Gene 21913 (Tetrahymena)

21913

Species: Tetrahymena
Alias: 21913, 917, PreTt21913, 117.m00165, TTHERM_00726480
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
21913.AA Protein None 1240 None Fasta, JSON
21913.kin_dom Protein Kinase Domain None 216 None Fasta, JSON
21913.NA RNA None 3723 None Fasta, JSON

Protein domain

Protein domains of 21913.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 21913.AA ULK 29-247 32 2.7e-88 299.65 In-house 51-329 (329) Show / Hide 
Range on Protein: 29-247
Range on HMM: 51-329/329
Sequence Identity: 32% (92 aa)

QALLKKVLNEVKIFHSLN--------HPNIMRFYNWYETR--NHLWVIFEYCPGGDLQTLIEQDKK----------LPEQLVKSFSKDLAAGLQYLHSKG
| ... . ||.|| . |.        |||| ..| |.||   |... |.|||.||||...|...||          |.|| ...| |....|...||...
QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN

IIYCDLKPSNILLNEF------------GQLKICDFGLSRRII-D------MITAD-EGKETVKK---GSPCYMAPELFQDDG----VYSFQADFWALGC
|| .|.||.|||...             |.|||.|||... .  |      | |.  |      |   |.| ||||...|. |     |.. .| | |||
IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE------KRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGC

VMYELATGKPPFVSKSFQDLVDQILNQEVQK--VSG------------------FSNEFNDLIEKLLQKNPIKRITWDSLILHPFW
..||. .|||||..  |.|...||.......  ...                  .|.|. ||| ..||... .||.|. |. ||..
IFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 21913.AA ULK 31-247 32 2.9e-88 299.52 In-house 56-324 (324) Show / Hide 
Range on Protein: 31-247
Range on HMM: 56-324/324
Sequence Identity: 32% (89 aa)

LLKKVLNEVKIFHSLNHPN--IMRFYNWYETR--NHLWVIFEYCPGGDLQTLIEQDKK---------LPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPS
|||.. ...|....|.|||  | ..| |.||   |... |.|||.||||...|...||         |.|| ...| |....|...||...|| .|.||.
LLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQ

NILLNEF------------GQLKICDFGLSRRIID-MITADEGKETV----KKGSPCYMAPELFQDDG----VYSFQADFWALGCVMYELATGKPPFVSK
|||...             |.|||.|||... . . .  ..  ...|     ||.| ||||...|. |     |.. .| | |||..||. .||.||.| 
NILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW

SFQDLVDQ--------------ILNQEVQKV-----SGFSNEFNDLIEKLLQKNPIKRITWDSLILHPFW
 |.|....              | || .|.        .|.|. ||| ..||... .||.|. .. ||..
-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase 21913.AA AGC 32-247 22 2.2e-76 196.14 In-house 52-395 (395) Show / Hide 
Range on Protein: 32-247
Range on HMM: 52-395/395
Sequence Identity: 22% (77 aa)

LKKVLNE------------VKIFHSLN----------HPNIMR-FYNWYETRNH--LWVIFEYCP---------GG-DLQTLIE---QDKKLPEQLVKSF
......|             .|.  .|          ||.| .  .  ... .|  |  . ||.|         || .| . .    . ....|. .. .
VEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFY

SKD-------LAAGLQYLHS-KGIIYCD-LKPSNILLNEFGQLKICDFGLSRRIID--------------------------------------------
          .. .|.|||| .|||. | ||| ||||.| | .|..||||. ....                                            
AAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQE

---MITADEGKETVKKG--SPCYMAPELFQDDGVYSFQADFWA--LGCVMYELATGKPPFVSKS----------FQDLVDQIL------NQEVQKV----
    .  .. . .   |  .| ||||| .     |....| |.  |||.|||. ||.||| ...            .. ..|.      |..|.      
DDTTR-KKRDRTWTFCGPCTPEYMAPEIL-----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPED

------SGFSNEFNDLIEKLLQKNPIKRIT----------WDSLILHPFW
      . ||.|  |||.|||.|.| ||..           . .  ||. 
PQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 21913.AA S_TKc 16-247 31 1.2e-71 245.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-247
Range on HMM: 1-231/231
Sequence Identity: 31% (82 aa)

YFILTI-----FSTSVFSQALL-----------KKVLNEVKIFHSLNHPNIMRFYNWYETRNHLWVIFEYCPG--GDLQTLIEQDKK------LPEQLVK
| || .     |..    .              .....|..| .. .|||| ..| .... .||....|||.|  ||| ..|.. ..      .||  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

SFSKDLAAGLQYLHSKGIIYCDLKPSNILLNEFGQLKICDFGLSRRIIDMITADEGKETVKKGSPCYMAPELFQDDGVYSF-QADFWALGCVMYELATGK
.. . .. .|.|.||.|||..||||.||||.|  ..|||||||.|..           |   |.| |||||..     |..  .| |..||..||...|.
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGY

PPFVSKSFQDLVDQILNQEVQKVSGFSNEFNDLIEKLLQKNPIKRITWDSLIL-------HPFW
|||     | . ..|.          | |. |.|.|.|||.| ||.|   .         ||. 
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 21913.AA Pkinase 33-247 30 1e-70 246.05 Pfam 43-293 (293) Show / Hide 
Range on Protein: 33-247
Range on HMM: 43-293/293
Sequence Identity: 30% (77 aa)

KKVLN--EVKIFHSLNHPNIMRFYNWYETRNHLWVIFEYCPGG----DLQTLIE--QDKKL--PEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPSNILLN
.  ..  |..| ..|||||| |.| |.|...|.....|||.||    || ..|.  .....  .|. .|.. . .. ||.|.||.|||..||||.|||..
QTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID

EFGQL----KICDFGLSRRIIDMITADEGKETVKKGSPCYMAPELFQDDGVYSFQADFWALGCVMYELATGKPPFVSK------SFQDLVDQILNQEVQK
. |..    |||||||.. .    .   .  |.  |.| |||||. ...  |.  .| |..||..||...|.||| ..      . . ....|.  ..  
NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHF

VSGFS---------------------NEFNDLIEKLLQKNPIKRITWDSLILHPFW
 .  .                      |. |.|...|.|.| ||.|.. .  ||..
DWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 21913.AA Ciliate-E2 33-247 27 1.2e-67 231.0 In-house 78-365 (365) Show / Hide 
Range on Protein: 33-247
Range on HMM: 78-365/365
Sequence Identity: 27% (85 aa)

KKVLNEVKIFHSLNHPNIMRFYNWYE--TRNHLWVIFEYCPGGDLQTLIE------------QDKKLPEQLVKSFSKDLAA---------------GLQY
||  || .|  .||||||...| ...  ..|..  ..||| ||||. .|.            . |.. |. .| ..| ..                .|.|
KKI-NEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEY

LHSKG-IIYCDLKPSNILLNEFGQLKICDFGLSRRIID------------MITADEGKETVKKG----------------SPCYMAPELFQDDGV-----
||||. ||. |.||.|||.     .||.|||||... |            ...   .....  |                .| ||||| ..  .      
LHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

---YSFQADFWALGCVMYELATGKPPFVSKSFQDLVDQILNQEVQ------------------KVSGFSNEFNDLIEK----LLQKNPIKRIT-WDSLIL
   |....|.|.||...||. .|||||         .||......                  .    |.|  ||| |    .|||.| |||| |. .. 
QKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

HPFW
||. 
HPWF
Kinase 21913.AA CAMK 2-247 19 2.8e-65 209.01 In-house 35-425 (425) Show / Hide 
Range on Protein: 2-247
Range on HMM: 35-425/425
Sequence Identity: 19% (78 aa)

AVKSLEKSRRNKVN---------YFILTIFSTSVF-SQALLKKVLNEVKIFHS-------LNHPNIMRFYNWYE------------TRNH--------LW
|.| ..|..  . .          .. .  . .   ..  .|.|..|..|  .       |.|||| ..| .||            | ..        ..
AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMY

VIF---EYCPGG----DLQTLIEQD---------------KKLPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPSNILLNEF-----------------G
 ..   |||.||    ||   | .                ....|. .. . . .. ...|.||..|. .|||| ||||..                  .
MVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNN

QLKICDFGLSRRIID-----MITADEGKETV---------------KKGSPCYMA-PELFQD-------------DGVYSFQADFWALGCVMYELATGKP
..||.|||.......     |..  .|.| .                 |.|.||| ||...                 |....| |..|...| . .|.|
NIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP

PFVSK-------------SFQDLVDQILNQEVQ-KVSGFSN-----------------------EFNDLIEKLLQKNPIKRITWDSLILHPFW
|| ..             . ..|  .|.. . .   . ||.                       |  ||| |.||..| ||.| .    ||. 
PFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 21913.AA Ciliate-E2-Unclassified 31-247 25 2.8e-60 206.57 In-house 51-352 (352) Show / Hide 
Range on Protein: 31-247
Range on HMM: 51-352/352
Sequence Identity: 25% (77 aa)

LLKKVLNEVK-------------IFHSLNHPNIMRFYNWYETRNHLWVIFEYCPGGDLQTLIEQDKK-----------------LPEQLVK-----SFSK
. .| .|. |             |. ...||.|.... . ......  . |||.||||.  |.. ||                 ..|| .|      . .
NEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFA

DLAAGLQYLHSKG-IIYCDLKPSNILLNEFG---QLKICDFGLSRRIIDMITADEGK------------ETVKKGSPCYM----APELFQDDGVYS---F
 .  ||.|||.|. ||. |.||.|||... |   ..||.|||.|.......  | ..             . . |.|.||    |||..|  . .    .
QILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAY

QADFWALGCVMYELATGKPPFVSKSFQD----------------LVDQILNQEVQKVS--------GFSNEFNDLIE----KLLQKNPIKRITWDSLILH
..|.|.||...||. .|..|| ...  .                | ..|.....|. .        . |.|  |.|.    |.|.||| ||||.. .. |
KCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

PFW
|. 
PWF
Kinase 21913.AA CAMKL 29-247 29 8.6e-59 186.19 In-house 54-297 (297) Show / Hide 
Range on Protein: 29-247
Range on HMM: 54-297/297
Sequence Identity: 29% (74 aa)

QALLKKVLNEVKIFHSLN---HPNIMRFYNWYETRNH------LWVIFEYCPGGD--LQTLIEQD----KKLPEQLVKSFSKDLAAGLQYLHSKGIIYCD
.. . ..  |..|  .||   ||||...|  .||..|      .. . |||.||.  |.  |..     ...||   . . . . ....|.||.||.  |
ESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRD

LKPSNILLNEFG--QLKICDFGLSRRIIDMITADEGKETVKKGSPCYMAPELFQD--DGVYSFQADFWALGCVMYELATGKPPFVSKS-------FQDLV
.|| |||| | |  ..||.|||.|  ....|  .. | .   |||.|||||.||.  .  . ...| |..| ..| . .|. ||   .        . . 
IKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YL

DQILNQEVQKVS---GFSNEFNDLIEKLLQKNPIKRITWDSLILHPFW
  . ..   .       | .  ||| |.||.|| ||.| . .  ||. 
YWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 21913.AA STE 32-247 28 1e-54 188.13 In-house 72-359 (359) Show / Hide 
Range on Protein: 32-247
Range on HMM: 72-359/359
Sequence Identity: 28% (84 aa)

LKKVLNEVKIFHSLN--HPNIMRFYNWYET-------RNHLWVIFEYCPGGDLQTLIE---QDKK-----------LPEQLVKSFSKDLAAG-LQYLHSK
....|.|.|| . .|  |||| ..|  |.        ...||.. ||..|| |  .|.     .|           .||.... . ...  | |.||||.
MQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSH

GIIYCDLKPSNILLNEFGQLKICDFGLSRRIIDMIT------------ADEGKETVKKGSPCYMAPELFQD-----DGVYSFQADFWALGCVMYELATGK
.||  |.||.||||      |.||||.. ...| ..               .| .   |.| .||||  |      |. |....| | |||.. |.||||
HIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

PPFVS-KSFQ---------------DLVDQILNQEVQKVSG--------------------FSNEFNDLIEKLLQKNPIKRITWDSLIL--HPFW
||.   . ..               ... .|.|..  .                       .| ||.| |.| |||.| || | . |.   ||| 
PPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 21913.AA RSK 32-247 27 1.1e-53 184.73 In-house 44-278 (278) Show / Hide 
Range on Protein: 32-247
Range on HMM: 44-278/278
Sequence Identity: 27% (66 aa)

LKKVLNEVKIFHSLN-HPNIMRFYNWYETRNHLWVIFEYCPGGDLQTLIEQDKK---LPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPSNILLNE---F
.. .. |..|    . ||.| . .  ..|  .|. | |||.||.| | ... |    . |  ..     ..  ...||..|||. ||||.|||...    
TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNE

GQLKICDFGLSRRIIDMITADEGKETVKKGSPC----YMAPELFQ---DDGVYSFQADFWALGCVMYELATGKPPFVS---KSFQDLVDQILNQE--VQK
| .|..|||...           ... .  ..|    |||||.      .| .. ..| | ||..|||. ||.||| .   .. ... ..|.. .  .  
GHIKLTDFGFCKQF-------RCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTM

V--SGFSNEFNDLIEKLLQKNPIKRIT-----WDSLILHPFW
   .  |.|. ||| |.|...| ||..      . .  ||..
PNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 21913.AA PLK 33-247 35 1.2e-53 173.16 In-house 44-258 (258) Show / Hide 
Range on Protein: 33-247
Range on HMM: 44-258/258
Sequence Identity: 35% (79 aa)

KKVLNEVKIFHSLNHPNIMRFYNWYETRNHLWVIFEYCPGGDLQTLIEQD-KKLPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPSNILLNEFGQLKICD
.|. .|..|  .|.|||| .|..  | ...  .  |||....|. .. .  |.| |  |...   .. ||.|||...||  |||..|..||.  ..||.|
EKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEPEVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGD

FGLSRRIIDMITADEGKETVKKGSPCYMAPELF--QDDGVYSFQADFWALGCVMYELATGKPPFVSKSFQDLVDQILNQEVQKVSG--FSNEFNDLIEKL
|||. |   .   .| | |.  | | | |||       | .|...| |.|||.|| | .||||| .|. ..    | ...    .    | | .||| |.
FGLATR---LEYDGERKKTM-CGTPNYIAPEVLDGNKQG-HSYEVDCWSLGCIMYTLLIGKPPFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKM

LQKNPIKRITWDSLILHPFW
|..|| .|.| | .. ||| 
LNWNPDERPTIDQILQHPFF
Kinase 21913.AA Pkinase_Tyr 28-205 28 8.6e-30 101.53 Pfam 41-228 (270) Show / Hide 
Range on Protein: 28-205
Range on HMM: 41-228/270
Sequence Identity: 28% (54 aa)

SQAL--LKKVLNEVKIFHSL-NHPNIMRFYNWYE-TRNH--LWVIFEYCPGGDLQTLIEQ----DKKLPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPS
..    ... ..|.|| ..| .|||| |.|      . .  .....||.|.||| .   .    ...|. .   ... . |.|..||.||..|  ||   
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NILLNEFGQLKICDFGLSRRIIDMITADE-GKETVKKGSPCYMAPELFQDDGVYSFQADFWALGCVMYELAT-GKPP-FVSKSFQDLVDQI
|.|..| .. |||||||.| |  . .     | .  |     |||| ...   .. . | |. | .|.|. | |. | .   | ......|
NCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
TyrKc 21913.AA TyrKc 1-247 22 3.8e-16 38.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-247
Range on HMM: 1-280/280
Sequence Identity: 22% (69 aa)

M-----------------------AVKSLEKSRRNKVNYFILTIFSTSVFSQALLKKVLNEVKIFHSL--NHPNIMRFYNWYETR-------NHLWVIFE
                        |||.| ..                      ..  ..| .| ..|  .|||| |.|    .          |....|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME

YCPGGDLQTLIEQDKK-LPEQLVKSFSKDLAAGLQYLHSKGIIYCDLKPSNILLNEFGQLKICDFGLSRRI--I-------DMITADE---GK--ETVKK
|.|.|||.  .   .. |. .   ||. . |.| .|||||..|  ||   |.|..| .. ||.|||||| |          |.... |   ||    .. 
YMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR-

GSPCYMAPELFQDDGVYSFQADFWALGCVMYELAT-GKPPFVS-----KSFQDLVDQILNQ-EVQKVSG--------FSNEFNDLIEKLLQKNPIKRITW
     |||| . ..|..... | |. | .|.|. | |..|        .| |... .. .     .            . |  .....  . .| .| | 
----WMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF

DSLILHPFW
  .  | ..
SEI--HECF