Gene 24896 (Tetrahymena)

24896

Species: Tetrahymena
Alias: PreTt24896, 24896, 41.m00303, 72, TTHERM_00390000
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
24896.AA Protein None 1766 None Fasta, JSON
24896.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
24896.NA RNA None 5301 None Fasta, JSON

Protein domain

Protein domains of 24896.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 24896.AA ULK 18-272 40 2e-142 479.49 In-house 1-324 (324) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-324/324
Sequence Identity: 40% (131 aa)

FSLSACIGKGSSG-TVYVGRHQQT---QQVVAIKAVD---MRSLKT----EYAWKMLCSEVKIMKKLK---HPH--VVRLLDVFQTK--NNTYIITEFCN
..|. |.|||| | .|| ||...|   .|.||.| .|   |.  |     .|.|..|..|..||||||   ||.  .|.|.|.|.|.  ||.|||.|.||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGDLRTYLKKKKS---------LTEREAITVISQIMSGLQELANNGIIHRDLKPANILIHDD-------------VFKITDFGFAKKLDS--MEDQLMDS
.|||..|.||.|          |.| ||| .. ||..|..|| ...|||||.||.|||||..             |.||.||||||..|.  ||.|.. .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LV------GTPLYMAPQILN----KQQYT-SKCDVWSIGLILYELLFGRTP---WPAVNVV----DLVQK-------MCTVPLQFP---KDQSISQALVN
.|      |||||||||||.    ...|. .|||.||.| |.||.|.|..|   | . . .    .|...       ... |.|||   ||. ||. . .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

FISKCLQFPESDRISIQEMCANSLF
.|...||. |.||||..|. .. .|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 24896.AA ULK 18-272 39 5.3e-140 471.42 In-house 1-329 (329) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-329/329
Sequence Identity: 39% (131 aa)

FSLSACIGKGSSGTVYVGRHQQT----QQVVAIKAVD---MRSLKT----EYAWKMLCSEVKIMKKLK--------HPHVVRLLDVFQTK--NNTYIITE
..|. |.|||| |.|| ||...|    ...||.| .|   |.  .     .|.|..|..|.|||||||        ||..|.|.|.|.|.  ||.|||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCNQGDLRTYLKKKKS----------LTEREAITVISQIMSGLQELANNGIIHRDLKPANILIHDD-------------VFKITDFGFAKKLDS--MEDQ
.||.|||..|.||.|           |.| ||| .. ||..|..||  ..|||||.||.|||||..             |.||.||||||..|.  ||.|
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

LMDSLV------GTPLYMAPQILN----KQQYT-SKCDVWSIGLILYELLFGRTP---WPAVNVV-----DLVQK-------MCTVPLQFP---KDQSIS
.| . |      |||||||||||.    ...|. .|||.||.| |.||.|.|..|   | .   .     .|...       ... |||||   .|. ||
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QALVNFISKCLQFPESDRISIQEMCANSLF
. . ..|...||. |.||||..|. .. .|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 24896.AA S_TKc 18-272 34 2.6e-93 317.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FSLSACIGKGSSGTVYVGRHQQTQQVVAIKAVDMRSLKTEYAWKMLCSEVKIMKKLKHPHVVRLLDVFQTKNNTYIITEFCNQ--GDLRTYLKKKKS---
. .   ||||. |.|| .||  |...|||| ..          .....|..|.|| .||..|.|.||||. .. |...|.|..  |||..|.||...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEREAITVISQIMSGLQELANNGIIHRDLKPANILIHDDVFKITDFGFAKKLDSMEDQLMDSLVGTPLYMAPQILNKQQYTS-KCDVWSIGLILYE
   ..| .|  .. || ..|. . ..|||||||||.|||. . . ||.|||.|..|        ....||| |||| .|   .|.  |||.||.| ||||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLFGRTPWPAVNVVDLVQKMCTVPLQFPKDQSISQALVNFISKCLQFPESDRISIQEMCA-------NSLF
.| |..|.|  ..  . .|..            |. . .||.||||.  ..|... |  .          |
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 24896.AA Pkinase 18-272 32 5.1e-87 300.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-293/293
Sequence Identity: 32% (96 aa)

