Gene 8636 (Tetrahymena)

8636

Species: Tetrahymena
Alias: 3697.m01699, PreTt08636, 8636, 551, 15.m00347, TTHERM_00188860
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
8636.AA Protein None 973 None Fasta, JSON
8636.NA RNA None 2925 None Fasta, JSON
8636.kin_dom Protein Kinase Domain None 254 None Fasta, JSON

Protein domain

Protein domains of 8636.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 8636.AA ULK 4-260 32 9.5e-125 420.74 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-324/324
Sequence Identity: 32% (105 aa)

YSLDEVIGSGQYG-KVYRATNIKT---NKVVAIKVVKIQKFKENPKL------EECTVNEIKTLSQMDD-----NRHVVSFIELLRSS--NNYYFVYEFC
|.|....|.|..| |||...|.||   |..||.|.. ..|.......       .   |||... ....     . |.| ... ...|  ||.|...|.|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

SGGTLEDQLKKK---------KIFKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNNQ-------------IKLADFGFCKSLTNPT---DMAQ
 ||.||. .||.         |.. |.||...| |....|| |.| ||.|||.|| |||.||.|             .|.|||||.|.. |..   .| |
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TML------GSPLYMAPEILR----GQDYC-VKADIWSLGVVLYELLFGICPFEEKSIVRLI----SLLN----------DGQLVIRK--DIQNISPQTE
|..      |.||||||.||     ...|.  |.||||||...||.|.| .||..  .  ..    .|.|          . .. ..|  ....|||...
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

ALLMAMLVKDPEQRISWDQLFQIQIN
 |.. ||..|...||||...|.. . 
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 8636.AA ULK 4-260 33 7.80000000001e-124 417.7 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-329/329
Sequence Identity: 33% (109 aa)

YSLDEVIGSGQYGKVYRATNIKT----NKVVAIKVVKIQKFKENPKLEE------CTVNEIKTLSQMD-------DNRHVVSFIELLRSS--NNYYFVYE
|.|....|.|..||||...|.||    |..||.|.. .||....... |      .  ||||.. ...        . ..| ... ...|  ||.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCSGGTLEDQLKKK----------KIFKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNNQ-------------IKLADFGFCKSLTNP---TD
.| ||.||. .||.          |.. |.||...| |.|..|| |.| ||.|||.|| |||.||.|             .|.|||||.|...|.    .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

MAQTML------GSPLYMAPEILR----GQDYC-VKADIWSLGVVLYELLFGICPFEEKSIVRLI-----SLLND----------GQLVIRK--DIQNIS
|..|..      |.||||||.||     ...|.  |.||||||...||.|.| .||..  .  ..     .|.|.           .| ..|  ....||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PQTEALLMAMLVKDPEQRISWDQLFQIQIN
|... |.  ||..|...||||..||.. . 
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 8636.AA S_TKc 4-257 30 2.4e-84 287.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YSLDEVIGSGQYGKVYRATNIKTNKVVAIKVVKIQKFKENPKLEECTVNEIKTLSQMDDNRHVVSFIELLRSSNNYYFVYEFCSG--GTLEDQLKKKKI-
| . ..||.| .||||.....||...||||..|           | . .||. |..  .  ..| ...  .. ...|.| |.|.|  |.| | .||..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNNQIKLADFGFCKSLTNPTDMAQTMLGSPLYMAPEILRGQDYCV-KADIWSLGVVLY
     | | .| ....|...| . . . .|.|||||| |||| . .||..|||... |        |. |.| |||||.|    |   |.|.||.|..||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLFGICPFEEKSIVRLISLLNDGQLVIRKDIQNISPQTEALLMAMLVKDPEQRISWDQLFQ----------I
|.| |  ||.   . ... ..              ||.   ... .|.||||.|..  ...|          .
EMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 8636.AA Ciliate-E2-Unclassified 4-260 26 2.5e-78 266.56 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-352/352
Sequence Identity: 26% (95 aa)

YSLDEVIGSGQYGKVYRATNIKTN--------KVVAIKVVKIQKFKENPKLEECTVNEIKTLSQMD-------------DNRHVVSFIELLRSSNNYYFV
| . ..||.|..||||.. ..|..        |.. |. .|....|.. ..|. ..|..|  ....             .. ..| ...  .. .| |.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

YEFCSGGTLEDQLKKK-----------------KIFKENEAL-----HVFAQLLEAFKVLRKFN-IMHRDLKPTNILLHNN----QIKLADFGFCKSLTN
.|.| ||.|.. .||.                 ||| |..|.     . |||.|.... | . | | |||.|| |||..||    .||..|||..| . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

P---------------TDMAQTMLGSPLYM----APEILRGQDYC----VKADIWSLGVVLYELLFGICPFEEKSIVR----------------LISLLN
.                .|..|. |.| ||    |||.|.|| |      |.|||||||.|||.||| .||. ..                   |..  .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

DGQLVIRK-DI----QNISPQTEALLM----AMLVKDPEQRISWDQLFQIQIN
.... ..| .     ...||. . ..      ||.|.|..||...|... .. 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 8636.AA Ciliate-E2 4-260 24 1.3e-76 260.82 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YSLDEVIGSGQYGKVYRATNIKTNKVVAIKVVKIQK-----------------FKENPKLEECTVNEIKTLS---------------QMDDNRHVVSFIE
| . ..||.|..|.||.....|..| .|||. . ||                    ...  | . .||. .                . ... ... ..|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

LLR--SSNNYYFVYEFCSGGTLED-----QLKKKKI------FKENEALHVFAQLLE---------------AFKVLRKFN-IMHRDLKPTNILLHNNQI
     . ||.|.| |.|.||.|.|     ..|....      |.|.|......|.|.               |.. | . | |.|||.|| |||.    |
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KLADFGFCKSLTNPTD-------------------------------MAQTMLGSPLYMAPEILRGQD---------YCVKADIWSLGVVLYELLFGICP
|..|||..| .... .                               |..| .|.| |||||||.|..         |  |.|||||||.|||.|||  |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEEKSIVRLISLLNDGQLVIRKD---------------IQNISPQTEALLMA----MLVKDPEQRIS-WDQLFQIQIN
|        .    .... ...                 ...|...  |.      ||.||||.||. |.|... .. 
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 8636.AA AGC 4-249 23 1.4e-75 193.99 In-house 1-374 (395) Show / Hide 
Range on Protein: 4-249
Range on HMM: 1-374/395
Sequence Identity: 23% (89 aa)

YSLDEVIGSGQYGKVYRATNI------KTNKVVAIKVVKIQK-FKENPK-LEECTVNE------------IKTLSQMDD---------NRHVVS-FIELL
. .  ||| | .|||| .          |.|. |.||.| ..  ... |  .|.| .|             . |....          .  .|.      
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RSSNN--YYFVYEFCS---------GG-TLEDQLK---KKKIFKENEALHVFAQ-------LLEAFKVLRK-FNIMHRD-LKPTNILLHN-NQIKLADFG
 . ..   ||| |...         ||  |  .|.   |...| |..| . .|.       .. |.  | .  .| ||| ||| |||| .   |||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FCKSLTNP--------------------------------------------------TDMAQTMLG--SPLYMAPEILRGQDYCVKADIWS--LGVVLY
.|| . |                                                   .|...|. |  .| |||||||    |   .|.||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELLFGICPFEEKSIV----------RLISLLNDGQLVIRKDIQ-------------NISPQTEALLMAMLVKDPEQRI
|.|.|. ||  .. .           .  .  .|...| ....             ..||.   |.  .|.||||.|.
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRL
Kinase 8636.AA CAMK 9-250 21 8.5e-75 240.25 In-house 1-415 (425) Show / Hide 
Range on Protein: 9-250
Range on HMM: 1-415/425
Sequence Identity: 21% (88 aa)

VIGSGQYGKVYRATNIKTN------------KVVAIKVVKIQKFKE------------------------NPKLEECTVNEIKTLSQMD------DNRHV
..|.|..|||.......|.            . ||||... .| |.                        .|| ..   .||. ....       | ...
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSFIELLRSSNN-------------------YYFVY---EFCSGG----TLEDQLKKK---------------KIFKENEALHVFAQLLEAFKVLRKFNI
....|   ....                   .|.|    |.||||     | | ....               . |.| || ..| |...| . . . ||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

MHRDLKPTNILL-HN-----------------NQIKLADFGFCKSLTN-----------------------PTDMAQTMLGSPLYMA-PEILRG------
.|||||| |||| .|                 |.||..|||| . ..                        .... .|. |.| ||| ||.|.|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------QDYC-VKADIWSLGVVLYELLFGICPFEEK-------------SIVRLISLLNDGQLV-IRKDIQNIS--------------------PQTEA
       ..|.  |.|.||.||.|| .| |  ||...             .. .|      |.   . . . .||                    ..   
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLMAMLVKDPEQRIS
|.  ||..|||.|..
LIRKMLQVDPEKRMT
Kinase 8636.AA Ciliate-E2c 4-260 31 1.6e-70 240.63 In-house 1-310 (310) Show / Hide 
Range on Protein: 4-260
Range on HMM: 1-310/310
Sequence Identity: 31% (99 aa)

YSLDEVIGSGQYGKVYRA-------TNIKT---NKVVAIKVVKIQKF----KENPKLEECTVNEIKTLSQMDDNRHVVSFIELLRSSNNYYFVYEFCSGG
.. ..  |||.|||||.|       . |.    |.. |||    . .        . .|   .||  . .| ...|.. |..    ... |.. |.|.||
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHM-NHPHIIKFYDAKQTDKHIYLIMEYCNGG

TLEDQLKKK-KIFKENEALHVFAQLLEAFKVLRKF-NIMHRDLKPTNILLHNNQIKLADFGFCKSLTNPTDM-AQ---TMLGSPLYMAPEILRG-QDYCV
|||. ...| |. .| . |  | |.. |||.| |  || |||.|| |||.|| .||.||||| |  .. ..   |   |  |.|.||||.||.| . |  
TLEQYIYHKPKP-NEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KADIWSLGVVLYELLFGICPFE-----------EKSIVRLISLLNDGQLVIRK---------------------DI--QNISPQTEALLMAMLVKDPEQR
|.|||||||.||. |.   |.|           ... .  ....     .|..                     .   ||||...  |.  ||..|.| |
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKR

ISWDQLFQIQIN
|.||..|   ..
IDWDEIFNHECI
Kinase 8636.AA CAMKL 4-254 29 2e-68 217.41 In-house 1-291 (297) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-291/297
Sequence Identity: 29% (86 aa)

YSLDEVIGSGQYGKVYRATNIKT-NKVVAIKVVKIQKFKENPKLEEC-----------TVNEIKTLSQMD--DNRHVVSFIELLRSSNN------YYFVY
| . ...| | .|||  ||.|.| .. ||||.....| ...|. .                ||. .....     ..... | .  ...      .| | 
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCSGGT--LEDQLKKK----KIFKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNNQ---IKLADFGFCKSLTN----PTDMAQTMLGSPLYM
| ||||   | | ..|.    . ..|.|| . | |...| . . . .| |||.|| |||| .|.   ||..||||.   ..    | ..  |  ||| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILRG--QDYC-VKADIWSLGVVLYELLFGICPFEEKSI------VRLISLLNDGQLVIRKDIQ-NISPQTEALLMAMLVKDPEQRISWDQL
||||. |  ..|.  |.||||.||.|| ...|  ||.. ..           .. . ..  . .|   .| . . |.  ||...||.|.. .|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI
Kinase 8636.AA Pkinase 4-256 26 1.1e-67 236.02 Pfam 1-289 (293) Show / Hide 
Range on Protein: 4-256
Range on HMM: 1-289/293
Sequence Identity: 26% (79 aa)

YSLDEVIGSGQYGKVYRATNIKTNKVVAIKVVKIQKFKENPKLEECTVN--EIKTLSQMDDNRHVVSFIELLRSSNNYYFVYEFCSGG----TLEDQLK-
| . ..|||| .|.||......|.|.||.|..| .  .|... ..  ..  ||. .  . .  ..| ...  ......|.| |.| ||     | | .. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KKKIF--KENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLH-NNQI----KLADFGFCKSL-TNPTDMAQTMLGSPLYMAPEILR-GQDYCVKADI
 ... |   |.|. ... |.|.. . . . .|.|||||| |||.. |..|    |..|||..| . . .   ..|  |.| |||||..| ||.|  |.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGVVLYELLFGICPFEEK----SIVRLISLLNDGQLVIRKDIQNIS---------------------PQTEALLMAMLVKDPEQRISWDQLFQ
||.|..|||.|.|  || ..    . .. . ...     . .     .                     .    ..  .| |||..|....|..|
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ
Kinase 8636.AA STE 4-257 21 2.3e-66 226.76 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-257
Range on HMM: 1-359/359
Sequence Identity: 21% (78 aa)

YSLDEVIGSGQYGKVYRATNI------KTNKV---------VAIKVVKIQKFK-------------ENPKLEECTVNEIKTLSQMDD-NRHVVSFIELLR
. . |.||.| .|.||.| |.      ||..|         .|||...... .              |.. ..   .|||.......   ..| ..    
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SS-------NNYYFVYEFCSGGTLEDQLK-KKKIFK-------------ENEALHVFAQLLEA-FKVLRKFNIMHRDLKPTNILLHNNQIKLADFGFCKS
         .. . . |...||.|.| .| |....|             |..  ..  |.|..  . | . .|.|||.|| ||||    .||.|||.|..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LTN---------------PTD-MAQTMLGSPLYMAPEILRG------QDYCVKADIWSLGVVLYELLFGICPFEEKSIVRLISLLNDGQLVIR-------
||.                .. . .|. |.| .||||....      ..| .|.|||||| .. |.. |  |. . .  | . . .... . .       
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--KDIQNIS-----------------------PQTEALLMAMLVKDPEQRISWDQLFQ-----I
  ...  .                        |     .   |.|||..| . .|| .     |
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 8636.AA STE20 4-199 31 1.1e-54 187.94 In-house 1-223 (288) Show / Hide 
Range on Protein: 4-199
Range on HMM: 1-223/288
Sequence Identity: 31% (70 aa)

YSLDEVIGSGQYGKVYRATNIKTNKV----VAIKVVKIQKFKEN-PKLEECTVNEIKTLSQMDDNRHVVSFIELLRSS----NNYYFVYEFCSGGTLEDQ
| | |.||.| |||||.|....|...    ||||.... | ..  ...|.  ..||  ..| . . ..|....    .    .. . | |.|.||.| | 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWED-IQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDI

LK---KKKI------FKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNN-QIKLADFGFCKSLTN----PTD-MAQTMLGSPLYMAPEILRG--
.|   |...      ..| .   .  ..|.. . | . .|.|||.|  ||||  . ..||||||.| .||.      .   .|. |.| .||||....  
MKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

---QDYCVKADIWSLGVVLYELLFG
   ..|  |.||||||  . |.. |
GPDKGYDYKCDIWSLGITAIEMAEG
Kinase 8636.AA TyrKc 4-259 19 2.5e-16 41.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-259
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

YSLDEVIGSGQYGKVYRATNIKTNKVVAIKVVKIQKFKENPKLEECTVNEIKTLSQM-DDNRHVVSFIELLRSS-------NNYYFVYEFCSGGTLEDQL
 .|....|.|..|.||..| .     ||.|..|  .       .|   .|.. ...   .. ..| ..   ...         .. | |....| | | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKKKI-FKENEALHVFAQLLEAFKVLRKFNIMHRDLKPTNILLHNNQ-IKLADFGFCKSLTNP--------TDMAQT--MLG--SPL-YMAPEILRGQDY
.|..  ..  . |.   |  .    | . |. ||||   |.|...|. .| .||| .. ...         . ....        |.  |||| ..   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

CVKADIWSLGVVLYELL-FGICPFEE-----KSIVRLISLLNDGQLVIRKDIQN------ISPQTEALLMAMLVKDPEQRISWDQLFQIQI
  | |.|| ||...|.. .|  | ..     .|  ..| .. .|    . .          ..    .       |||.| .  ..   ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase 8636.AA Pkinase_Tyr 134-219 28 1.3e-07 26.36 Pfam 141-233 (270) Show / Hide 
Range on Protein: 134-219
Range on HMM: 141-233/270
Sequence Identity: 28% (27 aa)

NILLH-NNQIKLADFGFCKSLTNPTDMA-QTMLGSPL---YMAPEILRGQDYCVKADIWSLGVVLYELLF-GICP-FEEKSIVRLISLL-NDGQ
|.|.. ||..| .||| .. .  ..|   ..  |..|    |||| ..   . .| |.|| ||...|..  |  | ... |  ... ..  ||.
NCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
Kinase 8636.AA Pkinase_Tyr 4-36 29 1e-06 22.96 Pfam 1-37 (270) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-37/270
Sequence Identity: 29% (11 aa)

YSLDEVIGSGQYGKVYRATNI----KTNKVVAIKVVK
 ......|.|..|.||..|      .|.  ||.|..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK