Gene 11359 (Tetrahymena)

11359

Species: Tetrahymena
Alias: 11359, PreTt11359, 3824.m03112, TTHERM_00051780, 3.m01955, 174
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
11359.NA RNA None 2838 None Fasta, JSON
11359.AA Protein None 945 None Fasta, JSON
11359.kin_dom Protein Kinase Domain None 278 None Fasta, JSON

Protein domain

Protein domains of 11359.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 11359.AA STE11-Unclassified 154-431 42 3.9e-176 591.44 In-house 1-308 (308) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-308/308
Sequence Identity: 42% (133 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDK---AVLEKE-VQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGGSIRQMLDK
..||..|..||.|.||.|...|||...|.|.|......   ....|| .||..||.|..|.|.|||||.|...|....|..|||..||..||||..||.|
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFGTLKLHKKD--------------AYINHSKSQSQLSHNQLDYGTIQSQK
.|.|.|.||..||.|.|.||.||||....||||||.|||||.||..||||||. |....|              .|.......||..|.....||.. | 
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPY-Q-

PFWTAPEVLKN--EDSHDASSDIWSVGCLVIEMITALPPYYNLND-KSSQEITKYIMDGNIPNFPEKLS-----------EQCLEFLQKTLKVNPKERAT
|||.||||.||  ...|...|||||.||.||||.|. .|..|... .....|.|..|...||..||.||           ..| .||.|.....||.|.|
PFWMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPT

VNELIQLKFI
.|.|.| .||
ANQLLQHPFI
Kinase 11359.AA STE11 154-431 40 2.2e-153 515.89 In-house 1-303 (303) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-303/303
Sequence Identity: 40% (122 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDK---AVLEKEVQS------LAKEIKEYKKLSHKNIVKYIDTELDE-DEKGINIILEYVSGGSI
..||.||..|..| ||.|. |.||.|.|.| |. ....   . .|||.||      ...||| .|.|.|||||.|....|.. .....||..||..|||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

RQMLD-KFGK--FNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGT-IKLTDFGTLKLHKKDAYINHSKSQSQLSHNQLDYGTIQS---QKP
..||. |.|.  |.|.||..||.|.|.||.||||... |||||| |||.|.||. .||.|||. | ...... .|.....|. |.. ..||...   ..|
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQN-HCKSMTGTPYNSMMGTP

FWTAPEVLKNEDS--HDASSDIWSVGCLVIEMITALPPYYNLNDKSSQEITKYIMD-GNIPNFPEKLS------EQCLEFLQKTLKVNPKERATVNELIQ
.| ||||.|.| .  .....||||.|| ||||.|. ||..|..... ... |..|  ...|..||..|      |.| .||..... .||.|.|.|.| |
MWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

LKFI
 .||
HPFI
Kinase 11359.AA STE 154-431 25 1.3e-96 327.29 In-house 1-359 (359) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

FKKGHIIDRGSYGEVYQCLEVN---------------TGQLYAIKTIRKNKDKA------------VLEKEVQSLAKEIKEYKKLS--HKNIVKYIDTEL
...  .| .|..|.||... ..               ||...||| ........            . ..|.|.. ||||  ||..  |.|||||.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DED-----EKGINIILEYVSGGSIRQMLD-KF-------------GKFNEKVISIYTNQVLQG-LKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFGTLK
.|.     .  ..|..||..|||...... |.             ..|.|..|.... |.|.| |.||||.|. |||||..|||.     .||.|||. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

LHKKDAYINHSKS-------QSQLSHNQLDYGTIQSQKPFWTAPEVLKN-----EDSHDASSDIWSVGCLVIEMITALPPYYNLNDK-SSQEITKY----
   ..   . . |       ... .... . ||       | ||||...     .. .|...||||.||..|||.|  ||. ....     .|..     
QLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP------WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

-------IMDGNIPNFPE-------------------KLSEQCLEFLQKTLKVNPKERATVNELIQ--LKFI
       |..|..| .|.                   |.|. . .|..| |. .|..|.|...|..   .||
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 11359.AA S_TKc 154-431 26 2.6e-75 257.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-231/231
Sequence Identity: 26% (77 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSG--GSIRQMLDKFG
.... .| .|..|.||.| ...||...||| |.            ... .||.  ||  |.||||..|.  |   . . ...||..|  |. .....| |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

K------FNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFGTLKLHKKDAYINHSKSQSQLSHNQLDYGTIQSQKPFWTAPEVLK
.      |.| ..  |. |....|.|.||... |||.|  |||.|.  .||..|||  ..                      .  . .  |.. ||||| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGT--PWYMAPEVL-

NEDSHDA-SSDIWSVGCLVIEMITALPPYYNLNDKSSQEITKYIMDGNIPNFPEKLSEQCLEFLQKTLKVNPKERATVNELIQ-------LKFI
   ...  ..|.||.||...||..  ||..       |.. | |.           |.....|..| |...|..| |. |. |         ..
---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 11359.AA Ciliate-E2-Unclassified 154-431 24 1.8e-62 213.82 In-house 1-352 (352) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-352/352
Sequence Identity: 24% (85 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQ---SLAKEIKEYKK---------------LSHKNIVKYIDTELDEDEKGINIIL
.|....| .|..|.||.| . ...|.||.|.. |....... .. .   .. ... . ||               |.|...... . . ..|.. | |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYVSGGSIRQMLDKFGK-----------------FNEKVIS-----IYTNQVLQGLKYLHSNH-VFHRDIKGGNILIDTDG---TIKLTDFGTLKLHKKD
||. ||. .|.. |..|                 | |. ..      |. |.||||.|||... . |||||  |||.| .|    ||..|||  |  ...
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

AYINHSKS-----QSQLSHNQLDYGTIQSQKPFWTAPEVLKN-EDSHDAS--SDIWSVGCLVIEMITALPPYYNLNDKSSQ-------------EITKYI
 ..   ..     . .  . .   ||.. .  . ||||||.. . .| ..  .||||.|..  ||..  .|.|  |....|             .. . |
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMP-QYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

MDGNIPNFP-------EKLSEQCLEFLQ----KTLKVNPKERATVNELIQLKFI
...|| ...        ..|... .|..    | ||.||..| | .....  ..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 11359.AA Ciliate-E2 154-431 21 5e-61 208.24 In-house 1-365 (365) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNK----------D------KAVLEKEVQSLAKEIKEYK----------------KLSHKNIVKYID
.|.  .| .|..| ||.|   ......||| |. .|          .      | . ....... .||....                .|.|.||.|...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

TELDEDEKGINIILEYVSGGSIRQMLDKF-----------GKFNEKVISIYTNQVLQ---------------GLKYLHSNH-VFHRDIKGGNILIDTDGT
.  ..|.. | ...||..||. .. . ..           ..|.|| |. .. |.||               .|.||||.. ..|||||  |||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

IKLTDFGT-LKLHKKDAYINHSKSQSQLSHNQLDYGTIQSQ----------------KPFWTAPEVLKNEDS--------HDASSDIWSVGCLVIEMITA
||..|||.  |....  .. | |.|...  .   . ....                  |   |||.|....         .| ..||||.|..  ||.. 
IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

LPPYYNLNDKSSQEITKYIMDGNIPNF-------------PEKLSEQCLEFLQK----TLKVNPKERAT-VNELIQLKFI
 ||.        |.| .   | . |..             ..|.|..|  ...|     |...|..| |  ..... ...
KPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 11359.AA MEKK15 154-431 37 7e-61 208.58 In-house 1-264 (264) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-264/264
Sequence Identity: 37% (105 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIR-KNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGGSIRQMLDKFGK
.||| |. .| || || |   ||||| |.| .   . ||   ... . |  |..  | | ||||| |. . |..    .|| ...| ||||  .. .|| 
WKKGNILGKGAYGTVY-CGLTNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNV--VNIFMQFVPGGSISSIINRFGP

FNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFGTLKLHKKDAYINHSKSQSQLSHNQLDYGTIQSQKPFWTAPEVLKNEDSHDA
 .| |   || |.||| .||| | | |||||| |...   | ||| |||     |. ..   ....|..       ||     |.| ||||. .|  .  
LDEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCA---KRLCWQGINRTHSDMLKSM--RGT-----PYWMAPEVI-METGYGR

SSDIWSVGCLVIEMITALPPYYNLNDKSSQEITKYIMDG--NIPNFPEKLSEQCLEFLQKTLKVNPKERATVNELIQLKFI
 |||||.|| | || |  ||. ...         ||  .   .|  |.| ||.  .| .  |    .||.|  .|..  ||
KSDIWSIGCTVFEMATRKPPWADMDRMA---AMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase 11359.AA ASK 159-431 34 1.6e-55 183.02 In-house 1-254 (254) Show / Hide 
Range on Protein: 159-431
Range on HMM: 1-254/254
Sequence Identity: 34% (96 aa)

IIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGGSIRQMLD-KFGKFN--E
.. .|.|| ||   . .|    ||| | . ...     .|| |  ||. .|.| |.|||.|. .  . ... . | .| | |||. ..|  |.| ..  |
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR-----YVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNE

KVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDT-DGTIKLTDFGTLKLHKKDAYINHSKSQSQLSHNQLDYGTIQSQKPFWTAPEVL-KNEDSHDAS
. .. || |.|.|||||| |.. |||||| |.|. |  | .|. ||||    |. | ||   .  .        ||.|     . ||||. . .  . ..
NTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTC---KRLAGINPCTETFT--------GTLQ-----YMAPEVIDQGQRGYGKP

SDIWSVGCLVIEMITALPPYYNLNDKSSQEITKYIMDGNIPNFPEKLSEQCLEFLQKTLKVNPKERATVNELIQLKFI
 ||||.|| ..|| |. ||.. | .     . |  |    |. ||.||..| .|. .. ...|..||. ..|.| .|.
ADIWSFGCTMVEMATGKPPFHELGEPQAA-MFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase 11359.AA Dicty2 154-302 45 9.5e-47 160.81 In-house 1-152 (264) Show / Hide 
Range on Protein: 154-302
Range on HMM: 1-152/264
Sequence Identity: 45% (70 aa)

FKKG-HIIDRGSYGEVYQCLEVNTGQLYAIKTIR-KNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGGSIRQMLDKFG
.. |  .| .|  | ||. |   ||.  ||| |    | .   |.  ||. .||.  |||.| ||||||. .  | |  ..|||||. .|| .  . |||
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINIMKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHI--ETENHLYIILEYIENGSLSKIIKKFG

KFNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGT---IKLTDFGT
.| |  ..||  |||.|| |||.. | |||||. |||| ..|    |||.|||.
CFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGV
Kinase 11359.AA MEKK2 154-301 41 2.7e-43 150.18 In-house 1-148 (262) Show / Hide 
Range on Protein: 154-301
Range on HMM: 1-148/262
Sequence Identity: 41% (62 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGGSIRQMLDKFGKF
...| ..  | .| || | .| ||   |.| .. . | .   ||||.|  ||.  | | |. ||.|     |. || . | .||..|||..  |  .|  
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

NEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFG
 |.|   || |.| |..|||.... |||||| ||| |  | .|| |||
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFG
Kinase 11359.AA Pkinase 154-301 35 5.8e-42 149.46 Pfam 1-157 (293) Show / Hide 
Range on Protein: 154-301
Range on HMM: 1-157/293
Sequence Identity: 35% (57 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGG----SIRQMLD-
...| .| .||.|.||.| ...||...|.|.|.| ..|   ...   |  ||.  |.|.|.|||...|.  |  .. | ...||. ||    .   ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-KFGKF--NEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTI----KLTDFG
 . |.|   |...  |  |.|.||.|.||. . |||.|  ||||| .|.|    |..|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFG
Kinase 11359.AA STE20 154-301 38 1.5e-40 141.01 In-house 1-162 (288) Show / Hide 
Range on Protein: 154-301
Range on HMM: 1-162/288
Sequence Identity: 38% (64 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQL----YAIKTIRKNKD---KAVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGIN---IILEYVSGGSI
... . | .||||.|| . .. ||..    .||| .  .|.   .    .|.... |||   |.. |.|||||... | .|..  .   |. || .|||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTC-DDELWIVMEYCGGGSL

RQMLD---KFGK------FNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFG
.....   | ||      .||. |.  . .|||||.||||||. |||||..|||...|| .||.|||
TDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFG
Kinase 11359.AA Pkinase 336-431 21 6.5e-21 75.03 Pfam 175-293 (293) Show / Hide 
Range on Protein: 336-431
Range on HMM: 175-293/293
Sequence Identity: 21% (26 aa)

PFWTAPEVLKNEDSHDASSDIWSVGCLVIEMITALPPYYNL----NDKSSQEITKYIMDGNIPNFPEKLS--------------------EQCLEFLQKT
|.. ||||..    .. ..|.||.||...||..  ||...     |  . ... . ||.. ..   ....                    | |..|. . 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LKVNPKERATVNELIQLKFI
|...||.| |  .. | ...
LCKDPKKRPTAEQILQHPWF
Kinase 11359.AA TyrKc 154-431 21 1.3e-16 45.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 154-431
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKL--SHKNIVKYIDTELDEDE-----KGINIILEYVSGGSIRQM
 ..|... .| .||||..      .  |.|......        .. . .|..  .||  .|.|||. .   ... .     . . |..||...|. .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

L-DKFGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFGTLKLHKKD-AYINHSKSQSQLSHNQLDYGTIQS--QKP-----F
| .. .|.. |    .  |. .|  ||||... |||.   |.|.. ..|.| .|||  . .. | .                || . ..  ..       
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------ESKDYYRKKEHKGGKTMLPIR

WTAPEVLKNEDSHDASSDIWSVGCLVIEMIT-ALPPYYN---LNDKSSQEITKYIMDGNIPNFPEK--------LSEQCLEFLQKTLKVNPKERATVNEL
|.|||.. |.      ||.|| | .  |. |   .||..     ..| ||. .|...|. .  |.          ..   .  ..  . .|..| | .|.
WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

IQLKFI
   ...
--HECF
Kinase 11359.AA Dicty2 336-377 46 8.3e-14 44.6 In-house 171-213 (264) Show / Hide 
Range on Protein: 336-377
Range on HMM: 171-213/264
Sequence Identity: 46% (20 aa)

PFWTAPEVLKNED-SHDASSDIWSVGCLVIEMITALPPYYNLN
|.| ||||    .  .  ..||||.|| .||. |  |||. ||
PYWMAPEVIQMSGNHCCTACDIWSLGCTIIELLTGNPPYWDLN
Kinase 11359.AA Pkinase_Tyr 154-301 26 2e-13 46.07 Pfam 1-156 (270) Show / Hide 
Range on Protein: 154-301
Range on HMM: 1-156/270
Sequence Identity: 26% (42 aa)

FKKGHIIDRGSYGEVYQCLEV----NTGQLYAIKTIRKNKDKAVLEKEVQSLAKEIKEYKKL-SHKNIVKYIDTELDEDEK-GINIILEYVSGGSIRQML
 ..|. . .|..||||..       ||..  |.|... . ..  .    ... .|.|  |.| .|.|||...   .|..|   | |..||. .|. .  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

DK----FGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIKGGNILIDTDGTIKLTDFG
 |     .... | .  .  |. .|. ||.|..  |||.   |.|.. ....| .|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase 11359.AA MEKK2 336-431 29 1e-12 42.45 In-house 170-262 (262) Show / Hide 
Range on Protein: 336-431
Range on HMM: 170-262/262
Sequence Identity: 29% (28 aa)

PFWTAPEVLKNEDSHDASSDIWSVGCLVIEMITALPPYYNLNDKSSQEITKYIMDGNIPNFPEKLSEQCLEFLQKTLKVNPKERATVNELIQLKFI
|.| .|||.  |       |.||.|| |.||.|  ||. .        | |       |  |...|..  .||..  .   ..|   .||.. .|.
PYWMSPEVINGE-GYGRKADVWSIGCTVVEMLTEKPPWAEYEAMAA--IFKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase 11359.AA STE20 336-377 39 1.1e-12 42.91 In-house 186-231 (288) Show / Hide 
Range on Protein: 336-377
Range on HMM: 186-231/288
Sequence Identity: 39% (18 aa)

PFWTAPEVLKN----EDSHDASSDIWSVGCLVIEMITALPPYYNLN
|.| ||||..     .  .|  .||||.|   |||..  |||....
PYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMH
Kinase 11359.AA STE20 397-431 34 5e-06 18.4 In-house 254-288 (288) Show / Hide 
Range on Protein: 397-431
Range on HMM: 254-288/288
Sequence Identity: 34% (12 aa)

PEKLSEQCLEFLQKTLKVNPKERATVNELIQLKFI
|.| | .  .|. | | ..|..|.|. .| . .||
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase 11359.AA Dicty2 396-431 27 0.070234 2.53 In-house 229-264 (264) Show / Hide 
Range on Protein: 396-431
Range on HMM: 229-264/264
Sequence Identity: 27% (10 aa)

FPEKLSEQCLEFLQKTLKVNPKERATVNELIQLKFI
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LPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase 11359.AA Pkinase_Tyr 337-399 30 1.140805 2.89 Pfam 179-240 (270) Show / Hide 
Range on Protein: 337-399
Range on HMM: 179-240/270
Sequence Identity: 30% (20 aa)

FWTAPEVLKNEDSHDASSDIWSVGCLVIEMIT-ALPP-YYNLNDKSSQEITKYI-MDGNIPNFPEK
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KWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE---VYEYIYEDGYRMPCPEN