FSLSACIGKGSSGTVYVGRHQQTQQVVAIKAVDMRSLKTEY---AWKMLCSEVKIMKKLKHPHVVRLLDVFQTKNNTYIITEFCNQG----DLRTYLK--
. .  .||.||.|.|| ..|. |...||.| .. |. | .    ...   ||..|||.|.||..|||.|.|..|.. |...|.|. |    || .|..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KKKSL--TEREAITVISQIMSGLQELANNGIIHRDLKPANILIH-DDVF----KITDFGFAKKLDSMEDQLMDSLVGTPLYMAPQILN-KQQYTSKCDVW
.....  .|.|.. .. || .||. . ..|||||||||.||||. ...     ||.|||.||..|   .. |....||| |||| ...  | |..|.|.|
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SIGLILYELLFGRTPWPAV------NVVDLVQKMCTVPLQFPKDQSIS-------------------QALVNFISKCLQFPESDRISIQEMCANSLF
|.|.||||.|.||.|.|        .   ....    || |. ....|                   ...  ||..||..  ..|..... .    |
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 24896.AA CAMK 23-272 23 8.7e-87 279.59 In-house 1-425 (425) Show / Hide 
Range on Protein: 23-272
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

CIGKGSSGTVYVGRHQQTQ------------QVVAIKAVDMRSLK-------------------------TEYAWKMLCSEVKIMKK-------LKHPHV
 .|.|| |.|. ..| .|.            | |||| .| . ||                         ...  |.. .|..||||       |.||..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLDVFQ------------TKNN--------TYIIT---EFCNQG----DLRTYLKKKKS---------------LTEREAITVISQIMSGLQELANNG
..|..|..            | ..         |...   |.|  |    ||  |......               .||||| ... || |... . ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIHRDLKPANILIHDD------------------VFKITDFGFAKKLDSME----------------------DQLMDSLVGTPLYMA-PQILNKQQ---
|.|||||| |||. |.                    ||.|||||.|.|. |                      .|.|   .||| ||| | .||...   
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YTSKCDVWSIGLILYELLFGRTPWPAV-------------NVVDLVQKMCTVPLQFPK--------------DQSISQA--------LV
           |. |||.||.| ||| .| |. |. .              |  .| .| ..   .||               . .||.           
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

NFISKCLQFPESDRISIQEMCANSLF
..|.|.||   ..|..|..  .   .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 24896.AA Ciliate-E2 18-272 23 6.7e-86 291.69 In-house 1-365 (365) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

FSLSACIGKGSSGTVYVGRH-----------------------QQTQQVVAIKAVDMRSLKTEYAWKMLCSEVK----------IMKKLKHPHVVRLLDV
. .  .||.|. |.|| ...                       ..... .|.| .  . ..     . .. |..          |...|.||..... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TKNNTYIITEFCNQGDLRTYLKKK-----------KSLTEREAITVISQIMS---------------GLQELANNG-IIHRDLKPANILIHDDVFK
||  ..|| |...|.|..|||. |.|..           |..||.|..... || .               .|..| ... |||||.|| |||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

ITDFGFAKKLDSMED------------------------------QLMDSLVGTPLYMAPQILNKQQ---------YTSKCDVWSIGLILYELLFGRTPW
|.|||..||.|  ..                              .. ....||| ||||.|||...         |. |||.||.| ||||.|||..|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

PAVNVVDLVQKMCTVPLQFP----------------KDQSISQALVNFISK----CLQFPESDRIS-IQEMCANSLF
         |. .  ...||                . ...||   ..|.|    .||  .. ||. ...   .  |
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 24896.AA CAMKL 18-272 27 1.3e-78 250.47 In-house 1-297 (297) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-297/297
Sequence Identity: 27% (83 aa)

FSLSACIGKGSSGTVYVGRH-QQTQQVVAIKAVDMRSLK-TEYAWKM-----------LCSEVKIMKKLK---HPHVVRLLDVFQTKNN------TYIIT
. .   .|||| |.|  ..| . |.. |||| .| . ..  ....|.           .  |..|||.|.   ||....|..|..|...       |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EFCNQGD--LRTYLKKK----KSLTEREAITVISQIMSGLQELANNGIIHRDLKPANILIH-DD--VFKITDFGFAKKLD---SMEDQLMDSLVGTPLYM
| |  |.  |  |..|.    ....|.||     ||.|... . ..||.|||.|| |||.  ..  . ||.||||. . .     ..|...   |.| ||
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APQILNK--QQYT-SKCDVWSIGLILYELLFGRTPWPAV--------NVVDLVQKMCTVPLQFPKDQSISQALVNFISKCLQFPESDRISIQEMCANSLF
|| |...  ..|   | |.||.| ||| ...|. |. .         |.  |  |  .   ..|.  ..|  . ..|.| ||   ..|..|..      .
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 24896.AA Ciliate-E2c 18-272 30 1.9e-78 266.91 In-house 1-310 (310) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-310/310
Sequence Identity: 30% (95 aa)

FSLSACIGKGSSGTVYVG---RHQQTQQVV-------AIKAVDMRSL----KTEYAWK-MLCSEVKIMKKLKHPHVVRLLDVFQTKNNTYIITEFCNQGD
..     |.|| |.|| .     .|... .       |||     ..     .|   |  .  |. .||...|||...  | .||... |.|.|.||.|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LRTYLKKKKSLTEREAITVISQIMSGLQELANN-GIIHRDLKPANILIHDDVFKITDFGFAKKLDSMEDQ---LMDSLVGTPLYMAPQILNK-QQYTSKC
|  |...|  ..|.. ..  ||| |....|  . .|.|||.||.|||||... || ||||.|. .  ..|        .|||.|||||||.  ..||.| 
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQNTQGFNTCCGTPMYMAPQILEGKNYYTEKS

DVWSIGLILYELLFGRTPWP-----------------AVN-VVDLVQKMC---------------TVPLQFPKD--QSISQALVNFISKCLQFPESDRIS
|.|| |  ||. |. . ||                    | .. |.|                  | ...||..  |.||| .  .| | ||. |..||.
DIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKRID

IQEMCANSLF
  |   ....
WDEIFNHECI
Kinase 24896.AA Ciliate-E2a 18-227 32 1.3e-74 219.07 In-house 1-227 (275) Show / Hide 
Range on Protein: 18-227
Range on HMM: 1-227/275
Sequence Identity: 32% (74 aa)

FSLSACIGKGSSGTVYVGRHQQTQQVVAIKAVDMRSLKTEYAWKMLCSEVKIMKKLKHPHVVRLLDVFQTKNNTYIITEFCNQGDLRTYLKKKKSLTER-
...   ||||. | ||. .| || .  |.|... .   ...  . .  |..||..|.||.. .| .|....|| |...|.|. |.|  ..|..|...|  
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-EAITVISQIMS-GLQELANNGIIHRDLKPANILIH------D--DVFKITDFGFAKKLDSMEDQLMDSLVGTPLYMA------PQILNKQQYTSKCDVW
 |.  .. |. . ||. . ...|.|||||| |||.       .     || |||.|.. |. | . | . .||| |.|      ...|...||. |||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SIGLILYELLFGRTPWPAVNVVDLVQK
|.|.|.| ||.|..| .. .. . .|.
SCGVIFYILLCGKPPFKGKTYNEILQQ
Kinase 24896.AA Ciliate-E2-Unclassified 18-272 27 9e-73 248.08 In-house 1-352 (352) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-352/352
Sequence Identity: 27% (96 aa)

FSLSACIGKGSSGTVYVGRHQQTQQV------VAIKAVDMRSLKTEYAWKMLC----SEVK-------------IMKKLKHPHVVRLLDVFQTKNNTYII
. .  .||.|. |.||  .| ...|.        |. ..... ...   .|..     . |             |.. ..||..|.....||.|.| ||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEFCNQGDLRTYLKKKKS-----------------LTEREAI-----TVISQIMSGLQELANNG-IIHRDLKPANILIHDD----VFKITDFGFAKKLDS
.|.|..|||. |.||.|.                 .||..|.     . . || .||. |  .. |||||.|| |||....      ||.|||..||...
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

M--------------EDQLMDSLVGTPLYM----APQILNKQQYT----SKCDVWSIGLILYELLFGRTPWPAVNVVD----------------LVQKMC
.               .|.|.. .||| ||    || .| .|.|      |||.|| | ||||.|||. | .. |  .                | |. .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

TVPLQFPK-DQ-----SISQALVNFIS----KCLQFPESDRISIQEMCANSLF
  ..|||| ..      .|.   .||.    |.|.   . ||.... .   .|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 24896.AA MARK 18-265 32 6.5e-69 224.44 In-house 1-255 (262) Show / Hide 
Range on Protein: 18-265
Range on HMM: 1-255/262
Sequence Identity: 32% (84 aa)

FSLSACIGKGSSGTVYVGRHQQTQQVVAIKAVDMRSLKTEYAWKMLCSEVKIMKKLKHPHVVRLLDVFQ--TKNN-TYIITEFCNQGDLRTYLKKK--KS
. .  .||.|| ..|....|. |.. |||| ..  .|    . |....|..|||||.||....|..|..  |... .|.| | .  |.|. |.|..    
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

