Gene 26687 (Tetrahymena)

26687

Species: Tetrahymena
Alias: 11.m00384, 3702.m00107, PreTt26687, 494, TTHERM_00143800, 26687
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
26687.AA Protein None 422 None Fasta, JSON
26687.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
26687.NA RNA None 1269 None Fasta, JSON

Protein domain

Protein domains of 26687.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26687.AA STE7-Unclassified 143-399 45 1.1e-159 536.73 In-house 1-301 (301) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-301/301
Sequence Identity: 45% (138 aa)

FEVVSELGKGAFGKVYKVCHKK------DGKIYAMKEIIMVDD-IELRQKILMEVKTLFICQ-SPYIVTYYGAFYTEGK---LHIILEYMDVGTLD---S
.|....||.|..|.|.|..||.      ||||.|.|.|...|. .|....||.|.|||..|| .||||.||||.|.|..   .||..||||.|.||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LLKKA-------GGKVSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSGE-----
..||.       ||...|.||....||...||.|||...||||||||||||||||||..||.|.|.||....||||..|.||...||||||..|.     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

SYSVKTDIWSFGLLLLEFSESKNPL-------QLNENA-----SFFEILAKVMNFSIPELNS-----IKSKEFIQFVEQCTKINPKERADVVQLLE-LPF
|||||.||||.||...|....|.|.       |.|.|.     ||.|.|....||..|.|..     |.||||..|...|.|..|.||.|..|||. .|.
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPW

V
.
I
Kinase 26687.AA STE7 143-399 39 1.2e-141 476.92 In-house 1-288 (288) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDD-IELRQKILMEVKTLFICQ-SPYIVTYYGAFYTEGK--LHIILEYMDVGTLD---SLLKKAG-
.|...|||.|..| |||..||..|||.|.|.| . ..  |....||||...|. |. .||||..||||||||.   .|..||||.|.||   ...|| . 
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GKVSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSG--ESYSVKTDIWSFG
    |...| .| . .....|||.|||....|||||.||.||||||.|..|..| |||| .. ..|...||||...||.|||..|  ..|.|..|.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LLL-LEFSESKNPL-----------QLNENAS----FFEILAKVMNF-SIPELNSIKSKEFIQFVEQCTKINPKERADVVQLLE-LPFV
. . .|... . |.           |.|....    .|| | ...|. ..|.|  . |.||..||..|.. .|.||..  ||..  ||.
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase 26687.AA STE 143-399 28 7.7e-100 338.0 In-house 1-359 (359) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-359/359
Sequence Identity: 28% (103 aa)

FEVVSELGKGAFGKVYKVCHKK---------------DGKIYAMKEIIMVDD----------------IELRQKILMEVKTLFICQ--SPYIVTYYGAFY
.| ....||||||.||| ...|                |.|.|.|.. . ..                .| .|.||.|.|..  |.  .|.||.|||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TEG-------KLHIILEYMDVGTLDSLLK---KAG----------GKVSEVVLKYLTYQILKG-LKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGIC
 ||       .|.|..|||| |.||...|   . |          ....| ...| ..||||| |.|||.   ||||||||.|||.     .|..| |.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GAINA---------------TLD-ERQTFVGTSIYMSPERLSG------ESYSVKTDIWSFGLLL-------LEFSESKNPLQLNENASF------FEIL
| ..                | . .|.|||||  .|.||....        |..| ||||.|...        .... ...  . . .        || |
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

AKVMNFSIPELNS-------------------IKSKEFIQFVEQCTKINPKERADVVQLLE--LPFV
 ...|. .| | .                     |.||..|...| ...|..|... |||.   ||.
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 26687.AA S_TKc 143-399 31 2.1e-81 277.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKILMEVKTLFICQSPYIVTYYGAFYTEGKLHIILEYMDV--GTLDSLLKKAGGK----
.|.. ..||||||||||. |||.|.|.|.|.|         ..|. |.. |   . |.||..|..|.. ..|....||.|   |.| ...|| |..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSGESYSV-KTDIWSFGLLLLEF
  .| . ....|||...|.|.|.  .|||||.|| |||...  .|||.| |..  .        ||.||  ||.|| |   .|.  | |.||.| .| |.
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

SESKNPLQLNENASFFEILAKVMNFSIPELNSIKSKEFIQFVEQCTKINPKERADVVQLLE-------LPFV
   . | .       .... |..           |.|...|...| . .|..|  . ..|.        |..
LCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26687.AA Pkinase 143-399 29 2.3e-74 258.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-293/293
Sequence Identity: 29% (86 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKIL---MEVKTLFICQSPYIVTYYGAFYTEGKLHIILEYMDVG----TLDSLLK-KAG
..... .|.|.||.||| .||..|||.|.|.|  ... .  ....   .|.. .  ...|.||..|..|..........||.. |     | .... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKV--SEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEI----KISDLGICGAI-NATLDERQTFVGTSIYMSPERLS-GESYSVKTDIWS
|..  || ..|   ||||.||.|.|.   |||||.|| |||....|.|    ||.| |..  . .      .||.||. ||.|| .  |. |. | |.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGLLLLEFSESKNPLQ-L------NENASFFEILAKVMNFSIPELNSIK----------------SKEFIQFVEQCTKINPKERADVVQLLELPFV
.|..| |.   . | .        .... ...|. .   |..|...||                 |.|...|.. | . .||.|    |.|. |..
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 26687.AA MEK1 143-334 47 7.4e-65 220.5 In-house 1-189 (297) Show / Hide 
Range on Protein: 143-334
Range on HMM: 1-189/297
Sequence Identity: 47% (92 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKILMEVKTLFICQSPYIVTYYGAFYTEGKLHIILEYMDVGTLDSLLKKAGGKVSEVVL
||...|||.|  | | |. |.. | | | | | .     .|..|. |.. |  | ||||| .||||| .| . | .|||| | || .|||| |.. | .|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-GRIPEKIL

KYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSGESYSVKTDIWSFGLLLLEF
  ..  .|.|| ||. . .|.|||.|| ||||||.||||. | |. | .   .     ||||  ||||||| |  |.|. ||||.|| | |.
GKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAN--SFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEM
Kinase 26687.AA STE20 143-341 33 1.9e-63 217.11 In-house 1-227 (288) Show / Hide 
Range on Protein: 143-341
Range on HMM: 1-227/288
Sequence Identity: 33% (76 aa)

FEVVSELGKGAFGKVYKVCHKKDGKI----YAMKEIIMVDDI---ELRQKILMEVKTLFICQSPYIVTYYGAFYTE----GKLHIILEYMDVGTLDSLLK
.| . ..|.|..|||||. ||. |..    .| | . . ..    . .. |. |.  .  |..|.||.|||... .     .| |. ||.. |.|  ..|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KAGG-----KVSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINA----TLD-ERQTFVGTSIYMSPERLSG---
   | |.     . .|.   | ....|.||.|||.  |||||||| .|||....||.|..| | |. ..     | . .|.|||||  .|.|| ...   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS-NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--ESYSVKTDIWSFGLLLLEFSESKNPL
    |  |.||||.|  ..|  | . |.
PDKGYDYKCDIWSLGITAIEMAEGEPPY
Kinase 26687.AA MEK5 144-399 36 4.2e-60 205.98 In-house 2-254 (254) Show / Hide 
Range on Protein: 144-399
Range on HMM: 2-254/254
Sequence Identity: 36% (94 aa)

EVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKILMEVKTLFICQSPYIVTYYGAFYTEGKLHIILEYMDVGTLDSLLKKAGGKVSEVVLK
     ||.|  | |||  |   ||| |.| |..   .||...|. |.. |. | ||||. .||||..| .. |  |.|| | ||        .. | .| 
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYR-----CIPEHILG

YLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSGESYSVKTDIWSFGLLLLEFSESKNP---
 .|  | ||| ||  .| |.|||.|| |.||| .|.||. | |.   .   .   .|..||  || |||.||. | .  |.|| |. ..|.   . |   
RMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSI--TRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQ

LQLNE-NASFFEILAKVMNFSIPELNSIK-SKEFIQFVEQCTKINPKERADVVQLLELPFV
.| .  . .  ..|  ...   | | . | |. |..|..|| .  ||.|    .|.. ||.
IQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase 26687.AA Ciliate-E2-Unclassified 143-399 25 2e-57 197.11 In-house 1-352 (352) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-352/352
Sequence Identity: 25% (89 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQK-----------ILMEVK-------------TLFICQSPYIVTYYGAFYTEGKLHIIL
....  .|.|.||||||. |||....||||... . ..  .|.           .... |              |  ...|.|| .. .| .. .. |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYMDVGTLDSLLKKAGG----------------KVSEVVLK-----YLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKG---EIKISDLGICGAINAT
||.. |.|   .|| ..                ...|   |     ....|||.||.|||. ..|||||||| |||....|   .|||.|.||.  ..  
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---------------LDERQTFVGTSIYM----SPERLSGESYS----VKTDIWSFGLLLLEFSESKNPLQLNENAS-------------FFEILAKVMN
                .. .||.|| .||    .|| | |. |.     | ||||.| .| |.   . | . |   .             ..... . ..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

--FSIPELNS-----IKSKEFIQFVE----QCTKINPKERADVVQLLELPFV
  ...|. .      . |.| . |..    .. | ||..| .  |.|. |. 
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 26687.AA SLK 143-399 32 4.7e-57 190.97 In-house 1-259 (259) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-259/259
Sequence Identity: 32% (87 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKILMEVKTLFICQSPYIVTYYGAFYTEGKLHIILEYMDVGTLDSLLKKAGGKVSEVVL
.|.. ||| ||||||||  || . |..|   .| ..| |  .  ..|.  |  |. |.||  |.|.| ..|| ...|. | | .|...   .  . |  .
WEIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQI

KYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINATLDERQTFVGTSIYMSPERLSGES-----YSVKTDIWSFGLLLLEFSES
.|. .... .|..||.. ..||||.| ||||.   |.... | |.      |.. | ||.||  .| || .  |      |  |.||||.|. |.|. . 
QYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQM

KNPLQLNENASFFEILAKVMNFSIPELN--SIKSKEFIQFVEQCTKINPKERADVVQLLELPFV
  |   ... .   .| |.     |.|   |  ||||  |...| . .|. |    ||.. ..|
EPP---HHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase 26687.AA Ciliate-E2 143-399 21 8.8e-56 189.95 In-house 1-365 (365) Show / Hide 
Range on Protein: 143-399
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMK----------------------EIIMVDDIELRQKILMEVK-------------TLFICQSPYIVTYYGA
....  .|.|.||.|||....|..| .|.|                      .|.. ..||   ... . .              |.. ..|.|. .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--TEGKLHIILEYMDVGTLDSLLK-----------KAGGKVSEVVLKYLTYQILK---------------GLKYLHKDLHIIHRDIKPGNILVNSKGE
|.  .. .. ...|| . |.| ...|           |. .. .|   ||...|||.               .|.|||.  .|||||||| |||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKISDLGICGAIN-------------ATLDER-------------------QTFVGTSIYMSPERLSGES---------YSVKTDIWSFGLLLLEFSESK
|||.|.|..  ..               .. .                   .|..||  ||.|| |.|..         |. | ||||.| .| |.   |
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

NPLQLNENASFFEILAKVMNFSIPE-------------LNSIKSKEFIQFVEQ----CTKINPKERAD-VVQLLELPFV
 |        . .|. .  .|. ||              .   |.| ...  .    . . .|..| .   |.|. |. 
PPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 26687.AA NEK 143-333 36 6e-52 178.9 In-house 1-216 (286) Show / Hide 
Range on Protein: 143-333
Range on HMM: 1-216/286
Sequence Identity: 36% (80 aa)

FEVVSELGKGAFGKVYKVCHKKDGKI-----YAMKEIIMVDDIE-LRQKIL-MEVKTLFICQSPYIVTYYGAFYTEG--KLHIILEYMD-VGTLDSL---
.|.. ..|.|.||||||| .|.|||.     |..|.| |    |  .|. .  ||. |   ..|.||.|| .|. |.  .|.|. || .  |.|. .   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LKKA---GGKVSE-VVLKYLTYQILKGLKYLHKDL----HIIHRDIKPGNILVNSKGE----IKISDLGICGAINATLDERQT-FVGTSIYMSPERLSGE
.||    |   .| ....... |....|||.|.      .|.|||||| ||  ....     .|| |.||    | | |  .| .|||  ||||| ....
IKKQKQKGKYFEEEQIWDWFI-QMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK

SYSVKTDIWSFGLLLLE
.|. | ||||.| .| |
PYNNKSDIWSLGCVLYE
Kinase 26687.AA TyrKc 143-397 25 2.2e-17 58.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 143-397
Range on HMM: 1-280/280
Sequence Identity: 25% (73 aa)

FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIMVDDIELRQKILMEVKTLFIC--QSPYIVTYYGAFYTE-------GKLHIILEYMDVGTLDSLLKKA
 .   .|| ||||.|||   |      | | .        |. .. | . .     . | ||  ||.  ..       . | |..|||. | |.. |.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GGKVSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGICGAINAT-------LDERQTF--VGT--SIY--MSPERLSGESYSV
..|..   | .  .|| .|  ||| . ..||||.   |.||.... .|||| | . .|             |..    |     .  |.|| .    .. 
RPKLCMKDLLSFCWQIACGMEYLH-SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

KTDIWSFGLLLLE-FSESKNPLQLNEN--ASFFEILAKVMNFSIPELNSI--------KSKEFIQFVEQCTKINPKERADVVQLLELP
|.|.|||| .. | |.  . |    .    | .|....|..   ..             ..|  |  .|| . .|..|    .. |. 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 26687.AA Pkinase_Tyr 143-288 29 3.5e-17 58.82 Pfam 1-158 (270) Show / Hide 
Range on Protein: 143-288
Range on HMM: 1-158/270
Sequence Identity: 29% (47 aa)

FEVVSELGKGAFGKVYKVCHK----KDGKIYAMKEIIMVDDIEL--RQKILMEVKTLFIC-QSPYIVTYYGAFY-TEGK--LHIILEYMDVGTLDSLLKK
 .   .||.||||.|||   |    ...   | | .    . |   |.. . |.|..    . | || .||. .  ..   . |..|||  | |.. |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

A---GGKVSEVVLKYLTYQILKGLKYLHKDLHIIHRDIKPGNILVNSKGEIKISDLGIC
    .....   |    .|| ||. ||. . ..||||.   |.||.... .||.| | .
HREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase 26687.AA STE20 369-399 41 1.3e-09 31.58 In-house 258-288 (288) Show / Hide 
Range on Protein: 369-399
Range on HMM: 258-288/288
Sequence Identity: 41% (13 aa)

SKEFIQFVEQCTKINPKERADVVQLLELPFV
|.|| .||..|  ..|..|. . |||. ||.
SPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 26687.AA MEK1 350-399 41 4.4e-09 26.63 In-house 247-297 (297) Show / Hide 
Range on Protein: 350-399
Range on HMM: 247-297/297
Sequence Identity: 41% (21 aa)

FEILAKVMNFSIPELNS-IKSKEFIQFVEQCTKINPKERADVVQLLELPFV
||.|  ..|   |.|.. . |.||..||..| . ||.||||. ||.  .|.
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase 26687.AA NEK 369-399 29 0.000136 12.54 In-house 256-286 (286) Show / Hide 
Range on Protein: 369-399
Range on HMM: 256-286/286
Sequence Identity: 29% (9 aa)

SKEFIQFVEQCTKINPKERADVVQLLELPFV
|..  ....|. . .|..| .. |.||.||.
SQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 26687.AA Pkinase_Tyr 308-331 41 0.005716 10.68 Pfam 181-204 (270) Show / Hide 
Range on Protein: 308-331
Range on HMM: 181-204/270
Sequence Identity: 41% (10 aa)

MSPERLSGESYSVKTDIWSFGLLL
|.|| ..   ...|.|.|||| |.
MAPECINYGKFTTKSDVWSFGVLM