Gene 5362 (Tetrahymena)

5362

Species: Tetrahymena
Alias: 5362, 36.m00326, 478, TTHERM_00353490, 3703.m00185, PreTt05362
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
5362.AA Protein None 907 None Fasta, JSON
5362.NA RNA None 2724 None Fasta, JSON
5362.kin_dom Protein Kinase Domain None 256 None Fasta, JSON

Protein domain

Protein domains of 5362.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 5362.AA ULK 15-270 36 1.2e-124 420.44 In-house 1-324 (324) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-324/324
Sequence Identity: 36% (118 aa)

WSEQDFLGKGAFG-SVFKGKNIET---GEQVAVKVLQ---MQHFKN----EQAKIQLDEEINVMKKLD---SPY--IVKLLGLQEEN--EQTVIILELCP
..  . ||||.||  |.||.|..|   ...||.|. .   |. .||    .... .|. ||..||||.   .|.  ||||.  .|.     . ||.|.|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

EGDLNNLLKSKGG--------SLNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIKDGF-------------YKVSDFGFATGVDI--KSQQLLKE
 ||| ...| ...         |.|||||... |.. ||| ......|||||||.||||..|.             .|..|||||  ||   ..||....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

CV------GTPLFMAPQLLR----SKEYS-SKSDIWSIGMMYYLMLFGKTP---WPARDLN----SFITN-------IELLPLRFP---YDKPISQESKD
||      ||||.||||.|      |.|. .|.||||.|...| ||.||.|   | ..|..    . | |       |.  |..||   .|..||.|.||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FLSQCLQVEEESRIDWSKLFEHPLT
.....||..|. ||.|  .|.||. 
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 5362.AA ULK 15-270 36 3.5e-122 412.22 In-house 1-329 (329) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-329/329
Sequence Identity: 36% (120 aa)

WSEQDFLGKGAFGSVFKGKNIET----GEQVAVKVLQ---MQHFKN----EQAKIQLDEEINVMKKLD----SPY----IVKLLGLQEEN--EQTVIILE
..  . ||||.|| |.||.|..|    .|.||.|...   |. ..|    .... .|. || .||||.    ...    ||||.  .|.     . ||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCPEGDLNNLLKSKGG---------SLNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIKDGF-------------YKVSDFGFATGVDIK--SQQ
.|. ||| ...| ...          |.|||||....|.| ||| ......|||||||.||||..|.             .|..|||||  ||    .||
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LLKECV------GTPLFMAPQLLR----SKEYS-SKSDIWSIGMMYYLMLFGKTP---WPARDLN-----SFITN-------IELLPLRFP---YDKPIS
... ||      ||||.||||.|      |.|. .|.||||.|...| ||.||.|   | ..|..     . | |       |.  ||.||   .|..||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QESKDFLSQCLQVEEESRIDWSKLFEHPLT
.|.||.....||..|. ||.|  ||.||. 
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 5362.AA S_TKc 15-270 29 5.2e-76 259.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-231/231
Sequence Identity: 29% (79 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQVAVKVLQMQHFKNEQAKIQLDEEINVMKKLDSPYIVKLLGLQEENEQTVIILELCPE--GDLNNLLKSKGGS--
.   . .||||||.|.|.....||..||.|..           ...  ||...|| . |.||||..  .. .   ...|.|.   |||  ..|..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIKDGFYKVSDFGFATGVDIKSQQLLKECVGTPLFMAPQLLRSKEYSS-KSDIWSIGMMYYL
   ..| .|  ...|.... . . ..| ||||.||.|||. .   |..|||.|. .        . ..||| .||| .|    |.  |.|.||.| . | 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLFGKTPWPARDLNSFITNIELLPLRFPYDKPISQESKDFLSQCLQVEEESRIDWSKLFE-------HPLT
|| |..|.|  ...  . .|             |.| |||...|||.. | |.   ....       ||  
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 5362.AA Pkinase 15-270 29 4.7e-73 253.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQVAVKVLQMQHFKNEQAKIQLD-EEINVMKKLDSPYIVKLLGLQEENEQTVIILELCPEG----DLNNLLK-SKG
.     .|.|.||.|.|.... ||..||||..  .| | .. .. .   || .||.|..|.||.|..  |..    ...|.|. |    ||  ... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSL--NEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIK-DGFY----KVSDFGFATGVDIKSQQLLKECVGTPLFMAPQLLR-SKEYSSKSDIWSI
|..   |.|..... |.| | . . ..| ||||.||.||||. .|      |..|||.|  .|. ... ..  .||| .||| ..| ...|..|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GMMYYLMLFGKTPWPAR------DLNSFITNIELLPLRFPYDKPIS-------------------QESKDFLSQCLQVEEESRIDWSKLFEHPLT
| . | ||.|..|.| .      | .  | .|   ||.|......|                   .| |||.. ||..  ..|. .  ...||  
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 5362.AA Ciliate-E2 15-270 23 8.2e-70 238.24 In-house 1-365 (365) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-365/365
Sequence Identity: 23% (87 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQVAVKVLQMQH----------------FKNE--QAKIQLDEEINVMK----------------KLDSPYIVKLLG
   .  .|.|.||||.|.|......|.| |. . |                  |.   . ..|.  ||..|.                .|..|.|.|.  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

LQE--ENEQTVIILELCPEGDLNNLLKSK----------GGSLNEQEAINILCQLLL---------------GFKKMVEQG-YIHRDIKPANILIKDGFY
  .   ..   ...|.|  |||  ..|..          .....|.|...|  |.|                ... . ...  ||||||| |||.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----I

KVSDFGFATGVDIK------------------------------SQQLLKECVGTPLFMAPQLLRSKE---------YSSKSDIWSIGMMYYLMLFGKTP
|..|||... .|..                              .|.. . ..||| .|||. |..|.         |. |.||||.|.. | |||||.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WPARDLNSFITNIELLPLRFPYD----------------KPISQESKDFLSQ----CLQVEEESRID-WSKLFEHPLT
.        . .|.  ...||                  | .||| ||....    .||...| ||. |.....||  
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 5362.AA CAMK 20-270 20 1.8e-66 212.93 In-house 1-425 (425) Show / Hide 
Range on Protein: 20-270
Range on HMM: 1-425/425
Sequence Identity: 20% (88 aa)

FLGKGAFGSVFKGKNIETG------------EQVAVKVLQMQHFKN-------------------------EQAKIQLDEEINVMKK-------LDSPYI
 ||.|.|| |.......|.            ..||.|..  .  |.                         .. . ..  ||..|||       || | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLLGLQEE-------------------NEQTVIIL---ELCPEG----DLNNLLKSKGG--------------SLNEQEAINILCQLLLGFKKMVEQGY
.||.   |                    ... ....   |.|. |    || . ....|.               ..|.||  .  |.. . . . ... 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPANILIKDGF------------------YKVSDFGFATGVDIKS----------------------QQLLKECVGTPLFMA-PQLLRSKE----
.|||.|| |||. | .                   |..|||||. .| ..                       |..|...||| .|| | .|..|     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YSSKSDIWSIGMMYYLMLFGKTPWPAR-------------DLNSFITNIELLPLRFP--YDKPIS--------------------QESKD
          |. |.|.||.| . | || |. |. .              ...    .|     .||  | .|||                    || ||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLSQCLQVEEESRIDWSKLFEHPLT
.....|||. | |.  .   .||  
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 5362.AA STE 15-270 26 9.6e-65 221.4 In-house 1-359 (359) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-359/359
Sequence Identity: 26% (96 aa)

WSEQDFLGKGAFGSVFKGKNI------ETGEQ---------VAVKVLQMQHF--------------KNEQAKIQLDEEINVMKKLD--SPYIVKLLGLQE
|  ....||||||.|.|..|.      .|||.         .|.|.. ...               ||.. . |. .||..|||..  .|.||| .|  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EN-------EQTVIILELCPEGDLNNLLK---SKGGSLN----------EQEAINILCQLLLG-FKKMVEQGYIHRDIKPANILIKDGFYKVSDFGFATG
 .       ..  |..|... | |  ..|   ..|..||          |.. . |..|.| |  .   ....|||||||||||.     | .|||... 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VDI---------------KSQQLLKECVGTPLFMAPQLLRS------KEYSSKSDIWSIGMMYYLMLFGKTPW----PARDLNSFITNI-----------
..                 .||  . .|||| .|||  ..       |.|. |.||||.| .   |. || ||    | | .  ...|.           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

