Gene 27664 (Tetrahymena)

27664

Species: Tetrahymena
Alias: PreTt27664, 27664, 218.m00039, 815, TTHERM_01070340
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
27664.AA Protein None 1158 None Fasta, JSON
27664.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
27664.NA RNA None 3477 None Fasta, JSON

Protein domain

Protein domains of 27664.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 27664.AA ULK 18-277 39 6.7e-140 471.08 In-house 1-324 (324) Show / Hide 
Range on Protein: 18-277
Range on HMM: 1-324/324
Sequence Identity: 39% (129 aa)

LNLDKILGQGSFG-SVYQAIDMKNG--DRQVAVKQISQTSMNKNADK-----LMQLLKNEIKTMKMIK---DKN--VVQLLDVRRSS--NNIYLIVEYCN
 .|...||.||||  ||.....|..  . .||.|.|.. .|||.  .     ..|||||||..||..|    .|  .|.|.|. ..|  ||||.|.||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGSLESYLNKNGK--------RLSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLHDGIPK-------------IADFGFSKVVEH-SMEQADLAS
|| ||.|..||.|        |||| |.. ... |..|||.|....|.|||.||.|||.|.|.||             ||||||.|.|.  .||| .. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GSPIYMCPQILN----CQTYS-SKLDVWSLGIIFYEMLYGKTP---WKAKSVF----DLANN-------INNTNLEFP---SAPVVSKRTQQ
.|      |.|.||.||||.    .. |. .| |.||||.|||||||||.|   | . . .    .| ||       |.|....||   ..|..|. ...
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIKNMLQKEEEKRLGWEDLFKIFLS
||. |||..|..|  ||..|.... 
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 27664.AA ULK 18-277 39 1.9e-136 459.59 In-house 1-329 (329) Show / Hide 
Range on Protein: 18-277
Range on HMM: 1-329/329
Sequence Identity: 39% (131 aa)

LNLDKILGQGSFGSVYQAIDMKNG---DRQVAVKQISQTSMNKNADK-----LMQLLKNEIKTMKMIK----DKN----VVQLLDVRRSS--NNIYLIVE
 .|...||.|||| ||.....|..   . .||.|.|.. .||.. .      ..||||||||.||..|     ||    .|.|.|. ..|  ||||.|.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGSLESYLNKNGK---------RLSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLHDGIPK-------------IADFGFSKVVEHS-MEQA
||||| ||.|..||.|         |||| |.. ... |..|||.|....|.|||.||.|||.|.|.||             ||||||.|.|. . |||.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

DLASLV------GSPIYMCPQILN----CQTYS-SKLDVWSLGIIFYEMLYGKTP---WKAKSVF-----DLANN-------INNTNLEFP---SAPVVS
.. . |      |.|.||.||||.    .. |. .| |.||||.|||||||||.|   | . . .     .| ||       |....|.||   ..|..|
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

KRTQQLIKNMLQKEEEKRLGWEDLFKIFLS
. ...||. |||..|..|  ||.||.... 
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 27664.AA S_TKc 18-276 27 4.5e-81 276.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQVAVKQISQTSMNKNADKLMQLLKNEIKTMKMIKDKNVVQLLDVRRSSNNIYLIVEYCNG--GSLESYLNKNGK
  . ...|.|.||.||.... |  .|.||.|.|.            . ...||. .|. . .|.|.|.|| .. ...|.. |||.|  |.| .|. |.|.
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

R-----LSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLHDGIPKIADFGFSKVVEHSMEQADLASLVGSPIYMCPQILNCQTYSS-KLDVWSLGI
.     ..| .. .....|... . . ...|.||||||.|||| .   ||.|||.....          ...|.| || | .|    |.  | |.||.|.
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

IFYEMLYGKTPWKAKSVFDLANNINNTNLEFPSAPVVSKRTQQLIKNMLQKEEEKRLGWEDLFK--------IFL
|.||||.|..|.    .. . ..|             |.   ..|...|||. |||..  ....         ..
ILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 27664.AA Ciliate-E2c 18-272 31 2.5e-78 266.52 In-house 1-305 (310) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-305/310
Sequence Identity: 31% (97 aa)

LNLDKILGQGSFGSVYQAIDMK--NGDRQV-------AVKQISQTSMNKNADKLMQLL---KNEIKTMKMIKDKNVVQLLDVRRSSNNIYLIVEYCNGGS
 . ..|||.||.|.|| |   .  ..   .       |.| .   . . .....   .   ..||  ||  . .....  |    ...|||| ||||||.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LESYLNKNGK-RLSETETLRIIREIVSGFKCLYEQ-KIVHRDLKPANILLHDGIPKIADFGFSKVVEHSMEQ--ADLASLVGSPIYMCPQILNC-QTYSS
||.|. .  | ...| . |     |.|.|| |... .| |||.||.|||.|.|..||||||||| .     |        .|.|.|| ||||.  . | .
LEQYIYH--KPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTE

KLDVWSLGIIFYEMLYGKTPWK------------------AKSVFDLANNIN---------------NTNLEFPSA--PVVSKRTQQLIKNMLQKEEEKR
| |.||||.  |.||. | ||.                  . ..  |  .|                ..|. || .    .|. ..|||..|||..||||
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKR

LGWEDLF
. |...|
IDWDEIF
Kinase 27664.AA Ciliate-E2 18-273 24 2.6e-76 259.84 In-house 1-361 (365) Show / Hide 
Range on Protein: 18-273
Range on HMM: 1-361/365
Sequence Identity: 24% (92 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQ-----------------VAVKQISQTSMNKNADKLMQLLKNEIK-------------TMKMIKDKNVVQLLDV
 .. |..|||.|||||.. . |.. ..                 |..|..   .|.||  . .   .....              .. .. .|.... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

RR--SSNNIYLIVEYCNGGSLESYLNKNGK----------RLSETETLRIIREIVS---------------GFKCLYEQK-IVHRDLKPANILLHDGIPK
    . |||||. |||.||.|..|...| |          ...| | ..|...|..               ... | ... |.|||.|| |||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFSK-----------------VVEHS-------------MEQADLASLVGSPIYMCPQILNCQT---------YSSKLDVWSLGIIFYEMLYGKTP
|.|||.||                   . .             . |    ...|.| ||.|.||| .          |. | |.||||.|.||||.||.|
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WKAKSVFDLANNINNTNLEFP----------------SAPVVSKRTQQLIKN----MLQKEEEKRLG-WEDLFK
.         ..| . ...||                |   .|. ...|||.    ||||..|||.. ||....
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase 27664.AA Pkinase 18-275 28 2.3e-75 261.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQVAVKQISQTSMNKNADKLMQLLKNEIKTMKMIKDKNVVQLLDVRRSSNNIYLIVEYCNGG----SLESYLN-K
. . ...|.||||.||.... ..|. .||||.|.  . ... |.   .| .||. ||... .|.|.|.|. .....||.. |||.||    .| .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

NGKRL--SETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLH-DGIP----KIADFGFSKVVEHSMEQADLASLVGSPIYMCPQILN-CQTYSSKLDV
.....  || |  .....|..| . .....|.||||||.|||.. .| .    ||.|||..|...    .  . ...|.| || | ... .| |..| |.
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGIIFYEMLYGKTPWKAK------SVFDLANNINNTNLEFPSAPVVS-------------------KRTQQLIKNMLQKEEEKRLGWEDLFKI--F
||.|.|.|||| |..|.. .      .   . ..|  . |.|..    |                   .  ...||..|.|  .||...|....   |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 27664.AA AGC 18-267 20 2.4e-73 188.13 In-house 1-375 (395) Show / Hide 
Range on Protein: 18-267
Range on HMM: 1-375/395
Sequence Identity: 20% (79 aa)

LNLDKILGQGSFGSVYQAIDMKNG-----DRQVAVKQISQTS-MNKNADKLMQLLKNE------------IKTMKMIK----------DKNVVQ-LLDVR
 .. |..|.|||| ||.. . ...     ... |.| ..    . ..  . ..  ..|             . .....            ..|. |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

RSSNN--IYLIVEYCN--------GGSLESYLNKNG--K--RLSETETLRIIRE-------IVSGFKCLYE-QKIVHRD-LKPANILLHD-GIPKIADFG
 . ..  .|.. ||..        || .|..| . |  |  |..| ..  .. |       ||...  | . ..|.||| ||| |||| . |  |..|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FSKVVEHSM------------------------------------------------EQADLASLVG--SPIYMCPQILNCQTYSSKLDVWS--LGIIFY
..|..  ..                                                ...   ...|  .| || | ||    |.   | ||  ||...|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGKTPWKAKS----------VFDLANNIN------NTNLEFPSA--------PVVSKRTQQLIKNMLQKEEEKRLG
|||.|..|  ...           ... ..|       | ...||.         . .|.  . ||| .|.|. |||||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLG
Kinase 27664.AA CAMK 23-266 21 4e-73 234.75 In-house 1-414 (425) Show / Hide 
Range on Protein: 23-266
Range on HMM: 1-414/425
Sequence Identity: 21% (87 aa)

ILGQGSFGSVYQAIDMKNGD-----------RQVAVKQISQTSMNKN-----------------------ADKLMQLLKNEIKTMKM-------IKDKNV
.||.|||| |. .|. ...            ..||.| |. . . ..                        .| .. ...||. ||.       .. .|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLLDVRRSSNN-------------------IYLIV---EYCNGG----SLESYLNKNGK--------------RLSETETLRIIREIVSGFKCLYEQKI
..|..|  ....                   .|..    ||| ||     | .|. ..|.              |..| |. |..| |.|. . . ...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPANILL-HD-----------------GIPKIADFGFSKVVEHSMEQA---------------------DLASLVGSPIYMC-PQILNCQT----
||||||| |||| ..                 .  ||.||||....... ..                       .   .|.| ||. | .|| ..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YSSKLDVWSLGIIFYEMLYGKTPWKAK-------------SVFDLANNINNTNLEFPSAPV----------------------VSKRTQQ
          |. | |.||.|.| | || |. |. ..             .  .|  .| . . .||. ..                      ||.  ..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIKNMLQKEEEKRL
||..|||.. |||.
LIRKMLQVDPEKRM
Kinase 27664.AA CAMKL 18-265 32 9.6e-68 215.22 In-house 1-285 (297) Show / Hide 
Range on Protein: 18-265
Range on HMM: 1-285/297
Sequence Identity: 32% (94 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQVAVKQIS--QTSM----------NKNADKLMQLLKNEIKTMKMIK---DKNVVQLLDVRRSSNN------IYL
 .. | ||.|||| |  |.. ..  ..||.| |    ...          .|. .. |  .. ||. |||..    .|...|..|.  ...      |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKH-ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

IVEYCNGGS--LESYLNKNG---KRLSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLH-DG--IPKIADFGFSKVVE-H-SMEQADLASLVGSPI
. ||| ||.  |  |. |.|   .|..| |. |. | |||. . . ...|||||.|| ||||  .|    ||.|||||   . .   .   |    ||| 
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YMCPQILNC--QTYS-SKLDVWSLGIIFYEMLYGKTPWKAK--------SVFDLANNINNTNLEFPSAPVVSKRTQQLIKNMLQKEEEKR
||.| |..   . |   | |.||.|.| | |..|. |...          .  | . |. .  ..|  . || . ..||. |||.  |||
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKR
Kinase 27664.AA Ciliate-E2-Unclassified 19-273 24 4.4e-64 219.22 In-house 2-348 (352) Show / Hide 
Range on Protein: 19-273
Range on HMM: 2-348/352
Sequence Identity: 24% (84 aa)

NLDKILGQGSFGSVYQAIDMKNGDRQVAVKQISQTSMNK-----NADKLMQLLKNEIKTMK----------------MIKDKNVVQLLDVRRSSNNIYLI
.. |..|||.||.||.... |..  . | |....  ..|     | |  . . ..|.. .|                .... ..| .... .. .|||..
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

VEYCNGGSLESYLNKNGK----------------RLSETETL-----RIIREIVSGF-KCLYEQKIVHRDLKPANILLHDG----IPKIADFGFSK-VVE
 |||.||.|. |..|..|                ...| ...     .....|..|. .. ....|.|||.|| |||....     .||.|||.||   .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

HSMEQAD-------------LASLVGSPIYM----CPQILNCQTYS----SKLDVWSLGIIFYEMLYGKTPWKAKSVFD----------------LANNI
 . .. .             . . .|.|.||     | .|  | |.     | |.||||.|.||||.|. | ....  .                | .||
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

NNTNLEFPSAP------VVSKRTQQLIK----NMLQKEEEKRLGWEDLFK
.. |..||..|       .|.  . .|.     ||.|  .||...|....
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILN
Kinase 27664.AA Ciliate-E2b 18-275 25 7.7e-63 189.82 In-house 1-272 (272) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-272/272
Sequence Identity: 25% (70 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQVAVKQISQTSMNKNADKLMQLLKNEIKTMKMIKDKNVVQLLDVRRSSNNIYLIVEYCNGGSLESYLNKNG-KR
.   | ||.| |||||.    || ... | |.||  .  ..   .   . .|........  .......  ......|...|.|||..|....   |   
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQ--NMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLL

LSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLHD-GIPKIADFGFSKVVEHSMEQA-DLASLVGSPIYMCPQILN-----CQTYSSKLDVWSLGI
||. . . .| .|. ... | .|.|..||.|| ||...  | .|..|.| .|. . . ||     ...| | || |.|..      . |. | |.||.||
LSTYDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGI

IFYEMLYGKTPW--KAKSVFDLANNINNT--NLEFPS--APVVS--KRTQQLIKNMLQKEEEKRLGWEDLFKIF
. ||.. |. ||  ..     .   |..   ...|||    ...  | ..|. . | .  .... .|. ... |
CLYEFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGSYSWLKSHPWF
Kinase 27664.AA STE 18-276 22 2.8e-61 209.88 In-house 1-359 (359) Show / Hide 
Range on Protein: 18-276
Range on HMM: 1-359/359
Sequence Identity: 22% (84 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQ--------------VAVKQIS-QTSMNKNAD------------KLMQLLKNEIKTMKMIK--DKNVVQLLDVR
. . ...|.|.||.||.|...||.. .              .|.||.. ... ||. .            . || ...|||.||  .   .|.|. ..  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

RSS-------NNIYLIVEYCNGGSLESYLNKNGKRLS-------------ETETLRIIREIVSG-FKCLYEQKIVHRDLKPANILLHDGIPKIADFGFSK
          ...... ||..||||.. ........              |..  .|.|.|. |  . | ...|.|||.|||||||     |..|||...
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCG

VVEHSM-------------EQA-DLASLVGSPIYMCPQILNC------QTYSSKLDVWSLGIIFYEMLYGKTPW---KAKSV-------------FDLAN
 ...||              ..    ..||.| .| | ....      . |. | |.||||.   ||. || ||   .  ..             |..  
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

NINN-TNLEFPSA-----------------PVVSKRTQQLIKNMLQKEEEKRLGWEDLFK---IFL
.|.| .   .|.                    .|.  .. |.. |||. .||   ..| |    |.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 27664.AA Pkinase_Tyr 18-171 28 1.9e-27 93.57 Pfam 1-163 (270) Show / Hide 
Range on Protein: 18-171
Range on HMM: 1-163/270
Sequence Identity: 28% (48 aa)

LNLDKILGQGSFGSVYQAIDM---KNGDRQVAVKQISQTSMNK-NADKLMQLLKNEIKTMKMI-KDKNVVQLLDVRR-SSNN--IYLIVEYCNGGSLESY
. ..| ||.|.||.||...     .|.. .|||| . ...| . |   ... . .|.|.|| . . .|.|.|. |    .    ||...||. .|.| .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LNKN---GKRLSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLH-DGIPKIADFGFSKVVEH
| |.   ...|.  . | . ..| .|   | .....||||   |.|.. ... ||.||| .. ...
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN
Kinase 27664.AA TyrKc 18-275 22 3.3e-26 94.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-275
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

LNLDKILGQGSFGSVYQAIDMKNGDRQVAVKQISQTSMNKNADKLMQLLKNEIKTMKMI--KDKNVVQLLDVRRSS-------NNIYLIVEYCNGGSLES
. |.|.|| | || ||... .|   .||||| .   .        .. . .|.. |...  . .|.|.|. | ...         .....||. .|.| .
ITLGKKLGEGAFGEVYKGT-WK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLNKNGKRLSETETLRIIREIVSGFKCLYEQKIVHRDLKPANILLHDG-IPKIADFGFSKVVEHS-----MEQADLASL--VG---SPI-YMCPQILNCQ
|| |....|.  . | .   | .|   | .....||||   |.|.... . ||.||| |. ...       ..   ..    |    ||  | |  .|  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

TYSSKLDVWSLGIIFYEML-YGKTPWKA-----KSVFDLANNINNTNLEFPSAPV-------VSKRTQQLIKNMLQKEEEKRLGWEDLFKIF
....| |||| |.  .|.. ||..|.       .| ... ... . .   . . .        ..   |..|   . . |.|   ... ..|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 27664.AA Pkinase_Tyr 198-235 26 0.01767 9.02 Pfam 191-231 (270) Show / Hide 
Range on Protein: 198-235
Range on HMM: 191-231/270
Sequence Identity: 26% (11 aa)

YSSKLDVWSLGIIFYEMLY-GKTP-WKAKSVFDLANNI-NN
...| |||| |.  .|..  |..| ..  | ... . |  .
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED