Gene 1557 (Tetrahymena)
1557
Sequence
Protein domains of 1557.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 1557.AA | STE7-Unclassified | 75-227 | 42 | 2.4e-91 | 309.78 | In-house | 127-301 (301) | Show / Hide |
Range on Protein: 75-227
Range on HMM: 127-301/301
Sequence Identity: 42% (74 aa)
QLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGN-----QYGLRSDIWSVGLVIIELATGLYPYD
|...||..||...|..||||||.|||.|..|.||..|||...|||.|. .| ||.. ||||||..|. .|...|||||.||.|.|.||| |||.
QVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRPSYSVKSDIWSLGLTIWECATGKYPYE
------VKNKS-------IVQFVSNILQSKEPTLPDNG---KYSAALMDFVKKCVAKEQKDRLDISDLLK-HEWI
..|.. .....|.|.....|.|||.. ..|...|||..||..|....| ||..||. |.||
YNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHPWI
|
|||||||||
| Kinase | 1557.AA | STE7 | 75-227 | 39 | 3e-80 | 272.92 | In-house | 118-288 (288) | Show / Hide |
Range on Protein: 75-227
Range on HMM: 118-288/288
Sequence Identity: 39% (68 aa)
QLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIG--NQYGLRSDIWSVGLVI-IELATGLYPYD--
...|||..||.... |||.||.|||.|.||.||| ||||..||. . . .|.||. ||.|||. | ..|. |||.||.|. . ||.||| |||.
AVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLGITMGIEMATGRYPYPNW
--------VKNKS------IVQFVSNILQS-KEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLK-HEWI
..|.. | .....|... . |.|| |.|. ..|||.|| |....| ....|.| |..|
NTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP---KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
|
|||||||||
| Kinase | 1557.AA | STE | 71-227 | 31 | 8.7e-62 | 211.59 | In-house | 155-359 (359) | Show / Hide |
Range on Protein: 71-227 Range on HMM: 155-359/359 Sequence Identity: 31% (67 aa) FILKQLLKG-LEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEK---------------TQQ-LCMTYVGTTLYMSPERLIG------NQYGL .|..|.||| |..||. . .|||||| |||. |||.|||...||.. |.| . | ||| .|.||.. . ..|. YICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDT RSDIWSVGLVIIELATGLYPY-DVKNKSI-------------VQFVSNILQSKEPTLPD-----------------NGKYSAALMDFVKKCVAKEQKDRL ..||||.|..|||.||| .|. | .. . .... .|.. . |.||| |.| . ||..|| |. ..| KCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP DISDLLK--HEWI . |.||| |..| TASQLLKSEHPFI |
|||||||||
| Kinase | 1557.AA | Pkinase | 8-227 | 23 | 5.4e-50 | 177.21 | Pfam | 53-293 (293) | Show / Hide |
Range on Protein: 8-227 Range on HMM: 53-293/293 Sequence Identity: 23% (60 aa) LLTQYTHPNLITCFGAYYEEGTIKIILELMDFG----SIRNLIDMLKEINYCYLSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINK .. ||| ........... | ...|... | . .| .. . .. |...|.|.|||..|. . .|||.|||||||.. IMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-------WRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDN RGNV----KLTDFGISKQL-EKTQQLCMTYVGTTLYMSPERLI-GNQYGLRSDIWSVGLVIIELATGLYPYDVK----NKSIVQFVSNILQSKEPTLPDN .|.. |..|||..||. . .. ..|..|| ||.|| . |. || ..|.||.|....|...| |.. . | ... . .... . NGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWP GKYS-------------------AALMDFVKKCVAKEQKDRLDISDLLKHEWI ..| .. ||.|.| .| |.|. . ..|.|.|. WWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
|||||||||
| Kinase | 1557.AA | YSK | 71-227 | 38 | 1.6e-46 | 137.84 | In-house | 103-257 (257) | Show / Hide |
Range on Protein: 71-227 Range on HMM: 103-257/257 Sequence Identity: 38% (62 aa) FILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIG--NQYGLRSDIWSVGLVIIELATGLYPY .||. .||||..||.|| .||||| |.|... |.||| |||.. |. ||. | ||| .| || .| ||||.| .|.|.|. || IILREILKGLDYLHSER-KIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY DVKNKSIVQFVSNILQSKEPTLPDNG-KYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI . .| ..| .. |.| | .|| .. .|| | |. ..|. ..||||. | CDYHPMRV--MFLIPKNNPPKL--EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
|||||||||
| Kinase | 1557.AA | STE20 | 71-227 | 39 | 8.6e-44 | 151.81 | In-house | 121-288 (288) | Show / Hide |
Range on Protein: 71-227 Range on HMM: 121-288/288 Sequence Identity: 39% (67 aa) FILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEK----TQQ-LCMTYVGTTLYMSPERLIG-----NQYGLRSDIWSVGLVIIE .|....|.||..||.. |..||||| |||....|.|||.||| . ||.| |.| | ||| .|.|| . . ..|. ..||||.| .|| YICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIE LATGLYPYDVKNKSIVQFVSNIL--QSKEPTLPD--NGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI .|.| || . . .. |. | . ||| | |.| . |||.|| |. ..| |.||||..| MAEGEPPY--FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
|||||||||
| Kinase | 1557.AA | Ciliate-E2 | 6-227 | 21 | 2.3e-43 | 146.68 | In-house | 83-365 (365) | Show / Hide |
Range on Protein: 6-227 Range on HMM: 83-365/365 Sequence Identity: 21% (65 aa) KVLLTQYTHPNLITCFGAYY--EEGTIKIILELMDFGSIRNLID-----MLKEINYCYLSKILCNQKYQYHFFILK-----------QLLKGLEFLHKER | .| | |||.| .. ... . .| ...|. . |. . .| ..||. . .. ... .. ||. .....||.||.. KNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN HQVHRDIKPENILINKRGNVKLTDFGISKQLEK-------------------------------TQQLCMTYVGTTLYMSPERLIGNQ---------YGL . .||||||||||. .|..|||.||.. . |.. |..|| ||.|| | | . |. NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY RSDIWSVGLVIIELATGLYPYDVKNKSIVQFVSNILQSKEPTLP----------------DNGKYSAALMDFVKK----CVAKEQKDRLD-ISDLLKHEW .||||.| .. |. .| .|. .. . .. .| .. | | .|. || . |... |.. ....|.|.| KCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPW I . F |
|||||||||
| Kinase | 1557.AA | MEK5 | 76-227 | 39 | 4.5e-42 | 146.09 | In-house | 102-254 (254) | Show / Hide |
Range on Protein: 76-227
Range on HMM: 102-254/254
Sequence Identity: 39% (62 aa)
LLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGLRSDIWSVGLVIIELATGLYPYDVKNKSI
. |||..| . .|||.|| |.|.| .|..|| |||.| || . . ||.|| || |||. |.|||. ||.||.|. ..|.||| .|| ..
IVKGLNYLWNLKI-MHRDVKPSNMLVNTQGQIKLCDFGVSTQL--VNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQIQRDQ
-----VQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
.| . | . . | || .|.|. ..|. .|. | ||| ||..| .|
GELMPIQLLQCIVDEHPPRLP-VDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
|
|||||||||
| Kinase | 1557.AA | ULK | 72-227 | 28 | 1.6e-41 | 144.23 | In-house | 131-324 (324) | Show / Hide |
Range on Protein: 72-227 Range on HMM: 131-324/324 Sequence Identity: 28% (56 aa) ILKQLLKGLEFLHKERHQVHRDIKPENILINKRGN------------VKLTDFGISKQLE---KTQQLCMTYV------GTTLYMSPERLIGN----QYG ..||.. |. .||| . .||||||.||||.. .|..||| .|... . ||.|.|.| || |||.|. | |. .|. FFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYY -LRSDIWSVGLVIIELATGLYP-----YDVKNKSIVQFVSN------ILQSKEPTLPDNG---KYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI .||||.| .. |. .| || .| ... | . . | . . . |... | | . |. ... ...||| .. ....|.|. DYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
|||||||||
| Kinase | 1557.AA | Ciliate-E2-Unclassified | 8-227 | 25 | 5.1e-41 | 140.02 | In-house | 70-352 (352) | Show / Hide |
Range on Protein: 8-227 Range on HMM: 70-352/352 Sequence Identity: 25% (74 aa) LLTQ--YTHPNLITCFGAYYE--EGTIKIILELMDFGSIRNLIDMLKE---INYCYLSKILCNQKYQ-YHF-----------FILKQLLKGLEFLHKERH .. | . ||... |.. . .| |..|... |. .. | | . . | ....| .| |...|.|.|||.||.. . IMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQK-----GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN QVHRDIKPENILINKRG---NVKLTDFGISKQLEKT---------------QQLCMTYVGTTLYM----SPERLIGNQYGLR----SDIWSVGLVIIELA .||||||||||... | ..|..||||||.... ||.. | .|| || .|| | |..|. . .||||.| .. |. IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEML TGLYPYDVKNKSI--------------VQFVSNILQSKEPTLPDN-----GKYSAALMDFVK----KCVAKEQKDRLDISDLLKHEWI .| ||.. .|. . |. .||.| . . . . | ||.. |. | .. |......|.| |. FGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
|||||||||
| S_TKc | 1557.AA | S_TKc | 2-227 | 20 | 7.7e-37 | 129.62 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 2-227
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)
LNDFKVL-----------------------------------LTQYTHPNLITCFGAYYEEGTIKIILELMDF--GSIRNLIDMLKEINY-CYLSKILCN
... | . |||.......... . . ...|..| |. . .|. . . .... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR
QKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGL-RSDIWSVGLVIIELA
|...|....||..|. . .|||.||||||... ..|..|||...|| .|..|| ||.|| | .|| ..|.||.| ...|..
-------FYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML
TGLYPYDVKNKSIVQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLK-------HEWI
.| |.. .| . ... | . ||..|| |. ..|. . ..|. |.|.
CGYPPFP-----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
|||||||||
| Kinase | 1557.AA | MEK1 | 15-167 | 40 | 4.7e-35 | 116.9 | In-house | 57-195 (297) | Show / Hide |
Range on Protein: 15-167 Range on HMM: 57-195/297 Sequence Identity: 40% (62 aa) PNLITCFGAYYEEGTIKIILELMDFGSIRNLIDMLKEINYCYLSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGI | .. .||.|..| | | .| || ||. .. . | | |. |.|| .|. . . .|||.|| |||.| || .|| |||. PYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILGKVSVA------------VLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGV SKQLEKTQQLCMTYVGTTLYMSPERLIGNQYGLRSDIWSVGLVIIELATGLYP | || . .||| ||||||| | | ..|||||.|| ..|.| | || SGQL--IDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYP |
|||||||||
| Kinase | 1557.AA | STE7-Unclassified | 14-51 | 43 | 1.9e-16 | 54.53 | In-house | 64-104 (301) | Show / Hide |
Range on Protein: 14-51 Range on HMM: 64-104/301 Sequence Identity: 43% (18 aa) HPNLITCFGAYYEEGT---IKIILELMDFGSIRNLIDMLKE ||......||||.|.. |.|..|.||.||..|.||..|. HPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKIDIYKK |
|||||||||
| Kinase | 1557.AA | STE7 | 14-52 | 31 | 5.9e-13 | 43.81 | In-house | 58-98 (288) | Show / Hide |
Range on Protein: 14-52 Range on HMM: 58-98/288 Sequence Identity: 31% (13 aa) HPNLITCFGAYYEEGT--IKIILELMDFGSIRNLIDMLKEI .|. ....||.| || |.|..|.||.|.........|.. CPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKV |
|||||||||
| TyrKc | 1557.AA | TyrKc | 2-227 | 16 | 1.4e-11 | -35.5 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 2-227
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)
LNDFKVL------------------------------------LTQY--THPNLITCFGAYYEE-------GTIKIILELMDFGSIRNLIDMLKEINYCY
. |.| .... |||.. ..|. .. . . |..|.|. |. .. . ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----
LSKILCNQKYQYHFFILKQLLKGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKT-------QQLCMTY--VGTTL----YMSPERLIGN
. . . | .| |.||. . .|||. |.|..... || .||| |. .. . .. | |. |.|| . .
-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG
QYGLRSDIWSVGLVIIELAT--GLYPYDVKN--KSIVQFVSNILQSKEPTLPDNGK------YSAALMDFVKKCVAKEQKDRLDISDLLKHEWI
. ||.|| | .. |. | . .... .| . . .. | . . |.|. .... . |.| . . .|| |.. || .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
|
|||||||||
| Kinase | 1557.AA | STE | 14-47 | 34 | 8.6e-08 | 23.73 | In-house | 89-129 (359) | Show / Hide |
Range on Protein: 14-47 Range on HMM: 89-129/359 Sequence Identity: 34% (14 aa) HPNLITCFGAYYEEG-------TIKIILELMDFGSIRNLID ||| ....|.|. || .. |..|.|| ||.. .|. HPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIK |
|||||||||
| Kinase | 1557.AA | MEK1 | 175-227 | 32 | 4.4e-07 | 19.69 | In-house | 246-297 (297) | Show / Hide |
Range on Protein: 175-227 Range on HMM: 246-297/297 Sequence Identity: 32% (17 aa) IVQFVSNILQSKEPTLPDNGKYSAALMDFVKKCVAKEQKDRLDISDLLKHEWI | .. | . . |.|| .. .| ..|||.||. |. ..| |. |. | .| IFEMLDYIVNEPPPKLP-HRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI |
|||||||||
| Kinase | 1557.AA | Pkinase_Tyr | 8-44 | 24 | 0.000653 | 13.87 | Pfam | 56-96 (270) | Show / Hide |
Range on Protein: 8-44 Range on HMM: 56-96/270 Sequence Identity: 24% (10 aa) LLTQY-THPNLITCFGAYY-EEGT--IKIILELMDFGSIRN ...|. |||.. . |. . ... | |..|.| |. .. IMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD |
|||||||||
| Kinase | 1557.AA | STE20 | 7-51 | 18 | 0.011931 | 5.86 | In-house | 56-116 (288) | Show / Hide |
Range on Protein: 7-51 Range on HMM: 56-116/288 Sequence Identity: 18% (11 aa) VLLTQYTHPNLITCFGAYYEE----GTIKIILELMDFGSIRNLID------------MLKE . . |. ||| .. .|.|. . . |. |... ||.. ... ..| SIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMKHCMKCGKNHKGHPMNE |
|||||||||
| Kinase | 1557.AA | Pkinase_Tyr | 78-121 | 31 | 0.024323 | 8.55 | Pfam | 122-164 (270) | Show / Hide |
Range on Protein: 78-121 Range on HMM: 122-164/270 Sequence Identity: 31% (14 aa) KGLEFLHKERHQVHRDIKPENILINKRGNVKLTDFGISKQLEKT ||.|.|. ... .|||. |.|... . || .||| .. .... KGMEYLE-SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYND |
|||||||||