Gene 20902 (Tetrahymena)

20902

Species: Tetrahymena
Alias: 3687.m00007, PreTt20902, 20902, 625, 31.m00204, TTHERM_00314920
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
20902.AA Protein None 538 None Fasta, JSON
20902.kin_dom Protein Kinase Domain None 255 None Fasta, JSON
20902.NA RNA None 1617 None Fasta, JSON

Protein domain

Protein domains of 20902.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20902.AA ULK 26-282 38 2.5e-133 449.24 In-house 1-324 (324) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-324/324
Sequence Identity: 38% (125 aa)

IYKDRILGKGTFG-YVFQGENTKN---KQIVAIKMVPLKEFKFKPEK-----IIPSLKNEIKNMQMLH---HKN--TVQLYDVIKTD--NNLYMVVEFCN
......||||.|| .|..|.| |.   .|.||.||...|... |. .     .. .|||||..|..|.   |.|  .|.|||. .|.  ||.|...|.||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

QGNLDKYIKQK----------NLSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDKT-------------VKIADFGFSKVVEAG-MDEPIITS
.|.|..|||..          .|||...|... ||..|||.|...||.|||.||.|||.|...             .|||||||.|.|. . |.. ....
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

FV------GTPLYMSPQILQ----KQNYS-SKTDIWSLGMIFYELIYTKRA---WEGKSYC----DLLDN-------ILKKPLQFP---EIPKVHQQTKQ
.|      ||||||.|||||    ...|. .|.||||||.||||..| |     |   ..     .|..|       | ..|.|||   ..||. ...|.
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

IIRRMLQQKEEDRISWEELFQFFSV
.|||||| .|.|||||||.|. . .
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase 20902.AA ULK 26-282 38 4.5e-131 441.74 In-house 1-329 (329) Show / Hide 
Range on Protein: 26-282
Range on HMM: 1-329/329
Sequence Identity: 38% (128 aa)

IYKDRILGKGTFGYVFQGENTKNK----QIVAIKMVPLKEFKFKP-----EKIIPSLKNEIKNMQMLH----HKN----TVQLYDVIKTD--NNLYMVVE
......||||.||.|..|.| |.|    ..||.||....... |.     . .. .||||||.|..|.    |||    .|.|||. .|.  ||.|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCNQGNLDKYIKQK-----------NLSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDK-------------TVKIADFGFSKVVEAG-MDEP
.||.|.|..|||..           .|||...|... ||..|||.|...||.|||.||.|||.|..             ..|||||||.|.|. . |.. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

IITSFV------GTPLYMSPQILQ----KQNYS-SKTDIWSLGMIFYELIYTKRA---WEGKSYC-----DLLDN-------ILKKPLQFP---EIPKVH
.....|      ||||||.|||||    ...|. .|.||||||.||||..| |     |   ..      .|..|       | |.|||||   ..|.. 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

QQTKQIIRRMLQQKEEDRISWEELFQFFSV
...|..|||||| .|.|||||||||. . .
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase 20902.AA Ciliate-E2c 26-277 34 1.9e-86 293.51 In-house 1-305 (310) Show / Hide 
Range on Protein: 26-277
Range on HMM: 1-305/310
Sequence Identity: 34% (106 aa)

IYKDRILGKGTFGYVFQG------ENTKNK----QIVAIKMVPLKEF--KFKPEKIIP-SLKNEIKNMQMLHHKNTVQLYDVIKTDNNLYMVVEFCNQGN
| .. |||.|..| |. .       | .|.    |. |||| .||..  .   ||.|  |...|| .|  . |.. .. || ..||...| . |.||.|.
IDRNNILGSGSYGKVYKAYYCEDYQNEINNVQMNQLFAIKMTCLKNKDIHMINEKDIKESIIREINMMKHMNHPHIIKFYDAKQTDKHIYLIMEYCNGGT

LDKYIKQK-NLSEEKCINIMFQIVEGFKCLNQN-NIVHRDLKPENILLHDKTVKIADFGFSKVVEAGMDEPIITS----FVGTPLYMSPQILQK-QNYSS
| .||. | ...|. |.    ||. .|| | .. || |||.||||||.|. ..||||||||| .  . .   .|.     .|||.||.||||   . | .
LEQYIYHKPKPNEKQCLYYFSQIISAFKYLHKEKNIFHRDIKPENILIHNGMIKIADFGFSKICQDDNIQ--NTQGFNTCCGTPMYMAPQILEGKNYYTE

KTDIWSLGMIFYELIYTKRAWE------------------GKSYCDLLDNIL---------------KKPLQFPEI--PKVHQQTKQIIRRMLQQKEEDR
| ||||||   |. .. |  ||                  . .   | ..|                .....|||    .. |..||.|..|||. ||.|
KSDIWSLGVTLYYMLCYKLPWESIQEYDSHNICNHCYPWWQNTMKHLKQHIWEYFNPQASAAGVSPITQNIHFPENYEQNISQEVKQLIHKMLQVDEEKR

ISWEELF
|.|.|.|
IDWDEIF
Kinase 20902.AA S_TKc 26-280 30 8.6e-79 268.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

IYKDRILGKGTFGYVFQGENTKNKQIVAIKMVPLKEFKFKPEKIIPSLKNEIKNMQMLHHKNTVQLYDVIKTDNNLYMVVEFCNQ--GNLDKYIKQKN--
  . |..|||.|| |... ..| ..|||||...             ....||. ... ||.| |.||||. . ..|||| |.|..  |.| .|||...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDKTVKIADFGFSKVVEAGMDEPIITSFVGTPLYMSPQILQKQNYSS-KTDIWSLGMI
     ..|  .  .| ||... . . ...|.||||||||||| . ..||.|||.....         |.|.||| ||.| .|    |.  | |.||.| |
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

FYELIYTKRAWEGKSYCDLLDNILKKPLQFPEIPKVHQQTKQIIRRMLQQKEEDRISWEELFQ---------FF
.||... .  ..   .  ....|.             .. |..||..||   |.|..  |..|         .|
LYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20902.AA Ciliate-E2 26-280 23 1.3e-77 264.13 In-house 1-365 (365) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-365/365
Sequence Identity: 23% (88 aa)

IYKDRILGKGTFGYVFQGENTKNKQI------------------VAIKMVPLKEFKFKPEKIIPSLKNEIK-------------NMQMLHHKNTVQLYDV
. . ...|.|.|| |..... |...                   |.||.. .| .| .  ..| . .....             ... | |.| ...|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IK--TDNNLYMVVEFCNQGNLDKYIKQK------------NLSEEKCINIMFQIVE---------------GFKCLNQNN-IVHRDLKPENILLHDKTVK
 .  .|||.|.| |.|..|.| .|||..            ...|.....|| ||..               ... | ..| |.|||.||||||.    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IADFGFSK-----------VVEAGMDEPII-------------------TSFVGTPLYMSPQILQKQN---------YSSKTDIWSLGMIFYELIYTKRA
|.|||.||            .....                         ...||| ||.|.||....         |. | ||||||.|.||... |. 
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

WEGKSYCDLLDNILKKPLQFP----------------EIPKVHQQTKQIIRR----MLQQKEEDRIS-WEELFQ--FF
.        ...|......||                .  |. |..|..|..    ||| ..| ||. ||....  .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 20902.AA Pkinase 26-280 28 6.3e-71 246.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

IYKDRILGKGTFGYVFQGENTKNKQIVAIKMVPLKEFKFKPEKIIPSLKNEIKNMQMLHHKNTVQLYDVIKTDNNLYMVVEFCNQG----NLDKYIK---
. . |..|.|.|| |... . .. .|||.| ..... | . ...   | .||. |..|.|.| |.|||.  .....||| |.|. |     |  ||.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QKNL--SEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLH-DKTV----KIADFGFSKVVEAGMDEPIITSFVGTPLYMSPQILQ-KQNYSSKTDIW
....  ||. |...| ||..| . . ...|.||||||||||.. . ..    ||.|||..|...     .  |.|.||| ||.| ...  | |..| |.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGMIFYELIYTKRAWEGK------SYCDLLDNILKKPLQFPEIPK-------------------VHQQTKQIIRRMLQQKEEDRISWEELFQF--F
|.| |.||..  .  . |.      .   ....|...|| |..  .                   ...  |..|...|... ..|...|...|   |
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 20902.AA CAMK 31-272 21 5e-68 218.06 In-house 1-415 (425) Show / Hide 
Range on Protein: 31-272
Range on HMM: 1-415/425
Sequence Identity: 21% (91 aa)

ILGKGTFGYVFQGENTKNK------------QIVAIKMVPLKEFKFK-----------------------PEKIIPSLKNEIKNMQM-------LHHKNT
.||.|.|| |. .......            | ||||... |  | |                        .|   ....||. |..       |.|.| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDVIK------------TDNN--------LYMVV---EFCNQG----NLDKYIKQK----------------NLSEEKCINIMFQIVEGFKCLNQNN
..||.|.             | ..        .|||    |.|  |     |  ||...                 ..|. .  .. ||... . . ..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPENILLHDK------------------TVKIADFGFSKVVEAGMDEP---------------------IITSFVGTPLYMS-PQILQKQN---
||||||||||||| |.                  ..||.||||..... | ..                        . |.||| ||. | .|...    
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

-----------YSSKTDIWSLGMIFYELIYTKRAWEGK-------------SYCDLLDNILKKPLQFPEIP----------------------KVHQQTK
           |. |.|.||.| | | .   .  ..|.             .. .|. .|.|   .||. .                      .| |. |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QIIRRMLQQKEEDRIS
. ||.|||   |.|..
DLIRKMLQVDPEKRMT
Kinase 20902.AA CAMKL 24-276 29 8.2e-61 192.74 In-house 1-291 (297) Show / Hide 
Range on Protein: 24-276
Range on HMM: 1-291/297
Sequence Identity: 29% (88 aa)

YKIYKDRILGKGTFGYVFQGENTKN-KQIVAIKMVPLKEFKFKPEKIIP----------SLKNEIKNMQMLH---HKNTVQLYDVIKTDNN------LYM
|.| |   ||||.|| |  ...... .. ||||..  |  . .| .              .. ||. |.||.   |.| ..||.|| |...      .|.
YRIGK--TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VVEFCNQGN--LDKYIKQKN-----LSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDKT---VKIADFGFSKVVEA--GMDEPIITSFVGTPL
| | |  |.  |  ||...      ..|. .  .  |||.. . . ...|||||.||||||| ..    .||.|||||   .     ..   . | |.| 
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YMSPQILQK--QNYS-SKTDIWSLGMIFYELIYTKRAWEGKSY-------CDLLDNILKKPLQFPEIP-KVHQQTKQIIRRMLQQKEEDRISWEEL
||.| |.|.  . |   |.||||.| | | ... .  ... .|         .| .. ..   .| |. .|  . ...||.||| . |.|.. ...
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI
Kinase 20902.AA STE 27-280 22 1.4e-59 204.26 In-house 1-359 (359) Show / Hide 
Range on Protein: 27-280
Range on HMM: 1-359/359
Sequence Identity: 22% (83 aa)

YKD-RILGKGTFGYVFQGENT------KNKQI---------VAIKMVPLKEF--------KFKPE------KIIPSLKNEIKNMQMLH--HKNTVQLYDV
... ...|||.|| |... |       |....         .||| ..|..         . . |      ... ....||| |. ..  |.| |. |. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

IKTD-------NNLYMVVEFCNQGNLDKYIK-----QKNLS----------EEKCINIMFQIVEG-FKCLNQNNIVHRDLKPENILLHDKTVKIADFGFS
   .       ..|... |... | ||. ||     .|.|.          |.  . | .||..|  . | ...|.|||.|| ||||    ||..|||..
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVC

KVVEAGMD--------------EPIITSFVGTPLYMSPQILQK------QNYSSKTDIWSLGMIFYELIYTKRAWEGKSYC----------------DLL
. ..  |.                  ..||||| .|.| ..|.      . |. | ||||||    |..  |  |   ..                 ..|
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

DNILK-KPLQFPEI-----------------PKVHQQTKQIIRRMLQQKEEDRISWEELFQ----FF
 .|.. .| ..|.                   |. .  |. |.. ||   ..| . ..| .    |.
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase 20902.AA Ciliate-E2-Unclassified 26-280 24 1.5e-59 204.13 In-house 1-352 (352) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-352/352
Sequence Identity: 24% (87 aa)

IYKDRILGKGTFGYVFQGENTKNKQIVAIKMVP-----LKEFKFKPEKIIPSLKNEIKNMQ----------------MLHHKNTVQLYDVIKTDNNLYMV
  . ...|.| || |.. .. |.||. |.|.        .  . . . .|   ..|..|..                .. | . | .... ....|.|.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

VEFCNQGNLDKYIKQ------------------KNLSEEKCI-----NIMFQIVEGF-KCLNQNNIVHRDLKPENILLHDK----TVKIADFGFSK----
 |.|..|.| .|||.                  | ..|....     ... ||..|. ..  .|||.|||.||||||....     .||.|||.||    
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

VVEAGMDE----------PIITSFVGTPLYM----SPQILQKQNYS----SKTDIWSLGMIFYELIYTKRAWEGKSYCD----------------LLDNI
 ..   ..           ....|.||| ||    .| .||.|||.     | ||||||.|.||... ..  ..... .                |..||
NNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

LKKPLQFPEIP------KVHQQTKQIIR----RMLQQKEEDRISWEELFQ--FF
..|..|||. |      ..... | .|.    .||. . . ||..|....  .|
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 20902.AA CAMK-Unique 26-220 21 2.1e-50 164.49 In-house 1-287 (363) Show / Hide 
Range on Protein: 26-220
Range on HMM: 1-287/363
Sequence Identity: 21% (63 aa)

IYKDRILGKGTFGYVFQGENTKNKQIVAIKMVPLKEFKFKPEKI---------------IPSLKNEIKNMQMLHHKNTVQLYDV----IKTDN-------
. . ||.|.|.|| |. . . ... . |.||| ..  . |  |.                 .||.|.  ..|. | | ..|||.      ...       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NLYMVVEFCNQGNLDKYIKQ---------------------KNLSE--EKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDK-------
        ..|.| |.|. | | ..| .                       .||     ..||.....  . . ...|||||||.|||..          
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------TVKIADFGFSKVVEAGMDEPIITSFVGTPLYMSP--------------QILQKQNYSSKT----DIWSLGMIFYELI
           .|..||| .. ..    .... ...|||.||.|              ...  | |...     |||||| | |...
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYML
Kinase 20902.AA NEK 24-282 28 9.2e-49 168.32 In-house 1-286 (286) Show / Hide 
Range on Protein: 24-282
Range on HMM: 1-286/286
Sequence Identity: 28% (85 aa)

YKIYKDRILGKGTFGYVFQGENTKNKQI-----VAIKMVPLKEFKFKPEKI--IPSLKNEIKNMQMLHHKNTVQLYDVIKTDN--NLYMVVEFCN-QGNL
|.| |   .|.| || |.  . ......     ...| . ... . |  .        ||..  ..|.| | |  || .  ..   |. | |.|.  |.|
YEIIK--KIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQN----NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDL

DKY---IKQK-----NLSEEKCINIMFQIVEGFKCLNQN-----NIVHRDLKPENILLHDK-----TVKIADFGFSKVVEAGMDEPIITS-FVGTPLYMS
..    ||..     ...||.  ....|.. . |.. ..     .|.|||.|| || | ..     .||| ||| ||| . ..|    .. .|||| |||
YQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTD--MAYTTQVGTPYYMS

PQILQKQNYSSKTDIWSLGMIFYELIYT--KRAWEGK--SYCDLLDNILKKPLQFPEIPKVH---QQTKQIIRRMLQQKEEDRISWEELFQFFSV
| ..| . |..| |||||| . ||.     |.. |..  .   |  .| |   |.| ||. .   |. ...|..|||   |.| | ......  .
PEVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 20902.AA Pkinase_Tyr 26-174 31 3e-27 92.91 Pfam 1-161 (270) Show / Hide 
Range on Protein: 26-174
Range on HMM: 1-161/270
Sequence Identity: 31% (51 aa)

IYKDRILGKGTFGYVFQGENT----KNKQIVAIKMVPLKEFKFKPEK-IIPSLKNEIKNMQML-HHKNTVQLYDVIK-TDNN--LYMVVEFCNQGNLDKY
| ... ||.| || |..|. .    ..|. ||.||.  || .  .|  .. .. .|.| |  | ||.| |.|| |.   .    .|.|.|..  |.|..|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IKQK-----NLSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLH-DKTVKIADFGFSKVV
 ...     .|. .  ... .|| .|   | ..|..||||   |.|.. ...|||.||| .. .
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase 20902.AA TyrKc 26-280 23 1.2e-19 72.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-280
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

IYKDRILGKGTFGYVFQGENTKNKQIVAIKMVPLKEFKFKPEKIIPSLKNEIKNMQML--HHKNTVQLYDVIKTD-------NNLYMVVEFCNQGNLDKY
| ....|| | || |..|. .   . ||.||.            .  . .|.. | .|  ||.| |.|| |. ..         |..|.|..  |.|..|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKQKN--LSEEKCINIMFQIVEGFKCLNQNNIVHRDLKPENILLHDKT-VKIADFGFSKVVEAG----MDEPIITSFV--GTP--L---YMSPQILQKQN
.. .   |. .. .....|| .|   | ..|..||||   |.|....  |||.||| |. .. .      .  ...    |.   |    |.|  ...  
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSSKTDIWSLGMIFYELI-YTKRAWEG-----KSYCDLLDNILKK-PLQFPEI------PKVHQQTKQIIRRMLQQKEEDRISWEELFQFF
...|.|.|| |   .|.  | .  ..|     .|  ... .. .   .  |.       .  ..   ||...  . . ||| . .|. ..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF