Gene 8181 (Tetrahymena)
8181
Sequence
Protein domains of 8181.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 8181.AA | ULK | 12-271 | 40 | 1.2e-149 | 503.42 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 12-271 Range on HMM: 1-324/324 Sequence Identity: 40% (130 aa) VCTNKQLGQGAFG-QVVKGFLKDNH--AQQVAVKIIS---LQKVASESN---FIKLLRREIEILQKIN---HPN--IVKLHYATRTT--NNLYMFLEYCA | |..||.|.|| .| ||. |... |.||.|.|. ..| .|.. ...||..||.|..|.. ||| ||||. ..|. ||.|...||| YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN DGDLKKLLEKRGG--------KLPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLHKGVAH-------------ITDFGFARTLDCSGMNNQLKMT .|||.....|... .|.|.||.|.|.|||.|||||.|.|||||||||.|||.|.|... |.|||||...|. .|. |. .| GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT YL------GTPLYMSPQILAEE-----YFSSKCDIWSLGMMFYELLYGRTP---WTGKTPN----ELLEN-------IRKKPLEFP---EQPPRSEIVKD .. ||||||.|||| .. | ..||||||||..|||.|||..| | . . .|..| |...|..|| ..|..|. .|| CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD MLRRMLVYEDSERISWDELFQHKII .||||.|. ..||||.|.|.|... LIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 8181.AA | ULK | 12-271 | 40 | 5.6e-149 | 501.23 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 12-271 Range on HMM: 1-329/329 Sequence Identity: 40% (133 aa) VCTNKQLGQGAFGQVVKGFLKDNH---AQQVAVKIISLQKVASESNF------IKLLRREIEILQKIN--------HPNIVKLHYATRTT--NNLYMFLE | |..||.|.||.| ||. |... ...||.|.|..|| ..| ..||..||.|..|.. |||||||. ..|. ||.|...| YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME YCADGDLKKLLEKRGG---------KLPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLHKGVAH-------------ITDFGFARTLDCSGMNNQ || .|||.....|... .|.|.||.|.|.||..|||||.|.|||||||||.|||.|.|... |.|||||...|...|..| YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ LKMTYL------GTPLYMSPQILAEE-----YFSSKCDIWSLGMMFYELLYGRTP---WTGKTPN-----ELLEN-------IRKKPLEFP---EQPPRS . ||.. ||||||.|||| .. | ..||||||||..|||.|||..| | . . .|..| |.|.||.|| ..|..| MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS EIVKDMLRRMLVYEDSERISWDELFQHKII . .|| .||||.|. ..||||.|||.|... PECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 8181.AA | S_TKc | 12-271 | 33 | 2.7e-89 | 303.86 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 12-271
Range on HMM: 1-231/231
Sequence Identity: 33% (93 aa)
VCTNKQLGQGAFGQVVKGFLKDNHAQQVAVKIISLQKVASESNFIKLLRREIEILQKINHPNIVKLHYATRTTNNLYMFLEYCAD--GDLKKLLEKRGGK
...|.||||.| |. |. ..||.|||. . .||||.||.| .|||||||... .. ..|||..||| |||.....|||..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH
-----LPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLHKGVAHITDFGFARTLDCSGMNNQLKMTYLGTPLYMSPQILAEEYFSS-KCDIWSLGM
.|| .| |..|||.. . . ...|||||.||.|||| . . |.|||.|| | .|. ||| ||.| .| .. |||.||.|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC
MFYELLYGRTPWTGKTPNELLENIRKKPLEFPEQPPRSEIVKDMLRRMLVYEDSERISWDELFQ-------HKII
..||.|.|..|. ........|. |. .||..|..|... ..|.. |..| | .
ILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 8181.AA | Pkinase | 12-271 | 30 | 2.8e-86 | 297.76 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 12-271 Range on HMM: 1-293/293 Sequence Identity: 30% (91 aa) VCTNKQLGQGAFGQVVKGFLKDNHAQQVAVKIISLQKVASESNFIKLLR-REIEILQKINHPNIVKLHYATRTTNNLYMFLEYCADG----DLKKLLE-K .. ...|.|.||.| |. |.. .||||||... .... . ..| .||.|....||||||.|... .. ...|| .||| | ||. ... . YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW RGGKL--PESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLH-KGVA----HITDFGFARTLDCSGMNNQLKMTYLGTPLYMSPQILA-EEYFSSKCD |.|.. .| |. |..||..| . .....|||||.||.|||.. .|. .|.|||.|. .| ||. .|. ||| ||.| .. .| ..|.| RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD IWSLGMMFYELLYGRTPWTGK------TPNELLENIRKKPLEFPEQPPRS-------------------EIVKDMLRRMLVYEDSERISWDELFQHKII .||.| ..||.| ||.|. |. ........|...||.|... ..| | || ....| . ..|.......||. . MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | 8181.AA | Ciliate-E2 | 12-271 | 23 | 5.4e-85 | 288.68 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 12-271
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)
VCTNKQLGQGAFGQVVKG--FLKDNHA--------------------QQVAVKIISLQKVASESNFIKLLR---------REIEILQKINHPNIVKLHYA
.|..|||.||.| |. .... ...|.||.. ... . .. |...| | .||...|||||.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
TR--TTNNLYMFLEYCADGDLKKLLE----KRGGKLP------ESEAVQYFRQICE---------------GFKELYKNN-IIHRDIKPANILLHKGVAH
..||.|. .||| |||..... ||. ... | |. ....||.. ....| ..| |||||||| |||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK
ITDFGFARTLD--------CSGMNNQLKMT---------------------YLGTPLYMSPQILA---------EEYFSSKCDIWSLGMMFYELLYGRTP
|.|||... .| ...... . ..||| ||.|.|| ... . ||||||||...||.|.|..|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
WTGKTPNELLENIRKKPLEFPEQ----------------PPRSEIVKDMLRR----MLVYEDSERIS-WDELFQHKII
. ...| .....||.. |. .||.... ||... ..||. |.....|...
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 8181.AA | Ciliate-E2c | 14-271 | 31 | 1.4e-84 | 287.31 | In-house | 3-310 (310) | Show / Hide |
Range on Protein: 14-271 Range on HMM: 3-310/310 Sequence Identity: 31% (97 aa) TNKQLGQGAFGQVVKGFLKD--NHAQQV-------AVKIISLQKV----ASESNFIKLLRREIEILQKINHPNIVKLHYATRTTNNLYMFLEYCADGDLK .|. ||.| .|.| |. . . . . |.|.. |. ..|.. . ..|||... . |||.|.| | |....| ..||| .|.|. RNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGTLE KLLEKRGGKLPESEAVQYFRQICEGFKELYKN-NIIHRDIKPANILLHKGVAHITDFGFARTLDCSGMNNQL-KMTYLGTPLYMSPQILAE-EYFSSKCD ...... |. | . . || || .||.|.|. ||.||||||.|||.|.|. | ||||.. . .| |. |||.||.|||| | .| | QYIYHK-PKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKSD IWSLGMMFYELLYGRTPWT------------------GKTPNELLENIR---------------KKPLEFPEQ--PPRSEIVKDMLRRMLVYEDSERISW ||||| . |. |. . || . | .| ..|. .... |||. .|. ||. ...||... . ||.| IWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRIDW DELFQHKII ||.| | .| DEIFNHECI |
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| Kinase | 8181.AA | CAMK | 17-271 | 23 | 1.4e-82 | 265.75 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 17-271
Range on HMM: 1-425/425
Sequence Identity: 23% (101 aa)
QLGQGAFGQVVKGFLK-DN-HA---------QQVAVKIISLQKVAS------------------------ESNFIKLLRREIEILQK-------INHPNI
.||.|.||.| ... | .. |.||.|||. .|. . . . | .||||||..| ..||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VKLHYATR------------TTNN--------LYMFL---EYCADG----D-LKKLLEKRG-------------GKLPESEAVQYFRQICEGFKELYKNN
.||. . | .. .||.. ||| | | . .. |... |...|.|| .||||||.. . . ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
IIHRDIKPANILL-HK-----------------GVAHITDFGFARTLDCSGMN--------------------NQLKMTYLGTPLYMS-PQILA------
|.|||.|| |||| .. . |.|||||. .| . | .|. |. ||| ||. | .|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------EEYFSSKCDIWSLGMMFYELLYGRTPWTGK-------------TPNELLENIRKKPLEFPEQPPRS----------------------EIVK
..| . |||.||.| . | .| |. |. |. ...||.|.|.| .||. . . .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DMLRRMLVYEDSERISWDELFQHKII
|..|.||... ..|.. .. .|. .
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | 8181.AA | AGC | 16-271 | 22 | 9.1e-79 | 202.45 | In-house | 5-395 (395) | Show / Hide |
Range on Protein: 16-271 Range on HMM: 5-395/395 Sequence Identity: 22% (88 aa) KQLGQGAFGQVVKGFLKDNH-----AQQVAVKIISLQK--VASESNFIKLLRRE------------IEILQKIN----------HPNIVK-LHYATRTTN | .|.|.||.| ||.. .. |.|... .. | . | .. .| .||.|.| ||.||| |||. . . KVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKD N--LYMFLEYCA----------DGDLKKLLEK--RGGKLPESEAVQYFRQ-------ICEGFKELYK-NNIIHRD-IKPANILLHK-GVAHITDFGFART . ||. .||. ...| | . . |...|..| |. . |. .. | . ..||||| .|| |||| . | ..||||.. HTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKE LDCSG-----------------------------------------------MNNQLKMTYLG--TPLYMSPQILAEEYFSSKCDIWS--LGMMFYELLY . .| .... | | || ||.| || . ||.|| || ..||.|. GMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLT GRTPWTGKTPN----------ELLENIR------KKPLEFP--------EQPPRSEIVKDMLRRMLVYEDSERIS----------WDELFQHKII |..| .|..|. |. ..|. .....|| |.. |. || ....|. . ..|. .|. .|. GYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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| Kinase | 8181.AA | Ciliate-E2-Unclassified | 14-271 | 26 | 1.8e-70 | 240.42 | In-house | 3-352 (352) | Show / Hide |
Range on Protein: 14-271 Range on HMM: 3-352/352 Sequence Identity: 26% (95 aa) TNKQLGQGAFGQVVKGFLKDNHAQQVAVKIIS-------LQKVASESNFIKLLRREIE---------------ILQKINHPNIVKLHYATRTTNNLYMFL .||.|||.||.| | |.. |. | |... .|. .. ... . .. . ||. ..||.|||..|. ....|.|. . IIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM EYCADGDLKKLLEKRGG----------------KLPESEAV-----QYFRQICEGFKELYKNN-IIHRDIKPANILLHKG----VAHITDFGFARTLD-- ||| .|||.. ..||.. ...| .|. .||.||..|.. | ..| |||||||| |||.... |.|||... .. EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN --CSGMNN---------QLKMTYLGTPLYM----SPQILAEEYFS----SKCDIWSLGMMFYELLYGRTPWTGKTPNE----------------LLENIR | |. |. | ||| || .| .| .. . ||||||||. .||.|.|. | ... .. |..|| NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK KKPLEFPEQPP------RSEIVKDMLR----RMLVYEDSERISWDELFQHKII .|...||..|. |. .||... .||.. ..||.......| .. QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 8181.AA | CAMKL | 10-271 | 30 | 1.6e-67 | 214.51 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 10-271 Range on HMM: 1-297/297 Sequence Identity: 30% (92 aa) FIVCTNKQLGQGAFGQVVKGFLKDNHAQQVAVKIISLQKVASESNFIKL-----------LRREIEILQKIN---HPNIVKLHYATRTTNN------LYM .... .||.|.||.| . . . ..||.||| .| . . | .||||.|....| ||||.||. | .. .|. YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL FLEYCADGD--LKKLLEKRG---GKLPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLH-KG--VAHITDFGFARTLD-CSGMNNQLKMTYLGTPL ..||| |. | ..|.| |..||.|| .|||||... . . ...|.|||||| |||| .| .. |.||||. . | ..|. .| |.| VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP YMSPQILAE--E-YFSSKCDIWSLGMMFYELLYGRTPWTGKTPN-------ELLENIRKKPLEFPEQPPRSEIVKDMLRRMLVYEDSERISWDELFQHKI ||.| |.. . | | ||||.| . | ...|. |. . | | .|.. |.. ..| . | ..|..|.||. ..|.. ... .|. YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW I M |
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| Kinase | 8181.AA | STE | 13-271 | 23 | 2.8e-60 | 206.55 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 13-271
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)
CTN-KQLGQGAFGQVVKGFLKDNH--------------AQQVAVKIISLQKV--------ASESN-------FIKLLRREIEILQKIN--HPNIVKLHYA
.. ...|.||||.|.|. ..|. . .|.|...|.. . . . .. . .||.|..| | |||||| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC
TRTT-------NNLYMFLEYCADGDLKKLLE---KRGGKLP----------ESEAVQYFRQICEG-FKELYKNNIIHRDIKPANILLHKGVAHITDFGFA
..|....||.. | | .... ..|. |. ||. . |||..| . | ...||||||||||||| . ..|||..
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC
RTLDCSGM------------NNQLKM-TYLGTPLYMSPQILAE------EYFSSKCDIWSLGMMFYELLYGRTPWTGKTPNELLENIRKKP---------
|. |. ..| | | ||| .|.| .. . |||||||| . |.. |. || .| . . .| ..
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL
----LEFPEQPPR--------------------SEIVKDMLRRMLVYEDSERISWDELFQ--HKII
. | |.. |. || ... |... ..| . ..| . |. |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | 8181.AA | RSK | 15-271 | 32 | 1.1e-59 | 204.55 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 15-271 Range on HMM: 1-278/278 Sequence Identity: 32% (91 aa) NKQLGQGAFGQV--VKGFLKDNHAQQVAVKIISLQKVASESNFIKLLRREIEILQKIN-HPNIVKLHYATRTTNNLYMFLEYCADGDLKKLLEKRGGK-- |.||||..| | .. .. |. |.|... |.. .. ..|..||. .. ||.||.|||| .| ||. .||| |.| . |.|.. . LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLHK----GVAHITDFGFARTLDCSGMNNQLKMTYLGTPLYMSPQILA---EEY-FSSKCDIWSL . |.|| .|...| . | . |||||.|| |||.. | .|||||.. ..|. .||. ||. .| || | .|. . . ||.||| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCD--HNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL GMMFYELLYGRTPWTG---KTPNELLENIRKKP--LEFPEQPPRSEIVKDMLRRMLVYEDSERIS-----WDELFQHKII | ||.| |..| .| ....|....|.|. |..|. . |. || .|.|| . . |.. .|. ||. . GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | 8181.AA | Pkinase_Tyr | 12-162 | 34 | 1.3e-36 | 124.61 | Pfam | 1-161 (270) | Show / Hide |
Range on Protein: 12-162 Range on HMM: 1-161/270 Sequence Identity: 34% (56 aa) VCTNKQLGQGAFGQVVKGFLK---DNHAQQVAVKIISLQKVASESNFIKLLRREIEILQKI-NHPNIVKLHYATR-TTNN--LYMFLEYCADGDLKKLLE . .|.||.||||.|.|| .| ||. ..||||.. .. .| |... . ||..|. .. .|||||.|. . .|. .||.. |||.. | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR KR---GGKLPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLH-KGVAHITDFGFARTL |. ...|. .. .|. .||..| | .|.||||. |.|.. ..|. |.||| ||.. KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI |
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| Kinase | 8181.AA | TyrKc | 12-271 | 26 | 5.8e-35 | 123.39 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-271 Range on HMM: 1-280/280 Sequence Identity: 26% (77 aa) VCTNKQLGQGAFGQVVKGFLKDNHAQQVAVKIISLQKVASESNFIKLLRREIEILQKI--NHPNIVKLHYATRTT-------NNLYMFLEYCADGDLKKL . .|.|| ||||.|.|| .| .||||| . . .. ..||..|. |. .|||||.|. . .. |.. .||.. ||||. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LEKRGGKLPESEAVQYFRQICEGFKELYKNNIIHRDIKPANILLHKGV-AHITDFGFARTLDCS---GMNNQLKMTYL--GTP--L---YMSPQILAEEY | |...||. .. ... ||..| | ..|.||||. |.|.... . |.||| .| .. | . . ... |. | |.| . . LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK FSSKCDIWSLGMMFYELL-YGRTPWTG-----KTPNELLENIRKKPLEFPEQPPR---------SEIVKDMLRRMLVYEDSERISWDELFQHKII |..| |.|| | . .|.. || .|. | ... |..|.... . ..||| .. . .. .. .. ..| . |. |... FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQG--YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 8181.AA | Pkinase_Tyr | 192-229 | 31 | 6.2e-05 | 17.33 | Pfam | 191-231 (270) | Show / Hide |
Range on Protein: 192-229 Range on HMM: 191-231/270 Sequence Identity: 31% (13 aa) FSSKCDIWSLGMMFYELLY-GRTP-WTGKTPNELLENI-RK |..| |.|| | .|.. |..| . | ...|..| | .. FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED |
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