Gene 1909 (Tetrahymena)

1909

Species: Tetrahymena
Alias: TTHERM_01111050, PreTt01909, 792, 240.m00032, 1909
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
1909.AA Protein None 2001 None Fasta, JSON
1909.kin_dom Protein Kinase Domain None 261 None Fasta, JSON
1909.NA RNA None 6006 None Fasta, JSON

Protein domain

Protein domains of 1909.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 1909.AA STE7-Unclassified 282-542 46 1.4e-166 559.71 In-house 1-301 (301) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-301/301
Sequence Identity: 46% (140 aa)

LRRVKVLGHGSSGLVELAVHDA------TGIVIGIKSIPLLMN-SSFRKQLDQELKTLIQCE-SDSIVKCYGAYIQKCM---INITLEYMDLGTVH---D
|.|.|.||||..| |....|..      .|.....|.||...| ..|.||...|||||..|. ...||..||||...||   |.|..||||.|...   |
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LVKKV--------GPLPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESAV-EVKNWVGTVTYMSPERFRGQ-----
..||.        |..||......|.||..||.|.|.|...|||||||.|.||||||||||.||||...||... |.|.|||...||||||..||     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

AYTANTDIWSLGLTICECALGTYPY---FDSNQYEKK---ENLSFWELLEYFNMKPAPRLPE-----NYSEEMKDFVAKCFKKSPLDRPHSHDLLN-HEM
.|....|||||||||.|||.|.|||   |.|.||...   ||.||||||......|.||||.     ..|.|..||..||.||.| .||..|.||| |..
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPW

V
.
I
Kinase 1909.AA STE7 282-542 39 6.9e-142 477.67 In-house 1-288 (288) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNS-SFRKQLDQELKTLIQCE-SDSIVKCYGAYIQKCM--INITLEYMDLGTVH---DLVKKV--
|.....||||..| |. ..|  .|... .| |.| .|. ...||. .||..| .|. .. ||..|||......  | | .||||.|. .   ..||||  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GPLPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESAV-EVKNWVGTVTYMSPERFRG--QAYTANTDIWSLG
    |..|| |....|..|.|||.| |.| |.||||.|||| ||||.||||..|||.. .|.  . . . .||...||.|||  |  | |.  .|.||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LTI-CECALGTYPY-------FDSNQYEKK---ENLSFWELLEYFNMK-PAPRLPENYSEEMKDFVAKCFKKSPLDRPHSHDLLN-HEMV
.|. .|.|.|.|||       .|..||...   | ....|.|..  .  |.|||| ..|.|..|||.||..| | .||. |.|.. |...
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPE-MAIFEQLTCIVNENPPPRLP-KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase 1909.AA STE 282-542 25 1.2e-90 307.45 In-house 1-359 (359) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-359/359
Sequence Identity: 25% (95 aa)

LRRVKVLGHGSSGLVELAVHD------ATGIV---------IGIKSIP----------------LLMNSSFRKQLDQELKTLIQCE--SDSIVKCYGAYI
.......|.|..| | .|..        || |         . || ..                  .|.. ..|. .|.|.. .|   .. |||.||.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QKC-------MINITLEYMDLGTVHDLVKKV--------------GPLPEIIVAIMAIQVLKG-LDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVS
...        ..| .|||| |.. |..|..              ...|| ..|... |.||| |.|.|..  .|||||||.| |.     ||..||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

ANLES-----------------AVEVKNWVGTVTYMSPERFRG------QAYTANTDIWSLGLTICECALGTYPYFD-SNQYEKKENLSF------WELL
..|..                 . . . .|||  .|.||. ..      . |..  ||||||.||.| | | .|..| .. .   . .        .|.|
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

EYFNMKPAPRLPE-------------------NYSEEMKDFVAKCFKKSPLDRPHSHDLLN--HEMV
 . ...| |.||.                   ..|.|.|||..||..| | .|| ...||.  |. .
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 1909.AA S_TKc 282-542 25 3e-64 220.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQCESDSIVKCYGAYIQKCMINITLEYMDL--GTVHDLVKKVGP-----
 . ....|.|. | | ...|  || .  || |.        ... .|.. | .   . |||.|...     . . .||.|   |...|. || |.     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESAVEVKNWVGTVTYMSPERFRGQAYTA-NTDIWSLGLTICECA
 .||  .. .. |....|.|.|.. ..||||.||.|.|...  ..||.|||... |      .  .||  ||.|| .    |.    |.||.| .. |..
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

LGTYPYFDSNQYEKKENLSFWELLEYFNMKPAPRLPENYSEEMKDFVAKCFKKSPLDRPHSHDLLN-------HEMV
 |  |.   ....  ...                     |.|.|||. ||..| | .||   ..|.       |. .
CGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 1909.AA MEK5 282-542 37 3.8e-63 216.11 In-house 1-254 (254) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-254/254
Sequence Identity: 37% (99 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQCESDSIVKCYGAYIQKCMINITLEYMDLGTVHDLVKKVGPLPEIIVA
.|    ||||  | |  | |  .| .. .| | | .   ..||.  ||. | .|.|  |.  |||.     | |  |.|| | . |. ...   || |. 
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSL-DMYRCI---PEHILG

IMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESAVEVKNWVGTVTYMSPERFRGQAYTANTDIWSLGLTICECALGTYPYFDS
 |.. . ||| |. |  |..|||.||||.||| .||.|. |||||. | ...  . ..||  || |||  |. |    |.||||. . | |.| .||   
RMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSI-TRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPY---

NQYEKKE-NLSFWELLEYFNMKPAPRLP-ENYSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
 | ..   .|.  .||       .|||| ...||   .|. .|..| | |||  .||..|  .
PQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase 1909.AA MEK1 282-477 43 2.8e-62 211.51 In-house 1-195 (297) Show / Hide 
Range on Protein: 282-477
Range on HMM: 1-195/297
Sequence Identity: 43% (86 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQCESDSIVKCYGAYIQKCMINITLEYMDLGTVHDLVKKVGPLPEIIVA
. ... ||||  | |  ..|  ||...  | | | .  . |.|. .||. | .| |  ||  |||...   | | .|||| | .  ..||.| .|| |. 
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

IMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESAVEVKNWVGTVTYMSPERFRGQAYTANTDIWSLGLTICECALGTYP
 ... ||.|| |...| |..|||.||||.||||.| .|. |||||  |  ..    .|||  |||||| .|  || . ||||.|| . | |.| ||
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM-ANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYP
Kinase 1909.AA Pkinase 282-542 24 5.2e-53 187.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 282-542
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQ---ELKTLIQCESDSIVKCYGAYIQKCMINITLEYMDLG----TVHDLVK--KV
.......| ||.| | ...|  ||..  .| |..  ..|  .| .    |.. .  . .. ||..|...  |  | . .||.. |      .|...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GPL--PEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQV----KIADFGVSAN--LESAVEVKNWVGTVTYMSPERFR-GQAYTANTDIWS
|..  .|  .  .. |.|.||.|.|.  ..||||.||.|.|....|..    ||.|||...   . . .  .  .||  ||.||  | || |.   |.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGLTICECALGTYPYFDSNQYEKKENLSFWELLEYFNMKPAPRLPENYS-----------------------EEMKDFVAKCFKKSPLDRPHSHDLLNHE
.|... | ..|  |. ...  ... .    . .. ....  |.|.....                       ||.|||. .|..| | .||  ...|.|.
CGCILYEMLCGRPPFPGHC-WHDN-H----DQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

MV
 .
WF
Kinase 1909.AA STE20 282-480 33 6.6e-48 165.48 In-house 1-229 (288) Show / Hide 
Range on Protein: 282-480
Range on HMM: 1-229/288
Sequence Identity: 33% (78 aa)

LRRVKVLGHGSSGLVELAVHDATGIV----IGIKSIPLLMNS---SFRKQLDQELKTLIQCESDSIVKCYGAYIQK----CMINITLEYMDLGTVHDLVK
   ....|.||.| | .| |  || .    . || ..|   .     .. . .|   . || .  ||| ||.|. .      . |  ||.. |...|..|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KVG------PLPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLES----AVE-V-KNWVGTVTYMSPERFRG---
   | |      |. |  .| .  .||.||||.|.. ..||||||  | |....|.||.|||||.| |..    .     .. |||  .|.||  ..   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--QAYTANTDIWSLGLTICECALGTYPYFD
  . |.  .|||||| |..| | |  ||||
PDKGYDYKCDIWSLGITAIEMAEGEPPYFD
Kinase 1909.AA TKL 288-540 17 6.1e-44 152.29 In-house 1-364 (364) Show / Hide 
Range on Protein: 288-540
Range on HMM: 1-364/364
Sequence Identity: 17% (63 aa)

LGHGSSGLVELAVHDA--------TGIVIGIKSIPLL--------------------------MNSSFRKQLDQELKTLIQCESDSIVKCYG-AYIQKCM
.| |..| |  ...          || .. .| ..                            ..| ||... .|.. ....  . ||...| .   .| 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------INITLEYMDLGTVHDLVKKVGPLPEIIVAIMAIQVLKGLDYIHNKAK-------VIHRDIKPSNLLVNSKGQ--------------VK
            . |  ||.. |. ....             .|... .|..| |..         .||||.|..|.||.....              .|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

IADFGVSANLE--------------------SAVEVKNWVGTVTYMSPERFRGQ----------------AYTANTDIWSLGLTICECALGTYPYFDSNQ
|.||| | ...                    ..    . .||  .|.|| .|||                 |.  .|..| |. ..|.. .  ||.| . 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

YEKKEN----LSFWELLEYFNMKPAP---------RLPENYSEEMKDFVAKCFKKSPLDRPHSHDLLNHE
.. . .    . |.   . ..  | |           ...  ..||.   .| .  | .||   ..| . 
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase 1909.AA YSK 283-480 37 1.5e-42 125.73 In-house 2-203 (257) Show / Hide 
Range on Protein: 283-480
Range on HMM: 2-203/257
Sequence Identity: 37% (76 aa)

RRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQCESDSIVKCYGAYIQKCMINITLEYMDLGTVHDLVKK--VGPLPEIIV
 .  . | || | |  ..   |. |. || | |   .     . ||   | ||.|  | | ||.| .   . |  ||   | . || |.  ||...|. .
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

AIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLE-SAVEVKNWVGTVTYMSPERFRG--QAYTANTDIWSLGLTICECALGTYP
||.   .||||||.| . ..||||||  | |.. .|.||..||||.. .  .       |||  .| ||       .| .  |||||| |  | | |  |
AIILREILKGLDYLH-SERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YFD
| |
YCD
Kinase 1909.AA MST 285-480 39 2e-35 110.0 In-house 4-199 (254) Show / Hide 
Range on Protein: 285-480
Range on HMM: 4-199/254
Sequence Identity: 39% (78 aa)

VKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQCESDSIVKCYGAYI--QKCMINITLEYMDLGTVHDLVKKVG-PLPEIIVA
|  || || | |  |.|  ||..  || .|   |. .  ..  |  .. || |. ||| || |.      . |  || . | | |..|  . .| |   |
VEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDL-QEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

IMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLES-AVEVKNWVGTVTYMSPERFRGQAYTANTDIWSLGLTICECALGTYPYFD
    ..|.||.| |.  | ||||||. | |.| .|  | ||||||. |     .    .||  .|.||    . |.  .|||||| |. | | |  ||.|
CILYDTLQGLQYLHDNKK-IHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSD
Kinase 1909.AA STE11 282-465 26 2.7e-31 110.3 In-house 1-225 (303) Show / Hide 
Range on Protein: 282-465
Range on HMM: 1-225/303
Sequence Identity: 26% (60 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSS-------FRKQ------LDQELKTLIQCESDSIVKCYGAYI---QKCMINITLEYMDLGTV
 .. ...| |. | | ...   || .. .| |.. .|..       . ..      . .|.| . .     ||. ||. .   |.  .|| .||.  |..
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

HDLVK-KVGP--LPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQ-VKIADFGVSANLESAV---EVKNW--------VGTVT-------
 .. . | ||  ..|  . .   |.|.|| | | . ..||||||. |.|..|.|. .|.|||| .  |..     . .|          ||.        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSH-GIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTP

-YMSPERFRGQA---YTANTDIWSLG
 .|.||  ...    |..  ||||||
MWMAPEVIKQEGRDGYGRKADIWSLG
Kinase 1909.AA TyrKc 282-545 23 9.3e-17 48.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 282-545
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPLLMNSSFRKQLDQELKTLIQC--ESDSIVKCYGAYIQK-------CMINITLEYMDLGTVHDLVKKV
..  |.||.|  | | ... .   |   .|..        |. . .|.. . .   . . ||..||. .|.         . | .|||..|  .|  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GP-LPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVSANLESA-------VEVK------NW-VGTVTYMSPERFRGQAYTA
.| |.      ...|. .| .|.| | ..||||.   | ||.....|||.||| | ....           .         .  .  |.|| ..   .| 
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

NTDIWSLGLTICE-CALGTYPYFDSNQYEKKENLSFWELLEYFNMKPAPRL--PEN----YSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMVKKF
 .|.|| | .. | . .|  || .  |  ...|    |...  .. | |    |       ..|| .   .| .  | |||   ..     ...|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase 1909.AA YSK 505-542 38 7.7e-12 31.56 In-house 219-257 (257) Show / Hide 
Range on Protein: 505-542
Range on HMM: 219-257/257
Sequence Identity: 38% (15 aa)

PRLPE-NYSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
|.|   .||  .|.||. | .| | .||   .|| |. .
PKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase 1909.AA MST 508-542 42 1e-10 30.18 In-house 220-254 (254) Show / Hide 
Range on Protein: 508-542
Range on HMM: 220-254/254
Sequence Identity: 42% (15 aa)

PENYSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
|| .| |  |||.||  |.| .|. . .||.|. .
PEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase 1909.AA MEK1 481-542 33 4.3e-10 30.16 In-house 235-297 (297) Show / Hide 
Range on Protein: 481-542
Range on HMM: 235-297/297
Sequence Identity: 33% (21 aa)

SNQYEKKENLSFWELLEYFNMKPAPRLPEN-YSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
|   .... .  .|.|.|    | |.||.  .|||..||| || .| | .|     |..|  .
SHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase 1909.AA STE11 502-542 38 4.4e-10 32.95 In-house 257-303 (303) Show / Hide 
Range on Protein: 502-542
Range on HMM: 257-303/303
Sequence Identity: 38% (18 aa)

KPAPRLPENYS------EEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
||.| .||. |      || .||. .||.. | .|| ...||.|  .
KPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase 1909.AA STE20 502-542 37 2.1e-09 30.83 In-house 244-288 (288) Show / Hide 
Range on Protein: 502-542
Range on HMM: 244-288/288
Sequence Identity: 37% (17 aa)

KPAPRLPE----NYSEEMKDFVAKCFKKSPLDRPHSHDLLNHEMV
.| |.| .    ..| | .|||.||  | | .|| . .||.|. .
NPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 1909.AA Pkinase_Tyr 282-426 30 2.7e-09 32.08 Pfam 1-158 (270) Show / Hide 
Range on Protein: 282-426
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

LRRVKVLGHGSSGLVELAVHD----ATGIVIGIKSI-PLLMNSS-FRKQLDQELKTLIQC-ESDSIVKCYGAYI-QKCM--INITLEYMDLGTVHDLVKK
..  |.||.|. | | ... .     |.|   .|.. .  | .  .|. . .|.|.. |    . ||..||. . |.    | | .||| .|  .|  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----VGPLPEIIVAIMAIQVLKGLDYIHNKAKVIHRDIKPSNLLVNSKGQVKIADFGVS
     .||.      |..|. ||..| ..|   ||||.   | ||.....|||.||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLA