAVKKFKMVHDENT--VRDFLSECHAMEAL-RHPNIVMFLGACT-KSPN--FCIILEYCQKGSLWGLLQS
.|   |. || .| .||..|.      ...||||. |  ...     .||..|   |  | .||||| ..|.|| ..     .|..||...|.|   |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----DVRLSWEDRRRIALDAARGVHYLHSSNPPILHRDL
    . .|. .|   .... |.|  ||.| |  . ||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDL
Kinase 5755.AA LRRK 760-883 28 2.4e-32 111.75 In-house 1-193 (351) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-193/351
Sequence Identity: 28% (56 aa)

LTTETKISEGGYG-IIYKAKWRE----------------------------TTVAVKKFKM------------------------------VHDENTVRD
|  | .| .||.| ..|.||||                             ..||.||...                              . .|.. | 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

FLS---ECHAMEALRHPNIVMFLGACTKSPNFCIILEYCQKGSLWGLLQ---SDV------RLSWEDRRRIALDAARGVHYLHSSNPPILHRDLK
| .   |.. |  |.|||||  .| |  .| .|...|| . |.|  .|.   .|       ..||  . .|||. |.|. ||||.||||.|||||
FREFRHEVWIMSHLNHPNIVSLKGFCI-HP-LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLK
Kinase 5755.AA Pkinase 760-883 28 7.8e-32 113.64 Pfam 1-135 (293) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-135/293
Sequence Identity: 28% (39 aa)

LTTETKISEGGYGIIYKAKWRETT--VAVKKFKMVHDENTVR--DFL-SECHAMEALRHPNIVMFLGACTKSPNFCIILEYCQKG----SLWGLLQ--SD
.... || .|..|  ||.... |   ||||..| .|..  ..  ... ||.. |  |.||||| ...... ... ....|||..|    .|. ...  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VRL--SWEDRRRIALDAARGVHYLHSSNPPILHRDLK
 ..  |... .....  .||. |.|| .  |.|||||
GCFYFSEWECKFYMYQILRGLEYCHS-M-GIIHRDLK
Kinase 5755.AA Shk 760-883 38 4e-29 101.46 In-house 1-130 (269) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-130/269
Sequence Identity: 38% (50 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKFKMV-HDENTVRDFLSECHAMEALRHPNIVMFLGACT-KSPNFCIILEYCQKGSLWGLLQSDVRLSWE---
 ..| ..  | .|  ||.. |   ||||. .    ||||  .|  | | |  ..||||. |.|||| ..    |. | . ||.|  || .. .   .   
INREDFLGQGSFGKVYKGRCRGKEVAVKVMHKQNFDENTMTSFRKEVHIMSKIFHPNICLFMGACTSQPGKCMIVTELMPKGNLEKLLHDQ-MVKKPFIL

-DR-RRIALDAARGVHYLHSSNPPILHRDLK
  |  |...||| |.  ||.||. |.|||||
YKRAMRMCRDAALGMNWLHGSNCNIIHRDLK
Kinase 5755.AA TK 760-882 17 8.1e-29 93.13 In-house 1-266 (486) Show / Hide 
Range on Protein: 760-882
Range on HMM: 1-266/486
Sequence Identity: 17% (46 aa)

LTTETKISEGGYG---IIYKAKWRE---------------------------TTVAVKKFKMVHDENTVR-------------DFLSECHAMEALR----
.| . |. || .|    .||..||.                           |.||||  |  ....  .             |||.|...|. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIVMFLGACTKS------------PNFCIILEYCQKGS----LWGLLQSDVR---------------------------------------------
 ||||| ..|.||..            . ..|..||...|.    |   |..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSWEDRRRIALDAARGVHYLHSSNP----PILHRDL
                               |. ...  .....|.|  |||| |      . ||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDL
Kinase 5755.AA ARK 760-883 32 1.7e-26 93.31 In-house 1-130 (280) Show / Hide 
Range on Protein: 760-883
Range on HMM: 1-130/280
Sequence Identity: 32% (42 aa)

LTTETKISEGGYGIIYKAKWRETTVAVKKFKM-VHDENTVRDFLSECHAMEALRHPNIVMFLGACTKSP----NFCIILEYCQKGSLWGLLQ-SDVRLSW
|.   || .| ..  ||.|.|   ||.| .|    |. .  .|. |.  | ..| |..| | ||| .        |.. |||..|||  ..       .|
LEYTCKIGSGSSCKVYKGKYRGKEVAIKVLKSIMTDSMQIEEFKKEFQIMSSIRSPHVVYFYGACIEPEPQKQKLCMVMEYCSRGSLYHIMNNNKMDFGW

EDRRRIALDAARGVHYLHSSNPPILHRDLK
.   . .  . ||. .||...|.|.|||||
DRFFKWMMQMVRGINCLHNWTPQIVHRDLK
Kinase 5755.AA Pkinase 906-1028 22 3.9e-25 89.95 Pfam 138-293 (293) Show / Hide 
Range on Protein: 906-1028
Range on HMM: 138-293/293
Sequence Identity: 22% (36 aa)

NLLLDDNLRC----KLADFGWTR---VKDDNYMTAKIGTYQWMAPEVIS-SNIYTEKADVFSYGIILWEIASREPPYRNK------SGTAVSVEVVKNNL
|.|.|.|  .    |..|||  .      .  ||   ||. .||||||  .. |. |.|..|.|.||.| ....||....      .  .. ... .  |
NILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPL

RPTIPKNCP-------------------PQFADLMQRCWDNNQNLRPSFNEIIKE--L
.  .|. |.                   . . |.. .|.. . . ||.. .| .   .
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5755.AA ARK 988-1027 60 4.4e-18 62.45 In-house 241-280 (280) Show / Hide 
Range on Protein: 988-1027
Range on HMM: 241-280/280
Sequence Identity: 60% (24 aa)

KNNLRPTIPKNCPPQFADLMQRCWDNNQNLRPSFNEIIKE
||||||||| |||.|. .| |.||| ....|||  ||. |
KNNLRPTIPQNCPEQLKNLIQCCWDQDPDNRPSCEEIMEE
Kinase 5755.AA ARK 904-970 40 7.5e-16 54.27 In-house 131-211 (280) Show / Hide 
Range on Protein: 904-970
Range on HMM: 131-211/280
Sequence Identity: 40% (33 aa)

SLNLLLDDNLRCKLADFGWTRVKD-DNYMTA-KI-GTYQWMAPEVIS-----------SNIYTEKADVFSYGIILWEIASR
|||||  .|  ||..||| .|    .|  |  |. ||.   ||||             .  ||.|.||.| |||.||...|
SLNLLVNENWTCKVCDFGLSRFNTMSNQETLGKMRGTFAYCAPEVYYFQDIDDDYVSNGKHYTTKSDVYSMGIIMWEMVYR