-ELLPLRFPYD-----------------KPISQESKDFLSQCLQVEEESRIDWSKLFE--HPLT
 .  | ..| .                 .  |.| |||...||| . . | . |.| .  ||  
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 5362.AA Ciliate-E2c 15-270 28 6.2e-60 205.42 In-house 1-310 (310) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-310/310
Sequence Identity: 28% (89 aa)

WSEQDFLGKGAFGSVFKGKNIE---TGEQV-------AVKVLQMQHF----KNEQAKI-QLDEEINVMKKLDSPYIVKLLGLQEENEQTVIILELCPEGD
 ..   ||.| .|.|.|... |   .   .       |.| .. . .     ||  .   .  ||| ||....|.|.|            .|.| |..|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LNNLLKSKGGSLNEQEAINILCQLLLGFKKMVEQ-GYIHRDIKPANILIKDGFYKVSDFGFATGVDIKSQQLLK---ECVGTPLFMAPQLLRS-KEYSSK
|  ....|   .||.. .    |.. .||   .. . .||||||.||||..|  |  ||||.  ...   |       |.|||..|||| |.. ..| .|
LEQYIYHK-PKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEK

SDIWSIGMMYYLMLFGKTPWP-----------------ARD-LNSFITNIE---------------LLPLRFPYD--KPISQESKDFLSQCLQVEEESRI
||||| | . | ||. | ||                    . .   . .|.                 ...|| .  . |||| |...   |||.|| ||
SDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRI

DWSKLFEHPLT
||. .| |.. 
DWDEIFNHECI
Kinase 5362.AA AGC 21-259 19 9.1e-60 152.18 In-house 7-374 (395) Show / Hide 
Range on Protein: 21-259
Range on HMM: 7-374/395
Sequence Identity: 19% (74 aa)

LGKGAFGSVFKGKNI------ETGEQVAVKVLQMQH---FKN--EQAKIQLD----------EEINVMKKLD----------SPYIVK-LLGLQEENEQ-
.|||.|| |.  .         ||.. |.|||. .|    |.  ......            || |...|..          .|.||| |    . ..  
IGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHT

-TVIILELCP--------EGDLNNLLKSKG----GSLNEQEAINILCQ-------LLLGFKKMVE-QGYIHRD-IKPANILIKD-GFYKVSDFGFATGVD
   ...|..|         |..  .|  .|    |...|..|  ....       ..|..  . . .|.|||| .|| |||. . |  | .|||... . 
YLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGM

IKS-------------------------------------------------QQLLKECVG--TPLFMAPQLLRSKEYSSKSDIWS--IGMMYYLMLFGK
 .                                                  ... .  .|  || .|||  |    |.   |.||   | . | ||.|.
NDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGY

TPWPARDLN--------SFITNIELL--------PLRFP--------YDKPISQESKDFLSQCLQVEEESRI
.|  . . .         . .    .        ...||        .|. .|.| ||.....|... | |.
PPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRL
Kinase 5362.AA CAMKL 15-270 27 3e-56 177.96 In-house 1-297 (297) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-297/297
Sequence Identity: 27% (83 aa)

WSEQDFLGKGAFGSVFKGKN-IETGEQVAVKVLQMQHFKNEQAKIQ------------LDEEINVMKKLD---SPYIVKLLGLQEENEQ------TVIIL
.   . ||||.|| |  ... . |||.||.|..  .  .|.. . .            .  ||. ||.|.    | |.||.   |  |        ....
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCPEGD--LNNLLKSKG---GSLNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIK-DG--FYKVSDFGFATGVD---IKSQQLLKECVGTPLFM
|.|. |.  | . ....|   |.. | ||  . .|.. . . . ..| .|||||| |||.  .|    |..||||..  .   ... |.||.. |.| .|
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APQLLRS--KEYS-SKSDIWSIGMMYYLMLFGKTPWPARDLN-------SFITNIELLPLRFPYDKPISQESKDFLSQCLQVEEESRIDWSKLFEHPLT
|| .. .  |.|   | ||||.| . | |..|. |. . ..|        .   |  .  ..|  . .| . .|.... |||  | |.    . .||  
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 5362.AA Ciliate-E2-Unclassified 15-270 22 1.4e-55 190.95 In-house 1-352 (352) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQV-------AVKVLQMQHFKNEQAKIQLDEEINVMK----------------KLDSPYIVKLLGLQEENEQTVII
   .  .|.|.||.|.| ...... |.        ...  ..  .|.. ...  .|.| .|                 ...|.|||..   .  .   |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LELCPEGDLNNLLKSKGG----------------SLNEQEAI-----NILCQLLLGFKKMVEQG-YIHRDIKPANILIKDG----FYKVSDFGFATGVD-
.|.|. ||| . .|....                 . ||.|.     ... |.|.|.... ...  ||||||| |||....      |..|||..   . 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

-------------IKSQQLLKECVGTPLFM----APQLLRSKEYS----SKSDIWSIGMMYYLMLFGKTPWPARDLNS----------------FITNIE
             | .||... ..||| .|    || .|....|.     |.|||| |.  | ||||. | .... ..                .. || 
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

LLPLRFPYDKP------ISQESKDFLS----QCLQVEEESRIDWSKLFEHPLT
  .. ||  ..      .|.| |||..    ..|..  ..||.......||. 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 5362.AA CAMK-Unique 15-270 22 1.7e-54 178.19 In-house 1-363 (363) Show / Hide 
Range on Protein: 15-270
Range on HMM: 1-363/363
Sequence Identity: 22% (80 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQVAVKVLQMQHFKNEQAKIQ-----------------LDEEINVMKKLDSPYIVKLLGL----QEENE-------
.     .|.|.|| |......|||   |.|... |  .|.  |.|                 |..|....|..| | |.||..      .  .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------QTVIILELCPEGDLNNLLKSK-------------------GGSLNE--QEAINILCQLLLGFKKMVEQGYIHRDIKPANILIKDGFY-----
          .|..|.|..|||. .. .                     |...|   ....|  .||   . | .|. .|||.|. ||...  |      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

------------KVSDFGFATGVD-IKSQQLLKECVGTPLFMAP--------------QLLRSKEYSSKS----DIWSIGMMYYLMLFGKTPWPARDLN-
            |..||| .. ..  |.  .... .|||..|||              ...    |....    ||||.| . |.||.|..|  . . . 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------SFITNIELLPL-RFP---YDKP--ISQESKDFLSQCLQVEEESRIDWSKLFEHPLT
       . . .|    . .|.   .. |  |||| |||. .|..|.  .|.  . | ||.  
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 5362.AA Pkinase_Tyr 21-199 29 1.3e-25 87.32 Pfam 7-199 (270) Show / Hide 
Range on Protein: 21-199
Range on HMM: 7-199/270
Sequence Identity: 29% (57 aa)

LGKGAFGSVFKGKNI----ETGEQVAVKVLQMQHFKNEQ-AKIQLDEEINVMKKL-DSPYIVKLLGLQE-ENEQ--TVIILELCPEGDLNNLLKSK---G
||.||||.|.||.      .|. .||||.|  ..   ||  .  . .|...||.| . | ||.|.|    . |.    |..|..| ||| . |...   .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDK

GSLNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIK-DGFYKVSDFGFATGVDIKSQQ-LLKECVGTPLF-MAPQLLRSKEYSSKSDIWS
..|. .. ...  |   |     ....||||.   |.|.. ... |..||| |  .  ...    ..    | . |||  .. .....|||.||
QPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
Kinase 5362.AA TyrKc 15-274 23 1.4e-21 78.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-274
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

WSEQDFLGKGAFGSVFKGKNIETGEQVAVKVLQMQHFKNEQAKIQLDEEINVMKKL--DSPYIVKLLGLQEEN-------EQTVIILELCPEGDLNNLLK
 .  . || |||| |.||. .   .|||||.|.  .      .  . .|...|.||  . | ||.|.|   .        |.  |..|..| |||.. |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SKGGSLNEQEAINILCQLLLGFKKMVEQGYIHRDIKPANILIKDGF-YKVSDFGFATGVDIK-----SQQLLKE----CVG--TPLF-MAPQLLRSKEYS
.... |. .. ...  |   |     ....||||.   |.|.....  |.|||| .  .. .     |..  .     .     |.  |||  .. ....
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKSDIWSIG-MMYYLMLFGKTPWPA--------RDLNSFITNIELLPLRFP-YDKP-----ISQESKDFLSQCLQVEEESRIDWSKLFEHPLTKKAL
.|||.|| | .|. .. .|..|.|         ...  .. . . .|     |  |      ..|  .  .|| . . |.|   | .      .. .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Efhand 5362.AA efhand 340-368 27 0.000216 20.49 Pfam 1-29 (29) Show / Hide 
Range on Protein: 340-368
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

DTDYLFKQIDENGDGSLSIHEFTKFFLEY
. . .||..| .||| ... || ... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5362.AA EFh 340-368 24 0.019868 10.22 SMART 1-29 (29) Show / Hide 
Range on Protein: 340-368
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

DTDYLFKQIDENGDGSLSIHEFTKFFLEY
. . .|. .| .||| .. .|| ... . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5362.AA efhand 394-422 34 2.8e-05 23.75 Pfam 1-29 (29) Show / Hide 
Range on Protein: 394-422
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

NLFEIFEKYDENKGGTLDLQEFTKMLKQV
 | |.|...| .. |..|..|| .|.|..
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5362.AA EFh 394-422 31 6.5e-05 23.57 SMART 1-29 (29) Show / Hide 
Range on Protein: 394-422
Range on HMM: 1-29/29
Sequence Identity: 31% (9 aa)

NLFEIFEKYDENKGGTLDLQEFTKMLKQV
 . |.|...| .. |..|..|| .|.| .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 5362.AA EFh 430-458 41 1.8e-05 25.43 SMART 1-29 (29) Show / Hide 
Range on Protein: 430-458
Range on HMM: 1-29/29
Sequence Identity: 41% (12 aa)

EILVIFRKFDSNNDQNIDFQEFVKVMTYG
|.  .||.|| ..|  |||.||...|.  
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5362.AA efhand 430-456 40 2.5e-05 23.9 Pfam 1-27 (29) Show / Hide 
Range on Protein: 430-456
Range on HMM: 1-27/29
Sequence Identity: 40% (11 aa)

EILVIFRKFDSNNDQNIDFQEFVKVMT
|.  .|..|| ..|  |||.||...|.
ELKEMFKEFDKDGDGYIDFEEFCEMMK
Efhand 5362.AA efhand 492-518 25 0.087268 10.95 Pfam 3-29 (29) Show / Hide 
Range on Protein: 492-518
Range on HMM: 3-29/29
Sequence Identity: 25% (7 aa)

QNIFQKFDVDFDKHLNRREFRDLIRII
...|..||.| |  ... ||..... .
KEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 5362.AA EFh 490-518 27 0.0972 4.66 SMART 1-29 (29) Show / Hide 
Range on Protein: 490-518
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

NEQNIFQKFDVDFDKHLNRREFRDLIRII
  . .|..||.| |  ..  ||.|... .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 5362.AA efhand 526-537 41 69.357638 0.33 Pfam 1-12 (29) Show / Hide 
Range on Protein: 526-537
Range on HMM: 1-12/29
Sequence Identity: 41% (5 aa)

EIHFIFDIFDMD
|.  .|..|| |
ELKEMFKEFDKD
Efhand 5362.AA efhand 694-708 40 12.961387 3.0 Pfam 15-29 (29) Show / Hide 
Range on Protein: 694-708
Range on HMM: 15-29/29
Sequence Identity: 40% (6 aa)

GTIPQQEFQKMMQQG
|.|  .||..||.. 
GYIDFEEFCEMMKKL