LTEREAITVISQIMSGLQELANNGIIHRDLKPANILIHDD---VFKITDFGFAKKLDSMEDQLMDSLVGTPLYMAPQILNKQQYT-SKCDVWSIGLILYE
|.|.|| .  .|| |... . ...|.|||.|| |||| ..     ||.||||. .   ...|. ..  ||| ||||.|..|. |.  | |.|| | .|| 
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICI--PPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYF

LLFGRTPWPAVN--VVDLVQKMCTVPLQFPKDQSISQALVNFISKCLQFPESDRISIQE
.. |. |. . .   ..| .|. .   ..|    .|  . |.|.. |... ..|..|.|
MVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEE
Kinase 24896.AA STE 18-272 22 1.1e-67 231.14 In-house 1-359 (359) Show / Hide 
Range on Protein: 18-272
Range on HMM: 1-359/359
Sequence Identity: 22% (82 aa)

FSLSACIGKGSSGTVYVGRHQ------QTQQV---------VAIKAVDMRSLKT--------------EYAWKMLCSEVKIMKKLK--HPHVVRLLDVFQ
. .  .||||..|||| ...       .|..|         .||| ..... ..              .  .. .  |.|||||..  ||..|. .. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TK-------NNTYIITEFCNQGDLRTYLKKK----KSLT----------EREAITVISQIMSG-LQELANNGIIHRDLKPANILIHDDVFKITDFGFAKK
 .       .. .|. |... | |.  .|.|    |.|.          | . .... ||  | |. | ...|||||.||||||.     |..|||....
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

LDS---------------MEDQLMDSLVGTPLYMAPQILNK------QQYTSKCDVWSIGLILYELLFGRTPWPAVNVVDLVQKMC--------------
|..                 .|  ...|||| .||| ....      ..|. |||.||.|. . |.. |. ||   .       .               
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--TVPLQFPKDQS-----------------ISQALVNFISKCLQFPESDRISIQEMCA--NSLF
    | ..| . |                  |. . .||.||||   ..| . ...     . .
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 24896.AA Pkinase_Tyr 18-227 30 3.4e-36 123.22 Pfam 1-227 (270) Show / Hide 
Range on Protein: 18-227
Range on HMM: 1-227/270
Sequence Identity: 30% (69 aa)

FSLSACIGKGSSGTVYVGRHQ----QTQQVVAIKAVDMRSLKTEYA--WKMLCSEVKIMKKL-KHPHVVRLLDVFQ-TKNN--TYIITEFCNQGDLRTYL
 ..   .|.|. |.|| |.      .|.. ||.| .  .   .. .  .... .|.||||.| .||..|||. |    .     ||..|..  |||..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KK----KKSLTEREAITVISQIMSGLQELANNGIIHRDLKPANILIH-DDVFKITDFGFAKKLDSMEDQLMDSLVGTPL---YMAPQILNKQQYTSKCDV
.|    |..||  . .    || .|.. |.....|||||   |.|.. . | ||.||| |. . . .   . .  |..|    |||  .|   .|.| ||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSIGLILYELLF-GRTP-WPAVNVVDLVQK
|| |  ..|..  |..| .| .   .....
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEY
Kinase 24896.AA TyrKc 18-271 23 1.6e-28 102.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 18-271
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

FSLSACIGKGSSGTVYVGRHQQTQQVVAIKAVDMRSLKTEYAWKMLCSEVKIMKKL--KHPHVVRLLDVFQTK-------NNTYIITEFCNQGDLRTYLK
 .|   .| |  |.|| |.     . ||.| .   .       .....| .||.||  .||..|||. |  ..          .|..|..  |||. ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KKKS-LTEREAITVISQIMSGLQELANNGIIHRDLKPANILIHDDV-FKITDFGFAKKLDSM------EDQLMDSL-VGTP--L---YMAPQILNKQQYT
|..  |. .. .    || .| . |. ...|||||   |.|....   ||.||| ......       .|  . .   |.   |    |||  .|.  .|
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

SKCDVWSIGLILYELL-FGRTPWPA-----VNVVDLVQKMCTV-PLQFPKDQS------ISQALVNFISKCLQFPESDRISIQEMCANSL
.| |||| |  ..|.. .| .|.|      ..  .....  .   .  |..         .... . ...| ..  .|| . .|     .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF